Stuttering, ChildhoodNCT05286151
Network Connectivity and Temporal Processing in Adolescents Who Stutter
A study testing Rhythm discrimination in people with Stuttering, Childhood and Stuttering, run by University of Michigan at 1 site in United States.
Trial summary
The specific purpose of this clinical trial is to compare performance on rhythm perception and production tasks between children who stutter and children who do not stutter. The overall project also aims to investigate how performance on rhythm tasks may be related to brain activity (non-clinical trial). Read more about this study
- Who is it for?
- Ages 9 to 13 yearsHealthy volunteers can take part
- Conditions the study is for
- Stuttering, Childhood, Stuttering
- What is being tested?
- Rhythm discrimination
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 500 participants
- Where
- 1 siteUnited States
- Study dates
- 23 Jul 2022to 31 Jan 2028
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 9 to 13 years
- All sexes
- Healthy volunteers accepted
- Child
Who may be able to join
- English as primary language
- Current or past stuttering diagnosis
- English as primary language
Who cannot join
- Diagnosed/under treatment for any neurological or psychiatric conditions
- Head trauma with loss of consciousness
- Major medical illness
- Hearing loss- Language/motor delay (below -2 standard deviations on standardized assessments)
- Face, motor, or reflex abnormalities
- Personal or family history of stuttering
Show all 12Show fewer
- Diagnosed/under treatment for any neurological or psychiatric conditions
- Head trauma with loss of consciousness
- Major medical illness
- Hearing loss
- Language/motor delay (below -2 standard deviations on standardized assessments
- Face, motor, or reflex abnormalities
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United States1 site, 1 recruiting
- Recruiting
University of Michigan
Ann Arbor, Michigan, 48109
Soo-Eun Chang, PhD, 734-232-0300, sooeunc@umich.edu
Soo-Eun Chang, PhD
About this study
Official title: Subcortical Network Connectivity and Temporal Processing in Children With Persistent and Recovered Stuttering
The specific purpose of this clinical trial is to compare performance on rhythm perception and production tasks between children who stutter and children who do not stutter. The overall project also aims to investigate how performance on rhythm tasks may be related to brain activity (non-clinical trial).
Read the detailed description
Participants in the clinical trial portion of this study will complete rhythm discrimination and finger tapping experiments once a year for 3 years. The study team will compare performance between groups. Participants will also participate in the non-trial portion of the project that includes having magnetic resonance imaging (MRI) each year for 3 years.
- Conditions
- Stuttering, Childhood, Stuttering
- Being tested
- Rhythm discrimination
- Keywords
- Rhythm, Temporal processing, Healthy children, Speech disorders, Timing
- Medical subject headings
- Stuttering, Speech Disorders
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Rhythm discriminationBehavioural
Participants will complete a rhythm discrimination task once per year for 3 years.
| Study group | Role | What they receive |
|---|---|---|
| Children who stutter | Experimental | Children who stutter Receives: Behavioral: Rhythm discrimination |
| Children who do not stutter | Experimental | Children who do not stutter Receives: Behavioral: Rhythm discrimination |
What is being measured
The primary outcome is the main question the study is designed to answer.
Rhythm discrimination (d')
Performance on the rhythm discrimination task will be assessed using a signal detection analysis to distinguish between participants' ability to discriminate same and different rhythms from any general tendency to respond same or different. Hit rates (HRs) and false alarm rates (FARs) will be obtained to calculate d' (a measure of sensitivity; determined by z(HR) - z(FAR)).
Measured: Year 1
Rhythm discrimination (d')
Performance on the rhythm discrimination task will be assessed using a signal detection analysis to distinguish between participants' ability to discriminate same and different rhythms from any general tendency to respond same or different. Hit rates (HRs) and false alarm rates (FARs) will be obtained to calculate d' (a measure of sensitivity; determined by z(HR) - z(FAR)).
Measured: Year 2
Rhythm discrimination (d')
Performance on the rhythm discrimination task will be assessed using a signal detection analysis to distinguish between participants' ability to discriminate same and different rhythms from any general tendency to respond same or different. Hit rates (HRs) and false alarm rates (FARs) will be obtained to calculate d' (a measure of sensitivity; determined by z(HR) - z(FAR)).
Measured: Year 3
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted18 Mar 2022
- Study start23 Jul 2022
- Primary completion31 Jan 2028 (estimated)
- Study completion31 Jan 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Stuttering, ChildhoodStudies of the same condition, open and under way.
- More trials run by University of MichiganThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 500 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of Michigan
- Sponsor type
- University, hospital or other
- Collaborators
- National Institute on Deafness and Other Communication Disorders (NIDCD)
- Responsible party
- Principal investigator, Soo-Eun Chang, University of Michigan
- Investigators
- Soo-Eun Chang, PhD, Principal investigator, University of Michigan
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05286151
- Sponsor's protocol ID
- HUM00196133
- Other IDs
- 2R01DC011277
- Status last verified
- Oct 2026
- First submitted
- 9 Mar 2022
- Last updated
- 15 Oct 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 15 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Subcortical Network Connectivity and Temporal Processing in Children With Persistent and Recovered Stuttering
- ClinicalTrials.gov ID
- NCT05286151
- Acronym / sponsor ID
- HUM00196133
- Conditions
- Stuttering, Childhood, Stuttering
- Keywords
- Rhythm, Temporal processing, Healthy children, Speech disorders, Timing
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 500 participants (estimated)
- Lead sponsor
- University of MichiganUniversity, hospital or other
- Collaborators
- National Institute on Deafness and Other Communication Disorders (NIDCD)
- Study start
- 23 Jul 2022 (actual)
- Primary completion
- 31 Jan 2028 (estimated)
- Study completion
- 31 Jan 2028 (estimated)
- First posted
- 18 Mar 2022 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The specific purpose of this clinical trial is to compare performance on rhythm perception and production tasks between children who stutter and children who do not stutter. The overall project also aims to investigate how performance on rhythm tasks may be related to brain activity (non-clinical trial).
Detailed description
Participants in the clinical trial portion of this study will complete rhythm discrimination and finger tapping experiments once a year for 3 years. The study team will compare performance between groups. Participants will also participate in the non-trial portion of the project that includes having magnetic resonance imaging (MRI) each year for 3 years.
Study design
- Primary purpose
- Basic science
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Children who stutter | Experimental | Behavioral: Rhythm discriminationChildren who stutter |
| Children who do not stutter | Experimental | Behavioral: Rhythm discriminationChildren who do not stutter |
Who may qualify
- Ages
- 9 to 13 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Child
Key inclusion criteria (3 listed)
- English as primary language
- Current or past stuttering diagnosis
- English as primary language
Key exclusion criteria (12 listed)
- Diagnosed/under treatment for any neurological or psychiatric conditions
- Head trauma with loss of consciousness
- Major medical illness
- Hearing loss- Language/motor delay (below -2 standard deviations on standardized assessments)
- Face, motor, or reflex abnormalities
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Rhythm discriminationParticipants will complete a rhythm discrimination task once per year for 3 years. | Behavioural | Children who do not stutter, Children who stutter |
Primary outcome
Rhythm discrimination (d')
Time frame: Year 1
Performance on the rhythm discrimination task will be assessed using a signal detection analysis to distinguish between participants' ability to discriminate same and different rhythms from any general tendency to respond same or different. Hit rates (HRs) and false alarm rates (FARs) will be obtained to calculate d' (a measure of sensitivity; determined by z(HR) - z(FAR)).
Rhythm discrimination (d')
Time frame: Year 2
Performance on the rhythm discrimination task will be assessed using a signal detection analysis to distinguish between participants' ability to discriminate same and different rhythms from any general tendency to respond same or different. Hit rates (HRs) and false alarm rates (FARs) will be obtained to calculate d' (a measure of sensitivity; determined by z(HR) - z(FAR)).
Rhythm discrimination (d')
Time frame: Year 3
Performance on the rhythm discrimination task will be assessed using a signal detection analysis to distinguish between participants' ability to discriminate same and different rhythms from any general tendency to respond same or different. Hit rates (HRs) and false alarm rates (FARs) will be obtained to calculate d' (a measure of sensitivity; determined by z(HR) - z(FAR)).
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 15 Oct 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Soo-Eun Chang, PhD principal investigator
University of Michigan
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Rhythm discrimination in people with Stuttering, Childhood and Stuttering, run by University of Michigan at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 12 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 15 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Soo-Eun Chang, PhD (734-232-0300, sooeunc@umich.edu), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Rhythm discrimination (d') (time frame: Year 1). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 15 Oct 2026.