Clinical trials: PreDiabetes, active
PreDiabetes, Diabetes Mellitus, Type 2
Metabolic and Inflammatory Outcomes of the Ketogenic Diet Comparing Saturated and Unsaturated Fat Sources
The goal of this clinical trial is to compare a healthy KETO diet supplemented with canola oil (KETO-Can) compared to a traditional KETO diet high in saturated fat (KETO-Sat) and low-fat diet (LFD) in adults at high risk of or…
- Conditions
- PreDiabetes, Diabetes Mellitus, Type 2, Overweight and Obesity
- Trial name
- KETO-IM (NCT05681468)
- Testing
- Keto-SAT, Keto-CAN, LFD
- Where
- Canada
- Volunteers
- 164 people
- Sponsor
- University of Alberta
Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
The Effect of Exercise and Nicotinamide Riboside Muscle Health and Insulin Resistance in Survivors of Childhood Cancer
This trial studies the effect of exercise and nicotinamide riboside on muscle health and insulin resistance in adult survivors of childhood cancer with prediabetes (elevated blood sugar level that is not high enough to be…
- Conditions
- Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm, Prediabetes
- Trial name
- NCT05023993
- Testing
- Exercise Intervention, Nicotinamide Riboside
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- City of Hope Medical Center
Prediabetes
Trial of CGM Technology in Persons Living With Prediabetes
Continuous glucose monitor (CGM) technology has become increasingly prevalent in the population and has the ability to transform care of patients living with prediabetes.
- Trial name
- CGM (NCT07639593)
- Testing
- Stelo CGM
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Wake Forest University Health Sciences
MAFLD in Prediabetes and Diabetes
Effect of SGLT2 Inhibitor on Metabolic-Dysfunction-Associated Fatty Liver Disease in Patients With Insulin Resistance
Metabolic-dysfunction-associated fatty liver disease (MAFLD) has evolved as a major health problem recently. Discovering ways to prevent or delay the progression of MAFLD has become a global focus.
- Trial name
- SGLT2 (NCT07891234)
- Testing
- Dapagliflozin 5Mg Tab, Metfomin 500 mg, Dapagliflozin (10mg Tab)
- Where
- Egypt
- Volunteers
- 66 people
- Sponsor
- Sherihan AboElyazed Mohamed Khalil
Prediabetes
Nested Pilot Study Comparing Two Treatments to Reduce Type 2 Diabetes Risk in At-Risk Delawareans
This nested pilot Randomized Clinical Trial will determine whether the Diabetes Prevention Program (DPP) enhanced with evidence-based sleep health and time restricted eating interventions ("DPP++") is more effective than the DPP…
- Trial name
- NCT07450118
- Testing
- National Diabetes Prevention Program (DPP), Sleep Health Digital Application, Time-Restricted Eating (TRE)
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Delaware
Nutritional and Metabolic Diseases, Prediabetes
LIfestyle MEtabotype Study B (LIME-B)
Glycemic responses vary significantly among individuals, even when consuming identical foods or meals, but the factors predicting individual glucose responses to food intake remain poorly investigated.
- Conditions
- Nutritional and Metabolic Diseases, Prediabetes, Type 2 Diabetes
- Trial name
- LIME-B (NCT07888257)
- Testing
- βHB drink (ketone ester), Carbohydrate drink
- Where
- 2 sites in Germany
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- German Institute of Human Nutrition
Prediabetes, Dietary Self-Management
Continuous Glucose Monitoring and Dietary Self-Management in Adults in Namwon
This study will test whether adding a continuous glucose monitoring (CGM) device, which shows personal glucose patterns, improves dietary self-management over the first 6 weeks.
- Conditions
- Prediabetes, Dietary Self-Management, Diabetes Mellitus, Type 2
- Trial name
- NCT07890740
- Testing
- Continuous Glucose Monitoring With Application-Based Biofeedback, Common Standardized Education and Behavioral Goal Setting, Common Digital Health Program and Basic Health Counseling
- Where
- 4 sites in South Korea
- Volunteers
- 860 people
- Sponsor
- Ji-Yeob Choi
Prediabetes, Type 2 Diabetes
New T-UP: Engaging Vulnerable Students in Diabetes Prevention
The goal of this study is to enhance reach and uptake of diabetes prevention among young adults, with a focus on recruiting underserved and high-need students who face additional challenges, including food and financial…
- Trial name
- NCT07225218
- Testing
- Tailored DPP Intervention
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of California, Los Angeles
Prediabetes
Efficacy of Diacylglycerol Oil on Metabolic Risk Factors in Prediabetes
This study will implement a four-week dietary intervention among middle-aged and older adults with pre-diabetes. Participants assigned to the intervention arm will replace their usual cooking oil with diacylglycerol (DAG) oil…
- Trial name
- NCT07289880
- Testing
- Diacylglycerol oil, Colza Oil
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Guangdong Pharmaceutical University
PreDiabetes, Adolescent Obesity
SMART GOALS for Youth With Prediabetes
The goal of this study is to compare the impact of a SMART ((specific, measurable, attainable, realistic, or timely) Goal setting protocol on body weight, metabolic parameters (Hemoglobin A1c, lipids), diet quality and physical…
- Conditions
- PreDiabetes, Adolescent Obesity, Behavior, Health, Nutritional and Metabolic Diseases
- Trial name
- NCT06067451
- Testing
- SMART GOALS Setting Tool/ Protocol
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Northwell Health
Prediabetes or Overweight, Obesity Type 2 Diabetes Mellitus
Real-World Outcomes of Tirzepatide in Pakistani Adults With Obesity, Prediabetes, and Type 2 Diabetes
This is a multicentre, prospective, observational study of the medicine tirzepatide as it is used in routine clinical care in Pakistan.
- Conditions
- Prediabetes or Overweight, Obesity Type 2 Diabetes Mellitus, Obesity & Overweight
- Trial name
- TRIBUTE-PK (NCT07809568)
- Where
- 9 sites in Pakistan
- Volunteers
- 330 people
- Sponsor
- Universiti Sains Malaysia
Prediabetes, Weight Loss
Diabetes Prevention Through Genetics, Familial History and Behavior Change
The goal of this clinical trial is to learn if adding a family engagement component to the standard Diabetes Prevention Program (DPP) improves outcomes for adults with prediabetes.
- Trial name
- NCT07815236
- Testing
- LEGACY DPP, DPP
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Morehouse School of Medicine
Prediabetes
Piloting FUERTE: Federally qUalified Health Centers Engaging Hispanic Men at Risk of diabeTEs
The goal of this study is to learn whether FUERTE (Federally qUalified Health Centers Engaging Hispanic Men at Risk of diabeTEs) can facilitate referrals of Hispanic men with prediabetes to the Diabetes Prevention Program (DPP)…
- Trial name
- FUERTE (NCT07878806)
- Testing
- FUERTE Arm, Standard care, No Intervention
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Weill Medical College of Cornell University
Type 2 Diabetes, Insulin Resistance
Understanding Metabolism and Inflammation Risks for Diabetes in Adolescents
This research study collects health-related information and blood samples to better understand how body composition, lifestyle habits, and diet influence meta-inflammatory monocytes (MiMos) in adolescents.
- Conditions
- Type 2 Diabetes, Insulin Resistance, Obesity, Metabolic Disease
- Trial name
- NCT06007404
- Where
- United States
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Obesity, Gestational Diabetes
Strategies for Implementing a Postpartum Lifestyle Intervention in WIC Clinics
The primary objective of the STRIVE study is to compare two implementation strategies for Diabetes Prevention Program delivery: an in-person health coach strategy (standard 24 in-person sessions at WIC clinics) vs.
- Conditions
- Obesity, Gestational Diabetes, Lifestyle, Healthy, Glucose Intolerance During Pregnancy
- Trial name
- STRIVE (NCT06116149)
- Testing
- In-person health coach delivery of the GLB, Technology-assisted health coach delivery of the GLB
- Where
- United States
- Volunteers
- 722 people, healthy volunteers welcome
- Sponsor
- Tulane University
Overweight or Obesity, Prediabetes or Diabetes
Remotely Delivered Resistance Training for Cardiometabolic Health Among Black Women
The purpose of this study is to collect preliminary data on the feasibility, acceptability, and potential effects of a novel, remotely delivered resistance training program.
- Conditions
- Overweight or Obesity, Prediabetes or Diabetes, Prehypertension (Elevated Blood Pressure) or Hypertension, Resistance Training
- Trial name
- OVERCOME-IT (NCT06360536)
- Testing
- Resistance Training
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- University of Alabama at Birmingham
Prediabetes
Glycemic Impact of NNS Via the Gut Microbiome
This pilot study will evaluate the feasibility and acceptability of a 30-day sucralose intervention among adults with prediabetes.
- Trial name
- NCT07868432
- Testing
- Sucralose
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Tufts University
Nutritional and Metabolic Diseases, Prediabetes
LIfestyle MEtabotype Study A
Glycemic responses vary significantly among individuals, even when consuming identical foods or meals, but the factors predicting individual glucose response to food intake remain poorly investigated.
- Conditions
- Nutritional and Metabolic Diseases, Prediabetes, Type 2 Diabetes
- Trial name
- LIME-A (NCT07868601)
- Where
- Germany
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- German Institute of Human Nutrition
Type 2 Diabetes, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance)
Effects of Different Fish Oil Types on Type 2 Diabetes Risk Factors in High-Risk Adults
The purpose of this clinical trial is to find out whether one type of fish oil works better than another at improving metabolic health in people who are at high risk of developing type 2 diabetes.
- Conditions
- Type 2 Diabetes, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance), Prediabetes / Type 2 Diabetes, Obesity & Overweight
- Trial name
- END-T2D (NCT07575438)
- Testing
- Fish Oil, Corn oil control
- Where
- Canada
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- May Faraj, PDt, PhD
PreDiabetes, Impaired Glucose Tolerance
Effect of Probiotics Versus Metformin on Glycemic Control, Insulin Sensitivity and Insulin Secretion in Prediabetes.
Pre diabetes (PD) is a term that refers to alterations in blood glucose levels, including impaired fasting glucose (IFG), impaired glucose tolerance (IGT) or both, and increase in glycated hemoglobin (HbA1c), all this factors…
- Conditions
- PreDiabetes, Impaired Glucose Tolerance, Hyperglycemia, Resistance, Insulin
- Trial name
- NCT04341571
- Testing
- Probiotics, Metformin
- Where
- Mexico
- Volunteers
- 30 people
- Sponsor
- University of Guadalajara