Clinical trials: Neurological Manifestations
Leber Congenital Amaurosis 10, Blindness
Study to Evaluate Sepofarsen in Subjects With Leber Congenital Amaurosis (LCA) Type 10 (HYPERION)
The purpose of this double-masked, randomized, placebo-controlled, paired-eye study is to evaluate the efficacy, safety and tolerability of Sepofarsen in subjects with Leber Congenital Amaurosis (LCA) due to the c.2991+1655A>G…
- Conditions
- Leber Congenital Amaurosis 10, Blindness, Leber Congenital Amaurosis, Sensation Disorders
- Trial name
- HYPERION (NCT06891443)
- Testing
- sepofarsen
- Where
- 18 sites in United States, Australia and 8 more
- Volunteers
- 32 people
- Sponsor
- Laboratoires Thea
Spinal Fusion, Hyperglycemia
Trans-Auricular Stimulation for Postoperative Inflammation in Spine Surgery
This study is a randomized controlled trial that will evaluate the effect of non-invasive auricular vagal nerve stimulation on inflammatory markers, glycemic control, postoperative pain, and inflammation-related clinical outcomes…
- Conditions
- Spinal Fusion, Hyperglycemia, Postoperative Pain Management, Postoperative Care
- Trial name
- TAPIS (NCT07218133)
- Testing
- Auricular vagus nerve stimulation
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Alexander T. Yahanda
Neurological Conditions
Neurosciences Research Repository
In order to expand neuroscience research and move laboratory advances to patients, there is a need to integrate reliable clinical data with biologic information from patient tissue specimens.
- Trial name
- NRR (NCT00857922)
- Testing
- tissue and data repository
- Where
- United States
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Covid19, Neurological Manifestations
Study of Morphological, Spectral and Metabolic Manifestations of Neurological Complications in Covid-19 Patients
Viral pandemics, such as HIV and SARS-Cov-V1, have shown that they can lead to acute and / or delayed neurological complications.
- Conditions
- Covid19, Neurological Manifestations, Brain Damage
- Trial name
- NSpectroCovid (NCT04546737)
- Testing
- Magnetic Resonance Spectroscopy (MRS).
- Where
- France
- Volunteers
- 21 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Metabolic Disease, Neurological and Mental Health Conditions
Singapore PREconception Study of Long-Term Maternal and Child Outcomes
We aim to test the following primary hypothesis that nutrition, lifestyle, and maternal emotional health prior to pregnancy and/or during the first trimester alter the expression of metabolic or neurodevelopmental endophenotypes…
- Conditions
- Metabolic Disease, Neurological and Mental Health Conditions, Genetics Predisposition, Skin Condition
- Trial name
- S-PRESTO (NCT03531658)
- Where
- Singapore
- Volunteers
- 1,054 people, healthy volunteers welcome
- Sponsor
- KK Women's and Children's Hospital
Primary Body Region (Arranged Most Common to Least), Lumbar/SI
ATI Evidence-based Guide Investigating Clinical Services
The goal of this study is to evaluate how standard-of-care outpatient rehabilitation is delivered and how variation in care delivery mechanisms relates to clinical outcomes, service utilization, and value in patients receiving…
- Conditions
- Primary Body Region (Arranged Most Common to Least), Lumbar/SI, Knee, Shoulder
- Trial name
- AEGIS (NCT02285868)
- Where
- United States
- Volunteers
- 4,000,000 people, healthy volunteers welcome
- Sponsor
- ATI Holdings, LLC
Neurological and Mental Health Conditions, Genetic Susceptibility
Mapping Antenatal Maternal Stress
This study recruits women from early-mid pregnancy and later follows their children after birth, tracking both the mother and child until the child reaches at least 4 years of age.
- Conditions
- Neurological and Mental Health Conditions, Genetic Susceptibility, Socioeconomic Factors, Psychology, Social
- Trial name
- MAMS (NCT07432217)
- Where
- Singapore
- Volunteers
- 1,419 people, healthy volunteers welcome
- Sponsor
- Institute for Human Development and Potential (IHDP), Singapore
Neurological and Mental Health Conditions, Genetic Susceptibility
Mapping Antenatal Maternal Stress - Child Outcomes
This study is a sub-study of Mapping Antenatal Maternal Stress (MAMS). Women previously enrolled in MAMS, their children and their partners/spouses were recruited for a set of more comprehensive assessments to characterise early…
- Conditions
- Neurological and Mental Health Conditions, Genetic Susceptibility, Socioeconomic Factors, Psychology, Social
- Trial name
- MAMS-CO (NCT07432243)
- Where
- Singapore
- Volunteers
- 587 people, healthy volunteers welcome
- Sponsor
- Institute for Human Development and Potential (IHDP), Singapore
Metabolic Diseases, Neurological and Mental Health Conditions
Growing Up in Singapore Towards Healthy Outcomes
This study aims to examine the role of genetic and epigenetic factors, maternal nutrition, lifestyle, emotional health, and other environmental factors in pregnancy or postpartum period that can influence future maternal risk of…
- Conditions
- Metabolic Diseases, Neurological and Mental Health Conditions, Genetic Predisposition, Skin Condition
- Trial name
- GUSTO (NCT01174875)
- Where
- Singapore
- Volunteers
- 1,247 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Functional Abdominal Pain Disorders, Irritable Bowel Syndrome (IBS)
Efficacy of Guided Imagery Therapy Mobile Application for Functional Abdominal Pain
Chronic abdominal pain is common among children, and the majority of cases are attributed to functional abdominal pain disorders. One approach to treating these disorders is by using psychological therapies.
- Conditions
- Functional Abdominal Pain Disorders, Irritable Bowel Syndrome (IBS), Functional Gastrointestinal Disorders, Functional Colonic Disease
- Trial name
- NCT06653647
- Testing
- Guided Imagery Therapy
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Baylor College of Medicine
Thrombotic Thrombocytopenic Purpura (TTP), Immune Thrombotic Thrombocytopenic Purpura
Retrospective Epidemiological Study of Patients in the National Cohort of the French TMA Center
Immune thrombotic thrombocytopenic purpura (iTTP) is a rare, life-threatening disorder characterized by microangiopathic hemolytic anemia, severe thrombocytopenia, and ischemic organ damage due to microvascular thrombosis.
- Conditions
- Thrombotic Thrombocytopenic Purpura (TTP), Immune Thrombotic Thrombocytopenic Purpura, Thrombotic Microangiopathies, Microangiopathy, Thromboic
- Trial name
- TWILIGHT (NCT07205861)
- Where
- France
- Volunteers
- 1,200 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Brain (Nervous System) Cancers, Brain Arterial Disease
A Vision-Language Foundation Model for Brain Disease Diagnosis From Multimodal Data
The goal of this observational study is to develop an innovative, comprehensive, and explainable AI vision-language foundation model (VLM) to advance the diagnosis and interpretation of brain diseases using multi-modal data.
- Conditions
- Brain (Nervous System) Cancers, Brain Arterial Disease, Neuro-Degenerative Disease, Brain Tumors
- Trial name
- NCT07126821
- Testing
- No Interventions
- Where
- China
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- Xiangya Hospital of Central South University
Post-operative Functional Decline, Severe Neurological Impairment
Post-operative Changes Study
The goal of this observational pilot study is to evaluate the feasibility and acceptability of the protocol to explore the functional post-operative trajectory in a developmentally and neurologically impaired pediatric…
- Trial name
- NCT07121660
- Where
- Canada
- Volunteers
- 17 people
- Sponsor
- University of British Columbia
Cardiac Arrest, Neurologic Symptoms
Early and Objective Assessment of Neurological Prognosis in Cardiac Arrest Patients
Cerebral lesions are responsible for two thirds of deaths in patients admitted to intensive care following cardiac arrest. Patients with neurological lesions should be the priority target for neuroprotective interventions, which…
- Conditions
- Cardiac Arrest, Neurologic Symptoms, Intensive Care Neurological Disorder
- Trial name
- HYPERION-2 (NCT06387225)
- Where
- 4 sites in France
- Volunteers
- 608 people
- Sponsor
- Nantes University Hospital
Cerebral Palsy, Brain Injury
Validation of a 3D Instrumented Serious Game to Evaluate Upper Limb Impairments in Children With Neuromotor Disorders
The goal of this clinical trial is to validate an instrumented 3D serious game to assess upper limb impairments in children with neuromotor disorders.
- Conditions
- Cerebral Palsy, Brain Injury, Neurological; Disorder, Nervous System
- Trial name
- Play2BEAPI (NCT06774456)
- Testing
- instrumented 3D serious game (BE API 3.0)
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Neurological Impairments
Nutritional Management of Neurologically Impaired Children Across China
A retrospective study to (1) investigate clinical characteristics, nutritional status, and nutritional management in neurologically impaired children in China, (2) assess whether enteral nutrition (particularly tube feeding)…
- Trial name
- NCT06612736
- Where
- China
- Volunteers
- 586 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Diagnostic Technics, Neurological
Measuring Fluid Flow in the Brain Using Alcohol and MRI in Healthy Participants
Intracranial interstitial fluid (ISF) flow is crucial for adequate clearance of extracellular waste products from the brain parenchyma.
- Trial name
- NCT04608292
- Testing
- Single-voxel MRS, Multi-voxel MRSI, Magnetization Transfer Imaging
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Sickle Cell Disease, Stroke
The Afolabi Stroke Registry for Children and Young Adults With SCD in Northern Nigeria
Sickle Cell Anemia (SCA) occurs in 300,000 newborns per year in the world, with 150,000 affected births in Nigeria, alone. With improvement in survival for children with SCA in both high- and low-resource countries, neurological…
- Conditions
- Sickle Cell Disease, Stroke, Neurologic Manifestations, Neurological Morbidity
- Trial name
- NCT04800809
- Testing
- This study does not entail offering any intervention; all data collected will be based on standard of care.
- Where
- 3 sites in United States, Nigeria
- Volunteers
- 350 people
- Sponsor
- Vanderbilt University Medical Center
Estimate, With the Contribution of Optimized MRI, the Prevalence of Neurological and Neurovascular Manifestations on Imaging in the Event of SARS-CoV-2
Imaging SARS-CoV-2 Involvement of Leptomeninges, Olfactory and Limbic Areas
When patients arrive in the waiting room of the MRI department, patients will be given the briefing note explaining the purpose of the study and how it is going.
- Trial name
- ICILOLA (NCT04448054)
- Testing
- MRI
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Carotid Stenosis, Postoperative Cognitive Dysfunction
Neurocognitive Function After Carotid Thrombendarterectomy
Previous studies did not reach a consensus on the influence of the type of anesthesiologic procedure and monitoring, during carotid thrombendarterectomy, on perioperative complications and cognitive outcomes.
- Conditions
- Carotid Stenosis, Postoperative Cognitive Dysfunction, Neurological Impairment
- Trial name
- NCT05739357
- Testing
- NIRS, EEG
- Where
- Croatia
- Volunteers
- 60 people
- Sponsor
- Clinical Hospital Centre Zagreb