Clinical trials: Out-of-hospital Cardiac Arrest (OHCA), open to volunteers
Cardiopulmonary Arrest
REBOA in Nontraumatic OHCA
The investigators propose a multicenter randomized controlled trial in South Korea and Taiwan to observe the clinical effects of REBOA on nontraumatic out-of-hospital-cardiac-arrest (OHCA) patients.
- Trial name
- REBOA (NCT06031623)
- Testing
- REBOA
- Where
- South Korea
- Volunteers
- 234 people
- Sponsor
- Seoul National University Hospital
Sudden Cardiac Arrest, Out-of-hospital Cardiac Arrest (OHCA)
FEMART-1 Pilot Study
The FEMART-1 Pilot Study is focused on evaluating the feasibility, safety, and procedural timing of prehospital femoral arterial sheath placement in patients with non-traumatic out-of-hospital cardiac arrest (OHCA), both during…
- Conditions
- Sudden Cardiac Arrest, Out-of-hospital Cardiac Arrest (OHCA), Cardiogenic Shock Acute
- Trial name
- FEMART-1 (NCT07596446)
- Testing
- Prehospital Ultrasound-Guided Femoral Arterial Sheath Placement
- Where
- Czechia
- Volunteers
- 60 people
- Sponsor
- Emergency Medical Service, Prague
Out-of-hospital Cardiac Arrest (OHCA)
Ketamine Sedation As Neuroprotective Agent Following Out-of-hospital Cardiac Arrest
OHCA is a critical medical emergency with significant mortality and morbidity primarily due to hypoxic-ischemic brain injury (HIBI).
- Trial name
- KETOHCA (NCT06744361)
- Testing
- esketamine hydrochloride, propofol
- Where
- 2 sites in Denmark
- Volunteers
- 282 people
- Sponsor
- Christian Hassager
Out-of-hospital Cardiac Arrest (OHCA)
Out-of-hospital Cardiac Arrest Epidemiology and Outcomes in Western Lithuania 2022-2028
Out-of-hospital cardiac arrest rate is common problem, because of high mortality rate. It is not clear incidence rate, epidemiology and outcomes in Lithuania
- Trial name
- NCT07622082
- Testing
- Protocol based
- Volunteers
- 4,000 people
- Sponsor
- Lithuanian University of Health Sciences
Cardiac Arrest, Out-of-hospital Cardiac Arrest (OHCA)
Mean Arterial Pressure After Out-of-hospital Cardiac Arrest
Out-of-hospital cardiac arrest is a public health problem for which overall survival is below 10%. Post-cardiac arrest syndrome is the principal cause of death in intensive care units (ICU), due to refractory shock or brain…
- Trial name
- METAPHORE (NCT05486884)
- Testing
- Maintain MAP ≥ 90 mmHg, Maintain MAP ≥ 65 mmHg
- Where
- 31 sites in France
- Volunteers
- 1,380 people
- Sponsor
- Centre Hospitalier le Mans
Out-of-hospital Cardiac Arrest (OHCA)
Resuscitation Enhancement to Avoid Rearrest Through Evidence-based Strategies in Prehospital Post-resuscitation Care
Out-of-hospital cardiac arrest (OHCA) remains a leading global emergency condition with low survival to hospital discharge despite advances in cardiopulmonary resuscitation.
- Trial name
- RE-ARREST (NCT07239908)
- Testing
- Prehospital post cardiac arrest care protocol
- Where
- Thailand
- Volunteers
- 318 people
- Sponsor
- Siriraj Hospital
Cardiac Arrest (CA), Out-of-hospital Cardiac Arrest (OHCA)
Abdominal Aortic Tourniquet Application for Non-Traumatic Out-of-Hospital Cardiac Arrest
The aim of the study is to investigate whether occluding the abdominal aorta with an external device could be a potential therapeutic option in cases of non-traumatic cardiac arrest occurring outside of a hospital.
- Conditions
- Cardiac Arrest (CA), Out-of-hospital Cardiac Arrest (OHCA), Asystole, Pulseless Electrical Activity
- Trial name
- ATTICA (NCT07573566)
- Testing
- Abdominal Aortic Junction Tourniquet in non-traumatic out-of-hospital cardiac arrest
- Where
- Austria
- Volunteers
- 5 people
- Sponsor
- Klinikum Klagenfurt am Wörthersee
Cardiac Arrest (CA)
Does Increasing the Compression Pause From 3 to 5 Seconds in Mechanical Compression Devices Increase Ventilation Success Rate and Return of Spontaneous Circulation?
To give chest compressions during cardiopulmonary resuscitation (CPR), mechanical chest compression devices can be used. During synchronous 30:2 CPR, the standard setting on these devices leave an automated 3-second chest…
- Trial name
- LUCASVP (NCT06824961)
- Testing
- 5-second ventilation pause duration during mechanical CPR, 3-second ventilation pause duration during mechanical CPR
- Where
- 2 sites in Netherlands
- Volunteers
- 692 people
- Sponsor
- Amsterdam UMC, location VUmc
Pain, Out-of-hospital Cardiac Arrest (OHCA)
Pain After Cardiac Arrest and Resuscitation (PAINCARE)
The PAINCARE substudy is an observational cohort substudy nested within the international STEPCARE trial, which evaluates sedation, temperature, and mean arterial pressure strategies after out-of-hospital cardiac arrest.
- Trial name
- PAINCARE (NCT07564778)
- Where
- 3 sites in Sweden
- Volunteers
- 300 people
- Sponsor
- Region Skane
Out-of-hospital Cardiac Arrest (OHCA), ECMO Treatment
Hypothermia Versus Normothermia After Extracorporeal Cardiopulmonary Resuscitation for Out-of-hospital Cardiac Arrest
The SAVE-J NEUROTHERM trial is a cluster randomized trial that evaluated and compared the mortality risk, neurological outcomes, and adverse events between patients who underwent hypothermia and those who underwent normothermia…
- Conditions
- Out-of-hospital Cardiac Arrest (OHCA), ECMO Treatment, Temperature, Post Cardiac Arrest Syndrome
- Trial name
- J-NEURO (NCT06776549)
- Testing
- Temperature control
- Where
- 29 sites in Japan
- Volunteers
- 468 people
- Sponsor
- Kagawa University
Cardiac Arrest, Out-Of-Hospital, Cardiac Arrest Due to Underlying Cardiac Condition
AID-OMIE - Artificial Intelligence in Detection of Occlusive Myocardial Infarction in Emergency Medicine
Study Objective and Hypothesis The study hypothesizes that artificial intelligence (AI)-assisted interpretation of the 12-lead electrocardiogram (ECG) can improve the care of patients resuscitated after out-of-hospital cardiac…
- Trial name
- AID-OMIE (NCT06767709)
- Volunteers
- 200 people
- Sponsor
- Institute of Mountain Emergency Medicine
Out-of-hospital Cardiac Arrest (OHCA)
Application of Transesophageal Echocardiography in Pre-hospital Cardiac Arrest Patients
The Use of Point-of-Care Ultrasound (POCUS), Transthoracic Echocardiography (TTE), and Transesophageal Echocardiography (TEE) in Cardiac Arrest and Acute Coronary Syndrome Patients Studies have shown that POCUS can rapidly change…
- Trial name
- TAPCAP (NCT06672315)
- Testing
- transesophageal echocardiography
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Jen-Tang Sun
Cardiac Arrest (CA)
Adapted Cardiopulmonary Resuscitation Study
The goal of this controlled single centre RCT is to compare frequency rates concerning return of spontaneous circulation (ROSC) in prehospital cardiac arrest.
- Trial name
- NCT07754656
- Testing
- aCPR algorithm, ERC ALS 2025
- Where
- Austria
- Volunteers
- 216 people
- Sponsor
- Johannes Kepler University of Linz
Cardiac Arrest (CA), Cardiogenic Shock
On Scene ECPR in Ostrava
On-scene extracorporeal pulmonary resuscitation (ECPR) for out-of-hospital cardiac arrest (OHCA) seems to speed up the start of extracorporeal membrane oxygenation (ECMO) and shorten low flow during cardiopulmonary resuscitation…
- Trial name
- NCT07374289
- Testing
- Prehospital ECMO cannulation on scene of cardiac arrest, Transfer with ongoing mechanical chest compression to hospital followed by hospital ECMO cannulation
- Where
- 2 sites in Czechia
- Volunteers
- 90 people
- Sponsor
- University Hospital Ostrava
Out-Of-Hospital Cardiac Arrest
The Validation and Development of Termination-of-Resuscitation (TOR) Rules in OHCA Patients in Asia Countries
Objectives/Hypotheses 1. Prehospital termination-of-resuscitation (TOR) rules were developed in North American and European sites.
- Trial name
- NCT05545176
- Testing
- termination of resuscitation rules
- Where
- Taiwan
- Volunteers
- 140,000 people
- Sponsor
- National Taiwan University Hospital
Out-of-hospital Cardiac Arrest (OHCA), Cardiac Arrest (CA)
the Effectiveness of Continuous Compression-synchronous Ventilation (Bio-CPR)
Bio-CPR is an innovative new mechanical resuscitation model proposed by our research group. A multi-center RCT study was established to comprehensively evaluate the efficacy of this model and the current standard CPR protocol…
- Conditions
- Out-of-hospital Cardiac Arrest (OHCA), Cardiac Arrest (CA), CPR, ACLS
- Trial name
- Bio-CPR (NCT07258823)
- Testing
- CPR
- Volunteers
- 408 people
- Sponsor
- Guangdong Provincial People's Hospital
Infection, Bacterial, Out-Of-Hospital Cardiac Arrest
Impact of Early Antibiotics on Non-Traumatic Out of Hospital Cardiac Arrest (OHCA)
Specific Aim : The specific aim is to conduct a randomized prospective clinical trial to determine whether no antibiotics in OHCA patients in the ED with very low likelihood of infection is non-inferior to early antibiotic…
- Trial name
- NCT05914779
- Testing
- No use of antibiotics, with antibiotics treatment
- Where
- Qatar
- Volunteers
- 1,000 people
- Sponsor
- Hamad Medical Corporation
Out-of-hospital Cardiac Arrest (OHCA)
Impact of Low Dose Epinephrine in the Management of Out-of-hospital Cardiac Arrest on Neurological Outcome
This study will test whether a lower dose of epinephrine (0.5 mg) given during emergency treatment for out-of-hospital cardiac arrest helps more patients survive with good brain function, compared to the standard dose (1 mg).
- Trial name
- Low-EPI (NCT07442071)
- Testing
- Epinephrine 0.5 mg intravenous bolus, Epinephrine 1 mg intravenous bolus
- Where
- 26 sites in France
- Volunteers
- 4,336 people
- Sponsor
- Central Hospital, Nancy, France
Cardiac Arrest (CA), Out-of-hospital Cardiac Arrest (OHCA)
Measurement of Airway Opening Index During Out-of-hospital Cardiac Arrest: The Lazarus AOI Trial.
Out-of-hospital cardiac arrest (OHCA) is a leading cause of death worldwide. Despite constantly improving resuscitation techniques, the chances of survival remain limited.
- Conditions
- Cardiac Arrest (CA), Out-of-hospital Cardiac Arrest (OHCA), Resuscitated Sudden Cardiac Death
- Trial name
- Lazarus-AOI (NCT07438938)
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- University Hospital, Ghent
Cardiac Arrest (CA), Cardiac Arrest With Successful Resuscitation
A Study on the Impact of a New Canton-Wide First Responder System in Zug, Switzerland, on Survival After Adult Cardiac Arrest-Examining Early Life-Saving Organized Help, Fast Defibrillation, and Improved Outcomes for Out of Hospital Cardiac Arrest
REVIVE Zug: Improving Emergency Response for Out-of-Hospital Cardiac Arrest Out-of-hospital cardiac arrest (OHCA) represents one of the most time-critical medical emergencies, where rapid recognition and immediate intervention…
- Conditions
- Cardiac Arrest (CA), Cardiac Arrest With Successful Resuscitation, Resuscitation, Emergency Medical Services
- Trial name
- REVIVE Zug (NCT07323667)
- Where
- Switzerland
- Volunteers
- 250 people
- Sponsor
- Felix Brinkmann