Cardiac Arrest (CA)NCT07526701
Clinical Application of Low-Field Magnetic Resonance Imaging in Patients on Extracorporeal Cardiopulmonary Resuscitation
An observational study of Cardiac Arrest (CA) and Extracorporeal Cardiopulmonary Resuscitation, run by Capital Medical University at 1 site in China.
Trial summary
Timely identification of acute brain injury (ABI) patterns in patients with extracorporeal cardiopulmonary resuscitation (ECPR) is essential for prognostic assessment and optimization of clinical management, particularly anticoagulation strategies. Read more about this study
- Who is it for?
- Ages 18 to 75 years
- Conditions the study is for
- Cardiac Arrest (CA), Extracorporeal Cardiopulmonary Resuscitation, Acute Brain Injury
- How many people
- 36 participants
- Where
- 1 siteChina
- Study dates
- 1 Nov 2024to 1 Jan 2026
- How long will I take part?
- 1 Year
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 75 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Enrolled patients were those with out-of-hospital cardiac arrest of presumed cardiac cause, supported by ECPR, who achieved ROSC but remained unconscious and unable to obey verbal commands.
Who may be able to join
- Enrolled patients were those with out-of-hospital cardiac arrest of presumed cardiac cause, supported by ECPR, who achieved ROSC but remained unconscious and unable to obey verbal commands.
Who cannot join
- age < 18 years
- unwitnessed cardiac arrest
- pregnancy
- contraindications to MRI (except ECPR, for which safety with 0.23-T MRI has been proved)
- physical dimensions exceeding scanner limits
- refusal of consent by the family
Trial locations and contacts
1 site in 1 country.
China1 site
Department of Emergency Medicine, Beijing Chaoyang Hospital, Capital Medical University
Beijing, Beijing Municipality, 100020
About this study
Timely identification of acute brain injury (ABI) patterns in patients with extracorporeal cardiopulmonary resuscitation (ECPR) is essential for prognostic assessment and optimization of clinical management, particularly anticoagulation strategies. This study aimed to evaluate the safety and feasibility of early 0.23-T MRI examination in ECPR patients. The investigators further assessed the image quality of the 0.23-T MRI and investigated the incidence and patterns of ABI, as well as their associations with neurological outcomes. This prospective observational study was conducted in the emergency intensive care unit (EICU) of Beijing Chaoyang Hospital, a high-volume ECPR center. The primary outcome was the feasibility of performing 0.23-T MRI in patients undergoing ECPR, defined as successful completion of the examination without serious adverse events (AEs).
- Keywords
- Cardiac Arrest, Extracorporeal Cardiopulmonary Resuscitation, Acute brain injury, Magnetic Resonance Imaging
- Medical subject headings
- Heart Arrest, Brain Injuries
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| Enrolled patients were those with out-of-hospital cardiac arrest of presumed cardiac cause | Not described |
What is being measured
The primary outcome is the main question the study is designed to answer.
Feasibility of 0.23-T MRI examination
Defined as the percentage of participants who successfully complete the MRI examination without experiencing serious adverse events (AEs).
AEs include a decrease in ECMO flow > 10%, a change in mean arterial pressure of ± 20%, or a change in minute ventilation > 20%.
Measured: From the initiation of the MRI scan until 6 hours after its completion.
Secondary outcomes (3)
Image Quality
Assessment of the diagnostic quality of 0.23-T MRI images by board-certified neuroradiologists to evaluate noise, artifacts, and anatomical clarity.
Measured: Within 6 hours after the completion of the MRI scan.
Incidence of Acute Brain Injury (ABI)
The proportion of patients identified with ABI patterns (such as ischemic stroke, intracranial hemorrhage, or cerebral edema) based on 0.23-T MRI findings.
Measured: From the onset of cardiac arrest to the completion of the MRI scan
The association between ABI and neurological outcomes
Neurological outcomes were assessed at 3 months after ROSC using the Glasgow-Pittsburgh Cerebral Performance Category (CPC) scale. The CPC scale ranges from 1 to 5, with 1 indicating good performance, 2 indicating moderate disability, 3 indicating severe disability, 4 indicating vegetative state and 5 indicating brain death or death. The neurological outcomes were categorized as favorable prognosis (CPC 1-2) and poor prognosis (CPC 3-5).
Measured: 3 months after ROSC.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted13 Apr 2026
- Study start1 Nov 2024
- Primary completion1 Jan 2026
- Study completion1 Jan 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Cardiac Arrest (CA)Studies of the same condition, open and under way.
- More trials run by Capital Medical UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 36 participants (actual)
- Target duration
- 1 Year
Sponsor and investigators
- Lead sponsor
- Capital Medical University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Tang Ziren, Capital Medical University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07526701
- Sponsor's protocol ID
- 2025-ke-783
- Status last verified
- Apr 2026
- First submitted
- 4 Apr 2026
- Last updated
- 13 Apr 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Data supporting the findings of this study could be obtained from the corresponding author upon reasonable request.
Publications
Suo Y, Du W, Xie X, Jiang Q, Zhang Z, Xu Y, Wei N, Zhu W, Qi N, Wang N, Xue B, Wang Y, Jiang Y, Meng X, Li Z, Zhao X, Li H, Wang Y, Jing J. Detecting acute ischemic lesions using mobile, low-field MRI in TIA and minor stroke in the emergency room. Int J Stroke. 2026 Apr;21(4):475-484. doi: 10.1177/17474930251378850. Epub 2025 Sep 4.
PubMed 40905643
Study at a glance
From the registry record, last updated by the sponsor on 13 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Clinical Application of Low-Field Magnetic Resonance Imaging in Patients on Extracorporeal Cardiopulmonary Resuscitation
- ClinicalTrials.gov ID
- NCT07526701
- Acronym / sponsor ID
- 2025-ke-783
- Keywords
- Cardiac Arrest, Extracorporeal Cardiopulmonary Resuscitation, Acute brain injury, Magnetic Resonance Imaging
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 36 participants (actual)
- Lead sponsor
- Capital Medical UniversityUniversity, hospital or other
- Study start
- 1 Nov 2024 (actual)
- Primary completion
- 1 Jan 2026 (actual)
- Study completion
- 1 Jan 2026 (actual)
- First posted
- 13 Apr 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Timely identification of acute brain injury (ABI) patterns in patients with extracorporeal cardiopulmonary resuscitation (ECPR) is essential for prognostic assessment and optimization of clinical management, particularly anticoagulation strategies. This study aimed to evaluate the safety and feasibility of early 0.23-T MRI examination in ECPR patients. The investigators further assessed the image quality of the 0.23-T MRI and investigated the incidence and patterns of ABI, as well as their associations with neurological outcomes. This prospective observational study was conducted in the emergency intensive care unit (EICU) of Beijing Chaoyang Hospital, a high-volume ECPR center. The primary outcome was the feasibility of performing 0.23-T MRI in patients undergoing ECPR, defined as successful completion of the examination without serious adverse events (AEs).
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Target follow-up
- 1 Year
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Enrolled patients were those with out-of-hospital cardiac arrest of presumed cardiac cause | – | – |
Who may qualify
- Ages
- 18 to 75 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Enrolled patients were those with out-of-hospital cardiac arrest of presumed cardiac cause, supported by ECPR, who achieved ROSC but remained unconscious and unable to obey verbal commands.
Key inclusion criteria (1 listed)
- Enrolled patients were those with out-of-hospital cardiac arrest of presumed cardiac cause, supported by ECPR, who achieved ROSC but remained unconscious and unable to obey verbal commands.
Key exclusion criteria (6 listed)
- age < 18 years
- unwitnessed cardiac arrest
- pregnancy
- contraindications to MRI (except ECPR, for which safety with 0.23-T MRI has been proved)
- physical dimensions exceeding scanner limits
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Feasibility of 0.23-T MRI examination
Time frame: From the initiation of the MRI scan until 6 hours after its completion.
Defined as the percentage of participants who successfully complete the MRI examination without experiencing serious adverse events (AEs). AEs include a decrease in ECMO flow > 10%, a change in mean arterial pressure of ± 20%, or a change in minute ventilation > 20%.
3 secondary outcomes
Image Quality
Time frame: Within 6 hours after the completion of the MRI scan.
Incidence of Acute Brain Injury (ABI)
Time frame: From the onset of cardiac arrest to the completion of the MRI scan
The association between ABI and neurological outcomes
Time frame: 3 months after ROSC.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 13 Apr 2026.
- Results publication: PubMed 40905643Suo Y, Du W, Xie X, Jiang Q, Zhang Z, Xu Y, Wei N, Zhu W, Qi N, Wang N, Xue B, Wang Y, Jiang Y, Meng X, Li Z, Zhao X, Li H, Wang Y, Jing J. Detecting acute ischemic lesions using mobile, low-field MRI in TIA and minor stroke in the emergency room. Int J Stroke. 2026 Apr;21(4):475-484. doi: 10.1177/17474930251378850. Epub 2025 Sep 4.
- Individual participant dataSharing planned: No. Data supporting the findings of this study could be obtained from the corresponding author upon reasonable request.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Cardiac Arrest (CA) and Extracorporeal Cardiopulmonary Resuscitation, run by Capital Medical University at 1 site in China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 13 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in China. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Feasibility of 0.23-T MRI examination (time frame: From the initiation of the MRI scan until 6 hours after its completion.). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07526701, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 13 Apr 2026.