Clinical trials: Platelet Activation
Healthy
Flavonoid Effect on Activation and Stimulation of Thrombocytes, hsCRP and Lipid Profile
The purpose of this study is to compare the effect of dark chocolate with green tea in healthy subjects on clot formation (platelet activity) cholesterol profile and markers of inflammation in two groups.
- Trial name
- FEAST-CAL (NCT00559663)
- Testing
- Green tea, 70% dark chocolate
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- LifeBridge Health
Thrombosis, Blood Coagulation Disorder
Dynamics of Platelet Activation in Patients With Ventricular Assist Device (VAD)
Consenting patients with end-stage heart failure that are implanted with/candidates for implant of a short-term/durable mechanical circulatory support device (e.g.: percutaneous microaxial pumps (Impella), extracorporeal membrane…
- Conditions
- Thrombosis, Blood Coagulation Disorder, Platelet Thrombus, Platelet Dysfunction Due to Aspirin
- Trial name
- PASVAD (NCT03255928)
- Testing
- PAS assay, TGT
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Scientific Institute San Raffaele
Platelet Function
Study of Polymorphisms in pear1 Gene Link to Platelet Activation and Signaling Pathway Variations
In this study PEAR1 polymorphisms effects will be analyze in blood platelets to determine how PEAR1 regulates platelet activation.
- Trial name
- NCT01352923
- Testing
- blood test
- Where
- Belgium
- Volunteers
- healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Oxidative Stress Induction, Endothelial Dysfunction
Role of Traditional Cigarettes, Electronic and IQOS Cigarettes on Oxidative Stress.
Electronic cigarettes (E-cigarettes) and new heat-not-burn tobacco products such as IQOS®, an electronic device that heats a cigarette-like stick without combustion, are a modern and technological surrogate of traditional tobacco…
- Conditions
- Oxidative Stress Induction, Endothelial Dysfunction, Platelet Activation
- Trial name
- NCT03301129
- Testing
- Smoke
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Aspirin, Circadian Rhythm
Aspirin AM or PM: Effect on Circadian Rhythm of Platelet Reactivity
Low-dose aspirin is a cornerstone in the secondary prevention of cardiovascular disease (CVD) and is usually taken on awakening, although evidence regarding optimal time of intake is lacking.
- Conditions
- Aspirin, Circadian Rhythm, Platelet Activation, Cardiovascular Diseases
- Trial name
- NCT01900639
- Testing
- change time of intake of aspirin
- Where
- Netherlands
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Coronary Artery Disease
Efficacy of Early Short-term Training on Thrombogenesis in Patients Following Coronary Bypass Surgery
Although the benefit of cardiac rehabilitation following coronary artery bypass graft (CABG) is well-established, it is underused.
- Trial name
- NCT02144480
- Testing
- Intensive training, traditional training
- Where
- Taiwan
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
HIV-1 Infection
Targeting Platelets in Chronic HIV Infection
Advances in antiretroviral therapy (ART) have resulted in increased survival of the HIV-infected population; however, this gain in longevity is associated with an increased risk of cardiovascular disease (CVD).
- Trial name
- NCT02578706
- Testing
- Clopidogrel, Aspirin
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Platelet Aggregation, Spontaneous, Vascular Thrombosis
The Effects of Dietary Erythritol on Platelet Reactivity and Vascular Inflammation
The purpose is to conduct a dietary intervention study in which human participants will consume beverages sweetened with erythritol or aspartame, each for 2 weeks, in a randomized crossover design
- Trial name
- EASI (NCT05967741)
- Testing
- Erythritol, Aspartame
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Collagen Analog, Platelet Activation
Platelet Activation by a Collagen Analogue in Hemorrhagic Situations
Dijon University Hospital and the Dijon-based NVH Medicinal Company have developed a recombinant mini-collagen NVH020B with platelet and Willebrand factor binding activity.
- Conditions
- Collagen Analog, Platelet Activation, Hemorrhage
- Trial name
- CAPTURE (NCT04483245)
- Testing
- Blood sampling
- Where
- France
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
Lichen Planus
Use of Injectable Platelet Rich Fibrin in Lichen Planus
Platelet Rich Fibrine (PRF), which promotes wound healing by supporting angiogenesis, immunity and epithelial proliferation phases.
- Trial name
- NCT03265093
- Testing
- Platelet Rich Fibrin Injection, Corticosteroid
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Arteriosclerosis, Stress, Psychological
The Effect of Beta-Blockers and Aspirin on Hemostasis and Endothelial Function After Acute Mental Stress
This randomized double-blinded controlled trial uses a factorial design to investigate whether application of beta-blockers (inderal 80 mg) or aspirin (100 mg) or a combination thereof has an effect on the activation of the…
- Trial name
- NCT00174902
- Testing
- inderal (drug), acetylsalicylic acid (drug)
- Where
- Switzerland
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Weight Loss
The Effects of Capsinoids on Brown Adipose Tissue Activation in Obesity
This research study is being done to determine whether taking a dietary supplement called capsinoids, derived from sweet peppers, can activate brown fat that is already present or even generate new brown fat in individuals with…
- Trial name
- BATCAP (NCT03110809)
- Testing
- Capsinoid
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Healthy Volunteers, Sepsis
The Role of the P2Y12 Receptor in Tissue Factor Induced Coagulation
Severe sepsis still carries a high mortality rate despite advantages in intensive care medicine and antimicrobial therapy. The inflammatory and procoagulant host response to infection are intricately linked and interactions…
- Trial name
- NCT01099566
- Testing
- Prasugrel
- Where
- Austria
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Bacterial Sepsis
Study and Role of Inflammasome in Platelet Activation During Bacterial And/or Viral Sepsis
: Sepsis, now defined as life-threatening organ dysfunction due to a dysregulated host response to infection, is an important global health problem representing about a fifth of all global deaths.
- Trial name
- PLAQSEPSIS (NCT06657781)
- Where
- Guadeloupe
- Volunteers
- 171 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de la Guadeloupe
Endothelial Function, Platelet Aggregation
Effect of Passive Smoking on Platelet Function and Endothelial Function
Passive smoking is associated with an increased risk for cardiovascular events. However, the exact mechanisms by which passive smoking affects cardiovascular health are not entirely understood.
- Trial name
- NCT00923988
- Testing
- secondhand smoke exposure
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Kantonsspital Graubünden
Cardiovascular Disease
Conjugated Linoleic Acid Supplementation Study
Cardiovascular disease is a major cause of mortality worldwide resulting in one out of three global deaths. One of the main characteristics of cardiovascular disease is impaired blood flow and increased formation of clots.
- Trial name
- CLASS (NCT01234636)
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Aberdeen
Cardiovascular Disease
Dark Chocolate and Platelet Function in Humans
Cardiovascular disease is a major cause of mortality worldwide and responsible for one out of three global deaths. A main characteristic of cardiovascular disease is impaired blood flow and formation of blood clots.
- Trial name
- NCT01099150
- Testing
- Dark chocolate enriched in flavan-3-ols and procyanidins, Standard dark chocolate, White chocolate
- Where
- United Kingdom
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Aberdeen
Knee Osteoarthritis
Autologous Adipose Stem Cells and Platelet Rich Plasma Therapy for Patients With Knee Osteoarthritis
Adipose stem cells and platelet rich plasma can regenerate the injured cartilage.
- Trial name
- NCT02142842
- Testing
- Autologous adipose tissue stromal vascular fraction and platelet rich plasma
- Where
- 3 sites in Vietnam
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Science Ho Chi Minh City
Platelet Thrombus
Characterization of Exosomes Platelets-released
Extracellular vesicles (EVs) play a key role in cell-to-cell communication. They are small vesicles that contain rich molecular cargo. Recently, they have been proposed as biomarkers for clinical diagnostics.
- Trial name
- EXOPLT (NCT06298682)
- Where
- Italy
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- Centro Cardiologico Monzino
Brain and Central Nervous System Tumors, Chronic Myeloproliferative Disorders
Influenza Vaccine in Preventing Flu in Patients Who Have Undergone Stem Cell Transplant and in Healthy Volunteers
RATIONALE: The influenza vaccine may help prevent flu in patients who have undergone stem cell transplant. PURPOSE: This clinical trial is studying how well the influenza vaccine works in preventing flu in patients who have…
- Conditions
- Brain and Central Nervous System Tumors, Chronic Myeloproliferative Disorders, Leukemia, Lymphoma
- Trial name
- NCT00952185
- Testing
- cytology specimen collection procedure, fluorescent antibody technique, assessment of therapy complications
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center