Clinical trials: Vitamin C
Mesopic Vision, Night Vision Loss
Safety and Efficacy of 0.75% Phentolamine Ophthalmic Solution in Subjects With Post-refractive Surgery Visual Disturbances
Safety and efficacy of 0.75% Phentolamine Ophthalmic Solution to improve mesopic low contrast visual acuity in subjects with post-refractive surgery visual disturbances.
- Trial name
- LYNX-2 (NCT06349759)
- Testing
- phentolamine ophthalmic solution 0.75%, a non-selective alpha-1 and alpha-2 adrenergic antagonist
- Where
- 25 sites in United States
- Volunteers
- 200 people
- Sponsor
- Opus Genetics, Inc
Melatonin, Breast Cancer Patients Diagnosed
Cardioprotective Effect of Melatonin Versus Vitamin D in Breast Cancer Patients Receiving Doxorubicin
This study aims to assess the cardioprotective effect of melatonin and vitamin D in breast cancer patients who receive doxorubicin.
- Conditions
- Melatonin, Breast Cancer Patients Diagnosed, Vitamin D Concentration, Doxorubicin
- Trial name
- NCT07349459
- Testing
- Group 1 (Doxorubicin group), Group 2: Vitamin D group, Group 3: melatonin group
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Tanta University
Healthy, Suboptimal Vitamin C Levels
The Impact of Qualia Vitamin C+ on Blood Vitamin C Levels
This is a double-blind, placebo-controlled, parallel-group, study evaluating the effect of a Qualia Vitamin C+ formulation on Whole Blood Vitamin C levels in the blood of healthy adults aged 25 years or older.
- Trial name
- NCT07285109
- Testing
- Qualia Vitamin C+
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Qualia Life Sciences
Pre-Eclampsia, Depression
Preeclampsia Research on Vitamin D, Inflammation, & Depression
This study is designed to comprehensively investigate the anti-inflammatory role of vitamin D in reproductive aged women, and its association with preeclampsia and depression.
- Conditions
- Pre-Eclampsia, Depression, Inflammation, Vitamin D Deficiency
- Trial name
- PROVIDE (NCT03018132)
- Testing
- mental health screening, education and referral program
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Hypovitaminosis D
The Effectiveness of a Weight-dependent Algorithm for Dosing Vitamin D.
Vitamin D is essential for calcium absorption and bone growth, brain development, and immune system function. Vitamin D is produced by the body in response to natural sunlight.
- Trial name
- NCT07876843
- Testing
- Vitamin D3, Calcium, and Vitamin C
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Atlantic Health System
Spinal Anesthesia-induced Hypotension, Vitamin D Deficiency
Effect of Vitamin D Deficiency on the Frequency and Severity of Spinal Anesthesia-Induced Hypotension in Pregnant Women Undergoing Cesarean Section
Spinal anesthesia-induced hypotension remains a common and significant complication during cesarean sections, posing risks for both mother and fetus.
- Conditions
- Spinal Anesthesia-induced Hypotension, Vitamin D Deficiency, Cesarean Section
- Trial name
- NCT07057362
- Testing
- Intraoperative Hemodynamic Monitoring
- Where
- Turkey (Türkiye)
- Volunteers
- 177 people
- Sponsor
- Duzce University
Vision Loss Night, Vision Disorders
OPI-NXYDLD-303 Safety and Efficacy of Phentolamine Ophthalmic Solution in Keratorefractive Surgery Participants With Decreased Mesopic Visual Acuity
The goal of this clinical trial is to learn if Phentolamine Ophthalmic Solution works to treat adults that have had keratorefractive surgery and have decreased visual acuity under mesopic conditions.
- Trial name
- LYNX-3 (NCT07140783)
- Testing
- 0.75% Phentolamine Ophthalmic Solution
- Where
- 20 sites in United States
- Volunteers
- 580 people
- Sponsor
- Opus Genetics, Inc
Critical Illness, Vitamin D Deficiency
The VITDALIZE Study: Effect of High-dose Vitamin D3 on 28-day Mortality in Adult Critically Ill Patients
In the VITdAL-ICU trial using a large oral dose of vitamin D3 in 480 adult critically ill patients, there was no benefit regarding the primary endpoint hospital length of stay.
- Conditions
- Critical Illness, Vitamin D Deficiency, Covid19
- Trial name
- VITDALIZE (NCT03188796)
- Testing
- Cholecalciferol
- Where
- 18 sites in Austria, Belgium and 2 more
- Volunteers
- 2,400 people
- Sponsor
- Medical University of Graz
Vitamin D 25-Hydroxylase Deficiency, Undernutrition
Impact of Trout Fish, Cow Milk With Egg, Vitamin D Supplementation, and Dietary Education on Vitamin D Status, Undernutrition, and Neurocognitive Outcomes Among School Children in Pakistan: An Open-label Individually Randomized Controlled Trial
Vitamin D deficiency and undernutrition are major public health concerns globally, particularly among children in low-resource and high-altitude settings.
- Conditions
- Vitamin D 25-Hydroxylase Deficiency, Undernutrition, Neurocognitive Development
- Trial name
- NCT07864662
- Testing
- Vitamin D supplement 4000 IU weekly, 200 grams of cooked trout fish, 250 milliliters of whole cow milk + whole egg
- Where
- Pakistan
- Volunteers
- 304 people
- Sponsor
- Aga Khan University
Vitamin D Deficiency
Vitamin D Status and Its Influencing Factors in Zhejiang Province: A Multicenter Cross-Sectional Study
Vitamin D deficiency is a global public health problem, with an estimated 1 billion people affected worldwide, and large-scale systematic data for Zhejiang Province remain scarce.
- Trial name
- NCT07866391
- Where
- 2 sites in China
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
Vitamin D Deficiency
Bone Myoregulation Reflex and Postural Control in Vitamin D Deficiency
This observational study aims to investigate the relationship between vitamin D deficiency, postural stability, and neuromuscular control mechanisms in adults.
- Trial name
- BMR-VITD (NCT07435935)
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Deficiencies Micronutrient, Nutrition Disorders
Effect of Consuming Vitamin A-fortified Sugar on Serum Retinol Levels in Children
The increase in vitamin A deficiency (<20 mcg/dL) among children under five in Colombia (2010-2015) is a public health problem (27.3%).
- Trial name
- NCT07860060
- Testing
- white sugar fortified with retinol, refined white sugar for culinary use
- Where
- Colombia
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Universidad del Valle, Colombia
Benign Paroxismal Positional Vertigo
BPPV Recurrence After CRM With & Without Supplementation
Benign paroxysmal positional vertigo (BPPV) may frequently recur even after successful canalith repositioning maneuvers (CRMs). This study investigates whether the addition of vitamin K₂ to vitamin D₃ offers additional benefits…
- Trial name
- RR-BPPV-DK (NCT07861464)
- Testing
- Combined vitamin D₃ and K₂ supplementation, Vitamin D₃ alone, Canalith repositioning maneuver (CRM) alone
- Where
- Jordan
- Volunteers
- 404 people
- Sponsor
- University of Jordan
Healthy, Suboptimal Vitamin C Levels
The Impact of Qualia Vitamin C+ on Individuals With Suboptimal and Adequate Vitamin C Levels
This is a double-blind, placebo-controlled, parallel-group, study evaluating the effect of a Qualia Vitamin C+ formulation on Whole Blood Vitamin C levels in the blood of healthy adults aged 25 years or older that have suboptimal…
- Conditions
- Healthy, Suboptimal Vitamin C Levels, Adequate Vitamin C Levels
- Trial name
- NCT07652346
- Testing
- Qualia Vitamin C+
- Where
- United States
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Qualia Life Sciences
Healthy Adult Participants, Vitamin D Insufficiency
Supplementation of Cholecalciferol and Related Active Metabolites Through Bioenhancing Layer's Eggs
The purpose of this research is to evaluate if 1) consumption of vitamin D3- or 25(OH)D3-biofortified eggs will increase vitamin D and 25(OH)D status in young adults who consume these bioenhanced eggs, 2) to determine if the gut…
- Trial name
- SCRAMBLE (NCT07859280)
- Testing
- Vitamin D3 bioenhanced eggs, 25(OH)D3 bioenhanced eggs
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cornell University
Vitamin D Deficiency, Pregnancy
Effects of Vitamin D on Health Promotion During Pregnancy and Its Impact on Prematurity-Related Outcome
The VitDTracking study focuses on the relevance of maternal vitamin D levels and their association with prematurity, aiming to improve maternal and child health outcomes, particularly by reducing avoidable preterm births.
- Trial name
- VitDTracking (NCT06292195)
- Testing
- Exposure
- Where
- 3 sites in Portugal
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- University of Évora
Osteoarthritis, Vitamin D Deficiency
Preoperative Correction of Vitamin D Deficiency in Total Joint Arthroplasty (TJA)
The purpose of this study is being conducted to determine whether correcting low levels of vitamin D with a single high-dose supplement reduces complications after the participant's primary TJA.
- Trial name
- NCT07006714
- Testing
- Vitamin D3
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Miami
Deficiency, Vitamin C, Chronic Disease
A Long-term Observational Study to Describe the Use of Vitamin-C Injektopas® 7.5 g in Patients With Vitamin C Deficiency
The goal of this observational study is to learn more about the disease and the symptoms where the product will use and in which patient groups. Further on, it is interesting to know clinical pictures, the symptoms improve.
- Conditions
- Deficiency, Vitamin C, Chronic Disease, Acute Disease
- Trial name
- NCT06983847
- Where
- Austria
- Volunteers
- 1,000 people
- Sponsor
- Pascoe Pharmazeutische Praeparate GmbH
Vitamin K-Dependent Coagulation Defect, Significant Bleeding Risk
Post Marketing Observational Study on Safety of BALFAXAR vs. KCENTRA for Reversal of Vitamin K Antagonist Induced Anticoagulation in Adults Undergoing Urgent Surgery or Invasive Procedure
Post marketing observational study on safety of BALFAXAR vs. KCENTRA for Reversal of Vitamin K Antagonist Induced Anticoagulation in Adults Undergoing Urgent Surgery or Invasive Procedure
- Trial name
- NCT06429787
- Testing
- Balfaxar, Kcentra
- Where
- United States
- Volunteers
- 3,574 people
- Sponsor
- Octapharma
Esophageal Cancer, Gastric Cancer
VITAMin Insufficiency in Esophagogastric Neoplasms
Rationale: Esophageal cancer and gastric cancer are among the top ten most common cancers worldwide. Both diseases have major impact on the nutritional status of patients and their quality of life.
- Conditions
- Esophageal Cancer, Gastric Cancer, Vitamin Disease, Quality of Life
- Trial name
- VITAMIN (NCT05281380)
- Testing
- GIKAVI
- Where
- Netherlands
- Volunteers
- 107 people
- Sponsor
- Zuyderland Medisch Centrum