StutteringNCT04929184
Speech Processing in Stuttering
A study testing Speech and non-speech tasks in people with Stuttering and Stuttering, Childhood, run by University of Michigan at 2 sites in United States.
Trial summary
This research is being done to better understand stuttering, specifically how people who stutter may process and/or produce speech. Eligible participants enrolled will complete a variety of computer and speech-based tasks on up to 2 visits. Read more about this study
- Who is it for?
- Ages 6 to 65 yearsHealthy volunteers can take part
- Conditions the study is for
- Stuttering, Stuttering, Childhood, Stuttering, Adult
- What is being tested?
- Speech and non-speech tasks
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 145 participants
- Where
- 2 sitesUnited States
- Study dates
- 4 Apr 2022to 16 Jun 2025
- Phase
- Interventional
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 6 to 65 years
- All sexes
- Healthy volunteers accepted
- Child, Adult, Older adult
Who may be able to join
- 18-65 years old
- English as primary language
- Normal speech, language, hearing, cognition
- Aged 18-65 years
- English as primary language
- Normal speech, language, hearing, cognition (other than stuttering)
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- Currently stutters
- Aged 6 to 17 years
- English as primary language
- Normal speech, language, hearing, cognition
- Aged 6 to 17 years
- English as primary language
- Normal speech, language, hearing, cognition (other than stuttering)
- Currently stutters
Who cannot join
- Personal or family history of stuttering
- Major medical or psychiatric illness
- Speech therapy within the past year
- Major medical or psychiatric illness
- Personal or family history of stuttering
- Major medical or psychiatric illness
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- Language/motor delay
- Major medical or psychiatric illness
- Language/motor delay
Trial locations and contacts
2 sites in 1 country.
United States2 sites
University of Michigan
Ann Arbor, Michigan, 48109
Michigan State University
East Lansing, Michigan, 48824
About this study
This research is being done to better understand stuttering, specifically how people who stutter may process and/or produce speech. Eligible participants enrolled will complete a variety of computer and speech-based tasks on up to 2 visits.
Read the detailed description
The study team will update the record to include the secondary identification number once the NIH has released the funds.
- Conditions
- Stuttering, Stuttering, Childhood, Stuttering, Adult
- Being tested
- Speech and non-speech tasks
- Keywords
- Healthy children, Healthy Adults
- Medical subject headings
- Stuttering
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Speech and non-speech tasksBehavioural
Participants will complete speech tasks such as listening to and/or producing speech and non-speech sounds.
| Study group | Role | What they receive |
|---|---|---|
| Adults who stutter (AWS) | Experimental | Participants will have 2 visits. Receives: Behavioral: Speech and non-speech tasks |
| Healthy Adults | Other | Participants will have 2 visits. Receives: Behavioral: Speech and non-speech tasks |
| Children who Stutter | Experimental | Participants will have 1 visit. Receives: Behavioral: Speech and non-speech tasks |
| Healthy Children | Other | Participants will have 1 visit. Receives: Behavioral: Speech and non-speech tasks |
What is being measured
The primary outcome is the main question the study is designed to answer.
Phase Locking Value (PLV) - Session 1 Speech Tasks
Participants will hear a series of single syllables spoken rhythmically and will be instructed to whisper the syllable "tah" repeatedly while the recording is playing.
The degree of synchronization (how well the participant's whispered syllables match the cadence of the recorded syllables they are listening to) will be measured by computing the PLV between subject's produced speech and the heard speech. The PLV is a vector with a value between 0 and 1 that reflects the phase difference between two signals, where 0 is a complete mis-match and a 1 is a perfect match. Adults were not instructed to attempt to match the cadence (Implicit task). Child participants were instructed to attempt to match the cadence (Explicit task).
Measured: Session 1 (up to 4 hours)
Phase Locking Value (PLV) - Session 2 Speech Tasks
Adult participants will hear a series of single syllables spoken rhythmically and will be instructed to whisper the syllable "tah" repeatedly while the recording is playing. Child participants did not attend Session 2.
The degree of synchronization (how well the participant's whispered syllables match the cadence of the recorded syllables they are listening to) will be measured by computing the PLV between subject's produced speech and the heard speech. The PLV is a vector with a value between 0 and 1 that reflects the phase difference between two signals, where 0 is a complete mis-match and a 1 is a perfect match. Adults completed this task twice. For the first test, they were not instructed to attempt to match the cadence (Implicit task). For the second test, they were instructed to attempt to match the cadence (Explicit task).
Measured: Session 2 (up to 4 hours)
Secondary outcomes (1)
R Statistic (Resultant Vector Length)
In tapping synchronization (sensorimotor synchronization) research, the R statistic generally refers to the resultant vector length derived from circular statistics, used to quantify the consistency and stability of a participant's tapping relative to a rhythmic stimulus. It ranges from 0 to 1. 0=Complete inconsistency (taps are uniformly distributed). 1=Perfect consistency (all taps occur at the exact same relative phase).
Measured: Session 1 (up to 4 hours)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted18 Jun 2021
- Study start4 Apr 2022
- Primary completion16 Jun 2025
- Study completion16 Jun 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Posted resultsParticipant flow, outcome measures and adverse events reported by the sponsor.
- Other trials for StutteringStudies of the same condition, open and under way.
- More trials run by University of MichiganThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Non-randomised
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 145 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Michigan
- Sponsor type
- University, hospital or other
- Collaborators
- National Institute on Deafness and Other Communication Disorders (NIDCD)
- Responsible party
- Principal investigator, Emily O'Dell Garnett, University of Michigan
- Investigators
- Emily Garnett, PhD, Principal investigator, University of Michigan
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT04929184
- Sponsor's protocol ID
- HUM00194953
- Other IDs
- 1R21DC019429-01
- Status last verified
- Jul 2026
- First submitted
- 10 Jun 2021
- Last updated
- 16 Jul 2026
- Results posted
- Yes, on ClinicalTrials.gov
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No