Clinical trials: Hepatectomy
Hepatic Ischemia
Application of Sodium Bicarbonate Ringer's Solution in Laparoscopic Hepatectomy
Compared the effects of Sodium bicarbonate Ringer's solution and lactate Ringer's solution on the internal environment and hemodynamics of patients during laparoscopic liver resection, to observe the application prospect of…
- Trial name
- NCT05830136
- Testing
- sodium bicarbonate Ringer's solution
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Liver Resection
A Trial to Compare Pringle Maneuver With Either Infrahepatic Inferior Vena Cava Clamping or Low Central Venous Pressure
The purpose of this study is to better comprehend the benefits and efficacy of portal triad clamping with infrahepatic IVC clamping during complex hepatectomy.
- Trial name
- NCT01355887
- Where
- China
- Volunteers
- 192 people
- Sponsor
- Huazhong University of Science and Technology
Hepatocellular Carcinoma
A Novel Laparoscopic Hepatectomy Posture, Left Lateral Position Plus Jackknife Position
Since the first report of laparoscopic resection of a benign hepatic tumor by Professor H. Reith in 1991, the laparoscope has been widely used in liver disease.
- Trial name
- NCT02809287
- Testing
- Jackknife posture
- Volunteers
- 10 people
- Sponsor
- Sun Yat-sen University
Hepatic Carcinoma
Liver Resection for Patients With Hepatocellular Carcinoma and Clinically Significant Portal Hypertension
Clinically significant portal hypertension limits the therapeutic options for hepatocellular carcinoma (HCC), which is closely associated with patient prognosis.
- Trial name
- NCT06245798
- Testing
- transarterial chemoembolisation
- Where
- 2 sites in China
- Volunteers
- 3,000 people
- Sponsor
- Tang-Du Hospital
Hepatocellular Carcinoma, Cirrhosis
Radiofrequency-assisted Hepatectomy on the Outcomes of HCC Patients With Cirrhosis
Surgical resection is the most effective treatment of primary and secondary liver tumors. Technical innovations have mainly focused on minimizing bleeding during transection of the hepatic parenchyma because excessive hemorrhage…
- Trial name
- NCT01992978
- Testing
- Radiofrequency-assisted Hepatectomy, Conventional Hepatectomy
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Southwest Hospital, China
Hepatocellular Carcinoma
Treatment for Patients With Multiple Hepatocellular Carcinomas Based on the NDR Scoring System
The aim of this study is to establish a selection criteria of hepatectomy for patients with multiple hepatocellular carcinomas based on the NDR Scoring System
- Trial name
- NCT02525952
- Testing
- Hepatectomy, TACE
- Where
- 2 sites in China
- Volunteers
- 320 people
- Sponsor
- Eastern Hepatobiliary Surgery Hospital
Hemorrhage
Infrahepatic Inferior Vena Cava Clamping During Hepatectomy
Intraoperative blood loss is a major concern during hepatic resection, as it has been shown to adversely affect patients' perioperative outcome.
- Trial name
- IVC CLAMP (NCT00732979)
- Testing
- Infrahepatic inferior vena cava clamping, No infrahepatic inferior vena cava clamping
- Where
- Germany
- Volunteers
- 152 people
- Sponsor
- Heidelberg University
Insulin Resistance
Surgical Stress After Laparoscopic Compared to Open Liver Resection
The purpose of this study is to determine whether the postoperative insulin resistance and cytokine release would be attenuated in laparoscopic compared with open liver resection.
- Trial name
- NCT01819688
- Testing
- laparoscopic liver resection
- Where
- China
- Volunteers
- 52 people
- Sponsor
- Sir Run Run Shaw Hospital
Intrahepatic Cholangiocarcinoma
Role of Bile Duct Resection in Major Hepatectomy Due to Intrahepatic Cholangiocarcinoma
To investigate the prognosis due to presence or absence of bile duct resection in intrahepatic cholangiocarcinoma that require hepatic lobectomy.
- Trial name
- NCT01862276
- Where
- Japan
- Volunteers
- 200 people
- Sponsor
- Kansai Hepatobiliary Oncology Group
Acute Pain
Transversus Abdominis Plane Block for Postoperative Analgesia in Living Donor Hepatectomy
Living donor organ transplantation has increased in recent years due to an increased need for organs. The objective of this study was to investigate the effects of a TAP block on postoperative analgesia and opioid consumption in…
- Trial name
- NCT02645903
- Testing
- Transversus Abdominis Plane Block, standard general anesthesia
- Volunteers
- 50 people
- Sponsor
- Inonu University
Cholangiocarcinoma
Liver Resection Versus Radio-chemotherapy-Transplantation for Hilar Cholangiocarcinoma
A prospective, open-label, randomised, multicentre, comparative study in two parallel groups comparing an interventional group with liver transplantation preceded by neoadjuvant radio-chemotherapy and a control group receiving…
- Trial name
- TRANSPHIL (NCT02232932)
- Testing
- CAPECITABINE-Radiotherapy -Liver Transplantation, RESECTION
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pathologic Stage I Gastric Cancer AJCC v8, Colorectal Cancer
Clinical Trial to Evaluate the Efficacy and Safety of a Thoracic and Abdominal Endoscopic Surgical System
Evaluation of the efficacy and safety of thoracic and abdominal endoscopic surgical systems manufactured by Shenzhen Cornerstone Robotics Technology Co., Ltd. for use in general, gynaecological and thoracic surgical procedures.
- Conditions
- Pathologic Stage I Gastric Cancer AJCC v8, Colorectal Cancer, Esophageal Cancer, Hepatectomy
- Trial name
- NCT06587152
- Testing
- Robot-assisted surgery
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Cornerstone Robotics
Post-hepatectomy Liver Failure, Hepatocellular Carcinoma
Usability and Clinical Effectiveness of an Interpretable Deep Learning Framework for Post-Hepatectomy Liver Failure Prediction
The goal of this in-silico clinical trial is to learn about the usability and clinical effectiveness of an interpretable deep learning framework (VAE-MLP) using counterfactual explanations and layerwise relevance propagation for…
- Conditions
- Post-hepatectomy Liver Failure, Hepatocellular Carcinoma, Artificial Intelligence
- Trial name
- NCT06031818
- Testing
- The explanation of deep learning framework (VAE-MLP) , including counterfactual explanations and layerwise relevance propagation, The model prediction, The model prediction and the explanation of deep learning framework (VAE-MLP) , including counterfactual explanations and layerwise relevance propagation
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Maastricht University
Secondary Malignant Neoplasm of Liver, Colorectal Neoplasms
Oslo Randomized Laparoscopic Versus Open Liver Resection for Colorectal Metastases Study
The purpose of the study is to compare outcomes of laparoscopic versus open liver resection for colorectal metastases in a prospective and randomized study.
- Trial name
- Oslo-CoMet (NCT01516710)
- Testing
- Open liver resection, Laparoscopic liver resection
- Where
- Norway
- Volunteers
- 280 people
- Sponsor
- Oslo University Hospital
Antibiotic Prophylaxis, Postoperative Infection
Comparison of 9 Doses vs 3 Doses of Post Operative Antibiotics in Live Liver Donors
Antibiotic resistance is a very serious and dangerous situation in modern world. Judicious use of antibiotics is therefore of extreme importance not just in preventing antibiotic resistance but also it decreases cost of the…
- Trial name
- NCT03765645
- Testing
- Piperacillin + Tazobactam
- Where
- India
- Volunteers
- 126 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Liver Cirrhosis
Opioid Sparing Anesthesia in Patients With Liver Cirrhosis Undergoing Liver Resection
This randomized clinical trial will investigate the opioid sparing effect of dexmedetomidine and ketmine infusion in cirrhotic patients undergoing liver resection
- Trial name
- NCT05674877
- Testing
- Opioid sparing group (OS) (dexmedetomidine (PRECEDEX™ "dexmedetomidine hydrochloride" - Pfizer) and ketamine)
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Cairo University
No Disease or Condition is Being Studied
ANI-Guided Fentanyl Infusion During Living Donor Liver Resections
Thу goal of this study was to learn whether intraoperative analgesia nociception monitoring (ANI) could be beneficial during intraoperative monitoring for patients undergoing living donor liver resections.
- Trial name
- NCT06619977
- Testing
- Analgesia nociception monitoring (ANI)
- Where
- Ukraine
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Bogomolets National Medical University
Liver Neoplasms
Complicated Outcome Prediction After Liver Resection
Although mortality after liver surgery reduced during the last three decades to less than 2%, post-operative course is still complicated in a range of 20-50% of cases.The identification of one or few factors which could detect…
- Trial name
- NCT03577067
- Testing
- Liver resection for primary and secondary disease
- Volunteers
- 183 people, healthy volunteers welcome
- Sponsor
- University of Milan
Liver Resection
Stapler vs. LigaSure in Elective Hepatic Resection
The optimal technique of parenchymal transection in liver surgery has remained a matter of controversial debate among hepatobiliary surgeons.
- Trial name
- CRUNSHII (NCT01858987)
- Testing
- Stapler hepatectomy, LigaSure hepatectomy, Ligasure
- Where
- Germany
- Volunteers
- 138 people
- Sponsor
- Heidelberg University
Hepatectomy
Ketamine, Lidocaine and Combination for Postoperative Analgesia in Open Liver Resection
Lidocaine and ketamine both are being used for perioperative analgesia. Perioperative lidocaine infusion has been shown to reduce postoperative pain and opioid consumption.
- Trial name
- NCT03391427
- Testing
- Lidocaine, Ketamine, Lidocaine+ketamine
- Where
- Canada
- Volunteers
- 124 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's