Cardiac Arrest (CA)NCT07374289
On Scene ECPR in Ostrava
A study testing Prehospital ECMO cannulation on scene of cardiac arrest and Transfer with ongoing mechanical chest compression to hospital followed by hospital ECMO cannulation in people with Cardiac Arrest (CA) and Cardiogenic Shock, run by University Hospital Ostrava at 2 sites in Czechia.
Trial summary
On-scene extracorporeal pulmonary resuscitation (ECPR) for out-of-hospital cardiac arrest (OHCA) seems to speed up the start of extracorporeal membrane oxygenation (ECMO) and shorten low flow during cardiopulmonary resuscitation (CPR) in case of refractory cardiac arrest. Read more about this study
- Who is it for?
- Ages 18 to 70 years
- Conditions the study is for
- Cardiac Arrest (CA), Cardiogenic Shock
- What is being tested?
- Prehospital ECMO cannulation on scene of cardiac arrest and Transfer with ongoing mechanical chest compression to hospital followed by hospital ECMO cannulation
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 90 participants
- Where
- 2 sitesCzechia
- Study dates
- 30 Jan 2026to 31 Dec 2029
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 70 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Presumed cardiac aetiology of the cardiac arrest
- Witnessed collapse
- Bystander CPR
- Estimated age ≤ 70 years
- Body weight ≥15 Kg
Who cannot join
- Known terminal malignant disease
- Known terminal chronic disease
Trial locations and contacts
2 sites in 1 country. Contact the study team or a site near you to ask about taking part.
Czechia2 sites, 2 recruiting
- Recruiting
Emergency Medical Services, Moravian-Silesian Region
Ostrava, Moravian-Silesian Region, 700 30
David Holeš, MD, PhD, +42059701 ext. 1401, zzsmsk@zzsmsk.cz
David Holeš, MD, PhD
- Recruiting
University Hospital Ostrava
Ostrava, Moravian-Silesian Region, 708 52
Jiří Hynčica, +42059737 ext. 2587, jiri.hyncica@fno.cz
Filip Burša, MD, PhD, EDEC
About this study
Official title: The Effectiveness of ECPR on the Scene and in Hospital for Out-of-hospital Cardi-ac Arrest (OHCA) in the Moravian-Silesian Region.
On-scene extracorporeal pulmonary resuscitation (ECPR) for out-of-hospital cardiac arrest (OHCA) seems to speed up the start of extracorporeal membrane oxygenation (ECMO) and shorten low flow during cardiopulmonary resuscitation (CPR) in case of refractory cardiac arrest. The primary goal is to verify the benefit of on-scene ECPR in terms of shortening the collapse-to-ECMO interval. The secondary goal is to compare outcomes in the on-scene ECPR group with hospital cannulation.
Read the detailed description
ECPR is a life-saving method for a selected group of patients who are refractory to standard resuscitation procedures. With the appropriate use of ECPR, it is possible to achieve a significant improvement in survival with good neurological outcomes even in patients who would otherwise die. The ECMO Centre Ostrava has been providing ECPR for OHCA since 2022 with cannulation in the hospital after prior transport from the scene under continuous resuscitation. A good neurological outcome is achieved in approximately 29% of patients, even though the collapse-ECMO interval is around 75 minutes. Shortening this interval, which is associated with improved outcomes, is possible by using a mobile team that per-forms cannulation directly on scene. Mobile ECPR will be carried out in cooperation with the Ostrava University Hospital and the Moravian-Silesian Region Emergency Medical Service. The primary objective is to verify the benefit of on-scene ECPR in terms of shortening the collapse-ECMO interval. The secondary objective is to compare the outcome in the on-scene ECPR group with hospital cannulation.
- Conditions
- Cardiac Arrest (CA), Cardiogenic Shock
- Being tested
- Prehospital ECMO cannulation on scene of cardiac arrest, Transfer with ongoing mechanical chest compression to hospital followed by hospital ECMO cannulation
- Keywords
- extracorporeal membrane oxygenation, out-of-hospital cardiac arrest, cardiac arrest, cardiogenic shock
- Medical subject headings
- Heart Arrest, Shock, Cardiogenic, Out-of-Hospital Cardiac Arrest
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Prehospital ECMO cannulation on scene of cardiac arrestProcedure or surgery
ECPR (Extracorporeal Cardiopulmonary Resuscitation) is a critical, advanced resuscitation technique using Veno-arterial Extracorporeal Membrane Oxygenation for patients in cardiac arrest where conventional CPR fails, functioning as a bridge to restore circulation and oxygenation by pumping and oxygenating blood outside the body before returning it.
Transfer with ongoing mechanical chest compression to hospital followed by hospital ECMO cannulationProcedure or surgery
ECPR (Extracorporeal Cardiopulmonary Resuscitation) is a critical, advanced resuscitation technique using Veno-arterial Extracorporeal Membrane Oxygenation for patients in cardiac arrest where conventional CPR fails, functioning as a bridge to restore circulation and oxygenation by pumping and oxygenating blood outside the body before returning it.
| Study group | Role | What they receive |
|---|---|---|
| ECPR on scene | Experimental | On-scene ECPR cannulation by mobile ECMO team according to protocol if the location of the arrest and circumstances appear to be suitable (distance from the ECMO centre, transport logistics, in an ambulance/at home, etc.) Receives: Procedure: Prehospital ECMO cannulation on scene of cardiac arrest |
| ECPR in hospital | Active comparator | Hospital ECPR cannulation at Emergency Department by ECMO team accord-ing to protocol if a on scene ECPR call-out was not indicated. Receives: Procedure: Transfer with ongoing mechanical chest compression to hospital followed by hospital ECMO cannulation |
What is being measured
The primary outcome is the main question the study is designed to answer.
Hospital survival
Hospital survival will be assessed 30 days after the cardiac arrest
Measured: 30 days after the cardiac arrest
ICU stay
The length of the Intensive Care Unit (ICU) stay will be assessed in days.
Measured: Through the ICU stay, on average 12 days
Neurologic outcomes
Neurologic outcomes will be assessed in patients using the Cerebral Performance Category (CPC) score. The CPC score is a 1-to-5 scale assessing neurological outcome, most commonly after cardiac arrest, where 1 is best (normal brain function) and 5 is worst (brain death).
Measured: 30 days after the cardiac arrest
Secondary outcomes (4)
Collapse to ECMO interval
The interval from the collapse (cardiac arrest) to ECMO initiation will be measured in minutes.
Measured: One hour
Collapse to ECMO interval
The interval from the collapse (cardiac arrest) to ECMO initiation will be measured in minutes.
Measured: From the collapse (cardiac arrest) to ECMO initiation
Long-term outcome - Survival
The long-term survival of patients will be assessed 6 months after the collapse.
Measured: 6 months after the collapse
Long-term outcome - Quality of Life
Long-term quality of life will be assessed 6 months after the collapse using standardised tools (questionnaires).
Measured: 6 months after the collapse
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted28 Jan 2026
- Study start30 Jan 2026 (estimated)
- Primary completion31 Dec 2028 (estimated)
- Study completion31 Dec 2029 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Cardiac Arrest (CA)Studies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Model description
- The study subjects will be enrolled in two parallel arms
- Masking
- None (open label)
- Enrolment
- 90 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University Hospital Ostrava
- Sponsor type
- University, hospital or other
- Collaborators
- Emergency Medical Services, Moravian-Silesian Region
- Responsible party
- Sponsor
- Investigators
- Filip Burša, MD, PhD, EDEC, Principal investigator, University Hospital Ostrava
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07374289
- Sponsor's protocol ID
- FNO-KARIM-On-Scene-ECPR
- Status last verified
- Jan 2026
- First submitted
- 9 Jan 2026
- Last updated
- 30 Jan 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: There is no plan to make individual participant data available to other researchers. The data may be provided upon reasonable request.
Study at a glance
From the registry record, last updated by the sponsor on 30 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effectiveness of ECPR on the Scene and in Hospital for Out-of-hospital Cardi-ac Arrest (OHCA) in the Moravian-Silesian Region.
- ClinicalTrials.gov ID
- NCT07374289
- Acronym / sponsor ID
- FNO-KARIM-On-Scene-ECPR
- Conditions
- Cardiac Arrest (CA), Cardiogenic Shock
- Keywords
- extracorporeal membrane oxygenation, out-of-hospital cardiac arrest, cardiac arrest, cardiogenic shock
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 90 participants (estimated)
- Lead sponsor
- University Hospital OstravaUniversity, hospital or other
- Collaborators
- Emergency Medical Services, Moravian-Silesian Region
- Study start
- 30 Jan 2026 (estimated)
- Primary completion
- 31 Dec 2028 (estimated)
- Study completion
- 31 Dec 2029 (estimated)
- First posted
- 28 Jan 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
On-scene extracorporeal pulmonary resuscitation (ECPR) for out-of-hospital cardiac arrest (OHCA) seems to speed up the start of extracorporeal membrane oxygenation (ECMO) and shorten low flow during cardiopulmonary resuscitation (CPR) in case of refractory cardiac arrest. The primary goal is to verify the benefit of on-scene ECPR in terms of shortening the collapse-to-ECMO interval. The secondary goal is to compare outcomes in the on-scene ECPR group with hospital cannulation.
Detailed description
ECPR is a life-saving method for a selected group of patients who are refractory to standard resuscitation procedures. With the appropriate use of ECPR, it is possible to achieve a significant improvement in survival with good neurological outcomes even in patients who would otherwise die. The ECMO Centre Ostrava has been providing ECPR for OHCA since 2022 with cannulation in the hospital after prior transport from the scene under continuous resuscitation. A good neurological outcome is achieved in approximately 29% of patients, even though the collapse-ECMO interval is around 75 minutes. Shortening this interval, which is associated with improved outcomes, is possible by using a mobile team that per-forms cannulation directly on scene. Mobile ECPR will be carried out in cooperation with the Ostrava University Hospital and the Moravian-Silesian Region Emergency Medical Service. The primary objective is to verify the benefit of on-scene ECPR in terms of shortening the collapse-ECMO interval. The secondary objective is to compare the outcome in the on-scene ECPR group with hospital cannulation.
Study design
- Primary purpose
- Treatment
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
- Model description
- The study subjects will be enrolled in two parallel arms
| Arm | Type | Receives |
|---|---|---|
| ECPR on scene | Experimental | Procedure: Prehospital ECMO cannulation on scene of cardiac arrestOn-scene ECPR cannulation by mobile ECMO team according to protocol if the location of the arrest and circumstances appear to be suitable (distance from the ECMO centre, transport logistics, in an ambulance/at home, etc.) |
| ECPR in hospital | Active comparator | Procedure: Transfer with ongoing mechanical chest compression to hospital followed by hospital ECMO cannulationHospital ECPR cannulation at Emergency Department by ECMO team accord-ing to protocol if a on scene ECPR call-out was not indicated. |
Who may qualify
- Ages
- 18 to 70 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (5 listed)
- Presumed cardiac aetiology of the cardiac arrest
- Witnessed collapse
- Bystander CPR
- Estimated age ≤ 70 years
- Body weight ≥15 Kg
Key exclusion criteria (2 listed)
- Known terminal malignant disease
- Known terminal chronic disease
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Prehospital ECMO cannulation on scene of cardiac arrestECPR (Extracorporeal Cardiopulmonary Resuscitation) is a critical, advanced resuscitation technique using Veno-arterial Extracorporeal Membrane Oxygenation for patients in cardiac arrest where conventional CPR fails, functioning as a bridge to restore circulation and oxygenation by pumping and oxygenating blood outside the body before returning it. | Procedure or surgery | ECPR on scene |
| Transfer with ongoing mechanical chest compression to hospital followed by hospital ECMO cannulationECPR (Extracorporeal Cardiopulmonary Resuscitation) is a critical, advanced resuscitation technique using Veno-arterial Extracorporeal Membrane Oxygenation for patients in cardiac arrest where conventional CPR fails, functioning as a bridge to restore circulation and oxygenation by pumping and oxygenating blood outside the body before returning it. | Procedure or surgery | ECPR in hospital |
Primary outcome
Hospital survival
Time frame: 30 days after the cardiac arrest
Hospital survival will be assessed 30 days after the cardiac arrest
ICU stay
Time frame: Through the ICU stay, on average 12 days
The length of the Intensive Care Unit (ICU) stay will be assessed in days.
Neurologic outcomes
Time frame: 30 days after the cardiac arrest
Neurologic outcomes will be assessed in patients using the Cerebral Performance Category (CPC) score. The CPC score is a 1-to-5 scale assessing neurological outcome, most commonly after cardiac arrest, where 1 is best (normal brain function) and 5 is worst (brain death).
4 secondary outcomes
Collapse to ECMO interval
Time frame: One hour
Collapse to ECMO interval
Time frame: From the collapse (cardiac arrest) to ECMO initiation
Long-term outcome - Survival
Time frame: 6 months after the collapse
Long-term outcome - Quality of Life
Time frame: 6 months after the collapse
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 30 Jan 2026.
- Individual participant dataSharing planned: No. There is no plan to make individual participant data available to other researchers. The data may be provided upon reasonable request.
Related trials for Cardiac Arrest (CA)
Recruiting
The VENTOR Clinical Study
Cardiac Arrest (CA)
RecruitingObservational study
Physiology-directed Epinephrine Dosing in Pediatric Cardiac Arrest
Cardiac Arrest (CA)
Recruiting
Optimal Ventilation for Cardiac Arrest
Cardiac Arrest (CA)
Not yet recruiting
The OXY-VENT Study
Cardiac Arrest (CA), Cardiopulmonary Resuscitation (CPR)
Not yet recruitingObservational study
Integrated Near-Infrared Spectroscopy and Hemodynamic Monitoring for Cerebral Autoregulation in Post-Cardiac Arrest Care Neuroprognostication
Cardiac Arrest (CA)
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Filip Burša, MD, PhD, EDEC principal investigator
University Hospital Ostrava
2 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Prehospital ECMO cannulation on scene of cardiac arrest and Transfer with ongoing mechanical chest compression to hospital followed by hospital ECMO cannulation in people with Cardiac Arrest (CA) and Cardiogenic Shock, run by University Hospital Ostrava at 2 sites in Czechia.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 30 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 2 sites in Czechia. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Jiří Hynčica (+42059737 ext. 2587, jiri.hyncica@fno.cz), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Hospital survival (time frame: 30 days after the cardiac arrest). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 30 Jan 2026.