Clinical trials: Real-world Study
Basal Cell Carcinoma of Skin, Optical Coherence Tomography (OCT)
Real-world Evaluation of the Implementation of LC-OCT in Daily Clinical Practice
Basal cell carcinoma (BCC) is the most common skin cancer in the Netherlands, with incidence rates continuing to rise. The current diagnostic standard combines clinical evaluation and dermoscopy, while biopsy followed by…
- Conditions
- Basal Cell Carcinoma of Skin, Optical Coherence Tomography (OCT), Neoplasms, Neoplasms, Basal Cell
- Trial name
- RELI (NCT07501780)
- Where
- Netherlands
- Volunteers
- 297 people
- Sponsor
- Maastricht University Medical Center
This Study Evaluates Interventions to Increase Surveillance Mammography Uptake for Early Breast Cancer Detection Among Singaporean Women in Real World
Community Study to Increase Mammogram Screening Among Overdue Women
Breast cancer is the most common cancer among women in Singapore, and regular mammogram screening can detect breast cancer early when treatment is more effective.
- Trial name
- IMPLEMENT (NCT07832396)
- Testing
- Evidence-based behavioural intervention
- Where
- Singapore
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Thyroid Diseases, Thyroid Neoplasms
Thyroid Health Outcomes Registry for Surgery
THORS is a single-center ambidirectional observational cohort study conducted at Moscow Multidisciplinary Clinical Center "Kommunarka".
- Conditions
- Thyroid Diseases, Thyroid Neoplasms, Thyroid Cancer, Thyroid Nodules
- Trial name
- THORS (NCT07812779)
- Volunteers
- 3,000 people
- Sponsor
- Pirogov Russian National Research Medical University
Real World Multi-cohort Study of Patients With Non-small Cell Lung Cancer (NSCLC) Initiating Approved Drugs Developed by AZ or as Part of an AZ Alliance
UmbREALung - A Retrospective and Prospective, Observational, Real World Multi-cohort Study of Patients With Non-small Cell Lung Cancer (NSCLC) Initiating Approved Drugs Developed by AZ or as Part of an AZ Alliance
This is an ambispective, observational, multicenter and multicohort study, targeting patients with NSCLC initiating approved drugs developed by AZ or as part of an AZ alliance, in the participating countries, as monotherapy or in…
- Trial name
- UmbREALung (NCT06726720)
- Where
- 70 sites in France, Germany
- Volunteers
- 300 people
- Sponsor
- AstraZeneca
COVID-19, Emergency Surgery
Treatment and Outcomes in Patients With COVID-19 and Competing Acute Surgical Diseases in Moscow
The COVID-19 pandemic has posed a significant challenge to surgical practice. This study aims to investigate the structure of hospitalizations, treatment outcomes, and surgical tactics in patients with COVID-19 and competing…
- Conditions
- COVID-19, Emergency Surgery, Abdominal Surgery, Real-World Data
- Trial name
- SurgCOVID-Mos (NCT07719166)
- Testing
- Surgical and Interventional Management of Acute Surgical Conditions
- Where
- Russia
- Volunteers
- 58,000 people
- Sponsor
- Pirogov Russian National Research Medical University
NSCLC Stage IV, PD-L1 Gene Mutation
TRIMPACT: Real-World First-Line Atezolizumab Use in Stage IV NSCLC With PD-L1 ≥50%
This prospective, multicenter, real-world observational study aims to evaluate the clinical outcomes of first-line atezolizumab monotherapy in patients with stage IV non-small cell lung cancer (NSCLC) with PD-L1 tumor cell…
- Conditions
- NSCLC Stage IV, PD-L1 Gene Mutation, Atezolizumab, Real World Study
- Trial name
- NCT07279402
- Where
- 25 sites in Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Antalya Training and Research Hospital
Renal Cell Carcinoma (Kidney Cancer), Renal Cell Carcinoma (RCC)
Validation of RCC Predicting Model With Emulated-target Trial
This single-center study utilizes real-world data (2012-2024) from 4700 renal cell carcinoma (RCC) patients at Peking University Third Hospital to: (1) Develop and validate a prognostic prediction model specifically for RCC…
- Conditions
- Renal Cell Carcinoma (Kidney Cancer), Renal Cell Carcinoma (RCC), Tumor Thrombus, Prognosis
- Trial name
- RCCETT (NCT07117227)
- Testing
- Model-guided adjuvant treatment, No adjuvant treatment
- Where
- China
- Volunteers
- 4,700 people
- Sponsor
- Peking University Third Hospital
Non-Small Cell Lung Cancer, ALK
Iruplinalkib in ALK-Positive Advanced Lung Adenocarcinoma After Lorlatinib
This observational study aims to evaluate the real-world effectiveness and safety of iruplinalkib in patients with advanced ALK-positive lung adenocarcinoma who have progressed on or are intolerant to prior lorlatinib therapy.
- Conditions
- Non-Small Cell Lung Cancer, ALK, Iruplinalkib, Lorlatinib
- Trial name
- SAILOR (NCT07374614)
- Testing
- Iruplinalkib tablets
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Peking University Shenzhen Hospital
Cardiovascular Risk Factors, Menopausal Women
CARAMEL: Retrospective Study for Personalized Risk Assessment of Cardiovascular Disease in Menopausal and Perimenopausal Women Using Real World Data
This retrospective observational study, part of the EU-funded CARAMEL project, aims to develop and validate personalized cardiovascular disease (CVD) risk assessment models specifically designed for menopausal and perimenopausal…
- Conditions
- Cardiovascular Risk Factors, Menopausal Women, Perimenopausal Women, Real World Data
- Trial name
- CARAMEL RS (NCT06999317)
- Volunteers
- 1,500,000 people
- Sponsor
- Hospital Universitario Virgen Macarena
Enhanced Recovery After Surgery, Multimodal Analgesia
Enhanced Recovery After Surgery-Based Multimodal Preemptive Analgesia for Perioperative Management in Transarterial Chemoembolization of Intermediate-to-Advanced Hepatocellular Carcinoma
To evaluate the effectiveness of the combination of hydrochloride hydromorphone and flurbiprofen ester for post-TACE intravenous patient-controlled intravenous analgesia (PCIA).
- Conditions
- Enhanced Recovery After Surgery, Multimodal Analgesia, Real-world Study, Transarterial Chemoembolization
- Trial name
- NCT07315022
- Testing
- hydrochloride hydromorphone + flurbiprofen axetil, conventional analgesia
- Where
- China
- Volunteers
- 129 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
ARDS (Acute Respiratory Distress Syndrome), Real World Study
A Real World Study of Respiratory Critical Disease.
Acute Respiratory Distress Syndrome (ARDS) is a form of acute diffuse lung injury caused by various etiologies, which rapidly progresses to acute respiratory failure.
- Trial name
- NCT07165717
- Testing
- No Intervention: Observational Cohort
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Ming Zhong
Chronic Kidney Disease, Acute Kidney Injuries
Dementia and Kidney Disease: Epidemiological Approaches to Risk Factors and Treatment Strategies
Kidney disease and dementia are both common in older adults, posing a significant burden on individuals and society. Growing evidence suggests that there may be links between the kidney and the brain.
- Conditions
- Chronic Kidney Disease, Acute Kidney Injuries, Real World Study, Dementia
- Trial name
- NCT07093684
- Testing
- Kidney disease
- Where
- Sweden
- Volunteers
- 200,000 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Healthy, Real World Data
Clinical and Radiographic Outcomes of the JointMedica Custom-Made Resurfacing Device
The Custom Resurfacing (CR) Implants are indicated for use for the reduction or relief of pain and/or improved hip function all skeletally mature patients where a total joint replacement is indicated, and where there is no other…
- Conditions
- Healthy, Real World Data, Safety and Effectiveness, Patient Reported Outcome (PRO)
- Trial name
- NCT07094139
- Where
- United Kingdom
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- JointMedica Inc.
Healthy, Real World Data
Clinical and Radiographic Outcomes of the JointMedica Polymotion Resurfacing (PHR) Device
The goal of this observational study is to generate Real World Evidence (RWE) on the device performance of the Polymotion Hip Resurfacing (PHR) system and its use in patients who have been implanted with the device for the…
- Conditions
- Healthy, Real World Data, Safety and Effectiveness, Patient Reported Outcome (PRO)
- Trial name
- NCT07080671
- Where
- 3 sites in Australia, Canada and 1 more
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- JointMedica Inc.
Hepatocellular Carcinoma (HCC), Real World Study
The Efficacy and Safety of First-line Treatment Combined With Immunotherapy for Advanced Hepatocellular Carcinoma: a Single Center, Real-world Study
In recent years, immunotherapy represented by PD-1/PD-L1 inhibitors has continuously brought breakthroughs in the treatment of hepatocellular carcinoma and has gradually become the cornerstone of advanced liver cancer treatment.
- Trial name
- NCT07078292
- Volunteers
- 400 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Comparative Efficacy and Safety of Thalidomide and Sulfasalazine in Moderate to Severe Ankylosing Spondylitis: A Real-World Study From Bangladesh, Condition ...Moderate to Severe Axial Spondyloarthopathy
Comparative Efficacy and Safety of Thalidomide and Sulfasalazine in Moderate to Severe Ankylosing Spondylitis: A Real-World Study From Bangladesh
the present study was conducted to determine the comparative efficacy and safety of thalidomide and SSZ in moderate to severe cases of ankylosing spondylitis in Bangladesh.
- Trial name
- NCT06985134
- Testing
- Comparative Efficacy and Safety of Thalidomide and Sulfasalazine in Moderate to Severe Ankylosing Spondylitis: A Real-World Study from Bangladesh
- Where
- Bangladesh
- Volunteers
- 93 people
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Real-world Study
AI-Assisted Medical Decision-Making
The study builds and applies an AI model to help doctors predict patient diagnoses and outcomes, such as survival or hospital stay.
- Trial name
- NCT06846229
- Testing
- AI-associated strategy
- Where
- 2 sites in China
- Volunteers
- 50,000,000 people, healthy volunteers welcome
- Sponsor
- The Eye Hospital of Wenzhou Medical University
Patient Outcomes: Real World Evidence in Rheumatoid Arthritis (POWER)
Patient Outcomes: Real World Evidence in Rheumatoid Arthritis (POWER)
This is a prospective, real-world observational study in which patients with RA who are initiating treatment with a JAK inhibitor medication will self-report disease activity and treatment satisfaction measures using their own…
- Trial name
- NCT04512573
- Where
- United States
- Volunteers
- 232 people
- Sponsor
- CorEvitas
Helicobacter Pylori Infection, Comorbidities and Coexisting Conditions
Real-world Treatment of H. Pylori Eradication in Patients with Comorbidity
Most of the studies of H. pylori eradication were conducted in academic institutes and designed to enrolled patients who did not have comorbidities.
- Conditions
- Helicobacter Pylori Infection, Comorbidities and Coexisting Conditions, Real-world Outcome, Medication Adherence
- Trial name
- Real-world_Hp (NCT05475431)
- Testing
- The sequential therapy, The triple therapy, The hybrid therapy
- Where
- 2 sites in Taiwan
- Volunteers
- 1,053 people
- Sponsor
- National Cheng-Kung University Hospital
Bleeding, Real-world Study
Post-marketing Safety and Efficacy Surveillance of Motherwort Injection
This study aims to provide evidence concerning the safety and efficacy of motherwort injection in real-world settings.
- Conditions
- Bleeding, Real-world Study, Adverse Events
- Trial name
- NCT06636422
- Testing
- Motherwort injection
- Volunteers
- 20,000 people
- Sponsor
- Zhong Wang