Clinical trials: active
Sarcopenia, Breast Cancer
Exercise Intervention for Breast Cancer Patients With Sarcopenia
Sarcopenia is a common yet underrecognized complication in breast cancer survivors during rehabilitation, characterized by loss of muscle mass, reduced muscle strength, and impaired physical function, which adversely affects…
- Trial name
- EX-BCSarc (NCT07732101)
- Testing
- "Exercise for Muscle Health" Program
- Where
- China
- Volunteers
- 104 people
- Sponsor
- Capital Medical University
Healthy Volunteers
Survey to Determine Incarcerated Persons' Views on Surrogate Decision Making
Background: About 180,000 of the people in US prisons are over 55 years old. Aging people often cannot make medical decisions on their own.
- Trial name
- NCT07751731
- Testing
- Survey
- Where
- United States
- Volunteers
- 75,000 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
IO Resistant Squamous and Nonsquamous NSCLC
A Study Comparing TAK-928 With Docetaxel in Adults With Non-Small Cell Lung Cancer
Lung cancer is one of the most common forms of cancer. One common type is non-small cell lung cancer (NSCLC). NSCLC happens when abnormal cells in the lungs grow too fast. This can stop the lungs from working normally.
- Trial name
- MarsLight-11 (NCT07217301)
- Testing
- TAK-928, Control Arm
- Where
- 50 sites in United States, China and 1 more
- Volunteers
- 1,200 people
- Sponsor
- Takeda
Methamphetamine Use Disorder, Substance Use Disorder
Closed-loop TBS Targeting rPO for the Core Clinical Features of Methamphetamine Use Disorder
The goal of this clinical trial is to evaluate whether closed-loop theta-burst stimulation (TBS) targeting the right parietal-occipital cortex (rPO) can improve core clinical symptoms in individuals with methamphetamine use…
- Conditions
- Methamphetamine Use Disorder, Substance Use Disorder, Cue-reactivity, Craving
- Trial name
- NCT07775807
- Testing
- Closed-loop Theta-Burst Stimulation (TBS) Targeting rPO
- Where
- China
- Volunteers
- 5 people
- Sponsor
- Shanghai Mental Health Center
Streptococcal Pharyngitis, Group A Streptococcal Infection
A Multicenter Evaluation of SalivIQ™ Strep A for Detecting Group A Streptococcus From Saliva and Throat Swabs in Patients With Acute Pharyngitis
The goal of this observational study is to learn how well the SalivIQ™ Strep A test detects Group A Streptococcus, the bacteria that cause strep throat.
- Trial name
- NCT07891728
- Testing
- qPCR
- Where
- 3 sites in United States
- Volunteers
- 668 people
- Sponsor
- SalivIQ Diagnostics, Inc.
Pain, Post Operative Analgesia
The Impact of Perioperative Lidocaine Infusions on Enhanced Recovery After Non-Cardiac Surgery
The goal of this single-center, pragmatic, randomized, blinded, placebo-controlled trial is to evaluate the impact of intravenous (IV) lidocaine within the existing Enhanced Recovery After Surgery (ERAS)program on outcomes in…
- Conditions
- Pain, Post Operative Analgesia, Opioid Consumption, Postoperative
- Trial name
- IMPALA ERAS (NCT07224711)
- Testing
- Lidocaine HCl 0.8% in D5W, Dextrose 5% in water
- Where
- United States
- Volunteers
- 2,290 people
- Sponsor
- Vanderbilt University Medical Center
Osteochondral Defect, Articular Cartilage Defect
Biologic Augmentation of Osteochondral Allograft Transplantation in the Knee
This prospective, single-center pilot study will evaluate biologic augmentation during osteochondral allograft transplantation of the knee using a combination of bone marrow aspirate concentrate (BMAC) and Arthrex AlloSync Pure.
- Trial name
- NCT07909928
- Testing
- Biologically Augmented Osteochondral Allograft Transplantation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Minnesota
Malignant Neoplastic Disease (Disorder)
Saruparib in HRDsig+ Solid Tumors
The main purpose of this study is to study the effect of saruparib, an experimental PARP inhibitor, on tumors that have an Homologous Recombination Deficiency Signature (HRDsig) positive tumor by the investigational…
- Trial name
- NCT07832630
- Testing
- Saruparib, FoundationOne®CDx
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Fallopian Tube Carcinoma, Ovarian Carcinoma
IGFBP-2 Vaccine to Prevent Ovarian Cancer Progression in Patients With Serologic Detection of Recurrence
This phase II trial studies how well giving the insulin-like growth factor binding protein 2 [pUMVC3-hIGFBP-2 multi-epitope plasmid deoxyribonucleic acid (DNA) (IGFBP-2)] vaccine after one dose of carboplatin works to stop…
- Conditions
- Fallopian Tube Carcinoma, Ovarian Carcinoma, Primary Peritoneal Carcinoma
- Trial name
- NCT07495124
- Testing
- pUMVC3-hIGFBP-2 Multi-epitope Plasmid DNA Vaccine, Carboplatin, Computed Tomography
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of Washington
Chronic Lymphocytic Leukemia, Small Lymphocytic Leukemia
Nemtabrutinib for Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Leukemia (SLL) Refractory to Covalent Bruton Tyrosine Kinase Inhibitor or Pirtobrutinib and Previously Treated With a BCL2 Inhibitor
Background: Chronic lymphocytic leukemia (CLL)/small lymphocytic leukemia (SLL) are diseases in which the body makes too many white blood cells that do not work properly.
- Trial name
- NCT07796373
- Testing
- Nemtabrutinib
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Trauma Centers/Statistics & Numerical Data, Trauma Blunt
Results of Medical and Nursing Record,PE, Blood Test and Radiological Examination ,Morality and Mobility of Multiple Trauma of Patient's
This study aims to analyze statistical data on physiological examination values, blood test results, and radiological findings in patients admitted to the emergency department for severe trauma.
- Conditions
- Trauma Centers/Statistics & Numerical Data, Trauma Blunt, Trauma (Including Fractures), Trauma Abdomen
- Trial name
- trauma (NCT07903727)
- Testing
- Collect results of trauma patients
- Volunteers
- 700 people
- Sponsor
- St. Martin De Porress Hospital
Kidney Cancers, Prostate Cancer
Assessment of Intelligent Algorithms for Detection, Diagnosis and Risk Stratification of Tumors of the Kidney and Prostate
The COMFORT study will evaluate an artificial intelligence-based platform developed to support the clinical assessment of kidney and prostate cancer.
- Trial name
- COMFORT (NCT07888322)
- Testing
- Medical Reading, AI assisted Medical reading
- Where
- 6 sites in Germany, Greece and 2 more
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Breast Cancer Patients at High Risk of Chemotherapy-induced Thrombocytopenia (CTIT)
A Clinical Study on Prophylactic RespOnse To hEtrombopag for Secondary Prevention in Anti-Cancer Therapy-induced Thrombocytopeniae
This study is a prospective clinical study enrolling breast cancer patients at high risk of chemotherapy-induced thrombocytopenia (CTIT).
- Trial name
- PROTECT (NCT07647029)
- Testing
- Continuous Hetrombopag for 2 Cycles, Cyclic 14-day Hetrombopag for 2 Cycles
- Where
- China
- Volunteers
- 126 people
- Sponsor
- Fudan University
Diffuse Large B-Cell Lymphoma
Efficacy and Safety of Polatuzumab Vedotin, Rituximab Combined With Reduced-dose Cyclophosphamide, Doxorubicin and Prednisone Regimen in the Treatment of Elderly Patients With Diffuse Large B-cell Lymphoma: A Multicenter, Single-arm, Prospective Study
This is a multicenter, single-arm, prospective study evaluating the efficacy and safety of polatuzumab vedotin and rituximab combined with a reduced-dose regimen of cyclophosphamide, doxorubicin and prednisone (Pola-R-miniCHP) as…
- Trial name
- NCT07908888
- Testing
- Polatuzumab Vedotin, Rituximab, Cyclophosphamide
- Where
- China
- Volunteers
- 26 people
- Sponsor
- The First Hospital of Jilin University
Pancreatic Ductal Adenocarcinoma (PDAC)
A Study of Perioperative Navlimetostat Combined With Modified FOLFIRINOX in Patients With MTAP-Deleted Pancreatic Cancer
The purpose of this study is to assess the safety, feasibility, and recommended dose of navlimetostat (BMS-986504) combined with mFOLFIRINOX before and after surgery in patients with localized pancreatic cancer with MTAP deletion.
- Trial name
- M-POP (NCT07905131)
- Testing
- Navlimetostat, mFOLFIRINOX Treatment Regimen
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Daniel Nussbaum, M.D.
Head and Neck Cancers
Feasibility of Cough Skill Training in Individuals With Head and Neck Cancer
This preliminary study will examine the feasibility of a cough skill training treatment approach to rehabilitate voluntary cough function in people with head and neck cancer.
- Trial name
- NCT07756684
- Testing
- Handheld cough device
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Boston University Charles River Campus
Healthy Volunteer
Effects of Urolithin A Supplementation on Glucose Metabolism in Healthy Adults 55 >= Years Old: A Randomized Triple-Masked Controlled Clinical Trial
Background: As people age, the cells in the pancreas that produce insulin begin to release less of this hormone, and levels of blood glucose (sugar) rise. This can lead to illnesses such as diabetes.
- Trial name
- NCT06274749
- Testing
- Urolithin A
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- National Institute on Aging (NIA)
Colorectal Adenoma, Cholecystectomy
Cholecystectomy, Biliary Diseases, and Colorectal Adenoma Risk: A Real-World Retrospective Study
This study is a retrospective real-world study based on the electronic medical record database of Nanjing First Hospital. By integrating data from the hospital information system, ultrasound system, endoscopy system, pathology…
- Conditions
- Colorectal Adenoma, Cholecystectomy, Biliary Tract Diseases
- Trial name
- NCT07908576
- Testing
- No intervention. This is an observational study.
- Volunteers
- 8,450 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Advanced Endometrial Carcinoma, Recurrent Endometrial Carcinoma
Testing the Addition of an Antiangiogenic Drug (Bevacizumab) to Chemotherapy (Carboplatin and Paclitaxel) Combined With Immunotherapy (Pembrolizumab) for pMMR, TP53 Mutated Endometrial Cancer
This phase III trial compares the effect of bevacizumab in combination with carboplatin, paclitaxel and pembrolizumab to the usual treatments of carboplatin and paclitaxel with or without pembrolizumab in treating patients with…
- Trial name
- NCT07198074
- Testing
- Bevacizumab, Biospecimen Collection, Carboplatin
- Where
- 304 sites in United States
- Volunteers
- 255 people
- Sponsor
- National Cancer Institute (NCI)
Pneumococcal Disease
A Clinical Study to Evaluate the Safety, Tolerability, and Immunogenicity of VAX-31 With Influenza Vaccine in Adults ≥ 50 Years of Age
This is a Phase 3, randomized, double-blind study to evaluate the safety and immunogenicity of VAX-31 and seasonal influenza vaccine in pneumococcal-naïve adults ≥ 50 years when the two vaccines are administered at the same visit…
- Trial name
- NCT07365826
- Testing
- 31-valent pneumococcal conjugate vaccine, Seasonal Influenza Vaccine (SIV) (Flublok)
- Where
- 25 sites in United States
- Volunteers
- 1,390 people, healthy volunteers welcome
- Sponsor
- Vaxcyte, Inc.
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