Clinical trials: Knee Arthropathy
Osteoarthritis, Postoperative Pain
Acute Pain Genomic Study
In preparation for future large-scale genome wide association studies, reliable methods must be developed for measuring perceived pain and for estimating the effects of potentially confounding factors such as appropriate…
- Trial name
- NCT01557751
- Testing
- Whole blood for genotyping
- Where
- United States
- Volunteers
- 156 people
- Sponsor
- University of Pittsburgh
Osteoarthritis, Knee
Vanguard TKA With KneeAlign 2 and Without KneeAlign 2
Purpose of this study is to determine the effectiveness of the KneeAlign 2 system in terms of precise implant alignment by demonstrating that KneeAlign 2 provides better tibial alignment compared to conventional instruments
- Trial name
- NCT02695329
- Testing
- KneeAlign 2
- Where
- Japan
- Volunteers
- 100 people
- Sponsor
- Zimmer Biomet
Osteoarthritis of the Knee
A Study of Duloxetine (LY248686) in Participants With Chronic Osteoarthritis and Knee Pain in Japan
The main purpose of this study is to evaluate the efficacy of the study drug known as duloxetine in participants with chronic osteoarthritis (OA) and knee pain in Japan.
- Trial name
- NCT02248480
- Testing
- Duloxetine
- Where
- Japan
- Volunteers
- 354 people
- Sponsor
- Eli Lilly and Company
Osteoarthritis Of Knee
Geniculate Artery Embolization for the Treatment of Knee Pain
This study is to test a new treatment method, geniculate artery embolization (GAE), to reduce the severity of pain and disability caused by knee osteoarthritis.
- Trial name
- GAE (NCT02850068)
- Testing
- Geniculate Artery Embolization
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- University of North Carolina, Chapel Hill
Osteoarthritis
Randomized Controlled Trial of Tranexamic Acid in Total Knee Arthroplasty: Intravenous vs. Topical
The purpose of this study is to determine whether topical or intravenous administration of tranexamic acid during unilateral total knee replacement is more effective at reducing bleeding in the first 24 hours following surgery.
- Trial name
- NCT01940523
- Testing
- Topical Tranexamic Acid, Intravenous Tranexamic Acid
- Where
- 2 sites in United States
- Volunteers
- 640 people
- Sponsor
- Hospital for Special Surgery, New York
Total Knee Arthroplasty, Osteoarthritis
Optimizing Physical Activity Outcomes After Total Knee Arthroplasty
Although total knee arthroplasty is an effective intervention for decreasing knee pain and improving physical function, physical activity levels remain low up to a year after surgery.
- Trial name
- NCT03226106
- Testing
- Physical Activity Behavior Intervention, Attention Control
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- VA Office of Research and Development
Knee Pain After Total Knee Arthroplasty, Osteoarthritis Pain
Open-label Milnacipran for Persistent Knee Pain One Year After Total Knee Arthroplasty (TKA)
The current study examines the effects of milnacipran in patients who have chronic persistent knee pain one year or longer after total knee arthroplasty (TKA) to evaluate for a pain-relieving effect.
- Trial name
- NCT01780389
- Testing
- Open-label flexibly dosed milnacipran
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Duke University
Knee Osteoarthritis
The Effect of Osteopathic Manual Therapy on Vascular Supply
The purpose of this study is to determine if the use of osteopathic manual therapy can influence the vascular supply to the knee, knee range of motion, balance and knee pain, in a group of subjects with knee osteoarthritis.
- Trial name
- NCT01020591
- Testing
- Osteopathic evaluation, Osteopathic evaluation with treatment
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Nova Scotia Health Authority
Osteoarthritis
Intra-articular Polyacrylamide Hydrogel in Knee Osteoarthritis
The aim of this double-blinded controlled study is to assess clinical efficacy and safety of intra-articular HBISA Endoprosthesis of Synovial Fluid (polyacrylamide hydrogel) in comparison with placebo (0.9% sodium chloride…
- Trial name
- NCT03897686
- Testing
- hydrous biopolymer with silver ions "Argiform", saline solution
- Where
- 4 sites in Russia
- Volunteers
- 144 people
- Sponsor
- Research Centre BIOFORM
Osteoarthritis, Knee
Calypso Knee System Clinical Study
A clinical study to evaluate the safety and effectiveness of the Calypso Knee System when used in subjects with symptomatic osteoarthritis of the medial compartment of the knee.
- Trial name
- NCT03671213
- Testing
- Calypso Knee System (Implantable Shock Absorber)
- Where
- 5 sites in United States
- Volunteers
- 81 people
- Sponsor
- Moximed
Osteoarthritis
Long-term Observational Study of Subjects From Tanezumab Studies Who Undergo a Total Knee, Hip or Shoulder Replacement
A4091064 is a multicenter, long-term observational study of subjects from tanezumab interventional studies (regardless of treatment group) who undergo a total knee, hip or shoulder replacement during participation in the study.
- Trial name
- NCT02674386
- Testing
- Investigational Medical Product (IMP) administered in parent study
- Where
- 79 sites in United States, Australia and 13 more
- Volunteers
- 154 people
- Sponsor
- Pfizer
Osteoarthritis
Intra-articular Polyacrylamide Hydrogel in Gonarthrosis
The OLE was aimed to assess long-term safety and efficacy of one and two courses of IA HBISA in patients with knee osteoarthritis.
- Trial name
- NCT06429319
- Testing
- Hydrous biopolymer with silver ions "Argiform" (HBISA) endoprosthesis of synovial fluid NOLTREX™
- Where
- 4 sites in Russia
- Volunteers
- 65 people
- Sponsor
- Research Centre BIOFORM
Osteoarthritis of the Knee
A Study to Evaluate Safety of Three Intra-articular Injections of Ampion in the Knee of Adults With Osteoarthritis Pain
Phase 1 will evaluate the safety of 3 intra-articular injections of Ampion™ administered 2 weeks apart to adults with osteoarthritis of the knee.
- Trial name
- NCT02184156
- Testing
- 4 mL injection of Ampion
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Ampio Pharmaceuticals. Inc.
Knee Osteoarthritis
Investigating Racial Differences in Diet Benefits for Knee Osteoarthritis
Knee osteoarthritis (OA) is the most prevalent form of arthritis and race is a risk factor for poor outcomes. African-Americans (AAs) report greater OA-related disability and pain severity compared to their Non-Hispanic White…
- Trial name
- NCT04343716
- Testing
- Low-carbohydrate diet
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Alabama at Birmingham
Osteoarthritis, Knee
An Open-Label Long-term Safety Study of Tramadol HCl OAD (Once A Day) 300 mg in the Treatment of Pain Due to Osteoarthritis of the Knee
The purpose of this study is to collect information regarding the long-term (6 and 12 months) safety of Tramadol HCl Once-A-Day(OAD) 300 mg.
- Trial name
- NCT00833911
- Testing
- Tramadol Once A Day
- Volunteers
- 392 people
- Sponsor
- Labopharm Inc.
Knee Osteoarthritis
Effect of Different Injection Regimens of Autologous Conditioned Plasma for Knee Osteoarthritis
The clinical efficacy of hyaluronic acid or corticosteroid injections has been reported, but effects are short lived. This has led to the development of additional injection options such as autologous derived blood products which…
- Trial name
- NCT03889925
- Testing
- Hyaluronan, Autologous conditioned plasma
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Andrews Research & Education Foundation
Knee Osteoarthritis
A Safety and Efficacy Study of Anti-inflammatory (Canakinumab) and Cartilage Stimulating (LNA043) Drugs Injected Into the Knee Joint of Participants With Knee Osteoarthritis (OA)
The study was established to show safety and efficacy of canakinumab and LNA043 in patients with knee osteoarthritis (OA).
- Trial name
- NCT04814368
- Testing
- canakinumab, LNA043
- Where
- 11 sites in United States, Czechia and 4 more
- Volunteers
- 23 people
- Sponsor
- Novartis Pharmaceuticals
Degenerative Joint Disease
Comparison of A Mobile-Bearing Total Knee System With A Fixed-Bearing Total Knee System In Cemented Total Knee Arthroplasty
Pain, weakness, instability, and progressive dysfunction are the hallmarks of arthritis of the knee. Total knee replacement may frequently be the only therapeutic intervention to provide adequate improvement in pain and function.
- Trial name
- NCT00589108
- Testing
- Sigma Knee System, Sigma Pressfit Condylar Posterior Cruciate Substituting System with a metal back tibial tray, Sigma Pressfit Condylar Posterior Cruciate Substituting System all polyethylene tray
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Mayo Clinic
Knee Osteoarthritis
A Study Evaluating the Safety and Efficacy of SM04690 for the Treatment of Moderately to Severely Symptomatic Knee Osteoarthritis
This phase 2 study is a placebo-controlled, double-blind, parallel group study of four concentrations of SM04690 (0.03, 0.07, 0.15, and 0.23 mg per 2 mL injection) injected intraarticularly (IA) into the target knee joint of…
- Trial name
- NCT03122860
- Testing
- SM04690
- Where
- 74 sites in United States
- Volunteers
- 700 people
- Sponsor
- Biosplice Therapeutics, Inc.
Knee Osteoarthritis
Efficacy of Micro-fragmented Adipose Tissue Injection for Knee Osteoarthritis.
Knee osteoarthritis (OA) causes patients considerable joint pain and leads to instability, reduced range of motion, and functional limitations.
- Trial name
- NCT03379168
- Testing
- Microfragmented Adipose Tissue (Lipogems), Corticosteroid injection, Saline
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Dustin L. Richter, MD