Neurological and Mental Health ConditionsMAMS-CONCT07432243
Mapping Antenatal Maternal Stress - Child Outcomes
An observational study of Neurological and Mental Health Conditions and Genetic Susceptibility, run by Institute for Human Development and Potential (IHDP), Singapore at 1 site in Singapore.
Trial summary
This study is a sub-study of Mapping Antenatal Maternal Stress (MAMS). Women previously enrolled in MAMS, their children and their partners/spouses were recruited for a set of more comprehensive assessments to characterise early neurodevelopmental outcomes in children, their associations with antenatal and postnatal… Read more about this study
- Who is it for?
- Ages 21 to 75 yearsHealthy volunteers can take part
- Conditions the study is for
- Neurological and Mental Health Conditions, Genetic Susceptibility, Socioeconomic Factors
- How many people
- 587 participants
- Where
- 1 siteSingapore
- Study dates
- 22 Sep 2021to Jun 2031
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 21 to 75 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Study population: Singapore residents
Who may be able to join
- Mother:
- Enrolled in MAMS study
- Intends for herself and her child to stay in Singapore for the next 5 years
- Access to a smartphone or standard laptop/ desktop
- Willing to take part in this study and able to provide written consent
- Aged 21-42 years
Show all 9Show fewer
- Father:
- Partner is already enrolled in MAMS study
- Aged 21-75 years
Who cannot join
- Mother:
- Women with pre-existing or a history of psychotic depression, schizophrenia and bipolar disorders
- Women currently on oral/IV steroids and/or thyroids medication
- Women with a history of thyroid disease
- Women currently involved in on-going interventional randomized controlled trials
Trial locations and contacts
1 site in 1 country.
Singapore1 site
Institute for Human Development and Potential
Singapore, 117609
About this study
Official title: Mapping Antenatal Maternal Stress - Child Outcomes (MAMS-CO)
This study is a sub-study of Mapping Antenatal Maternal Stress (MAMS). Women previously enrolled in MAMS, their children and their partners/spouses were recruited for a set of more comprehensive assessments to characterise early neurodevelopmental outcomes in children, their associations with antenatal and postnatal maternal emotional health, and how paternal genetics, mental health and parenting styles and perceptions may influence this relationship.
Read the detailed description
There is considerable evidence that maternal symptoms of depression and anxiety are associated, independent of birth outcomes, with detrimental outcomes in offspring, including cognitive, emotional and social development, as well as increased risk for psychopathology. Prior neuroimaging evidence has revealed effects of prenatal maternal symptoms of depression or anxiety on offspring brain structure and connectivity. In particular, individual differences in the volume and structure of limbic regions (i.e., hippocampus and amygdala) as well as prefrontal cortical regions implicated in psychopathology are associated with the quality of pre- and post-natal maternal mental health. The more recent studies reveal effects on critical connections between cortical and limbic regions, such as those from the amygdala to the insular cortex. There is also increasing evidence that the effects of maternal antenatal mood are of equal or greater importance in predicting child outcomes than maternal symptoms in the postnatal period.
In addition, whilst literature on paternal involvement has largely reflected a positive impact on child outcomes, these studies were done in western populations and may not be generalised in the context of local population, given the differences in ethnic and cultural backgrounds.
As such, the current study builds on the MAMS study's focus on maternal mental health and wellbeing, by undertaking more comprehensive assessments related to child outcomes and parent-child interactions, including paternal factors. The polygenic risk score (PRS) framework used in MAMS can be extended to fathers and children to investigate inter-individual variations in response to adversity.
Data will be collected through questionnaires done online, measurements, and assessments done during lab-based visits.
- Collection of samples such as buccal swabs and saliva
- Sleep actigraphy measures on infants
- Body measurements such as height, weight, and blood pressure
- Child developmental and behavioral assessments, including cognitive and language assessments
- Cognitive, socio-emotional and parenting tasks for mothers
- Mother-child interaction tasks
- Mother and infant EEG measurements
- Child eye-tracking tasks
- MRI measurements from the infant at postnatal 1 and 6 months
- Questionnaires related to depression, anxiety, psychosocial risk factors such as life stressors, social and partner support, socioeconomic factors, medical history, behavior, cognition, lifestyle, health status, parental bonding, childhood adversity experienced, socio-emotional factors, executive function, family dynamics, sleep quality, personality traits
- Conditions
- Neurological and Mental Health Conditions, Genetic Susceptibility, Socioeconomic Factors, Psychology, Social
- Keywords
- Neurodevelopment, Genetics, Mental Health
- Medical subject headings
- Neurologic Manifestations, Genetic Predisposition to Disease, Psychological Well-Being
What is being measured
The primary outcome is the main question the study is designed to answer.
Determine specific contribution of maternal prenatal mood factor components to specific child developmental outcomes
Analyses of maternal prenatal mood factors (e.g: maternal positive health, anxiety, depressive symptoms etc) to determine which components contribute to specific neurocognitive, socio-emotional and developmental outcomes in children
Measured: From pregnancy to postnatal 6 years
Functional and structural neuroimaging during infancy and early childhood
To examine functional dynamics and structural patterns of the brain anatomy and connectivity and its relation to child neurocognitive outcomes
Measured: From birth to postnatal 6 years
Contextual variables that moderate association between parental mental health and child outcomes
To assess perinatal parental mental health in relation to child developmental outcomes using standardized clinical measures that have predictive validity for cognitive, emotional and social outcomes in young children, including SES, family cohesion, parental attitudes and genetics
Measured: From pregnancy to postnatal 6 years
Influence of paternal factors on relationship between maternal mental mood and child outcomes
To examine examine paternal factors such as genetics, emotional health and parenting perceptions as modulators and mediators of maternal mental mood on child's socio-emotional, cognitive and developmental outcomes
Measured: From pregnancy to postnatal 6 years
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted25 Feb 2026
- Study start22 Sep 2021
- Primary completionJun 2031 (estimated)
- Study completionJun 2031 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Neurological and Mental Health ConditionsStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 587 participants (actual)
Sponsor and investigators
- Lead sponsor
- Institute for Human Development and Potential (IHDP), Singapore
- Sponsor type
- University, hospital or other
- Collaborators
- McGill University, KK Women's and Children's Hospital, National University Hospital, Singapore
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07432243
- Sponsor's protocol ID
- 2021/00189
- Acronym
- MAMS-CO
- Status last verified
- Jan 2026
- First submitted
- 12 Feb 2026
- Last updated
- 25 Feb 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 25 Feb 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Mapping Antenatal Maternal Stress - Child Outcomes (MAMS-CO)
- ClinicalTrials.gov ID
- NCT07432243
- Acronym / sponsor ID
- MAMS-CO / 2021/00189
- Conditions
- Neurological and Mental Health Conditions, Genetic Susceptibility, Socioeconomic Factors, Psychology, Social
- Keywords
- Neurodevelopment, Genetics, Mental Health
- Study type
- Observational
- Recruitment status
- Active, not recruiting
- Enrolment
- 587 participants (actual)
- Lead sponsor
- Institute for Human Development and Potential (IHDP), SingaporeUniversity, hospital or other
- Collaborators
- McGill University, KK Women's and Children's Hospital, National University Hospital, Singapore
- Study start
- 22 Sep 2021 (actual)
- Primary completion
- Jun 2031 (estimated)
- Study completion
- Jun 2031 (estimated)
- First posted
- 25 Feb 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study is a sub-study of Mapping Antenatal Maternal Stress (MAMS). Women previously enrolled in MAMS, their children and their partners/spouses were recruited for a set of more comprehensive assessments to characterise early neurodevelopmental outcomes in children, their associations with antenatal and postnatal maternal emotional health, and how paternal genetics, mental health and parenting styles and perceptions may influence this relationship.
Detailed description
There is considerable evidence that maternal symptoms of depression and anxiety are associated, independent of birth outcomes, with detrimental outcomes in offspring, including cognitive, emotional and social development, as well as increased risk for psychopathology. Prior neuroimaging evidence has revealed effects of prenatal maternal symptoms of depression or anxiety on offspring brain structure and connectivity. In particular, individual differences in the volume and structure of limbic regions (i.e., hippocampus and amygdala) as well as prefrontal cortical regions implicated in psychopathology are associated with the quality of pre- and post-natal maternal mental health. The more recent studies reveal effects on critical connections between cortical and limbic regions, such as those from the amygdala to the insular cortex. There is also increasing evidence that the effects of maternal antenatal mood are of equal or greater importance in predicting child outcomes than maternal symptoms in the postnatal period.
In addition, whilst literature on paternal involvement has largely reflected a positive impact on child outcomes, these studies were done in western populations and may not be generalised in the context of local population, given the differences in ethnic and cultural backgrounds.
As such, the current study builds on the MAMS study's focus on maternal mental health and wellbeing, by undertaking more comprehensive assessments related to child outcomes and parent-child interactions, including paternal factors. The polygenic risk score (PRS) framework used in MAMS can be extended to fathers and children to investigate inter-individual variations in response to adversity.
Data will be collected through questionnaires done online, measurements, and assessments done during lab-based visits.
- Collection of samples such as buccal swabs and saliva
- Sleep actigraphy measures on infants
- Body measurements such as height, weight, and blood pressure
- Child developmental and behavioral assessments, including cognitive and language assessments
- Cognitive, socio-emotional and parenting tasks for mothers
- Mother-child interaction tasks
- Mother and infant EEG measurements
- Child eye-tracking tasks
- MRI measurements from the infant at postnatal 1 and 6 months
- Questionnaires related to depression, anxiety, psychosocial risk factors such as life stressors, social and partner support, socioeconomic factors, medical history, behavior, cognition, lifestyle, health status, parental bonding, childhood adversity experienced, socio-emotional factors, executive function, family dynamics, sleep quality, personality traits
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
Who may qualify
- Ages
- 21 to 75 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
- Study population
- Singapore residents
Key inclusion criteria (9 listed)
- Enrolled in MAMS study
- Intends for herself and her child to stay in Singapore for the next 5 years
- Access to a smartphone or standard laptop/ desktop
- Willing to take part in this study and able to provide written consent
- Aged 21-42 years
Key exclusion criteria (5 listed)
- Women with pre-existing or a history of psychotic depression, schizophrenia and bipolar disorders
- Women currently on oral/IV steroids and/or thyroids medication
- Women with a history of thyroid disease
- Women currently involved in on-going interventional randomized controlled trials
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Determine specific contribution of maternal prenatal mood factor components to specific child developmental outcomes
Time frame: From pregnancy to postnatal 6 years
Analyses of maternal prenatal mood factors (e.g: maternal positive health, anxiety, depressive symptoms etc) to determine which components contribute to specific neurocognitive, socio-emotional and developmental outcomes in children
Functional and structural neuroimaging during infancy and early childhood
Time frame: From birth to postnatal 6 years
To examine functional dynamics and structural patterns of the brain anatomy and connectivity and its relation to child neurocognitive outcomes
Contextual variables that moderate association between parental mental health and child outcomes
Time frame: From pregnancy to postnatal 6 years
To assess perinatal parental mental health in relation to child developmental outcomes using standardized clinical measures that have predictive validity for cognitive, emotional and social outcomes in young children, including SES, family cohesion, parental attitudes and genetics
Influence of paternal factors on relationship between maternal mental mood and child outcomes
Time frame: From pregnancy to postnatal 6 years
To examine examine paternal factors such as genetics, emotional health and parenting perceptions as modulators and mediators of maternal mental mood on child's socio-emotional, cognitive and developmental outcomes
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 25 Feb 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Neurological and Mental Health Conditions and Genetic Susceptibility, run by Institute for Human Development and Potential (IHDP), Singapore at 1 site in Singapore.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 9 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 25 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Singapore. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Determine specific contribution of maternal prenatal mood factor components to specific child developmental outcomes (time frame: From pregnancy to postnatal 6 years). The study lists 4 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 25 Feb 2026.