Clinical trials: Renal Function
Renal Function
Urinary Creatinine Excretion Time in the Neonatal Period
Newborn's renal function is difficult to assess and its physiology during the first days of life is still incompletely known. Studies suggest that the newborn almost completely reabsorbs creatinine during the first 48 to 72 hours…
- Trial name
- C-Rex (NCT05813730)
- Testing
- urinary creatinine excretion measurement
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
End Stage Renal Disease on Dialysis, Peritoneal Dialysis Complication
Empagliflozin on Residual Kidney Function in Incident Peritoneal Dialysis Patients
Empagliflozin, a new class of diabetes medication, has demonstrated a reduction in renal function decline among patients with chronic kidney disease, regardless of their diabetes status.
- Conditions
- End Stage Renal Disease on Dialysis, Peritoneal Dialysis Complication, Sodium-glucose Cotransporter-2 Inhibitor, Residual Kidney Function
- Trial name
- EMPIRIC-PD (NCT06483074)
- Testing
- Empagliflozin 10 MG
- Where
- Hong Kong
- Volunteers
- 48 people
- Sponsor
- Chinese University of Hong Kong
Acute and Long Term Effects of COVID-19 on Systemic Inflammation, Acute and Long Term Effects of COVID-19 on Lung Function
Cardiopulmonary Inflammation and Multi-System Imaging During the Clinical Course of COVID-19 Infection in Asymptomatic and Symptomatic Persons
Background: COVID-19 virus infection differs among people. Some people have no or mild symptoms. For others, COVID-19 is life threatening and causes damage to the body s organs.
- Conditions
- Acute and Long Term Effects of COVID-19 on Systemic Inflammation, Acute and Long Term Effects of COVID-19 on Lung Function, Acute and Long Term Effects of COVID-19 on Cardiac Function, Acute and Long Term Effects of COVID-19 on Kidney Function
- Trial name
- NCT04401449
- Where
- 2 sites in United States
- Volunteers
- 202 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Heart Failure and Impaired Kidney Function
Study to Evaluate the Effect of Balcinrenone/Dapagliflozin in Patients With Heart Failure and Impaired Kidney Function
This is a Phase III, international, multi-centre, randomised, double-blind, parallel-group, double-dummy, active-controlled, event-driven study in patients with chronic HF and impaired kidney function who had a recent HF event.
- Trial name
- BalanceD-HF (NCT06307652)
- Where
- 852 sites in United States, Argentina and 37 more
- Volunteers
- 3,850 people
- Sponsor
- AstraZeneca
CKD - Chronic Kidney Disease, Renal Function
Walnuts for Cardiorenal Protection in Adults With Chronic Kidney Disease
To date, no rigorous randomized controlled trials have demonstrated a protective effect of daily moderate walnut consumption on kidney function or chronic kidney disease (CKD) progression in individuals with CKD.
- Conditions
- CKD - Chronic Kidney Disease, Renal Function, Cardiovascular Biomarkers
- Trial name
- NutReCard (NCT07851454)
- Testing
- Daily Walnut Consumption
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- Institut Investigacio Sanitaria Pere Virgili
Kidney Failure, Chronic, Kidney Transplantation
Drone Transport of Deceased-Donor Kidney Grafts Between Two French Hospitals Before Transplantation: a Pilot Safety Study
Cold ischemia time, the period during which a donated kidney is kept cold outside the body between its removal from the donor and its transplantation into the recipient, is one of the main modifiable factors influencing how…
- Conditions
- Kidney Failure, Chronic, Kidney Transplantation, Delayed Graft Function, Cold Ischemia
- Trial name
- RAfALREIN (NCT07851571)
- Testing
- Kidney graft transport by autonomous unmanned aircraft (drone) between the procurement and transplantation centres
- Volunteers
- 5 people
- Sponsor
- Nantes University Hospital
Kidney Transplant, Kidney Transplant Recipient
Rituximab in Renal Allograft Recipients Who Develop Early De Novo Anti-HLA Alloantibodies
The purpose of this study is to determine whether treatment with rituximab (anti-CD20, Rituxan®, MabThera®) in individuals who develop new anti-HLA antibodies after renal (kidney) transplant will promote longer-term survival of…
- Conditions
- Kidney Transplant, Kidney Transplant Recipient, Graft Function/Survival, de Novo HLA Antibodies Development
- Trial name
- NCT00307125
- Testing
- Rituximab plus immunosuppression
- Where
- 17 sites in United States
- Volunteers
- 757 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Pyeloplasty, Pediatric Patients
Pyeloplasty in Pediatric Patients With Differential Renal Function Less Than 10%
This study aims to evaluate the postoperative outcomes of pyeloplasty in pediatric patients presenting with ureteropelvic junction obstruction and preoperative differential renal function less than 10%, focusing on: Improvement…
- Conditions
- Pyeloplasty, Pediatric Patients, Differential Renal Function
- Trial name
- NCT07836621
- Testing
- Pyeloplasty
- Where
- Egypt
- Volunteers
- 26 people
- Sponsor
- Tanta University
Delayed Graft Function, Kidney Transplantation
The Impact of Intraoperative Diuretic Use on Delayed Graft Function Following Deceased Donor Renal Transplantation
Delayed graft function, defined as the need for dialysis within seven days of kidney transplantation, is a common complication affecting deceased-donor kidney transplant recipients.
- Trial name
- NCT07726134
- Testing
- Furosemide, Mannitol
- Where
- 2 sites in Canada
- Volunteers
- 160 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Kidney Transplantation
Ex Vivo Normothermic Perfusion in Kidney Transplantation.
A multicenter, prospective and open-label clinical investigation to evaluate the viability, performance and safety of ex vivo normothermic perfusion in kidney transplantation from DCD and DBD donors.
- Trial name
- KidneyARK (NCT05175885)
- Testing
- Ex vivo normothermic perfusion, Cold preservation
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Ebers Medical Technology, S.L.
Cirrhosis, Liver, Splenectomy; Status
Effect of LSD on Renal Function in Cirrhotic Patients With Portal Hypertension
Patients with liver cirrhosis and portal hypertension often have impaired kidney function due to reduced blood flow to the kidneys and fluid buildup in the abdomen (ascites).
- Conditions
- Cirrhosis, Liver, Splenectomy; Status, Renal Function Abnormal, Portal Hypertension
- Trial name
- NCT07811713
- Testing
- Laparoscopic splenectomy and azygoportal disconnection
- Volunteers
- 496 people
- Sponsor
- Northern Jiangsu People's Hospital
Delayed Graft Function, End Stage Renal Disease
Study to Evaluate the Efficacy and Safety of Pegcetacoplan in Adults at High Risk of Delayed Graft Function (DGF) Following Kidney Allograft Transplantation
A Phase 3 Study to Evaluate the Efficacy and Safety of Pegcetacoplan in Adults at High Risk of Delayed Graft Function (DGF) Following Kidney Allograft Transplantation
- Conditions
- Delayed Graft Function, End Stage Renal Disease, Deceased Donor Kidney Transplant
- Trial name
- NCT07020832
- Testing
- Pegcetacoplan
- Where
- Brazil
- Sponsor
- Apellis Pharmaceuticals, Inc.
Kidney Disease, Kidney Transplant
A Multicenter, Prospective Blood Collection Study in a Kidney Transplant Population
The purpose of this research is to collect blood samples and data from kidney transplant patients. The samples and data will be used for research and development of non-invasive test to detect donor-derived cell-free DNA…
- Conditions
- Kidney Disease, Kidney Transplant, Transplant Recipient, Renal Function
- Trial name
- Accept cfDNA (NCT07006831)
- Where
- 6 sites in United States
- Volunteers
- 400 people
- Sponsor
- Devyser Inc.
Cardiovascular Diseases, Mortality
Prospective Cohort Study of 4,837 Post-myocardial Infarction Patients (Alpha Omega Cohort)
The Alpha Omega Cohort is a prospective study of 4,837 state-of-the-art drug-treated Dutch patients aged 60-80 years who had a clinically diagnosed myocardial infarction up to 10 years before enrolment.
- Conditions
- Cardiovascular Diseases, Mortality, Type 2 Diabetes Mellitus, Cognitive Decline
- Trial name
- NCT03192410
- Testing
- Dietary intake, Lifestyle factors, Blood biomarkers
- Where
- Netherlands
- Volunteers
- 4,837 people
- Sponsor
- Wageningen University
Kidney Function Decline, Chronic Kidney Disease
Comprehensive Kidney Function Assessment and Early Warning in Older Adults
This completed observational cohort study evaluates a comprehensive set of clinical and molecular markers of kidney function in two established cohorts of Chinese adults aged 60 years or older.
- Conditions
- Kidney Function Decline, Chronic Kidney Disease, Kidney Failure
- Trial name
- NCT07765134
- Where
- China
- Volunteers
- 5,588 people, healthy volunteers welcome
- Sponsor
- Huashan Hospital
Type 1 Diabetes, T1D Heart Failure
Precision T1D Platform - New Therapies for Cardio-Renal Complications
Breakthrough T1D has awarded support for a joint University of Michigan-Oregon Health \& Science University Center of Excellence (CoE) to address cardio-renal complications in T1D.
- Conditions
- Type 1 Diabetes, T1D Heart Failure, Cardio-renal Vascular Function and Failure, Diabetic Chronic Kidney Disease
- Trial name
- NCT07594145
- Testing
- Finerenone, Sotagliflozin
- Where
- 2 sites in United States
- Volunteers
- 57 people
- Sponsor
- Oregon Health and Science University
Postoperative Renal Function
Intraoperative Laser Speckle Imaging Predicts Early Renal Function After Kidney Transplantation
This observational study aims to explore the predictive value of intraoperative laser speckle contrast imaging for early postoperative renal function in kidney transplant recipients.
- Trial name
- NCT07753434
- Testing
- laser speckle contrast imaging (LSCI)
- Where
- China
- Volunteers
- 80 people
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University
Kidney Function, Kidney Transplant; Complications
Furosemide Stress Test Predicting Early Graft Function in Kidney Transplantation
Furosemide is an old drug that has been used frequently in the postoperative period of kidney transplantation, aiming to achieve adequate urine output.
- Conditions
- Kidney Function, Kidney Transplant; Complications, Delayed Graft Function
- Trial name
- FOSTIK (NCT03071536)
- Testing
- Furosemide Injection
- Where
- Thailand
- Volunteers
- 360 people
- Sponsor
- King Chulalongkorn Memorial Hospital
Brain Death, Kidney Transplantation
Cyclosporine A Pretreatment and Kidney Graft Function
Organ donors included in the study are randomized to a control group or an intervention group receiving 2.5 mg/kg of cyclosporine A before organ procurement.
- Trial name
- Cis-A-Rein (NCT02907554)
- Testing
- cyclosporine A
- Where
- France
- Volunteers
- 648 people
- Sponsor
- University Hospital, Clermont-Ferrand
Non-alcoholic Fatty Liver Disease, Renal Function Impairment
Analysis of Renal Impairment Characteristics and High-Risk Factors in Chronic Hepatitis B Patients on Long-Term Oral Nucleos(t)Ide Analogues
This is a single-center retrospective observational study. A total of 300 patients with non-alcoholic fatty liver disease treated in our hospital will be included.
- Trial name
- NCT07730905
- Testing
- Long-term oral nucleos(t)ide analogs antiviral therapy
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Foshan Hospital of Traditional Chinese Medicine