Clinical trials: Cardiac Arrest (CA)
Brain Injury, Coma, Cardiac Arrest (CA)
Prediction for Coma Recovery With Comaweb
The general objective of the comaScore project is to provide an external validation of the accuracy of the comaScore, a score derived from magnetic resonance imaging (MRI), to predict 1 year outcome of patients unresponsive to…
- Conditions
- Brain Injury, Coma, Cardiac Arrest (CA), Traumatic Brain Injury (TBI), Aneurysmal Subarachnoid Hemorrhages (aSAH)
- Trial name
- COMASCORE (NCT03874208)
- Testing
- MRI sequence, MRI
- Where
- France
- Volunteers
- 611 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cardiac Arrest (CA), In-Hospital Cardiac Arrest
The Ventilation During In-hospital Cardiac Arrest Study
The goal of this prospective observational study is to learn how ventilation quality parameters during cardiopulmonary resuscitation (CPR) are associated with short-term survival following in-hospital cardiac arrest of adult…
- Conditions
- Cardiac Arrest (CA), In-Hospital Cardiac Arrest, Heart Arrest
- Trial name
- VENT-IHCA (NCT06809309)
- Testing
- Positive pressure ventilation during cardiopulmonary resuscitation
- Where
- 11 sites in Denmark, Norway
- Volunteers
- 900 people
- Sponsor
- University of Aarhus
Cardiac Arrest (CA), Extracorporeal Cardiopulmonary Resuscitation
Clinical Application of Low-Field Magnetic Resonance Imaging in Patients on Extracorporeal Cardiopulmonary Resuscitation
Timely identification of acute brain injury (ABI) patterns in patients with extracorporeal cardiopulmonary resuscitation (ECPR) is essential for prognostic assessment and optimization of clinical management, particularly…
- Conditions
- Cardiac Arrest (CA), Extracorporeal Cardiopulmonary Resuscitation, Acute Brain Injury
- Trial name
- NCT07526701
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Capital Medical University
Cardiac Arrest (CA), Intensive Care Unit (ICU) Admission
Kinetics and Prognostic Value of NeuroFilament Light in Post-cardiac Arrest: A Prospective Multicenter Study
The purpose of this study is to assess the prognostic value of absolute value and kinetic of neurofilament light chain (NFL) collected at different time points (at admission, 12h, 24h, 48h, 72h, 96h, and day 7 after ICU…
- Conditions
- Cardiac Arrest (CA), Intensive Care Unit (ICU) Admission, Return of Spontaneous Circulation, Comatose
- Trial name
- CINEFIL (NCT07760636)
- Testing
- Value of neurofilament light chain (NFL) at different time points
- Where
- France
- Volunteers
- 270 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cardiac Arrest (CA)
Does Increasing the Compression Pause From 3 to 5 Seconds in Mechanical Compression Devices Increase Ventilation Success Rate and Return of Spontaneous Circulation?
To give chest compressions during cardiopulmonary resuscitation (CPR), mechanical chest compression devices can be used. During synchronous 30:2 CPR, the standard setting on these devices leave an automated 3-second chest…
- Trial name
- LUCASVP (NCT06824961)
- Testing
- 5-second ventilation pause duration during mechanical CPR, 3-second ventilation pause duration during mechanical CPR
- Where
- 2 sites in Netherlands
- Volunteers
- 692 people
- Sponsor
- Amsterdam UMC, location VUmc
Cardiac Arrest (CA), Out-of-hospital Cardiac Arrest (OHCA)
Measurement of Airway Opening Index During Out-of-hospital Cardiac Arrest: The Lazarus AOI Trial.
Out-of-hospital cardiac arrest (OHCA) is a leading cause of death worldwide. Despite constantly improving resuscitation techniques, the chances of survival remain limited.
- Conditions
- Cardiac Arrest (CA), Out-of-hospital Cardiac Arrest (OHCA), Resuscitated Sudden Cardiac Death
- Trial name
- Lazarus-AOI (NCT07438938)
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- University Hospital, Ghent
Cardiopulmonary Resuscitation (CPR), Basic Life Support Training Course
Evaluation of Mixed Reality Cardiopulmonary Resuscitation Training
<Study Design> This study is a cluster-randomized, stratified, non-inferiority trial designed to evaluate the feasibility, efficacy, and educational effectiveness of HEROS 4.0, a mixed-reality (MR)-based cardiopulmonary…
- Conditions
- Cardiopulmonary Resuscitation (CPR), Basic Life Support Training Course, Cardiac Arrest (CA)
- Trial name
- HEROS 4 (NCT07363772)
- Testing
- HEROS 4.0, Conventional CPR training
- Where
- South Korea
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Extracorporeal Membrane Oxygenation Complication, ARDS (Acute Respiratory Distress Syndrome)
RECOMMEND Platform Trial
The goal of this platform trial is to determine the efficacy, safety and cost-effectiveness of various interventions in patients with acute cardiorespiratory failure requiring extracorporeal membrane oxygenation (ECMO) The main…
- Conditions
- Extracorporeal Membrane Oxygenation Complication, ARDS (Acute Respiratory Distress Syndrome), Intensive Care Medicine, Cardiac Arrest (CA)
- Trial name
- RECOMMEND (NCT06526533)
- Testing
- Liberal RBC Transfusion, Restrictive RBC Transfusion
- Where
- 3 sites in Australia
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Medical Education, Simulation-based Methodology
MIxed ReAlity Versus Manikin Simulation in Basic Life Support Training for Medical Students: a Noninferiority Randomized Controlled Trial (MIRA).
Purpose: To compare the effectiveness of mixed reality and traditional manikin-based simulation in basic life support (BLS) training, making the hypothesis that mixed reality was non-inferior to manikin-based simulation.
- Conditions
- Medical Education, Simulation-based Methodology, Virtual Reality, Cardiac Arrest (CA)
- Trial name
- MIRA (NCT06832072)
- Testing
- MR-BLS
- Where
- France
- Volunteers
- 225 people
- Sponsor
- Sorbonne University
Sepsis, Septic Shock
Nucleosome Monitoring Relevance for Outcome Prediction in Critically Ill Patients
NUROPI is a single-centre, prospective, non-interventional study in the Intensive Care Unit (ICU) of Erasme Hospital (Hôpital Universitaire de Bruxelles, Brussels, Belgium).
- Conditions
- Sepsis, Septic Shock, Cardiac Arrest (CA), Pancreatitis
- Trial name
- NuROPI (NCT07184593)
- Testing
- Plasma H3.1 nucleosome measurement
- Volunteers
- 1,000 people
- Sponsor
- Erasme University Hospital
Emotional Distress, Cardiac Arrest (CA)
Mind-body Resilience Program for Cardiac Arrest Survivors and Their Caregivers: Recovering Together After Cardiac Arrest
The purpose of this study is to pilot two resilience interventions for cardiac arrest survivors and their informal caregivers, Recovering Together after Cardiac Arrest 1 and Recovering Together after Cardiac Arrest 2 .
- Conditions
- Emotional Distress, Cardiac Arrest (CA), Anxiety, Depression
- Trial name
- RT-CA (NCT07143357)
- Testing
- Recovering Together after Cardiac Arrest 1, Recovering Together after Cardiac Arrest 2
- Where
- 2 sites in United States
- Volunteers
- 84 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Cardiac Arrest (CA), Return of Spontaneous Circulation
Pulse Detection in Cardiac Arrest Patients Using a Doppler Ultrasound Patch on the Carotid Artery
The purpose of this study is to find out if a Doppler ultrasound patch placed on the neck can accurately and quickly detect when a cardiac arrest patient's heart starts beating again (return of spontaneous circulation, or ROSC)…
- Conditions
- Cardiac Arrest (CA), Return of Spontaneous Circulation, CPR Quality Assessment
- Trial name
- NCT07729228
- Testing
- Ultrasound doppler perfusion monitoring
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Heartstream US LLC
Out of Hospital Cardiac Arrest, Cardiac Arrest (CA)
Prehospital ETI in OHCA
This prospective observational study evaluated the association of prehospital endotracheal intubation (ETI) status with return of spontaneous circulation (ROSC), 28-day survival, and favorable neurological outcome in adult…
- Conditions
- Out of Hospital Cardiac Arrest, Cardiac Arrest (CA), Endotracheal Intubation, Prehospital Airway Management in Patients With Cardiac Arrest
- Trial name
- ETIOHCA (NCT07524881)
- Testing
- Demographics, Comorbidities, Prehospital Variables
- Where
- Turkey (Türkiye)
- Volunteers
- 297 people
- Sponsor
- Haseki Training and Research Hospital
Cardiac Arrest (CA), Anoxic Brain Injury
Early WAKE-up Predictors After Out-of-Hospital Cardiac Arrest
WAKE-OHCA is a prospective observational substudy of the Danish Out-of-Hospital Cardiac Arrest (DANOHCA) trial, identifier NCT05895838.
- Conditions
- Cardiac Arrest (CA), Anoxic Brain Injury, Comatose Survivors of Cardiac Arrest, EEG
- Trial name
- WAKE-OHCA (NCT06979700)
- Testing
- Automated Pupillometry, Transcranial Doppler Ultrasound, Optic Nerve Sheath Diameter
- Where
- 2 sites in Denmark
- Volunteers
- 250 people
- Sponsor
- University of Aarhus
PTSD - Post Traumatic Stress Disorder, Cardiac Arrest (CA)
Trial of Acceptance and Mindfulness-based Exposure Therapy (AMBET) and Present Centered Therapy (PCT)
The goal of this clinical trial is to learn if a new therapy called Acceptance- and Mindfulness-Based Exposure Therapy (AMBET) helps treat post-traumatic stress disorder (PTSD) in people who survived a cardiac arrest.
- Trial name
- NCT07410481
- Testing
- Acceptance and Mindfulness Based Exposure Therapy, Present-Centered Therapy
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Columbia University
Out of Hospital Cardiac Arrest, Cardiac Arrest (CA)
Predicting 28-Day Survival in OHCA Patients
This prospective study aimed to identify clinical and laboratory predictors of return of spontaneous circulation (ROSC), 28-day survival, and favorable neurological outcomes in adult patients experiencing out-of-hospital cardiac…
- Trial name
- OHCAstd (NCT07023159)
- Testing
- Demographics, Comorbidities, Prehospital Variables
- Where
- Turkey (Türkiye)
- Volunteers
- 327 people
- Sponsor
- Haseki Training and Research Hospital
Cardiac Arrest (CA)
Adjusting CPR Location With TEE Guidance
Use Transesophageal ultrasound in OHCA patients to identify the proper compression location
- Trial name
- NCT07017075
- Testing
- adjustment of CPR location
- Where
- 2 sites in Taiwan
- Volunteers
- 50 people
- Sponsor
- National Taiwan University Hospital
Cardiac Arrest (CA)
Self-training and Resuscitation Techniques: Evaluation of the Performance and Impact on the Quality of Cardiopulmonary Resuscitation (CPR)
Cardiac arrest (CA) remains one of the leading causes of death worldwide, and its incidence continues to increase. The median survival rate following in-hospital cardiac arrest in France is 19%.
- Trial name
- ATIPIQ (NCT07820605)
- Where
- France
- Volunteers
- 265 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Chronic Stress, Cardiac Arrest (CA)
The Role of Stress in Cardiac Arrest (Cortizol CPR)
The aim of this study is to assess long-term stress in patients after an out-of-hospital cardiac arrest. To do this, we will measure levels of the stress hormone cortisol in hair samples.
- Conditions
- Chronic Stress, Cardiac Arrest (CA), Post-Resuscitation Syndrome, Heart Attack
- Trial name
- Cortizol (NCT07285915)
- Testing
- Sample of hair
- Where
- Czechia
- Volunteers
- 136 people
- Sponsor
- University Hospital Pilsen
Major Adverse Cardiac Events, Acute Myocardial Infarction (AMI)
Preoperative Cardiology Consultation and the Incidence of Major Adverse Cardiac Events（MACE）
This cohort study aims to determine when preoperative cardiology consultation is needed to reduce the incidence of major adverse cardiac events (MACE) in elderly patients undergoing non-cardiac surgery.
- Conditions
- Major Adverse Cardiac Events, Acute Myocardial Infarction (AMI), Cardiac Death, Sudden, Cardiac Arrest (CA)
- Trial name
- MACE (NCT06884436)
- Where
- China
- Volunteers
- 22,000 people
- Sponsor
- Chinese PLA General Hospital