Edentulous JawNCT07177521
Primary Stability and Peri-implant Outcomes of Short Implants in Post-extraction Single-tooth Sites
A study testing Insertion of implants in post-extraction tooth in people with Edentulous Jaw and Tooth Loss, run by University of Bari Aldo Moro at 1 site in Italy.
Trial summary
The placement of short implants in post-extraction sockets is a valuable option when residual bone height is limited, minimizing morbidity and treatment time. The management of the peri-implant gap and soft tissues may influence primary stability, hard/soft tissue remodeling, and implant success. Read more about this study
- Who is it for?
- Ages 18 to 75 yearsHealthy volunteers can take part
- Conditions the study is for
- Edentulous Jaw, Tooth Loss, Toothless Mouth
- What is being tested?
- Insertion of implants in post-extraction tooth
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 10 participants
- Where
- 1 siteItaly
- Study dates
- 10 Jan 2025to 10 Aug 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 75 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Age ≥18 years.
- Single-tooth post-extraction sites requiring immediate implant placement in posterior regions (premolars/molars) or selected anterior sites.
- Planned short implant (≤7-8 mm length, 3.5-5.0 mm diameter).
- Adequate oral hygiene, no active periodontal disease.
- Written informed consent.
Who cannot join
- Heavy smoking (>20 cigarettes/day).
- Uncontrolled diabetes or systemic conditions affecting bone healing.
- Current bisphosphonate/antiresorptive therapy.
- Immunosuppression, pregnancy.
- Poor oral hygiene or acute infection at site.
- Severe bone dehiscence preventing primary stability.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Saverio Capodiferro contact
Italy1 site, 1 recruiting
- Recruiting
University of Bari Aldo Moro
Bari, 70021
Giuseppe D'Albis, +393495103642, dalbisgiuseppe@hotmail.com
About this study
Official title: Primary Stability and Peri-implant Outcomes of Short Implants in Post-extraction Single-tooth Sites: a Randomized Controlled Trial.
The placement of short implants in post-extraction sockets is a valuable option when residual bone height is limited, minimizing morbidity and treatment time. The management of the peri-implant gap and soft tissues may influence primary stability, hard/soft tissue remodeling, and implant success.
- Conditions
- Edentulous Jaw, Tooth Loss, Toothless Mouth
- Being tested
- Insertion of implants in post-extraction tooth
- Medical subject headings
- Jaw, Edentulous, Tooth Loss, Mouth, Edentulous
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Insertion of implants in post-extraction toothProcedure or surgery
Two widely used approaches include:
- Socket grafting with a fully resorbable synthetic biomaterial (β-tricalcium phosphate + calcium sulfate).
- Socket grafting with a xenograft and a custom Sealing Socket Abutment (SSA) with a concave emergence profile.
No randomized controlled trials have yet compared these protocols with integrated outcomes including resonance frequency analysis, peri-implant health indices, radiographic bone level changes, and digital intraoral scanning (IOS)-based morphometric analysis.
| Study group | Role | What they receive |
|---|---|---|
| Group 1 | Experimental | Socket grafting with a fully resorbable synthetic biomaterial (β-tricalcium phosphate + calcium sulfate). Receives: Procedure: Insertion of implants in post-extraction tooth |
| Group 2 | Active comparator | Socket grafting with a xenograft and a custom Sealing Socket Abutment with a concave emergence profile. Receives: Procedure: Insertion of implants in post-extraction tooth |
What is being measured
The primary outcome is the main question the study is designed to answer.
Primary stability
To compare the primary stability (ISQ values at implant insertion) of short implants placed in post-extraction sockets using the two grafting protocols.
Measured: 1 month
Secondary outcomes (2)
Clinical Indices
To assess peri-implant health indices (PD)
Measured: 12 months
Clinical Indices
To assess peri-implant health indices (BoP)
Measured: 12 month
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted17 Sep 2025
- Study start10 Jan 2025
- Primary completion1 Jun 2026 (estimated)
- Study completion10 Aug 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Edentulous JawStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 10 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of Bari Aldo Moro
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Giuseppe D'Albis, University of Bari Aldo Moro
- Investigators
- Giuseppe D'Albis, Dr, Principal investigator, University of Bari Aldo MoroSaverio Capodiferro, Prof, Study chair, University of Bari Aldo Moro
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07177521
- Sponsor's protocol ID
- Post-extraction-implants
- Status last verified
- Jan 2026
- First submitted
- 8 Sep 2025
- Last updated
- 27 Jan 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 27 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Primary Stability and Peri-implant Outcomes of Short Implants in Post-extraction Single-tooth Sites: a Randomized Controlled Trial.
- ClinicalTrials.gov ID
- NCT07177521
- Acronym / sponsor ID
- Post-extraction-implants
- Conditions
- Edentulous Jaw, Tooth Loss, Toothless Mouth
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 10 participants (estimated)
- Lead sponsor
- University of Bari Aldo MoroUniversity, hospital or other
- Study start
- 10 Jan 2025 (actual)
- Primary completion
- 1 Jun 2026 (estimated)
- Study completion
- 10 Aug 2026 (estimated)
- First posted
- 17 Sep 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The placement of short implants in post-extraction sockets is a valuable option when residual bone height is limited, minimizing morbidity and treatment time. The management of the peri-implant gap and soft tissues may influence primary stability, hard/soft tissue remodeling, and implant success.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Group 1 | Experimental | Procedure: Insertion of implants in post-extraction toothSocket grafting with a fully resorbable synthetic biomaterial (β-tricalcium phosphate + calcium sulfate). |
| Group 2 | Active comparator | Procedure: Insertion of implants in post-extraction toothSocket grafting with a xenograft and a custom Sealing Socket Abutment with a concave emergence profile. |
Who may qualify
- Ages
- 18 to 75 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (5 listed)
- Age ≥18 years.
- Single-tooth post-extraction sites requiring immediate implant placement in posterior regions (premolars/molars) or selected anterior sites.
- Planned short implant (≤7-8 mm length, 3.5-5.0 mm diameter).
- Adequate oral hygiene, no active periodontal disease.
- Written informed consent.
Key exclusion criteria (6 listed)
- Heavy smoking (>20 cigarettes/day).
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Insertion of implants in post-extraction toothTwo widely used approaches include: 1. Socket grafting with a fully resorbable synthetic biomaterial (β-tricalcium phosphate + calcium sulfate). 2. Socket grafting with a xenograft and a custom Sealing Socket Abutment (SSA) with a concave emergence profile. No randomized controlled trials have yet compared these protocols with integrated outcomes including resonance frequency analysis, peri-implant health indices, radiographic bone level changes, and digital intraoral scanning (IOS)-based morphometric analysis. | Procedure or surgery | Group 1, Group 2 |
Primary outcome
Primary stability
Time frame: 1 month
To compare the primary stability (ISQ values at implant insertion) of short implants placed in post-extraction sockets using the two grafting protocols.
2 secondary outcomes
Clinical Indices
Time frame: 12 months
Clinical Indices
Time frame: 12 month
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 27 Jan 2026.
- Individual participant dataSharing planned: No
Related trials for Edentulous Jaw
Active, not recruiting
L-PRF Block vs Composite Graft for Horizontal Ridge Augmentation
Alveolar Ridge Resorption After Extraction, Alveolar Bone Loss
Not yet recruitingObservational study
Digital and Conventional Clasp-retained Partial Dentures (DIGICLASP)
Partial Edentulism
Recruiting
Dynamic vs. Static Jaw Relations in Implant-Supported Prostheses: Chewing Efficiency
Chewing Efficiency in Completely Edentulous Patients Rehabilitated With Implant-Supported Full-Arch Prostheses
Active, not recruiting
Multicenter Study to Evaluate the Clinical Outcome of PrimeTaper EV Implant in Single Tooth Restorations
Jaw, Edentulous, Partially
Recruiting
Clinical and Radiographic Evaluation of UV-Treated Dental Implants With or Without Melatonin in the Upper Posterior Jaw
Jaw, Edentulous, Partially, Bone Resorption
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Saverio Capodiferro contact
Giuseppe D'Albis, Dr principal investigator
University of Bari Aldo Moro
Saverio Capodiferro, Prof study chair
University of Bari Aldo Moro
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Insertion of implants in post-extraction tooth in people with Edentulous Jaw and Tooth Loss, run by University of Bari Aldo Moro at 1 site in Italy.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 27 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Italy. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Giuseppe D'Albis, Dr (+393495103642, giuseppe.dalbis@uniba.it), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Primary stability (time frame: 1 month). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 27 Jan 2026.