Clinical trials: Older Patients
Chronic Obstructive Pulmonary Disease
Quality of Life in Daxas-treated Patients Older Than 18 Years With Severe Chronic Obstructive Pulmonary Disease (COPD) (DACOTA)
Chronic obstructive pulmonary disease (COPD) is a progressive and largely irreversible lung disease characterized by chronic bronchitis and/or emphysema, resulting in breathlessness, cough and sputum.
- Trial name
- DACOTA (NCT01285167)
- Testing
- Daxas
- Where
- 605 sites in Germany
- Volunteers
- 3,645 people
- Sponsor
- AstraZeneca
Cognitive/Functional Effects, Colorectal Cancer
Combination Chemotherapy Plus Bevacizumab With or Without Oxaliplatin in Treating Older Patients With Metastatic Colorectal Cancer
This randomized phase III trial studies how well combination chemotherapy plus bevacizumab with or without oxaliplatin works in treating older patients with colorectal cancer that has spread to other places in the body.
- Conditions
- Cognitive/Functional Effects, Colorectal Cancer, Neurotoxicity
- Trial name
- NCT01279681
- Testing
- bevacizumab, capecitabine, fluorouracil
- Volunteers
- 32 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Delivery of Health Care, Health Services
The COPACC Study: Utilization, Health and Economic Evaluation of a Community-Based Primary Care Geriatric Hub at Whampoa
This study evaluates the Community for Successful Ageing (ComSA) Patient-Centered Medical Home (PCMH), a model of community-based primary care geriatric hub at Whampoa, Singapore.
- Conditions
- Delivery of Health Care, Health Services, Costs and Cost Analysis, Quality of Life
- Trial name
- NCT04594967
- Testing
- Patient-centred care home (PCMH)
- Where
- Singapore
- Volunteers
- 184 people
- Sponsor
- Geriatric Education and Research Institute
Diabetes
The Effect of Clinic Visit Audio Recordings for Self-management in Older Adults
The objective of this study is to conduct a multisite trial evaluating the impact of adding an audio recording of clinic visits (AUDIO) to usual care in older adults with multimorbidity, including diabetes, compared to After…
- Trial name
- REPLAY (NCT05824572)
- Testing
- Clinic visit audio recordings for self-management in older adults, Usual Care
- Where
- 3 sites in United States
- Volunteers
- 336 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Delirium in Old Age
Quality Contract: Prevention of Postoperative Delirium in the Care of Older Patients (QV-POD-2)
The project "QV-POD-2" is a prolongation based on "QV-POD-1", which was a quality contract program of the IQTIG - Institute for Quality and Transparency in Health Care.
- Trial name
- NCT04355195
- Where
- 2 sites in Germany
- Volunteers
- 18,100 people
- Sponsor
- Charite University, Berlin, Germany
Multi Drug Resistant Department, Multi Drug Resistant Bacteria
Testing Carriage of Resistant Bacteria Using Swabs on Surfaces and Staff in a Complex Nursing Unit for Patients with Resistant Bacteria
Impact of Care Team and Surfaces on the Spread of Resistant Bacteria in a Specialized Complex Nursing Unit for MDR Pathogen Carriers Background Multi-drug resistant (MDR) bacteria present a severe clinical and epidemiological…
- Trial name
- NCT06696144
- Testing
- Skin swabs for multi drug resistant bacteria
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Shmuel Harofeh Hospital, Geriatric Medical Center
Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
Ofatumumab for Patients With Previously Untreated Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
The risk of immunosuppression deters many patients from receiving fludarabine, while combination chemotherapy regimens are poorly tolerated by elderly or infirm chronic lymphocytic leukemia (CLL) patients.
- Trial name
- NCT01113632
- Testing
- Ofatumumab
- Where
- 13 sites in United States
- Volunteers
- 77 people
- Sponsor
- SCRI Development Innovations, LLC
Healthy Ageing
Exploring Blood Flow Restriction as an Accessible Fitness Solution for Healthy Aging in Seniors
As people age, it can become harder to stay active and independent, especially when dealing with fatigue, joint pain, or other health problems.
- Trial name
- NCT07460609
- Testing
- Blood Flow Restriction Training Exercise, Health Education
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Baylor University
Osteoporosis, Management Care, Fracture
Optimization of Osteoporosis Management Among Patients Older Than 45 Years Old With Low Energy Fracture.
Harrington's metaphorical depiction captures the essence of the problem : "Osteoporosis care of fracture patients has been characterized as the Bermuda Triangle made up of orthopaedists, primary care physicians and osteoporosis…
- Trial name
- OPTIPOST (NCT02060747)
- Testing
- Coordinator-based post fracture program
- Where
- France
- Volunteers
- 480 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Multiple Myeloma
Study of Treatment for Newly Diagnosed Multiple Myeloma Patients Older Than 65 Years With Sequential Melphalan/Prednisone/Velcade (MPV) Followed by Revlimid/Low Dose Dexamethasone (Rd) Versus Alternating Velcade/Melphalan/Prednisone (MPV) With Revlimid/Low Dose Dexamethasone
This is a national, multicenter, open-label, randomized, comparative study designed to compare, first, the TTP of the two treatment schemes proposed (MPV followed by Rd or MPV alternating with Rd) in newly diagnosed MM patients…
- Trial name
- NCT01237249
- Testing
- Melphalan, Prednisone, Velcade
- Where
- 63 sites in Spain
- Volunteers
- 250 people
- Sponsor
- PETHEMA Foundation
COPD,Pulmonary Disease, Chronic Obstructive ,Pulmonary Disease, Chronic Obstructive
Effect of Introducing Digital Multimedia Nursing on Improving With COPD
COPD is a progressive and irreversible lung disease characterized by persistent airflow limitation, dyspnea, chronic cough, and impaired daily functioning, often accompanied by comorbidities that reduce quality of life.
- Trial name
- COPD (NCT07419906)
- Testing
- E-book on Pulmonary Obstruction
- Where
- Taiwan
- Volunteers
- 51 people
- Sponsor
- Fu Jen Catholic University Hospital
Older Patients, Colorectal Cancer
DOSAGE Study: Upfront Dose-Reduced Chemotherapy in Older Patients with Metastatic Colorectal Cancer
The goal of this phase III, open-label, non-inferiority randomized controlled clinical trial is compare upfront dose-reduced chemotherapy with the standard dose chemotherapy in older patients ( ≥70 years) with metastasized…
- Conditions
- Older Patients, Colorectal Cancer, Metastatic Cancer, Candidates for Palliative Chemotherapy
- Trial name
- DOSAGE (NCT06275958)
- Testing
- Doublet Chemotherapy, Standard Dose (100%), Doublet Chemotherapy, Dose-reduced (75%), Monotherapy, Standard Dose (100%)
- Where
- 36 sites in Netherlands
- Volunteers
- 587 people
- Sponsor
- Leiden University Medical Center
Frailty in Older Adults
Allogeneic Human Mesenchymal Stem Cell Infusion for Frailty Patient
Subjects will be provided a written informed consent to participate in the study and then undergo any screening. Subjects who meet all the inclusion criteria and none of the exclusion criteria based on the screening test results…
- Trial name
- NCT07449364
- Testing
- Daewoong Biologics Indonesia Umbilical Cord-derived Mesenchymal Stem Cell (DBI UC-MSC)
- Where
- Indonesia
- Volunteers
- 10 people
- Sponsor
- Daewoong Group Indonesia
Multiple Sclerosis (MS), Cerebral Small Vessel Diseases
MRI-Based Lesion Differentiation in Older Patients With Multiple Sclerosis
This study investigates whether an advanced MRI technique called Quantitative Susceptibility Mapping (QSM) can improve the differentiation of white matter lesions in people aged 50-70 years with multiple sclerosis (MS).
- Trial name
- NCT07444047
- Where
- Norway
- Volunteers
- 1,000 people
- Sponsor
- Oslo University Hospital
Delirium, Dementia
Delirium and Cognitive Impairment Development in Hospitalized Older Adults Under Isolation Conditions
The goal of this observational study is to examine if older patients who need to be under isolation precautions due to multidrug resistant bacteria or other reasons have an increased risk of suffering from delirium or cognitive…
- Conditions
- Delirium, Dementia, Cognitive Impairment
- Trial name
- DELiso (NCT07114458)
- Where
- Germany
- Volunteers
- 404 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Cancer
A Multicomponent Technology Supported Care Delivery for Older Patients With Hematologic Malignancies (The M-Tech Study)
This is a randomized controlled trial to assess the feasibility and preliminary efficacy of a multicomponent technology-supported care delivery intervention trial in 110 older patients with hematologic malignancies [acute myeloid…
- Trial name
- M-Tech (NCT05153447)
- Testing
- M-Tech, Usual Care
- Where
- United States
- Sponsor
- Kah Poh Loh
Health Risk Behaviors
Feasibility, Acceptability, and Preliminary Efficacy of an HIV Prevention Intervention for Older Black Women
The goal of this clinical trial is to learn whether a group-based HIV prevention program can improve HIV knowledge, prevention behaviors, and testing in older Black women aged 50 and older who live in subsidized housing.
- Trial name
- NCT07181616
- Testing
- Adapted W2W, Waitlist Control
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Laneshia Conner
Total Knee Arthroplasty
Intraoperative VR for Older Patients Undergoing TKA
The objective of this study is to investigate whether the use of virtual reality (VR) during total knee arthroplasty (TKA) can facilitate reductions in intraoperative sedative requirements while maintaining high levels of patient…
- Trial name
- NCT04748549
- Testing
- Virtual Reality Immersive Relaxation, Immersive Audio Experience
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- Beth Israel Deaconess Medical Center
Postoperative Delirium, Aging Disorder
Non-pharmacological Prevention of Postoperative Delirium by Occupational Therapy Teams
In the world, 230 million surgeries are performed every year and US data indicates that more than a third of patients who undergo surgery are older than 65 years, in which between 10 and 70% develop postoperative delirium (POD).
- Trial name
- PREPODOT (NCT03704090)
- Testing
- Occupational therapy intervention, Standard non-pharmacological prevention intervention
- Where
- Chile
- Volunteers
- 160 people
- Sponsor
- University of Chile
Aging, Hospitalization
An ESD Model of Care for Older Adults Admitted to Hospital: a Protocol for a Descriptive Cohort Study
The MidWest multidisciplinary Community Intervention Teams (MD-CIT) comprise of specialist, healthcare teams that provide a rapid and integrated response to a patient with an acute episode of illness who requires enhanced…
- Conditions
- Aging, Hospitalization, Function
- Trial name
- NCT05731362
- Testing
- MDCIT Intervention
- Where
- Ireland
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Limerick
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