Clinical trials: Cadmium
Quantitative Analysis of SPECT MPI
Single-scan Rest/Stress Imaging With Cadmium Zinc Telluride-based SPECT for Coronary Flow Quantification
The investigators aim to address this issue with novel image quantification methods using CZT-based SPECT, which is capable of dynamic data acquisition and therefore feasible for the quantification of the coronary flow.
- Trial name
- NCT02985931
- Testing
- Diagnostic imaging scans of SPECT and MRI
- Volunteers
- 30 people
- Sponsor
- Chang Gung Memorial Hospital
Breast Cancer, BRCA1 Mutation
Endocrine Disruptors and Life STILe in Breast Cancer Development
The aim of the study is to evaluate the role of lifestyle and environmental factors ( environmental contaminants such as Cd) on the penetrance of BRCA1/2 genes in BRCAm patients with Breast cancer and/or Ovarian cancer and in…
- Conditions
- Breast Cancer, BRCA1 Mutation, BRCA2 Mutation, Ovarian Cancer
- Trial name
- STILVARCA (NCT05748353)
- Where
- Italy
- Volunteers
- 275 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Lung Cancer, Chronic Obstructive Pulmonary Disease
Blood, Hair and Lung Concentrations of Metals and Metalloids in Patients With Lung Cancer or Chronic Obstructive Pulmonary Disease
Prospective research to study the relationship between concentrations of metals/metalloids in blood, hair and lung tissue with the occurence of lung cancer or chronic obstructive pulmonary disease.
- Conditions
- Lung Cancer, Chronic Obstructive Pulmonary Disease, Emphysema, Lung Surgery
- Trial name
- Métaux/Poumons (NCT01949181)
- Testing
- Lung surgery
- Where
- 2 sites in France
- Volunteers
- 251 people
- Sponsor
- Hopital Foch
Cadmium, Placenta
Cadmium Exposure During Pregnancy and Fetal Growth
Cadmium is a toxic heavy metal naturally present in the environment, whose human exposure has increased over recent decades due to diffuse anthropogenic contamination, particularly related to industrial activities and the use of…
- Conditions
- Cadmium, Placenta, Fetal Growth, Birth Weight
- Trial name
- CADNAT (NCT07855237)
- Testing
- maternal blood samples, Placental tissue samples, maternal urine samples
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Cadmium Exceeds the Standard
Study on Neuropsychiatric Behavior in Cadmium-exposed People
This study hypothesized that excessive cadmium is related to clinical pain, depression, and cognitive impairment, and that related indicators will improve after cadmium is eliminated.
- Trial name
- NCT06572566
- Testing
- Non-invasive examination and assessment.
- Where
- China
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Jianersheng (Zhuhai) Pharmaceutical Technology Co., Ltd.
Cardiac Disease
The CZT Dynamic Myocardial Perfusion Imaging
To develop and validate the noninvasive measurement of MBF and MFR by using dynamic imaging with a CZT camera, and evaluate the diagnostic and prognostic implications in various heart disease.
- Trial name
- CZT (NCT02697760)
- Testing
- thallium-201
- Where
- Taiwan
- Volunteers
- 234 people
- Sponsor
- Far Eastern Memorial Hospital
Device
Comparison of Record in VERITON Camera to the Anger Camera Procedure in Patients Treated by 131-iodine
The aim of this study is to show that the SPECT/CT whole body recording procedure lasting less than or equal to 30 minutes in a VERITON-CT™ camera, can be substituted for the classic procedure, giving at least equivalent…
- Trial name
- VERICATH (NCT05713123)
- Testing
- A SPECT-CT whole body is added in VERITON-CT camera
- Where
- France
- Volunteers
- 77 people
- Sponsor
- Central Hospital, Nancy, France
Cadmium Exceeds the Standard
The Safety and Efficacy of GMDTC for Injection in Subjects With Elevated Cadmium Levels
This is a randomized, double-blind, placebo-controlled, single-center Phase IIa clinical study.
- Trial name
- NCT07057414
- Testing
- GMDTC for injection, 0.9% Sodium Chloride Injection(0.9% NaCl)
- Where
- China
- Volunteers
- 11 people
- Sponsor
- Guangdong Jianersheng Pharmaceutical Technology Co., Ltd.
Infertility, Male
Influence of Pb&Cd Seminal Plasma Level & ICSI
To evaluate the influence of lead (pb) and cadmium (cd) seminal plasma level on embryo development and pregnancy rate during intracytoplasmic sperm injection (ICSI).
- Trial name
- NCT04286633
- Volunteers
- 50 people
- Sponsor
- Assiut University
Prostate Cancer
Quantification With Lutetium-177 on Cadmium-Zinc-Telluride Camera 3D
The main of this study is to demonstrate the feasibility of carrying out quantitative acquisitions regardless of the energy peak considered (113 keV (kiloelectronVolts) or 208 keV or a combination of the 2 energy peaks).
- Trial name
- QUADO (NCT06783088)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Central Hospital, Nancy, France
Bone Scan
Evaluation of an Artificial Intelligence Algorithm Reducing Noise on Fast Whole-body Bone Tomoscintigraphy Acquisitions Recorded by a 360 Degree Cadmium-Zinc-Tellurid Camera
Recently, artificial intelligence algorithms reducing noise by deep learning have been developed with application to SPECT and PET images.
- Trial name
- IATOS2 (NCT06782438)
- Testing
- artificial intelligence algorithm
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Central Hospital, Nancy, France
Cadmium Exceeds the Standard
Safety Study of GMDTC Injection in Participants With Excessive Cadmium
This trial is a randomized, double-blind, single-center, single-dose escalating Phase I clinical trial designed to evaluate the safety, tolerability, and pharmacokinetic characteristics of GMDTC for injection after repeated…
- Trial name
- NCT06199349
- Testing
- GMDTC for injection, Normal saline
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Jianersheng (Zhuhai) Pharmaceutical Technology Co., Ltd.
Coronary Artery Disease
Myocardial Flow Reserve and 99mTc-DTPA Cardiac Dynamic SPECT
New CZT-based SPECT cameras are potentially capable of dynamic 3-D acquisition. Preliminary results suggested that dynamic acquisitions could allow the assessment of myocardial flow reserve using 99mTc-labelled perfusion tracers.
- Trial name
- Flow-Heart (NCT02844686)
- Testing
- Cardiac SPECT
- Volunteers
- 20 people
- Sponsor
- University Hospital, Caen
Dialysis
Trace Elements Concentration in Dialysis
In hemodialysis population the study team finds high concentrations of toxic trace elements (2 times higher than the general population for cadmium 4 to 13 times for lead).
- Trial name
- EMTDialyse (NCT05031013)
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pancreatic Cancer, Precancerous Condition
Urine Cadmium Levels in Predicting Pancreatic Cancer Risk in Patients With Chronic Pancreatitis
RATIONALE: Measuring cadmium levels in urine samples from patients with chronic pancreatitis may help doctors predict which patients may develop pancreatic cancer. It may also help the study of cancer in the future.
- Trial name
- NCT00489671
- Volunteers
- 32 people
- Sponsor
- Wake Forest University Health Sciences
Cadmium Exposure
Safety Study of GMDTC Injection in Healthy Participants
This trial is a randomized, double-blind, single-center, single-dose escalating Phase I clinical trial designed to evaluate the safety, tolerability, and pharmacokinetic characteristics of injectable GMDTC in healthy subjects
- Trial name
- NCT05908383
- Testing
- GMDTC for injection, Normal saline
- Where
- China
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Jianersheng (Zhuhai) Pharmaceutical Technology Co., Ltd.
Bone Metastases
Evaluation of an Accelerated Body-whole Bone CT Procedure With the CZT(Cadmium-Zinc-Telluride) "VERITON-CT ™" Camera
The purpose of the OSS study is to evaluate a procedure involving a single full body SPECT/CT (Single photon emission computed tomography coupled with a computerized tomography) 3D recording with a new semiconductor camera,his…
- Trial name
- OSS (NCT04157166)
- Testing
- Group 1 to record a 25 minutes whole body 3D in camera VERITON-CT ™ after scintigraphy + SPECT/CT in camera d'Anger
- Where
- 2 sites in France
- Volunteers
- 146 people
- Sponsor
- Central Hospital, Nancy, France
Non-Small-Cell Lung Carcinoma, Head and Neck Squamous Cell Cancer
LIFE-Lung Bronchoscopy in Patients at Risk for Developing Lung Cancer
The purpose of the study is to evaluate the usefulness and accuracy of the "LIFE-Lung Bronchoscopy" to identify early changes in lung tissues that show precancerous, cancer in situ (just beginning and not spread) and microscopic…
- Conditions
- Non-Small-Cell Lung Carcinoma, Head and Neck Squamous Cell Cancer, Pulmonary Disease, Chronic Obstructive
- Trial name
- NCT00260598
- Testing
- LIFE Bronchoscopy
- Where
- United States
- Volunteers
- 142 people
- Sponsor
- University of Pittsburgh
Infectious Disease of Lung
Tracheobronchitis in Respiratory Involvement on the Lung SPECT/CT Images of Coronavirus Disease (COVID-19) Patients
Tracheobronchitis signs may be observed on ventilation lung scintigraphy during coronavirus disease (COVID-19) infection. This case report study aimed to analyze the rates and associated factors of such tracheobronchitis in…
- Trial name
- NCT04629222
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Central Hospital, Nancy, France
Coronary Artery Disease
Accuracy of Half of the Usual Radiotracer Dose in SPECT
There has been a shortage of nuclear isotopes, not only in Canada but around the world. New, more sensitive SPECT cameras can obtain better images in shorter scan times.
- Trial name
- SPECT-Light (NCT01412827)
- Testing
- 1/2 dose of 99mTc OR 201Tl tracers
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- Ottawa Heart Institute Research Corporation