Clinical trials: Osteochondritis Dissecans Knee
Defect of Articular Cartilage, Osteochondritis Dissecans
Cartilage Autograft Implantation System (CAIS) for the Repair of Knee Cartilage Through Cartilage Regeneration
The Cartilage Autograft Implantation System (CAIS) is designed as a single surgical treatment of damaged knee cartilage using the subject's own healthy cartilage obtained from a non-weight or low weight-bearing region.
- Trial name
- CAIS (NCT00881023)
- Testing
- Microfracture, Cartilage Autograft Implantation System
- Where
- 29 sites in United States, Canada
- Volunteers
- 75 people
- Sponsor
- DePuy Mitek
Osteochondritis Dissecans Knee, Psychological Stress
Psychological Response and Readiness Associated With OCD of the Knee
This study primarily aims to determine whether patients diagnosed with osteochondritis dissecans (OCD) of the knee experience psychological stress due to their diagnosis and treatment plan.
- Trial name
- NCT04649905
- Testing
- Surgical Treatment, Nonoperative Treatment
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- Boston Children's Hospital
Cartilage Injury, Osteochondritis Dissecans
A Randomized Controlled Trial Comparing Chondro-Gide® to Microfracture Alone for Treatment of Knee Cartilage Defects.
The purpose of this study is to evaluate the safety and effectiveness of using Chondro-Gide® collagen membrane either sutured or glued compared to microfracture alone in the treatment of symptomatic cartilage defects of the knee.
- Trial name
- NCT02993510
- Testing
- Microfracture, Chondro-Gide sutured, Chondro-Gide glued
- Where
- 7 sites in Germany
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Geistlich Pharma AG
Osteoarthritis, Knee Osteoarthritis
Transplantation of Bone Marrow Stem Cells Stimulated by Proteins Scaffold to Heal Defects Articular Cartilage of the Knee
The purpose of this pilot study is to investigate the efficacy and safety of autologous transplantation, under arthroscopy, of Bone Marrow Mesenchymal stem cells, using, with a cell separator, a fresh non-culture expanded…
- Conditions
- Osteoarthritis, Knee Osteoarthritis, Osteochondritis Dissecans, Osteonecrosis
- Trial name
- NCT01159899
- Testing
- Transplantation of Bone Marrow Stem Cells Activated in Knee Arthrosis
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Michel Assor, MD
Osteochondritis Dissecans
Intra Articular Injections With Platelet Rich Plasma in Patients With Juvenile Osteochondritis Dissecans of the Knee
This study plans to learn more about ways to treat a joint problem in the knee called Juvenile Osteochondritis Dissecans (OCD). The goal of this study is to see if injecting platelet-rich plasma (PRP) into the knee can help knee…
- Trial name
- NCT02397278
- Testing
- Platelet rich plasma (PRP)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Colorado, Denver
Juvenile Osteochondritis Dissecans
Study of Two Surgical Drilling Techniques to Treat Juvenile Osteochondritis Dissecans of the Knee
The purpose of this study is to compare the functional, clinical and radiographic outcomes associated with trans-articular drilling versus retro-articular drilling, two commonly employed techniques of operative treatment for…
- Trial name
- NCT01754298
- Testing
- Retro-articular drilling, Trans-articular drilling
- Where
- 14 sites in United States, Canada
- Volunteers
- 91 people
- Sponsor
- Boston Children's Hospital
Cartilage Diseases, Osteochondritis Dissecans
Evaluation of the Agili-C Biphasic Implant in the Knee Joint
The purpose of this study is to determine the performance of the Agili-C implants. The study hypothesis is that Agili-C implants are effective in the treatment of focal cartilage and cartilage-bone joint surface defects.
- Trial name
- NCT01471236
- Testing
- Agili-C Bi-phasic Implant, mini-arthrotomy
- Where
- 9 sites in Croatia, Czechia and 6 more
- Volunteers
- 65 people
- Sponsor
- Smith & Nephew, Inc.
Articular Cartilage Disorder, Degeneration; Articular Cartilage
Chondrofix Osteochondral Allograft Prospective Study
The overall study objective is to evaluate Chondrofix Osteochondral Allograft ("Chondrofix") for the repair of osteochondral lesions in the knee.
- Conditions
- Articular Cartilage Disorder, Degeneration; Articular Cartilage, Chronic Cartilage Injury, Acute Cartilage Injury
- Trial name
- NCT01410136
- Testing
- Chondrofix Osteochondral Allograft
- Where
- 5 sites in United States
- Volunteers
- 29 people
- Sponsor
- Zimmer Orthobiologics, Inc.
Osteochondritis Dissecans
Use of Demineralised Bone Matrix (DBX) in Osteochondritis Dissecans (OCD)
This is a 1:1 randomised pilot study in 30 patients in 1 site in Helsinki, Finland. The investigators hypothesize that function, pain, type and quality of cartilage in adult patients with osteochondritis dissecans of the knee…
- Trial name
- NCT01283737
- Testing
- DBX Putty, Mosaicplasty
- Where
- Finland
- Sponsor
- Synthes GmbH
Osteochondritis Dissecans Knee
Triphasic Osteochondral Scaffold for the Treatment of the OCD of the Knee: Observational Study
The objective of the present study is to evaluate the clinical results of reconstructive treatment of knee OCD defects treated with osteochondral scaffolds implanted with specific instrumentation.The evaluation will be performed…
- Trial name
- MAIOCD (NCT05332288)
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Istituto Ortopedico Rizzoli
Degenerative Lesion of Articular Cartilage of Knee, Osteochondritis Dissecans
DeNovo NT Longitudinal Data Collection (LDC) Knee Study
The purpose of this study is to evaluate the long-term outcomes of DeNovo NT, a tissue product used for the repair of cartilage damage in the knee.
- Trial name
- NCT01329445
- Testing
- DeNovo NT, Natural Tissue Graft
- Where
- 15 sites in United States
- Volunteers
- 160 people
- Sponsor
- Zimmer Orthobiologics, Inc.
Osteochondral Lesions of the Knee Joint, Osteochondritis Dissecans (OCD)
MaioRegen Prime Study for the Treatment of Deep Osteochondral Lesion of the Knee
The present study aims to compare the efficacy and the safety of MaioRegen Prime to Debridement (SSOC) in patients with deep osteochondral lesions of the knee joint.
- Conditions
- Osteochondral Lesions of the Knee Joint, Osteochondritis Dissecans (OCD), Early Osteoarthritis
- Trial name
- OSTEOCONFIRM (NCT07332182)
- Testing
- osteochondral scaffold implant, SSOC
- Where
- 10 sites in United States, Italy
- Volunteers
- 400 people
- Sponsor
- Fin-Ceramica Faenza Spa
Osteochondritis Dissecans Knee, Osteochondritis Dissecans (OCD)
Treatment Outcomes for Osteochondritis Dissecans of the Knee: A Cohort Study
This is a non-randomized, observational, ambidirectional cohort study. Approximately 254 participants with knee OCD will be recruited from Peking University Third Hospital, China, comprising a prospective cohort (n=177) and a…
- Trial name
- NCT07439107
- Testing
- Clinical Management for OCD (Observed)
- Where
- China
- Volunteers
- 254 people
- Sponsor
- Peking University Third Hospital
Osteochondritis Dissecans, Juvenile Osteochondritis Dissecans
Osteochondritis Dissecans of the Knee
Osteochondritis dissecans is a relatively common...
- Trial name
- KYSOCD (NCT01455987)
- Volunteers
- 265 people
- Sponsor
- Kuopio University Hospital
Osteochondral Defect, Osteochondritis Dissecans
Evaluation of Clinical and Radiological Outcomes in Patients Undergoing Fixation of Osteochondral Fragments With Reasorbable Screws in the Knee Joint
Various techniques for the fixation of unstable osteochondral fragments have been used over the years, each with associated advantages and disadvantages, and differing clinical outcomes.
- Conditions
- Osteochondral Defect, Osteochondritis Dissecans, Osteochondral Fracture, Osteochondral Fracture of Patella
- Trial name
- OC-FIX (NCT06462040)
- Testing
- Fixation of osteochdral fragments with reabsorbable screws
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Istituto Ortopedico Rizzoli
Osteochondritis Dissecans, Osteoarthritis
ACI-C Versus AMIC. A Randomized Trial Comparing Two Methods for Repair of Cartilage Defects in the Knee
ACI-C versus AMIC: A controlled randomized trial comparing Autologous Chondrocyte Implantation ( ACI) and Autologous Matrix Induced Chondrogenesis (AMIC) for repair of cartilage defects in the knee.
- Conditions
- Osteochondritis Dissecans, Osteoarthritis, Cartilage Injury, Osteonecrosis
- Trial name
- NCT01458782
- Testing
- Treatment of cartilage defects in the knee
- Where
- Norway
- Volunteers
- 41 people
- Sponsor
- University Hospital of North Norway
Osteochondritis Dissecans
Osteochondritis Dissecans of Knee Prospective Cohort
The Cohort is a multi-site prospective data collection study that will enroll any patient with diagnosis of knee OCD (confirmed by a standard of care x-ray or MRI).
- Trial name
- NCT02771496
- Testing
- Other: observational only- no intervention
- Where
- United States
- Volunteers
- 3,000 people
- Sponsor
- University of Pennsylvania
Knee Pathology, Osteoarthritis, Knee
Knee Registry (Knieregister)
Rationale: In view of patient care, patient characteristics and treatment parameters are registered for all patients visiting the Mobility Clinic of the University Medical Center Utrecht for orthopaedic knee treatment.
- Conditions
- Knee Pathology, Osteoarthritis, Knee, Osteochondritis Dissecans, Chondral Defect
- Trial name
- NCT04364334
- Where
- Netherlands
- Volunteers
- 1,000,000 people
- Sponsor
- UMC Utrecht
Osteochondral Defect, Osteochondritis Dissecans
Post-Operative Rehabilitation of Knee Osteochondral Defect: A Case Series
A case-series review was performed on five collegiate athletes with osteochondral lesions of the knee at California State University, Northridge (CSUN). All subjects received surgical intervention to treat the defect.
- Trial name
- NCT03452098
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- California State University, Northridge
Chondral Defect, Osteochondritis Dissecans (OCD)
A Study of MACI in Patients Aged 10 to 17 Years With Symptomatic Chondral or Osteochondral Defects of the Knee
The objective of this study is to compare the efficacy and safety of MACI® vs arthroscopic microfracture in the treatment of participants aged 10 to 17 years with symptomatic articular chondral or osteochondral defects of the…
- Conditions
- Chondral Defect, Osteochondritis Dissecans (OCD), Articular Cartilage Defect, Articular Cartilage Disorder of Knee
- Trial name
- PEAK (NCT03588975)
- Testing
- MACI, microfracture
- Where
- 15 sites in United States
- Volunteers
- 45 people
- Sponsor
- Vericel Corporation