Cognitive Dysfunction, Cognitive DisorderNCT07753382
Effects of Adaptive Difficulty Computerized Cognitive Training on Cognitive Function Improvement in Older Adults With Mild Cognitive Impairment
A study testing Adaptive Computerized Cognitive Training in people with Cognitive Dysfunction, Cognitive Disorder and Cognitive Training, run by China Medical University, China at 1 site in China.
Trial summary
This study aims to evaluate the effectiveness of adaptive computerized cognitive training (CCT) in improving cognitive function among community-dwelling older adults with mild cognitive impairment (MCI) and to compare the maintenance effects of different training frequencies after the initial intervention. Read more about this study
- Who is it for?
- Ages 60 years and older
- Conditions the study is for
- Cognitive Dysfunction, Cognitive Disorder, Cognitive Training
- What is being tested?
- Adaptive Computerized Cognitive Training
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 36 participants
- Where
- 1 siteChina
- Study dates
- 10 Aug 2026to 10 Jan 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 60 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Age >= 60 years;
- Planning to reside in the community for at least 12 months, with no intention to move into a nursing home;
- No clinical diagnosis of dementia;
- Meeting the diagnostic criteria for mild cognitive impairment (MCI) as defined in the Chinese Expert Consensus on the Diagnosis and Treatment of Alzheimer's Disease-Related Mild Cognitive Impairment (2021), The cut-off scores for the Beijing version of the Montreal Cognitive Assessment (MoCA) were adjusted for educational level: <=13 for junior high school or below, <=19 for high school, and <=24 for college education or above. Mini-Mental State Examination (MMSE) score >= 24; Activities of Daily Living (ADL) score <23.
- Able to use a mobile application (mini program) to perform cognitive training.
Who cannot join
- Individuals unable to complete the questionnaires due to hearing or visual impairments;
- Those with other organic diseases of the central nervous system, such as brain tumors, epilepsy, or Parkinson's disease;
- Those diagnosed with severe mental disorders, such as schizophrenia, depression, or anxiety disorders.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
China1 site
Ren'ai Changwan Community Elderly Care Service Station, Dadong
Shenyang, Liaoning, 110000
Yu Liu, PhD, +8618193218315, 2968500699@qq.com
About this study
This study aims to evaluate the effectiveness of adaptive computerized cognitive training (CCT) in improving cognitive function among community-dwelling older adults with mild cognitive impairment (MCI) and to compare the maintenance effects of different training frequencies after the initial intervention. A quasi-experimental study will be conducted in three communities in Shenyang, Liaoning Province, China. All participants will receive a 12-week adaptive CCT program. Participants will be assigned to either a high-frequency maintenance training group or a training discontinuation group. Cognitive assessments will be performed at baseline, immediately after the intervention, and during follow-up. The primary outcome is global cognitive function, while secondary outcomes include memory, attention, executive function, language, visuospatial ability, and activities of daily living. The findings of this study are expected to provide evidence for optimizing computerized cognitive training programs and long-term management strategies for older adults with MCI in community settings.
Read the detailed description
With the rapid aging of the global population, mild cognitive impairment (MCI) has become a critical stage for dementia prevention and early intervention. Cognitive training is recognized as one of the most effective non-pharmacological interventions for individuals with MCI. Among various approaches, adaptive computerized cognitive training (CCT) can dynamically adjust task difficulty according to an individual's performance, thereby improving training personalization, engagement, and adherence. However, evidence regarding the optimal maintenance training frequency and the long-term sustainability of cognitive benefits remains limited.
This study adopts a quasi-experimental design and will recruit community-dwelling adults aged 60 years and older with MCI from three communities in Shenyang, Liaoning Province, China. All participants will complete a 12-week adaptive computerized cognitive training program using the Heling Brain Planet WeChat mini-program, with training sessions lasting 30 minutes, three times per week. After the initial intervention, participants will be assigned to either a high-frequency maintenance training group, which will continue training three times per week, or a training discontinuation group, which will receive routine community health management only. Follow-up cognitive assessments will be conducted after the intervention and during the follow-up period.
The primary outcome will be global cognitive function assessed by the Montreal Cognitive Assessment (MoCA). Secondary outcomes will include memory (Auditory Verbal Learning Test, AVLT), attention (Trail Making Test Part A, TMT-A), executive function (Stroop Color-Word Test), language (Boston Naming Test, BNT), visuospatial ability (Clock Drawing Test, CDT), and activities of daily living (ADL). The effects of different maintenance training frequencies on cognitive improvement and the persistence of intervention benefits will be compared.
This study is expected to evaluate the effectiveness of adaptive computerized cognitive training for improving cognitive function in community-dwelling older adults with MCI and to determine whether continued maintenance training can prolong cognitive benefits. The findings will provide evidence for optimizing community-based digital cognitive training programs and developing sustainable intervention strategies for the long-term management of older adults with MCI.
- Being tested
- Adaptive Computerized Cognitive Training
- Medical subject headings
- Cognitive Dysfunction
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Adaptive Computerized Cognitive TrainingBehavioural
Participants receive adaptive computerized cognitive training delivered through the Heling Brain Planet WeChat mini- program. The intervention consists of individualized cognitive exercises targeting multiple cognitive domains, including attention, memory, executive function, language, visuospatial ability, perceptual-motor function, and social cognition. The training difficulty is automatically adjusted according to each participant's performance to provide personalized cognitive stimulation. During the initial intervention phase, all participants complete 30-minute training sessions three times per week for 3 months. After the initial intervention, participants choose to continue training receive maintenance adaptive computerized cognitive training.
Adaptive Computerized Cognitive TrainingBehavioural
Participants receive adaptive computerized cognitive training delivered through the Heling Brain Planet WeChat mini- program. The intervention consists of individualized cognitive exercises targeting multiple cognitive domains, including attention, memory, executive function, language, visuospatial ability, perceptual-motor function, and social cognition. The training difficulty is automatically adjusted according to each participant's performance to provide personalized cognitive stimulation. During the initial intervention phase, all participants complete 30-minute training sessions three times per week for 3 months. After the initial intervention, participants not to continue discontinue the intervention and undergo follow-up assessments only.
| Study group | Role | What they receive |
|---|---|---|
| High-Frequency Maintenance Training | Experimental | Participants will receive adaptive computerized cognitive training using the Heling Brain Planet WeChat mini-program. During the initial intervention phase, participants will complete training sessions three times per week for 30 minutes per session over 12 weeks. After the initial intervention, participants will continue maintenance training three times per week until the end of the follow-up period. The training program automatically adjusts task difficulty according to individual performance and includes exercises targeting attention, memory, executive function, language, visuospatial ability, and other cognitive domains. Receives: Behavioral: Adaptive Computerized Cognitive Training |
| Training Discontinuation Group | Other | Participants will receive the same 12-week adaptive computerized cognitive training program during the initial intervention phase. After completing the initial intervention, no further computerized cognitive training will be provided. Participants will continue to receive routine community health management and will complete follow-up cognitive assessments according to the study schedule. Receives: Behavioral: Adaptive Computerized Cognitive Training |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in global cognitive function assessed by the Montreal Cognitive Assessment (MoCA)
Measured: Baseline, Month 3, Month 4, and Month 6
Secondary outcomes (6)
Change in cognitive function assessed by the Mini-Mental State Examination (MMSE)
Measured: Baseline, Month 3, Month 4, and Month 6
Change in language function assessed by the Boston Naming Test (BNT)
Measured: Baseline, Month 3, Month 4, and Month 6
Change in attention assessed by the Trail Making Test Part A (TMT-A)
Measured: Baseline, Month 3, Month 4, and Month 6
Change in executive function assessed by the Stroop Color-Word Test
Measured: Baseline, Month 3, Month 4, and Month 6
Change in visuospatial function assessed by the Clock Drawing Test (CDT)
Measured: Baseline, Month 3, Month 4, and Month 6
Change in activities of daily living assessed by the Activities of Daily Living (ADL) scale
Measured: Baseline, Month 3, Month 4, and Month 6
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted7 Aug 2026
- Study start10 Aug 2026 (estimated)
- Primary completion10 Jan 2027 (estimated)
- Study completion10 Jan 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Cognitive Dysfunction, Cognitive DisorderStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 36 participants (estimated)
Sponsor and investigators
- Lead sponsor
- China Medical University, China
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Zhang Ziyi, China Medical University, China
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07753382
- Sponsor's protocol ID
- China Medical University
- Status last verified
- Aug 2026
- First submitted
- 4 Aug 2026
- Last updated
- 7 Aug 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 7 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of Adaptive Difficulty Computerized Cognitive Training on Cognitive Function Improvement in Older Adults With Mild Cognitive Impairment
- ClinicalTrials.gov ID
- NCT07753382
- Acronym / sponsor ID
- China Medical University
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 36 participants (estimated)
- Lead sponsor
- China Medical University, ChinaUniversity, hospital or other
- Study start
- 10 Aug 2026 (estimated)
- Primary completion
- 10 Jan 2027 (estimated)
- Study completion
- 10 Jan 2027 (estimated)
- First posted
- 7 Aug 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study aims to evaluate the effectiveness of adaptive computerized cognitive training (CCT) in improving cognitive function among community-dwelling older adults with mild cognitive impairment (MCI) and to compare the maintenance effects of different training frequencies after the initial intervention. A quasi-experimental study will be conducted in three communities in Shenyang, Liaoning Province, China. All participants will receive a 12-week adaptive CCT program. Participants will be assigned to either a high-frequency maintenance training group or a training discontinuation group. Cognitive assessments will be performed at baseline, immediately after the intervention, and during follow-up. The primary outcome is global cognitive function, while secondary outcomes include memory, attention, executive function, language, visuospatial ability, and activities of daily living. The findings of this study are expected to provide evidence for optimizing computerized cognitive training programs and long-term management strategies for older adults with MCI in community settings.
Detailed description
With the rapid aging of the global population, mild cognitive impairment (MCI) has become a critical stage for dementia prevention and early intervention. Cognitive training is recognized as one of the most effective non-pharmacological interventions for individuals with MCI. Among various approaches, adaptive computerized cognitive training (CCT) can dynamically adjust task difficulty according to an individual's performance, thereby improving training personalization, engagement, and adherence. However, evidence regarding the optimal maintenance training frequency and the long-term sustainability of cognitive benefits remains limited.
This study adopts a quasi-experimental design and will recruit community-dwelling adults aged 60 years and older with MCI from three communities in Shenyang, Liaoning Province, China. All participants will complete a 12-week adaptive computerized cognitive training program using the Heling Brain Planet WeChat mini-program, with training sessions lasting 30 minutes, three times per week. After the initial intervention, participants will be assigned to either a high-frequency maintenance training group, which will continue training three times per week, or a training discontinuation group, which will receive routine community health management only. Follow-up cognitive assessments will be conducted after the intervention and during the follow-up period.
The primary outcome will be global cognitive function assessed by the Montreal Cognitive Assessment (MoCA). Secondary outcomes will include memory (Auditory Verbal Learning Test, AVLT), attention (Trail Making Test Part A, TMT-A), executive function (Stroop Color-Word Test), language (Boston Naming Test, BNT), visuospatial ability (Clock Drawing Test, CDT), and activities of daily living (ADL). The effects of different maintenance training frequencies on cognitive improvement and the persistence of intervention benefits will be compared.
This study is expected to evaluate the effectiveness of adaptive computerized cognitive training for improving cognitive function in community-dwelling older adults with MCI and to determine whether continued maintenance training can prolong cognitive benefits. The findings will provide evidence for optimizing community-based digital cognitive training programs and developing sustainable intervention strategies for the long-term management of older adults with MCI.
Study design
- Primary purpose
- Treatment
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| High-Frequency Maintenance Training | Experimental | Behavioral: Adaptive Computerized Cognitive TrainingParticipants will receive adaptive computerized cognitive training using the Heling Brain Planet WeChat mini-program. During the initial intervention phase, participants will complete training sessions three times per week for 30 minutes per session over 12 weeks. After the initial intervention, participants will continue maintenance training three times per week until the end of the follow-up period. The training program automatically adjusts task difficulty according to individual performance and includes exercises targeting attention, memory, executive function, language, visuospatial ability, and other cognitive domains. |
| Training Discontinuation Group | Other | Behavioral: Adaptive Computerized Cognitive TrainingParticipants will receive the same 12-week adaptive computerized cognitive training program during the initial intervention phase. After completing the initial intervention, no further computerized cognitive training will be provided. Participants will continue to receive routine community health management and will complete follow-up cognitive assessments according to the study schedule. |
Who may qualify
- Ages
- 60 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (5 listed)
- Age >= 60 years;
- Planning to reside in the community for at least 12 months, with no intention to move into a nursing home;
- No clinical diagnosis of dementia;
- Meeting the diagnostic criteria for mild cognitive impairment (MCI) as defined in the Chinese Expert Consensus on the Diagnosis and Treatment of Alzheimer's Disease-Related Mild Cognitive Impairment (2021), The cut-off scores for the Beijing version of the Montreal Cognitive Assessment (MoCA) were adjusted for educational level: <=13 for junior high school or below, <=19 for high school, and <=24 for college education or above. Mini-Mental State Examination (MMSE) score >= 24; Activities of Daily Living (ADL) score <23.
- Able to use a mobile application (mini program) to perform cognitive training.
Key exclusion criteria (3 listed)
- Individuals unable to complete the questionnaires due to hearing or visual impairments;
- Those with other organic diseases of the central nervous system, such as brain tumors, epilepsy, or Parkinson's disease;
- Those diagnosed with severe mental disorders, such as schizophrenia, depression, or anxiety disorders.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Adaptive Computerized Cognitive TrainingParticipants receive adaptive computerized cognitive training delivered through the Heling Brain Planet WeChat mini- program. The intervention consists of individualized cognitive exercises targeting multiple cognitive domains, including attention, memory, executive function, language, visuospatial ability, perceptual-motor function, and social cognition. The training difficulty is automatically adjusted according to each participant's performance to provide personalized cognitive stimulation. During the initial intervention phase, all participants complete 30-minute training sessions three times per week for 3 months. After the initial intervention, participants choose to continue training receive maintenance adaptive computerized cognitive training. | Behavioural | High-Frequency Maintenance Training |
| Adaptive Computerized Cognitive TrainingParticipants receive adaptive computerized cognitive training delivered through the Heling Brain Planet WeChat mini- program. The intervention consists of individualized cognitive exercises targeting multiple cognitive domains, including attention, memory, executive function, language, visuospatial ability, perceptual-motor function, and social cognition. The training difficulty is automatically adjusted according to each participant's performance to provide personalized cognitive stimulation. During the initial intervention phase, all participants complete 30-minute training sessions three times per week for 3 months. After the initial intervention, participants not to continue discontinue the intervention and undergo follow-up assessments only. | Behavioural | Training Discontinuation Group |
Primary outcome
Change in global cognitive function assessed by the Montreal Cognitive Assessment (MoCA)
Time frame: Baseline, Month 3, Month 4, and Month 6
6 secondary outcomes
Change in cognitive function assessed by the Mini-Mental State Examination (MMSE)
Time frame: Baseline, Month 3, Month 4, and Month 6
Change in language function assessed by the Boston Naming Test (BNT)
Time frame: Baseline, Month 3, Month 4, and Month 6
Change in attention assessed by the Trail Making Test Part A (TMT-A)
Time frame: Baseline, Month 3, Month 4, and Month 6
Change in executive function assessed by the Stroop Color-Word Test
Time frame: Baseline, Month 3, Month 4, and Month 6
Change in visuospatial function assessed by the Clock Drawing Test (CDT)
Time frame: Baseline, Month 3, Month 4, and Month 6
Change in activities of daily living assessed by the Activities of Daily Living (ADL) scale
Time frame: Baseline, Month 3, Month 4, and Month 6
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 7 Aug 2026.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Adaptive Computerized Cognitive Training in people with Cognitive Dysfunction, Cognitive Disorder and Cognitive Training, run by China Medical University, China at 1 site in China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 7 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in China. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Ziyi Zhang (+8613314010321, zhangziyi202058@163.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in global cognitive function assessed by the Montreal Cognitive Assessment (MoCA) (time frame: Baseline, Month 3, Month 4, and Month 6). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 7 Aug 2026.