Clinical trials: Cardiogenic Shock
Cardiogenic Shock
ECMOsorb Trial - Impact of a VA-ECMO in Combination With CytoSorb in Critically Ill Patients With Cardiogenic Shock
In the ECMOsorb study the impact of a veno-arterial -ECMO in combination with an extracorporeal cytokine hemadsorption system in critically ill patients with cardiogenic shock is to be examined
- Trial name
- ECMOsorb (NCT05027529)
- Testing
- CytoSorb, VA-ECMO only
- Where
- Germany
- Volunteers
- 42 people
- Sponsor
- Christian Schulze
Cardiogenic Shock
Physiology of Unloading VA ECMO Trial
The goal of this clinical trial is to compare the use of veno-arterial extracorporeal membrane oxygenation (VA ECMO) with and without left ventricular (LV) unloading in patients being treated for cardiogenic shock (CS).
- Trial name
- NCT06336655
- Testing
- IABP
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- University of Utah
Shock, Cardiogenic, Surgery
Validity of Cardiac Output Measurement Using Niccomo Device After Cardiac Surgery
Cardiac surgery is at high risk of low cardiac output syndrome after procedure. Monitoring cardiac function, and especially cardiac output, is important to identify cardiovascular dysfunction and to introduce and adjust optimal…
- Conditions
- Shock, Cardiogenic, Surgery, Output, Low Cardiac
- Trial name
- Niccomo-Card (NCT04643509)
- Testing
- Niccomo
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Rouen
Cardiogenic Shock, Heart Failure
Left Ventricular Volume Index in the Adjustment of Initial Dose of Dobutamine in Heart Failure and Cardiogenic Shock
Recent studies have suggested that the use of left ventricular ejection volume index calculation may aid in the hemodynamic management of critically ill patients.
- Trial name
- NCT03727282
- Testing
- adjust dobutamine according to the ejection volume index, adjust dobutamine according to the attending physician
- Volunteers
- 30 people
- Sponsor
- University of Sao Paulo General Hospital
Cardiogenic Shock, Mechanical Circulatory Support
OPTIMIZE 5.5 - Optimizing Impella 5.5 Outcomes Through Advanced Data Science
The main goal of this observational, study is to develop a clinical decision support tool utilizing Impella 5.5 pump parameters to predict native heart recovery and prevent adverse events, by leveraging data science and…
- Conditions
- Cardiogenic Shock, Mechanical Circulatory Support, Cardiogenic Shock Post Myocardial Infarction
- Trial name
- OPTIMIZE (NCT07619144)
- Testing
- Micro-axial flow pump support
- Where
- Austria
- Volunteers
- 100 people
- Sponsor
- Medical University of Vienna
Cardiogenic Shock
Genomic Determinants of Outcome in Cardiogenic Shock
The aim of this project is to understand the heterogeneity of both the immune consequences and treatment responses in CS. We will explore this heterogeneity through identification of transcriptomic sub-phenotypes and their…
- Trial name
- Goldilocs (NCT05728359)
- Testing
- Observational study
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- Barts & The London NHS Trust
Cardiogenic Shock, Heart Failure
CORTISHOCK-P: Trial of Corticosteroids in Inflammation-Enriched Heart Failure Cardiogenic Shock
This pilot study investigates whether giving a short course of intravenous corticosteroids (methylprednisolone) alongside standard medical care can help patients recovering from heart failure-related cardiogenic shock.
- Conditions
- Cardiogenic Shock, Heart Failure, Inflammation
- Trial name
- CORTISHOCK-P (NCT07461961)
- Testing
- Methylprednisone, Standard of Care (SOC)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Brigham and Women's Hospital
Cardiogenic Shock
Evaluation of Speckle Tracking Parameters as Predictors of Successful VA SPECKLE ECMO
Purpose of this study is to assess whether measurements obtained through speckle tracking (LV longitudinal and circumferential strain, RV longitudinal strain) can give additional information in identifying patients who develop…
- Trial name
- SPECKLE-ECMO (NCT03532529)
- Testing
- not applicable, it is an observational study
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Cardiogenic Shock, Acute Myocardial Infarction (AMI)
Routine Microaxial Heart Pump Support and Protocolized Pulmonary Artery Catheter Monitoring Versus Standard Care in Heart Attack-Related Cardiogenic Shock
The goal of this clinical trial is to learn which treatment strategies improve survival in adult patients with acute myocardial infarction complicated by cardiogenic shock (AMI-CS).
- Conditions
- Cardiogenic Shock, Acute Myocardial Infarction (AMI), Heart Failure, Acute
- Trial name
- DOUBLE-SHOCK (NCT07762560)
- Testing
- Microaxial flow pump (left ventricular assist device), Pulmonary artery catheter, Conventional hemodynamic monitoring
- Where
- Germany
- Volunteers
- 780 people
- Sponsor
- Leipzig Heart Science gGmbH
Heart Failure, Cardiogenic Shock
Cardiac Power Output in Cardiogenic Shock Patients
The main purpose of this study is to determine whether differences in myocardial reserve predict clinical outcomes for heart failure patients.
- Trial name
- NCT05700617
- Testing
- 1:1 Randomization to receive milrinone
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Chicago
Cardiogenic Shock, Extracorporeal Membrane Oxygenation Complication
Efficacy and Clinical Outcomes of Levosimendan in E-CPR
Treatment of refractory cardiac arrest requiring cardiopulmonary resuscitation (CPR) may be augmented with Extracorporeal membrane oxygenation (ECMO) to re-establish perfusion in the absence of return of spontaneous circulation.
- Trial name
- ECPR (NCT05730907)
- Testing
- Levosimendan
- Where
- Qatar
- Volunteers
- 100 people
- Sponsor
- Hamad Medical Corporation
Cardiogenic Shock, Acute Decompensated Heart Failure
Study of Patients Admitted to a Cardiac Intensive Care Unit With Acute CardioVascular Disease
This is a registry of the patients that are admitted to CICU and treated by the Scientific Staff of the 2nd Department of Cardiology, due to an acute cardiovascular disease (acute coronary syndrome, acute heart failure…
- Conditions
- Cardiogenic Shock, Acute Decompensated Heart Failure, Acute Pulmonary Embolism, Acute Myocardial Infarction
- Trial name
- NCT06081205
- Testing
- Admission in the Cardiac Intensive Care Unit (CICU)
- Where
- Greece
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Ioannina
Acute Cardiogenic Shock
Transient Circulatory Support in Cardiogenic Shock
The purpose of this multicenter prospective study is to determine if the decision of transient circulatory support (TCS) in cardiogenic shock is relevant.
- Trial name
- ALLOASSIST (NCT03528291)
- Where
- France
- Volunteers
- 240 people
- Sponsor
- University Hospital, Montpellier
Medical Condition Requiring Extracorporeal Organ Support
The University of Freiburg Medical Center Extracorporeal Organ Support Device Registry
A prospective registry collecting pseudonymized clinical and treatment data from all patients treated with extracorporeal organ support (i.e., VV ECMO, VA ECMO, ECPR, Impella, IABP, and others) on the wards of the Department of…
- Trial name
- NCT05811780
- Where
- Germany
- Volunteers
- 1,500 people
- Sponsor
- University Hospital Freiburg
ST Elevation Myocardial Infarction, Cardiogenic Shock
Clinical Characteristics and Outcomes Among STEMI Patients With Cardiogenic Shock at Abu Dhabi City
A retrospective study on the clinical characteristics and treatment outcomes of patients admitted with ST-elevation Myocardial Infarction (STEMI) complicated with cardiogenic shock (CS) during admission or CS development during…
- Trial name
- NCT06535503
- Where
- 2 sites in United Arab Emirates
- Volunteers
- 400 people
- Sponsor
- Abu Dhabi Health Services Company
STEMI, Cardiogenic Shock
Circulating microRNAs in Patients With STEMI Complicated With Cardiogenic Shock
The aim of the study is knowing the prognostic value of circulating miRNAs in patients admitted to our hospital with STEMI complicated with cardiogenic shock.
- Conditions
- STEMI, Cardiogenic Shock, Acute Coronary Syndrome, microRNA
- Trial name
- NCT02691286
- Where
- Spain
- Volunteers
- 142 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Cardiogenic Shock
Cardiac Rehabilitation in Patients Acutely Managed for Cardiogenic Shock (ENIGMA)
This is a prospective and retrospective multicentre study conducted under the scientific coordination of the IRCCS Fondazione Don Gnocchi and funded by the Italian Ministry of Health (PNRR-MCNT2-2023-12377767).
- Trial name
- ENIGMA (NCT06572826)
- Testing
- Cardiac Rehabilitation intervention
- Where
- Italy
- Volunteers
- 2,000 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Right Ventricular Infarction
The Effects of Nitric Oxide for Inhalation in Right Ventricular Infarction Patients
This study is designed to better understand the effects of nitric oxide, a gas for inhalation, on patients with right ventricular infarction.
- Trial name
- NCT00782652
- Testing
- inhaled nitric oxide, nitrogen gas
- Where
- 6 sites in United States, Belgium and 3 more
- Volunteers
- 3 people
- Sponsor
- Mallinckrodt
Cardiogenic Shock, Resuscitation
Post-Cardiotomy Extra-Corporeal Life Support Study
Extracorporeal life support is increasingly used after cardiac surgery. Despite improved technology, outcome still remains poor.
- Conditions
- Cardiogenic Shock, Resuscitation, Cardiac Surgery
- Trial name
- PELS (NCT03857217)
- Testing
- Extra-Corporeal Membrane Oxygenation
- Where
- Netherlands
- Volunteers
- 2,000 people
- Sponsor
- Maastricht University Medical Center
Acute; Myocardial Infarction, Complications, Cardiogenic Shock
Mild Hypothermia in Cardiogenic Shock Complicating Myocardial Infarction
Prospective, randomized, single-center, controlled, open-label Pilot-study to investigate whether induction of mild hypothermia in addition to primary percutaneous coronary intervention and optimal medical therapy in myocardial…
- Trial name
- SHOCK-COOL (NCT01890317)
- Testing
- Mild hypothermia
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- University of Leipzig