Clinical trials: Hepatectomy, active
Preoperative Prehabilitation in Older Adults Undergoing Hepatectomy
Prehabilitation Before Liver Surgery in Older Adults
Many older adults who need liver surgery (hepatectomy) are physically weak before their operation. This can make recovery harder and may lead to more complications after surgery.
- Trial name
- NCT07877311
- Testing
- Preoperative Prehabilitation Program
- Where
- 6 sites in China
- Volunteers
- 500 people
- Sponsor
- Lining Xu
Colorectal Liver Metastasis (CRLM), Liver Resection
The Use of Artificial Intelligence for the Prediction of Recurrence After Resection of Colorectal Liver Metastases
Colorectal cancer is the third most common cancer worldwide and the fourth most common cause of cancer-related death. Survival is primarily determined by stage of disease and the presence of metastases.
- Conditions
- Colorectal Liver Metastasis (CRLM), Liver Resection, Hepatectomy, Liver Ablation
- Trial name
- AI-RECOLMET (NCT07385521)
- Testing
- AI-analysis
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- Francesco De Cobelli
Acute Kidney Injury, Hepatectomy
Renal Oxygenation-Guided AKI Reduction Trial
Acute kidney injury (AKI) is a common complication after major liver surgery. This study will evaluate whether intraoperative management guided by renal regional oxygen saturation (RrSO₂), measured using near-infrared…
- Trial name
- ROGAR (NCT07816640)
- Testing
- INVOS 5100C regional oxygen saturation monitoring system, RrSO2-guided perioperative management, Usual perioperative management
- Where
- 20 sites in China
- Volunteers
- 1,200 people
- Sponsor
- Chinese PLA General Hospital
Hepatic Malignancies, Comprehensive Geriatric Assessment
Preoperative Oncogeriatric Assessment in Patients Undergoing Hepatectomy
This study aims to bridge the gap between geriatric medicine and surgical oncology. The findings will provide valuable insights into optimizing perioperative care for older adults, enhancing surgical safety, and improving…
- Conditions
- Hepatic Malignancies, Comprehensive Geriatric Assessment, Hepatectomy
- Trial name
- NCT07537569
- Testing
- Comprehensive Geriatric Assessment (CGA)
- Where
- Italy
- Volunteers
- 242 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Intraoperative Hypotension, Hepatectomy
Remimazolam Versus Propofol for Maintenance of Anaesthesia During Major Hepatectomy Under Low Central Venous Pressure
The goal of this clinical trial is to learn whether remimazolam helps prevent low blood pressure better than propofol during major liver surgery in adults.
- Trial name
- NCT07789275
- Testing
- Remimazolam, Propofol
- Where
- China
- Volunteers
- 224 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Post-Hepatectomy Liver Failure, Liver Failure
CT Volumetry and Hepatic Vascular Deformation Mapping to Predict Post-Hepatectomy Liver Failure
Removing a large part of the liver (major hepatectomy) can cure primary and secondary liver cancers, but it carries the risk of post-hepatectomy liver failure (PHLF), a serious complication in which the liver left behind - the…
- Conditions
- Post-Hepatectomy Liver Failure, Liver Failure, Liver Neoplasms, Carcinoma, Hepatocellular
- Trial name
- BEYOND-SIZE (NCT07727759)
- Testing
- Preoperative CT volumetry with hepatic vascular deformation mapping (VDM)
- Where
- 3 sites in Egypt
- Volunteers
- 1,070 people
- Sponsor
- Minia University
Bile Leak, Liver Resection
Routine White Test for Early Detection of Bile Leak in Elective Liver Resection (DELiveR Trial)
Bile leakage is a clinically important complication following liver resection and is associated with increased postoperative morbidity, need for reintervention and prolonged hospitalisation.
- Conditions
- Bile Leak, Liver Resection, Hepatectomy
- Trial name
- DELiveR (NCT07511907)
- Testing
- White Test, Standard Gauze Test
- Where
- Poland
- Volunteers
- 270 people
- Sponsor
- Medical University of Warsaw
Chronic Liver Disease and Cirrhosis, Liver Transplant; Complications
Magnetic Resonance Cholangiopancreatography in Living Liver Donors and Its Relationship With Post Operative Recipient Biliary Complications
Living donor liver transplantation is widely accepted as an life-saving treatment for patients with end-stage liver diseases. Careful donor selection is essential to maximize the success and minimize the risk of postoperative…
- Conditions
- Chronic Liver Disease and Cirrhosis, Liver Transplant; Complications, Donor Hepatectomy
- Trial name
- NCT07715500
- Testing
- Magnetic Resonance Cholangiopancreatography
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Hepatectomy
A Study of Methylprednisolone in People Having Liver Surgery
The purpose of this study is to test whether receiving methylprednisolone before surgery will reduce the side effects of having surgery, such as infections and longer hospital stays.
- Trial name
- NCT07507643
- Testing
- Methylprednisolone
- Where
- 19 sites in United States
- Volunteers
- 750 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Donor Hepatectomy
Drain vs No Drain After Live Donor Hepatectomy
Prophylactic abdominal drain placement after donor hepatectomy has been a common or even mandatory practice in most transplant centers.
- Trial name
- NCT06769776
- Testing
- No Drain i.e. Omission of abdominal drain placement
- Where
- India
- Volunteers
- 80 people
- Sponsor
- Marengo Asia Hospitals
Post-hepatectomy Hypoalbuminemia
Rice-derived Recombinant Human Serum Albumin for the Treatment of Hypoalbuminemia After Hepatectomy: A Prospective, Single-Arm, Exploratory Clinical Trial
Rice-derived recombinant human serum albumin (OsrHSA) possesses an identical primary, secondary, and higher-order structure to plasma-derived human albumin.
- Trial name
- NCT07634549
- Testing
- Rice-derived recombinant human serum albumin (OsrHSA)
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Cheng Qi
Hepatectomy
EOI Block vs. TAP Block in Minimally Invasive Hepatectomy
This study aims to compare the analgesic efficacy of two different ultrasound-guided nerve blocks-the External Oblique Intercostal (EOI) block and the Subcostal Transversus Abdominis Plane (TAP) block-in patients undergoing…
- Trial name
- EOIvsTAP (NCT07615231)
- Testing
- External Oblique Intercostal Block, TAP Block
- Where
- South Korea
- Volunteers
- 140 people
- Sponsor
- Seoul National University Hospital
Hepatectomy, Transfusion Requirements
Reducing Red Blood Cell Transfusion Requirements for Adults Undergoing Surgical Resection of the Liver - A Quality Improvement Project
The goal of this clinical trial is to determine if implementing a controlled blood removal protocol (i.e. hypovolemic phlebotomy [HP] where approximately 10% of the patient's blood is removed and reinfused following hepatic…
- Conditions
- Hepatectomy, Transfusion Requirements, Intraoperative Bleeding, Intraoperative Monitoring
- Trial name
- NCT07629648
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Dr. Glenio Mizubuti (MD, PhD, FRCPC)
Hepatectomy
Intravenous Lidocaine for Hepatectomy
Liver resection is increasingly performed for hepatic tumors, mainly primary liver cancers and resectable metastases, but also for some benign lesions.
- Trial name
- ILHEP (NCT07590830)
- Testing
- Standardized General Anesthesia Induction and Maintenance Protocol incorporating Intravenous Lidocaine
- Where
- 9 sites in France
- Volunteers
- 312 people
- Sponsor
- Rennes University Hospital
Hepatectomy, Pain, Postoperative
Spinal Anesthesia For Enhanced Recovery After Liver Surgery
This project proposes to compare epidural versus spinal anesthesia in patients having liver resection surgery. The investigators hypothesize that spinal anesthesia will result in improved blood pressure control postoperatively…
- Conditions
- Hepatectomy, Pain, Postoperative, Liver Neoplasms
- Trial name
- SAFER-L (NCT03715517)
- Testing
- Continuous thoracic epidural analgesia, Spinal anesthesia with intrathecal morphine, Bupivacaine 0.75% in Dextrose Inj 8.25%
- Where
- Canada
- Volunteers
- 128 people
- Sponsor
- University of Manitoba
Colorectal Cancer, Esophageal Cancer
Clinical Trial Protocol for Evaluating the Efficacy and Safety of Thoracoabdominal Endoscopic Surgery System in Remote Laparoscopic Surgery for Urology, General Surgery, Gynecology and Thoracic Surgery
Evaluation of the Efficacy and Safety of the Thoracoabdominal Endoscopic Surgery System Produced by Shenzhen Cornerstone Robotics Technology Co., Ltd.
- Conditions
- Colorectal Cancer, Esophageal Cancer, Hepatectomy, Radical Hysterectomy
- Trial name
- NCT07382635
- Testing
- Robot-assisted surgery
- Volunteers
- 98 people
- Sponsor
- Cornerstone Robotics
Pain; Cancer, Hepatectomy
Ultrasound Guided External Oblique Intercostal Plane Block Versus Erector Spinae Block for Post Hepatectomy Pain
Management of acute post-operative pain has received keen attention in recent years with considerable concurrent advancement in the field.
- Conditions
- Pain; Cancer, Hepatectomy, Nerve Block
- Trial name
- NCT07337330
- Testing
- Ultrasound guided external oblique intercostal (EOI) plane block, Ultrasound guided erector spinae block
- Where
- Egypt
- Volunteers
- 52 people
- Sponsor
- National Cancer Institute, Egypt
Hepatecellular Carcinoma, Hepatectomy
AI-Based Prediction of HCC Recurrence Patterns After Resection (APAR)
This observational study aims to validate a deep learning model for predicting aggressive recurrence patterns in patients with early-stage liver cancer (HCC) after surgery.
- Trial name
- NCT07062380
- Testing
- Curative liver resection, Real-world multimodal therapy
- Where
- China
- Volunteers
- 353 people
- Sponsor
- Tongji Hospital
Liver Neoplasms, Hepatectomy
Hypovolemic Phlebotomy to Reduce Blood Transfusions in Major Hepatic Resections
Major liver resection is associated with substantial intraoperative blood loss and subsequently blood transfusions. Blood transfusion in elective liver surgery is a significant factor of perioperative morbidity and mortality, as…
- Conditions
- Liver Neoplasms, Hepatectomy, Blood Transfusion, Blood Loss, Surgical
- Trial name
- PRICE2 (NCT03651154)
- Testing
- Hypovolemic Phlebotomy
- Where
- 4 sites in Canada
- Volunteers
- 440 people
- Sponsor
- Ottawa Hospital Research Institute
Hepatectomy, Intertransverse Process Block
Intertransverse Process Block for Quality of Recovery Post-Open Hepatectomy
The study aims to assess the analgesic efficacy of the ITPB at the retro-SCTL space in patients undergoing major open hepatectomy surgery.
- Conditions
- Hepatectomy, Intertransverse Process Block, Quality of Recovery (QoR-15)
- Trial name
- ITPB QoR (NCT06957041)
- Testing
- Intertransverse process block
- Volunteers
- 20 people
- Sponsor
- Chinese University of Hong Kong