Clinical trials: Peri-Implantation Loss
Platelet-rich Fibrin, Simvastatin
Effect of Local Application of Platelet-rich Fibrin Scaffold Loaded With Simvastatin on Peri-implant Bone Changes
ACKGROUND: Simvastatin (SIM), a pharmacological drug used for hypercholesterolemia, has been found to have pleotropic effects on bones. Simvastatin together with the appropriate carrier may decrease bone loss around implants.
- Trial name
- NCT05008068
- Testing
- Simvastatin
- Where
- Egypt
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- British University In Egypt
Tooth Loss, Surface Treatment
Effect of Different Loading Protocols on Photofunctionalized Implants in the Posterior Maxilla
This randomized clinical trial evaluates different loading protocols for UV-photofunctionalized dental implants in the posterior maxilla. Clinical and radiographic outcomes will be assessed during follow
- Conditions
- Tooth Loss, Surface Treatment, Immediate Dental Implant Loading, Implant Loading
- Trial name
- PHOTOLOAD (NCT07700914)
- Testing
- Immediate loading of UV-photofunctionalized dental implants, Early loading of UV-photofunctionalized dental implants, Conventional loading of UV-photofunctionalized dental implants
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mansoura University
Dental Implant, Soft Tissue
Effect of Bone-related and Soft-tissue-related Variables on the Marginal Bone Loss of Platform-matched and Platform Switched Dental Implants
In this clinical trial the effect of the implant-abutment morphology (platform-switched vs platform matched) will be assessed in both soft tissue (soft tissue thickness) and hard tissue (marginal bone loss) outcomes.
- Conditions
- Dental Implant, Soft Tissue, Partial-edentulism, Bone Loss
- Trial name
- NCT05670340
- Testing
- Switched Prosthetic Profile, Matched Prosthetic Profile
- Where
- Spain
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Salamanca
Sensitivity, Peri-implant Mucositis
Sensitivity and Specificity of Peri-Implantitis-Related Parameters
Bleeding on probing demonstrated to have high specificity with certain level of sensitivity to detect periodontal disease. Again, understanding the weak hemidesmosome attachment to the implant surface is imperative to discern on…
- Conditions
- Sensitivity, Peri-implant Mucositis, Peri-Implantational Loss, Peri-Implantitis
- Trial name
- NCT03031392
- Testing
- Sensitivity test
- Where
- Spain
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- Center of Implantology, Oral and Maxillofacial Surgery, Badajoz, Spain
Partially Edentulous Patients, Implant Stability
Comparative Clinical Study of Implant Stability and Peri-implant Bone Loss in Two Implant Designs
This clinical study was conducted to evaluate the effect of different dental implant designs on implant stability and peri-implant bone levels during the early healing phase.
- Conditions
- Partially Edentulous Patients, Implant Stability, Peri-implant Marginal Bone Loss
- Trial name
- NCT07557836
- Testing
- Double-threaded straight-body dental implant, Triple-threaded conical-body dental implant
- Where
- India
- Volunteers
- 30 people
- Sponsor
- Career Postgraduate Institute of Dental Science and Hospital Lucknow
Peri-Implantitis and Peri-implant Mucositis, Peri-implant Mucositis
Salivary Minerals in Patients With Peri-implantitis
Patients included in the study will be recruited after arriving at the Faculty of Dentistry of the University of Zagreb. During the clinical examination, the patient's periodontal status (bleeding during probing, and the depth of…
- Conditions
- Peri-Implantitis and Peri-implant Mucositis, Peri-implant Mucositis, Periimplant Bone Loss, Periimplant Diseases
- Trial name
- mineral-perio (NCT05897736)
- Volunteers
- 25 people
- Sponsor
- University of Zagreb
Edentulism, Dental Implantation, Endosseous
Subcrestal vs Juxtacrestal PRAMA Implants With Variable Necks
The goal of this clinical trial is to understand how different implant neck designs and placement depths affect the surrounding bone and peri-implant tissue (the tissue around a dental implant) in adults who need implants in the…
- Conditions
- Edentulism, Dental Implantation, Endosseous, Marginal Bone Loss, Periimplant Bone Loss
- Trial name
- NCT07107464
- Testing
- Short Neck Implant - Crestal Placement, Standard Neck Implant - 1 mm Subcrestal Placement, Long Neck Implant - 2 mm Subcrestal Placement
- Where
- Cuba
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- ARDEC Academy
Edentulous Jaw, Tooth Loss
Primary Stability and Peri-implant Outcomes of Short Implants in Post-extraction Single-tooth Sites
The placement of short implants in post-extraction sockets is a valuable option when residual bone height is limited, minimizing morbidity and treatment time.
- Conditions
- Edentulous Jaw, Tooth Loss, Toothless Mouth
- Trial name
- NCT07177521
- Testing
- Insertion of implants in post-extraction tooth
- Where
- Italy
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Bari Aldo Moro
Cochlear Implants, Cochlear Implantation
Investigation of a Device to Deliver Intra-Operative Therapeutic Hypothermia for Hearing Preservation in Cochlear Implantation
The goal of this interventional clinical study is to investigate the use of mild therapeutic hypothermia for preservation of residual hearing in cochlear implant surgery. The main questions the trial aims to answer are: 1.
- Conditions
- Cochlear Implants, Cochlear Implantation, Hearing Loss
- Trial name
- NCT06375278
- Testing
- Intra-Ear Canal Cooling Catheter
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Restorear Devices LLC
Bone Loss
Radiographic Evaluation of All-on-4 Implant Prosthesis With Different Materials and Bar Construction Techniques
Eighteen patients will be selected from the outpatient clinic of the Prosthodontic Department, Faculty of Dentistry, Mansoura University seeking prosthetic rehabilitation.
- Trial name
- NCT06071689
- Testing
- screw retained prosthesis
- Where
- Egypt
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Partial Edentulism, Dental Implants
Comparison of Two Dental Implant Types and Placement Depths on Bone Around the Implant in Adults Missing Back Teeth
The goal of this clinical trial was to compare two ways of placing and restoring dental implants in adults missing one or more back teeth.
- Conditions
- Partial Edentulism, Dental Implants, Alveolar Bone Loss
- Trial name
- NCT07886762
- Testing
- issue-level implant placed at crestal level (Klockner Essential Cone), Bone-level implant placed 2 mm subcrestally with one-abutment-one-time protocol (Klockner Vega)
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Markel Diéguez-Pereira
Peri-Implantitis, Implant Complication
"Surgical Vs. Non-surgical Peri-implant Therapy"
The aim of this randomized clinical trial is to evaluate the effectiveness, in terms of clinical and radiographic changes, of non-surgical peri-implant therapy (mechanical/chemical) versus regenerative surgical therapy (xenograft…
- Conditions
- Peri-Implantitis, Implant Complication, Bone Loss
- Trial name
- NCT05168891
- Testing
- Surgical therapy, Non-surgical therapy of peri-implantitis
- Where
- Spain
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Universitat Internacional de Catalunya
Jaw, Edentulous
Retention of Telescopic Versus Locator Attachments
Forty patients ( 24female and16 male )with completely edentulous maxilla and mandible . All patients received implant supported mandibular and maxillary overdentures.
- Trial name
- NCT06349525
- Testing
- telescopic overdenture, Locator overdenture
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Delta University for Science and Technology
Bone Loss, Alveolar
Grafting of the Peri-implant Bony Defects Around Immediate Implants Using Xenogenic Versus Alloplastic Sticky Grafts
In patients with a single non restorable tooth, does filling the peri-implant buccal gap with alloplastic sticky grafts result comparable results compared to xenogenic sticky grafts?
- Trial name
- NCT06653868
- Testing
- Immediate dental implant with filling the peri implant gap with xenogenic sticky bone
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Edentulous Jaw, Bone Loss, Alveolar
Effects of Different Centrifuged Platelet Concentrates on Bone Remodelling Around Dental Implants
Platelet concentrates obtained from blood have been used as regenerative biomaterials in periodontal surgery. Along with the migration and proliferation of osteogenic cells, platelets accelerate bone regeneration by increasing…
- Conditions
- Edentulous Jaw, Bone Loss, Alveolar, Resorption, Bone
- Trial name
- NCT04851002
- Testing
- Application of concentrated growth factor with dental implants, Application of advanced platelet rich fibrin with dental implants, Control side of concentrated growth factor study group
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Muhammet Atilgan
Hearing Loss, Cochlear Implant
AB-Intra- and Post-Operative Measures of Auditory Function
The purpose of this study is to see how the inner ear responds to sound delivered to the ear canal during and after your cochlear implant surgery.
- Trial name
- AB-ECOG (NCT03685461)
- Testing
- Electrocochleography
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Medical College of Wisconsin
Peri-implant Bone Loss, Peri-implant Marginal Bone Loss
Evaluation of Fluid Biomarkers Around Implants Exhibiting Early Stage Periimplant Bone Loss
This study aimed to compare biological mediators known to be important in peri-implant diseases in implants with and without early stage marginal bone loss.
- Conditions
- Peri-implant Bone Loss, Peri-implant Marginal Bone Loss, Marginal Bone Loss, Peri-Implant Health
- Trial name
- NCT07584759
- Testing
- Collecting of peri-implant sulcus fluid, Periapical radiography
- Where
- Turkey (Türkiye)
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Pamukkale University
Periodontal Diseases, Periimplant Diseases
Markers of Bone Destruction and Oxidative Stress in Peri-implantitis
The aim of this study is to evaluate and compare the levels of bone resorption (RANKL, OPG) and oxidative stress (Nitrotyrosine, NQO1) markers, along with pro-inflammatory cytokines (IL-1β), in the saliva and peri-implant…
- Trial name
- NCT07397884
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Peri Implant Mucositis, Peri Implant Bone Loss
Local and Systemic Inflammatory Bone Alterations Related to Dental Implant Survival.
Introduction: Dental implants offer a durable, aesthetic, and functional option for tooth replacement. However, they are not immune to failure.
- Conditions
- Peri Implant Mucositis, Peri Implant Bone Loss, Peri Implantitis, Calcium Deficiency
- Trial name
- NCT07766707
- Where
- Spain
- Volunteers
- 192 people
- Sponsor
- University of Barcelona
Tooth Loss, Disorder Related to Renal Transplantation
Osseointegrated Dental Implants in Kidney Transplanted Patients
The evaluation of the bone, using several techniques and on several aspects will be the purpose to study the possible impact of the kidney transplant (and, extensively, the pre-transplant dialysis, the organ replacement and the…
- Trial name
- NCT02513602
- Testing
- Dental implant insertion
- Where
- Italy
- Volunteers
- 26 people
- Sponsor
- University of Trieste