Clinical trials: Speech Impairment
Stroke, Brain Injuries
Brain Mechanisms Underlying Reading Improvement in Central Alexia
Central alexia is a common reading disorder caused by stroke. Patients with central alexia (CA) are slow to read and make frequent errors, and have additional problems with their spoken language. This study has 3 aims: 1.
- Conditions
- Stroke, Brain Injuries, Aphasia
- Trial name
- NCT02062619
- Testing
- Computer-based behavioural word reading therapy, Real tDCS
- Where
- United Kingdom
- Volunteers
- 23 people
- Sponsor
- University College, London
Mild Cognitive Impairment, Primary Progressive Aphasia
Home-based tDCS in Frontotemporal Dementia or Alzheimer's Disease
The primary objective of this research is to evaluate the effects of non-invasive brain stimulation and computerized cognitive training on executive functioning in individuals with Primary Progressive Aphasia (PPA), mild…
- Conditions
- Mild Cognitive Impairment, Primary Progressive Aphasia, Dementia
- Trial name
- NCT05978804
- Testing
- Computerized Cognitive Training, Active tDCS (tDCS) on DLPFC
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Johns Hopkins University
Hearing Loss
AM-111 in the Treatment of Acute Inner Ear Hearing Loss
The purpose of this research study is to test the effectiveness and safety of the study drug, AM-111. AM-111 is tested for the treatment of sudden sensorineural hearing loss where the cause is unknown.
- Trial name
- HEALOS (NCT02561091)
- Testing
- AM-111 0.4 mg/ml, AM-111 0.8 mg/ml
- Where
- Bulgaria
- Volunteers
- 256 people
- Sponsor
- Auris Medical AG
Hearing-Impairment
Telephone vs. Voice Over IP Speech Comprehension in Hearing Aided Subjects.
Despite modern hearing aids such as cochlear implants, speech comprehension during telephone conversation is challenging for hearing-impaired patients.
- Trial name
- NCT03005912
- Testing
- Conventional acoustic telephony, Conventional bluetooth telephony, VoIP acoustic telephony
- Where
- Switzerland
- Volunteers
- 10 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Stroke, Aphasia
Efficacy of START (Startle Rehabilitation Therapy) in the Treatment Stroke-induced Aphasia/Apraxia
A stratified, parallel-group, double-blind, randomized controlled trial of remotely delivered START treatment to individuals with severe-to-moderate stroke (with recruitment focused on individuals with low SES) will be conducted.
- Conditions
- Stroke, Aphasia, Apraxia of Speech
- Trial name
- START (NCT04816799)
- Testing
- Startle Adjuvant Rehabilitation Therapy (START)
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Arizona State University
Aphasia
Rhythm-based Intervention in Aphasia
Every year, approximately 100,000 people are diagnosed with aphasia-a language disorder leading to substantial difficulties in their daily communication.
- Trial name
- NCT04581564
- Testing
- Rhythm-based speech therapy app (i.e., Speech Hero), Non-rhythm based (singing) application (conventional speech therapy)
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- The University of Texas at Dallas
Childhood Apraxia of Speech
Motor-based Intervention for Childhood Apraxia of Speech: DTTC-Connect
Childhood apraxia of speech (CAS) is a complex motor speech disorder that significantly limits a child's ability to communicate in daily activities, with difficulties often persisting into adolescence and adulthood.
- Trial name
- NCT07526246
- Testing
- Dynamic Temporal and Tactile Cueing - Connect (DTTC-Connect)
- Where
- 2 sites in United States
- Volunteers
- 68 people
- Sponsor
- New York University
Primary Progressive Aphasia
HDtDCS in Logopenic Variant PPA: Effects on Language and Neural Mechanisms
This study aims to evaluate the effectiveness of a therapy called High-Definition Transcranial Direct Current Stimulation (HD-tDCS) for the treatment of the language deficits experienced by people with a type of Primary…
- Trial name
- NCT03805659
- Testing
- HD-tDCS
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Medical College of Wisconsin
Brain Injury, Vascular, Aphasia
Treatment of Grammatical Time Marking in Post-Stroke Aphasia
The study aims to assess an individual or self-administered computer therapy's effectiveness in grammatical time marking. The main objective is to examine whether the therapy improves grammatical time marking of inflected verbs…
- Conditions
- Brain Injury, Vascular, Aphasia, Stroke
- Trial name
- NCT05656638
- Testing
- Speech and language therapy
- Where
- Switzerland
- Volunteers
- 6 people
- Sponsor
- University of Neuchatel
Aphasia, Malignant Brain Tumor
Listen Aphasia Pilot Study
This is a feasibility and pilot study to refine and test LISTEN, an AI-based augmentative and alternative communication (AAC) smartphone app, integrated into the patient's personal electronic device, to augment and facilitate…
- Trial name
- LISTEN (NCT07732140)
- Testing
- LISTEN (AI-based AAC smartphone app)
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Dana-Farber Cancer Institute
Aphasia, Broca
Effects of MTS-r on Speech Production in Non-fluent Aphasia Post-ischemic Stroke Patients
Aphasia is one of the most disabling complications in language production in patients with left hemisphere stroke. About 19% of patients who experience aphasia may have a spontaneously recovery after several weeks or months.
- Trial name
- Aphasia-ACV (NCT02241213)
- Testing
- Transcranial Magnetic Stimulation (TMS-r)
- Where
- Colombia
- Volunteers
- 100 people
- Sponsor
- Fundación Cardiovascular de Colombia
Aphasia
Modulating Intensity and Dosage of Aphasia Scripts
The purpose of this study is to evaluate how changing conditions of speech-language treatment (namely, amount of repetition and distribution of practice schedule) affects the language outcome of participants with aphasia…
- Trial name
- MIDAS (NCT04138940)
- Testing
- Script Training
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- Shirley Ryan AbilityLab
Primary Progressive Nonfluent Aphasia
Transcranial Magnetic Stimulation in Nonfluent/Agrammatic Variant Primary Progressive Aphasia
Nonfluent/agrammatic variant primary progressive aphasia (nf/avPPA) is a fatal neurodegenerative disease that begins with isolated language deficits. There is currently no cure or treatment for this disease.
- Trial name
- NCT03153540
- Testing
- Active iTBS
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- University of British Columbia
Oculopharyngeal Muscular Dystrophy
Screening in Oculopharyngeal Muscular Dystrophy
Oculopharyngeal muscular dystrophy (OPMD) is a rare myopathic disease that results in progressive degeneration of the oral and pharyngeal muscular, resulting in severe dysphagia and dysarthria.
- Trial name
- NCT02877784
- Testing
- Videofluoroscopic swallowing study, Functional Oral Intake Scale, Eating Assessment Tool-10
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Florida
Aphasia
Learning to Communicate Successfully Approach for Urdu Speaking Patients With Chronic Aphasia
This study aims to develop and validate the Learning to Communicate Successfully Approach (LCSA), a culturally sensitive communication intervention manual for Urdu-speaking adults with chronic aphasia.
- Trial name
- LCSA (NCT07889778)
- Testing
- Learning to Communicate Successfully Approach (LCSA)
- Where
- 2 sites in Pakistan
- Volunteers
- 30 people
- Sponsor
- University of Lahore
Aphasia, Acquired, Stroke, Acute
Neolexon® Aphasia-App in Acute Aphasia After Stroke
Up to now there is proven evidence of traditional logopedic therapy in aphasia, but recent computer-based algorithms also showed their evidence so far.
- Trial name
- Lexi (NCT04080817)
- Testing
- Neolexon, Speech therapy, Self training
- Where
- Germany
- Volunteers
- 70 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Aphasia
TMS in Aphasia Recovery
Stroke often causes substantial problems in speaking or understanding speech. Treatments for these problems are currently very limited.
- Trial name
- NCT04777214
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Pennsylvania
Stuttering, Fluency Disorders
Enhancing Speech Fluency With Non-invasive Brain Stimulation in Developmental Stuttering
This study aims to test whether the addition of transcranial direct current stimulation (TDCS) to speech fluency training results in improvements in speech fluency in adults with developmental stuttering.
- Conditions
- Stuttering, Fluency Disorders, Speech Disorders
- Trial name
- NCT02288598
- Testing
- Anodal TDCS, Fluency Training
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Oxford
Aphasia
Speeded Anomia Treatment in Chronic Post-stroke Aphasia
The main aim of the study is to investigate the effect of a novel, speeded anomia therapy (Conroy et al., 2018) in a large population of patients with chronic post-stroke aphasia.
- Trial name
- NCT05512884
- Testing
- Speeded anomia therapy
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- University of Cambridge
Stuttering, Stuttering, Childhood
Speech Processing in Stuttering
This research is being done to better understand stuttering, specifically how people who stutter may process and/or produce speech.
- Conditions
- Stuttering, Stuttering, Childhood, Stuttering, Adult
- Trial name
- NCT04929184
- Testing
- Speech and non-speech tasks
- Where
- 2 sites in United States
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- University of Michigan