Clinical trials: Morality
Moral Injury
A Novel Posttraumatic Stress Disorder Treatment for Veterans With Moral Injury
The objective of this project is to test the efficacy of an individual treatment for post-traumatic stress disorder (PTSD) stemming from moral injury called Impact of Killing (IOK), compared to a present-centered therapy (PCT)…
- Trial name
- IOK (NCT03764033)
- Testing
- Impact of Killing (IOK), Present Centered Therapy
- Where
- 3 sites in United States
- Volunteers
- 100 people
- Sponsor
- VA Office of Research and Development
Testosterone, Placebos
A Multinomial Process Model of Moral Judgment
The main goal of this project to investigate the psychological processes underlying moral judgments in social dilemmas. We will examine neuroendocrine determinants of moral judgment by investigating the effects of exogenous…
- Trial name
- PSY (NCT02799277)
- Testing
- Testosterone
- Where
- United States
- Volunteers
- 206 people
- Sponsor
- Robert Josephs
Healthy
National Survey to Understand Ethical, Legal and Social Issues in Communicating to the Public About Epigenetics
Few people realize that environmental pollution and some behaviors like physical activity and tobacco smoking can affect their health by "turning on" or "turning off" certain genes through a process called "epigenetic…
- Trial name
- NCT07020234
- Testing
- Epigenetics Video, Nanotechnology Video
- Where
- United States
- Volunteers
- 2,040 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Posttraumatic Stress Disorder, Moral Injury
Pilot Study Testing a Web-Based Moral Elevation Intervention for Veterans With PTSD and Moral Injury
Given the prevalence of posttraumatic stress disorder (PTSD) and moral injury in combat Veterans and the limitations to current treatments, novel approaches are needed to target both PTSD and moral injury and directly impact…
- Trial name
- NCT03906240
- Testing
- Moral Elevation intervention
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- VA Office of Research and Development
COVID-19, Vaccinations
COVID-19 Testing and Vaccination Among Spanish Speakers
Latinx communities are disproportionately affected by the COVID-19 pandemic, with Spanish-speaking Latinx communities carrying even heavier burdens of infection, hospitalization, and mortality.
- Trial name
- NCT05302908
- Testing
- NuestraSaludSegura
- Where
- United States
- Volunteers
- 274 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Emergencies
Video Images About Decisions for Ethical Outcomes in the Emergency Department (VIDEO-ED)
A randomized controlled trial of a video decision aid in the Emergency Department Setting to improve advance care planning documentation.
- Trial name
- VIDEO-ED (NCT04931797)
- Testing
- video decision aid, control arm ACP information sheet
- Where
- 4 sites in United States
- Volunteers
- 598 people
- Sponsor
- Massachusetts General Hospital
Resistance Bacterial, Morality
Azithromycin for Child Survival in Niger: Programmatic Trial (AVENIR)
The MORDOR trial found that biannual distribution of azithromycin to children 1-59 months old reduced child mortality. The World Health Organization (WHO) released conditional guidelines for this intervention, which include…
- Conditions
- Resistance Bacterial, Morality, Child Health, Implementation
- Trial name
- AVENIR (NCT05288023)
- Testing
- Azithromycin for Oral Suspension
- Where
- United States
- Volunteers
- 169,707 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Encephalopathy, Birth Defect
Clinical Utility of Pediatric Whole Exome Sequencing
The investigator aims to examine the clinical utility of WES, including assessment of a variety of clinical outcomes in undiagnosed pediatric cases.
- Conditions
- Encephalopathy, Birth Defect, Intellectual Disability, Multiple Congenital Anomaly
- Trial name
- NCT03525431
- Testing
- Whole Exome Sequencing
- Where
- 4 sites in United States
- Volunteers
- 529 people
- Sponsor
- University of California, San Francisco
Long QT Syndrome
KCNQ1 Cascade Screening
The objectives of the protocol are to: (1) evaluate the uptake of cascade screening and preventative therapies after the implementation of a simplified screening process and (2) assess proband and family member perspectives about…
- Trial name
- NCT03783975
- Testing
- Simplified Cascade Screening
- Where
- United States
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Moral Injury
Thriving in the Midst of Moral Pain: The Acceptability and Feasibility of Acceptance and Commitment Therapy for Moral Injury (ACT-MI) Among Warzone Veterans
The need for moral injury interventions is increasingly being recognized as a domain in Veteran care that must be addressed. Consequences of exposure to morally injurious events include risk for suicide, substance abuse, and…
- Trial name
- NCT03760731
- Testing
- Acceptance and Commitment Therapy for Moral Injury (ACT-MI), Present Centered Therapy for Moral Injury (PCT-MI)
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- VA Office of Research and Development
Cataract
EYEFILL® C. -US Viscoelastic Clinical Investigation
The purpose of this multicenter, prospective, randomized clinical study is to determine the safety and effectiveness of the EYEFILL® C.-US Viscoelastic in patients undergoing cataract extraction and intraocular lens (IOL)…
- Trial name
- NCT02024711
- Testing
- EYEFILL® C.-US Viscoelastic, Healon® Viscoelastic (CONTROL)
- Where
- 8 sites in United States
- Volunteers
- 262 people
- Sponsor
- Bausch Health Americas, Inc.
Post-traumatic Stress Disorder, Moral Injury
Psychosocial Rehabilitation After Moral Injury and Loss With Adaptive Disclosure
The aim of this study was to determine the efficacy of Adaptive Disclosure for Moral Injury and Loss (AD-MIL), a combat-specific psychotherapy for war-related PTSD stemming from Moral Injury (MI) and traumatic loss (TL) with Iraq…
- Conditions
- Post-traumatic Stress Disorder, Moral Injury, Traumatic Loss
- Trial name
- NCT03056157
- Testing
- Adaptive Disclosure for Moral Injury and Loss, Present Centered Therapy
- Where
- 5 sites in United States
- Volunteers
- 174 people
- Sponsor
- VA Office of Research and Development
Polypharmacy, Surgical Procedure, Operative
Polypharmacy and Outcomes After Elective Noncardiac Surgery
This study investigates the association of preoperative polypharmacy with outcomes and healthcare resource utilization in a population-based sample of older patients enrolled in a universal pharmacare program
- Conditions
- Polypharmacy, Surgical Procedure, Operative, Morality, Epidemiology
- Trial name
- NCT03133182
- Testing
- Polypharmacy
- Volunteers
- 266,499 people
- Sponsor
- Ottawa Hospital Research Institute
Burnout, Caregiver, Burnout, Professional
Frontline Clinician Psilocybin Study
This study aims to investigate the effects of a single dose of psilocybin, delivered in the contextof pre- and post-dose psychotherapy, on symptoms of depression and burnout suffered by healthcare clinicians as a result of…
- Conditions
- Burnout, Caregiver, Burnout, Professional, COVID-19, Depression
- Trial name
- NCT05163496
- Testing
- Psilocybin (Usona Institute)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Washington
Social Exclusion, Prejudice, Racial
Developing Inclusive Youth: Promoting Intergroup Friendships and Inclusive Classrooms in Childhood
The goal of this clinical trial is to test the beneficial impacts of a web based intervention program called Developing Inclusive Youth for children in 3rd, 4th, and 5th grade.
- Conditions
- Social Exclusion, Prejudice, Racial, Prejudice, Sexism
- Trial name
- DIY (NCT05619523)
- Testing
- Developing Inclusive Youth (DIY)
- Where
- United States
- Volunteers
- 885 people, healthy volunteers welcome
- Sponsor
- University of Maryland, College Park
Substance Use Disorder, Post-traumatic Stress Disorder
Mindful Self Compassion for Combat Deployed Veterans With Moral Injury and Co-occurring PTSD-SUD
Veterans with co-occurring Posttraumatic Stress Disorder and Substance Use Disorder (PTSD-SUD) experience more severe symptomatology and poorer response to existing treatments than Veterans with either disorder alone.
- Conditions
- Substance Use Disorder, Post-traumatic Stress Disorder, Moral Injury
- Trial name
- NCT03681288
- Testing
- Mindful Self-Compassion
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- VA Office of Research and Development
Antisocial Personality Disorder, Substance Use Disorder
Justice-Involved Veterans and Moral Reconation Therapy
The purpose of this study is to determine whether Moral Reconation Therapy (MRT) is effective for reducing risk of criminal recidivism and improving other health-related outcomes (substance use, mental health, housing, and…
- Trial name
- MRT (NCT02524171)
- Testing
- Moral Reconation Therapy (MRT)
- Where
- 3 sites in United States
- Volunteers
- 344 people
- Sponsor
- VA Office of Research and Development