Clinical trials: Older Adults With Mild Neurocognitive Disorders, active
Dementia, tDCS
The Efficacy of HD-tDCS-Augmented Step Training in Older Adults With Mild Dementia
Falls and mobility decline are major health concerns among older adults with dementia, often linked to deterioration in executive function and cognitive-motor control.
- Conditions
- Dementia, tDCS, Physical Exercise, Neuromodulation
- Trial name
- NCT07841145
- Testing
- Step training, active HD-tDCS
- Where
- Hong Kong
- Volunteers
- 68 people
- Sponsor
- The Hong Kong Polytechnic University
Mild Cognitive Impairment, Accidental Falls
A Study of Dual-task Exercise Training to Prevent Falls Among Older Adults With Mild Cognitive Impairment
To determine the efficacy of a dual-task tai ji quan training therapy in reducing the incidence of falls in older adults with mild cognitive impairment.
- Conditions
- Mild Cognitive Impairment, Accidental Falls, Aging
- Trial name
- NCT05725668
- Testing
- dual-task tai ji quan, standard tai ji quan, stretching
- Where
- United States
- Volunteers
- 336 people, healthy volunteers welcome
- Sponsor
- Oregon Research Institute
Mild Cognitive Impairment
Resistance Exercise Training in Individuals Aged 60 and Older With Mild Cognitive Impairment
The aging population in Chile and worldwide is increasing, with older people expected to represent 32.1% of the population by 2050.
- Trial name
- RET-MCI (NCT06470568)
- Testing
- Progressive Resistance exercise training
- Where
- Chile
- Volunteers
- 60 people
- Sponsor
- Universidad de La Frontera
Mild Cognitive Impairment (MCI)
Effects of Tadalafil on Cognition and Cerebral Hemodynamics in Elderly Patients With Mild Cognitive Impairment
The goal of this clinical trial is to determine if taking four weeks of a daily low dose of tadalafil is possible and safe in elderly males and females with mild cognitive impairment.
- Trial name
- NCT07882901
- Testing
- Tadalafil 5 mg
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Los Angeles Brain Science Project
Chronic Disease, Mild Cognitive Impairment
Virtual Outreach and Individualized Coaching Extension
This study tests whether a nurse-led program that uses a voice-controlled smart speaker in the home helps older adults better manage their chronic health conditions.
- Trial name
- VOICE (NCT07836114)
- Testing
- Virtual Outreach and Individualized Coaching Extension
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Emory University
Cognitive Impairment, Cognitive Impairment, Mild
Comparative Evaluation of Immediate vs Progressive Standing Dual Task Training in Elderly With Mild and Moderate Cognitive Impairment
older adults with mild and moderate cognitive impairment. compare immediate vs progressive standing dual-task training. assess balance, cognition, executive function, mobility, and quality of life.
- Conditions
- Cognitive Impairment, Cognitive Impairment, Mild, Moderate Cognitive Impairment
- Trial name
- NCT07764250
- Testing
- Immediate standing dual task training, progressive standing dual task training
- Where
- Pakistan
- Volunteers
- 96 people
- Sponsor
- Shifa Tameer-e-Millat University
Cognition
Impact of NANO-PSO on Cognition in Older Adults with Mild to Moderate Cognitive Impairment
The objective of this randomized, triple-blind, placebo-controlled clinical trial is to compare NANO-PSO therapy against placebo in improving cognitive abilities in older adults with mild to moderate non-vascular cognitive…
- Trial name
- COGMEG5 (NCT06520878)
- Testing
- NANO-PSO (pomegranate seed oil)
- Where
- Mexico
- Volunteers
- 60 people
- Sponsor
- Distribuidora Biolife SA de CV
Mild Cognitive Impairment (MCI), Moderate Cognitive Impairment
Comparative Effects of Integrated Versus Sequential Approaches to Dual-Task Training in Elderly With Mild to Moderate Cognitive Impairment
Mild and Moderate cognitive impairment is a condition characterized by a noticeable decline in cognitive abilities, including memory and thinking skills, which is greater than expected for an individual's age but does not…
- Trial name
- nill (NCT07775079)
- Testing
- Integrated Dual-Task Training, Sequential Dual-Task Training
- Where
- Pakistan
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Shifa Tameer-e-Millat University
Mild Cognitive Impairment (MCI)
Hippocampal Temporal Interference Stimulation for Memory and Dual-Task Postural Control in Older Adults With Mild Cognitive Impairment
This trial aims to investigate whether a single session of 40 Hz hippocampal temporal interference stimulation can improve memory function and dual-task postural control among older adults with mild cognitive impairment (MCI).
- Trial name
- NCT07771036
- Testing
- Temporal Interference Stimulation
- Where
- China
- Volunteers
- 21 people
- Sponsor
- Shanghai University of Sport
Mild Cognitive Impairment
The Impact of Physical Exercise on Working Memory in Elderly People With Mild Cognitive Impairment
Age-related cognitive decline has evolved into a global public health concern, with deteriorated executive function serving as its predominant manifestation.
- Trial name
- NCT07644156
- Testing
- Resistance band exercise intervention, Brisk walking intervention, Eight-Section brocade exercise intervention
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Shanghai University of Sport
Mild Cognitive Impairment (MCI)
A Comparison of the Efficacy of Different Rehabilitation Strategies in Mild Cognitive Impairment
The aim of this study is to conduct a comparative analysis of the effects of two different rehabilitation approaches on cognitive and functional outcomes in older adults diagnosed with mild cognitive impairment (MCI).
- Trial name
- NCT07547111
- Testing
- Dual Task Training, The computer-assisted cognitive rehabilitation
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Istanbul University - Cerrahpasa
Aging, Mild Cognitive Impairment
bpMedManage: Digital Technology to Support Adherence to Hypertension Medications
The purpose of the bpMedManage study is to rigorously test the efficacy of a smartphone technology to help improve high blood pressure medication adherence among older adults with mild cognitive impairment (MCI) in a 16-week…
- Conditions
- Aging, Mild Cognitive Impairment, Hypertension
- Trial name
- NCT06307574
- Testing
- bpMedManage
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- University of Arizona
Cognitive Decline, Alzheimer Disease
Effects of Real vs. Soundless Acoustic Stimulation During Deep Sleep on Brain Activity, Memory, and Blood Biomarkers in Older Adults (60-85) With Mild Memory Impairment
This study aims to explore a non-invasive way to improve memory and slow cognitive decline in older adults by enhancing sleep quality.
- Conditions
- Cognitive Decline, Alzheimer Disease, Subjective Cognitive Decline (SCD), Mild Cognitive Impairment (MCI)
- Trial name
- NCT06669546
- Testing
- Phase-locked auditory stimulation (PLAS)
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- University of Bern
Cognitive Dysfunction, Cognitive Disorder, Cognitive Training
Effects of Adaptive Difficulty Computerized Cognitive Training on Cognitive Function Improvement in Older Adults With Mild Cognitive Impairment
This study aims to evaluate the effectiveness of adaptive computerized cognitive training (CCT) in improving cognitive function among community-dwelling older adults with mild cognitive impairment (MCI) and to compare the…
- Trial name
- NCT07753382
- Testing
- Adaptive Computerized Cognitive Training
- Where
- China
- Volunteers
- 36 people
- Sponsor
- China Medical University, China
Mild Cognitive Impairment
Effectiveness of an ACT-Based Cognitive Intervention on Quality of Life and Cognitive Function in Elderly Residents With MCI
This study investigates the effects of an Acceptance and Commitment Therapy (ACT)-based cognitive intervention on Quality of Life (QOL) and cognitive function among elderly residents with Mild Cognitive Impairment (MCI) in…
- Trial name
- EACT (NCT06753578)
- Testing
- Acceptance and Commitment Therapy (ACT), standard care
- Where
- Spain
- Volunteers
- 215 people
- Sponsor
- Instituto de Investigación Marqués de Valdecilla
Cognition Disorders
EFFECTS OF AN OUTDOOR MAT PILATES PROGRAM ON NEUROPHYSIOLOGICAL INDICATORS OF ELDERLY INDIVIDUALS WITH MILD COGNITIVE IMPAIRMENT
Introduction: As individuals age, the quality of cognitive function becomes an increasingly important topic. Elderly people, naturally, due to the aging process, may experience a reduction in cognitive function.
- Trial name
- NCT07899372
- Testing
- Mat Pilates outdoor, Mat pilates closed environment
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Letícia Maria Da Silva
Choroid Disease, Caregiver
Dyadic Management Intervention in Older People With Co-occurring Cognitive Impairment and Diabetes as a Supplementary Approach to Chronic Diseases Self-Management Program
The goal of this study is to evaluate the effectiveness and implementation of a dyadic management of the Chronic Disease Self-Management Program (CDSMP) for older adults with co-occurring cognitive impairment and diabetes with…
- Conditions
- Choroid Disease, Caregiver, Self-management, Diabetes
- Trial name
- NCT07496359
- Testing
- CDSMP + caregiver support, Usual Care
- Where
- Hong Kong
- Volunteers
- 309 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Dementia, Mild Cognitive Impairment
Effectiveness of Strength-based Intervention for Elderly With Dementia Living in the Community
In the realm of dementia care, the imperative to intervene at the earliest stages of cognitive decline is paramount. Recognizing this pivotal moment, the development of innovative and effective interventions becomes imperative in…
- Conditions
- Dementia, Mild Cognitive Impairment, Caregiver, Dementia Alzheimer Type
- Trial name
- STRENGTH-B (NCT07037550)
- Testing
- Strength-based intervention
- Where
- Hong Kong
- Volunteers
- 272 people
- Sponsor
- The University of Hong Kong
Cognitive Dysfunction, Alzheimer Disease
ALA-enriched Nutrition for Prevention of Cognitive Decline in APOE4 Older Adults
This randomized, double-blind, placebo-controlled pilot trial will evaluate the effects of alpha-linolenic acid (ALA) supplementation on cognitive function, blood-brain barrier integrity, and brain vascular health in older adults…
- Conditions
- Cognitive Dysfunction, Alzheimer Disease, Blood-Brain Barrier, Apolipoprotein E, Deficiency or Defect of
- Trial name
- NCT07392723
- Testing
- Alpha-Linolenic Acid (2.6 g/day)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Michal Schnaider Beeri, Ph.D.
Alzheimer Disease, Anxiety
Cannabidiol Solution for the Treatment of Behavioral Symptoms in Older Adults With Mild Cognitive Impairment or Alzheimer's Dementia
This is an open label, eight week, clinical trial of a proprietary high CBD/low THC sublingual solution for the treatment of clinically significant anxiety and agitation in individuals with mild cognitive impairment (MCI) or mild…
- Conditions
- Alzheimer Disease, Anxiety, Agitation,Psychomotor, Mild Cognitive Impairment (MCI) Due to Alzheimer's Disease
- Trial name
- CBD (NCT04075435)
- Testing
- high CBD/low THC sublingual solution
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Mclean Hospital