Clinical trials: ICU
Infection in ICU, Sepsis
Early Optimization of Ceftazidime Regimen in Critical Care
Hospital-acquired infections, most of which are caused by Gram-negative bacteria, are common in intensive care units and have a major impact on patient prognosis.
- Conditions
- Infection in ICU, Sepsis, Septic Shock, Pseudomonas Aeruginosa Infection
- Trial name
- FORTOPTIM_1 (NCT07085624)
- Testing
- ceftazidime, plasma ceftazidime dosage
- Where
- 8 sites in France
- Volunteers
- 128 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Post-ICU Patients, PICS
Measuring the Effects of Music-Listening On Distress After Intensive Care
The primary goal of this single-case experimental design study is to investigate the effectiveness of personalised music listening on daily levels of distress after discharge from a critical care ward.
- Trial name
- MELODIC (NCT07762196)
- Testing
- Music intervention
- Where
- United Kingdom
- Volunteers
- 9 people
- Sponsor
- University of Edinburgh
Diaphragm Issues, Mechanical Ventilation Complication
Diaphragm Atrophy and Dysfunction in Mechanical Ventilation
The gold standard of twitch transdiaphragmatic pressure recordings would ultimately clear the fog around the rate of development of Ventilator induced Diaphragm Dysfunction (VIDD) in mechanically ventilated patients over time.
- Conditions
- Diaphragm Issues, Mechanical Ventilation Complication, Respiratory Failure, Intensive Care (ICU) Myopathy
- Trial name
- DAM (NCT05211661)
- Testing
- Respiratory Muscle Testing
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- RWTH Aachen University
Hospitalized Patients, ICU Hospitalization
Virtual Reality in Intensive Care Unit: Patient Satisfaction, Clinical and Functional Outcomes, Feasibility
Background: Virtual reality is recognized as a progressive technology with the potential to enhance the rehabilitation process. Immersive virtual reality-based treatments can improve motor outcomes in physical rehabilitation…
- Conditions
- Hospitalized Patients, ICU Hospitalization, Intensive Care Unit-acquired Weakness
- Trial name
- NCT07089134
- Testing
- reabilitação fisioterapêutica tradicional, fisioterapia utilizando realidade virtual imersiva
- Where
- Brazil
- Volunteers
- 90 people
- Sponsor
- Hospital Sirio-Libanes
Diaphragm Dysfunction, Weaning Invasive Mechanical Ventilation
Diaphragm Hibernation and Its Driving Factors in Mechanically Ventilated ICU Patients
Rationale: Patients with invasive mechanical ventilation (IMV) frequently develop diaphragm dysfunction and experience difficult weaning.
- Conditions
- Diaphragm Dysfunction, Weaning Invasive Mechanical Ventilation, Respiratory Failure, ICU
- Trial name
- DISSECT (NCT07819864)
- Where
- Netherlands
- Volunteers
- 112 people
- Sponsor
- Radboud University Medical Center
ICU Patients
Digital Stimulation and Anxiety and Sleep Quality in Intensive Care Unit Patients
The aim of this study is to examine the effect of digital visual and auditory stimulation on anxiety and sleep quality in patients hospitalized in the intensive care unit (ICU).
- Trial name
- NCT07820839
- Testing
- Digital Visual and Auditory Stimulation
- Volunteers
- 70 people
- Sponsor
- Cumhuriyet University
Fluid Balance of ICU Patients, Fluid Overload
Impact of Rational Control of Fluid Balance in the Intensive Care Unit
Patients admitted in the Intensive Care Unit (ICU) frequently display and excessive fluid balance over a very short period of time.
- Trial name
- IRIHS-REA (NCT02345681)
- Testing
- Furosemide
- Where
- 3 sites in France
- Volunteers
- 171 people
- Sponsor
- Nantes University Hospital
Nutritional Therapy in an ICU, Critically Ill Patients Requiring Mechanical Ventilation
Will the Use of Respiratory Quotient ''RQ'' Improve Treatment Outcomes for Intensive Care Unit (ICU) Patients?
Introduction and assumptions of the research project: Patients treated in intensive care units (ICUs) require comprehensive treatment. Nutrition is an important and integral part of this therapy.
- Trial name
- RQCal (NCT07457554)
- Testing
- RQ guided nutrition, Standard Treatment (Guideline-Based)
- Where
- Poland
- Volunteers
- 236 people
- Sponsor
- Poznan University of Medical Sciences
Critical Illness, Intensive Care (ICU)
PRotEin Provision in Critical IllneSs -2
When patients survive a life-threatening condition in the intensive care unit (ICU), they often face a prolonged recovery process marked by persistent health issues that significantly reduce their quality of life.
- Trial name
- PRECISe-2 (NCT07529522)
- Testing
- enteral nutrition
- Where
- 15 sites in Belgium, Netherlands
- Volunteers
- 1,026 people
- Sponsor
- Ziekenhuis Oost-Limburg
Glucose, Metabolism
Tracing Of Real-time glu13Cose Metabolism in Human Immune Cells - Intensive Care Unit
The purpose of this study is to understand how cells of the immune system use the common sugar glucose during critical illness. Investigators will intravenously infuse a non-radioactive carbon-13 glucose tracer into adult…
- Conditions
- Glucose, Metabolism, Isotope Labeling, Immune System and Related Disorders
- Trial name
- TORCH-ICU (NCT07811180)
- Testing
- 13C6-Glucose
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Vanderbilt University Medical Center
Neuro ICU, Sub Arachnoid Hemorrhage
Comparison of Ultrasound Cerebral Perfusion Imaging With Routine Perfusion CT
The primary goal of neurocritical care is to prevent secondary brain injury, which worsens neurological outcomes. Because clinical monitoring is often insufficient due to the patient's condition and medical treatments, multimodal…
- Conditions
- Neuro ICU, Sub Arachnoid Hemorrhage, Neurological Complication, Cerebral Ischemia
- Trial name
- SCULPT (NCT07324421)
- Testing
- Ultrasound contrast agent (Contrast-enhanced ultrasound)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Resolve Stroke
Feeding, ICU
mNEED: a Multicentre, Cluster-randomized, Controlled Trial
Project Name: Improved Feeding Regimen for Critically Ill Patients (mNEED) Based on Feeding Intolerance Prediction Model Solution version number and version date: Version 5.0; 2024.12.16 Informed consent version number and…
- Trial name
- mNEED (NCT06827275)
- Testing
- Feeding process
- Where
- 2 sites in China
- Volunteers
- 2,250 people
- Sponsor
- The First Hospital of Jilin University
Critically Ill Patients Who Are Not Allowed to Eat Orally But Can Initiate Enteral Nutrition Within 48 Hours of ICU
Association of Biomarkers and Gastric Antral Motility Index With Feeding Intolerance in Critically Ill Patients
When the subjects are admitted to the department, the researchers will monitor potential biomarkers of gastrointestinal injury before administering enteral nutrition (a small amount of blood is drawn, serum is separated by…
- Trial name
- NCT07178626
- Testing
- Not applicable- observational study
- Where
- China
- Volunteers
- 160 people
- Sponsor
- The First Hospital of Jilin University
Hydromorphone, Analgesia
Hydromorphone for ICU-analgesia in Patients With Non-mechanical Ventilation
Hydromorphone has a clear analgesic effect, and has few advantages in respiratory depression and gastrointestinal motility. The study will further explore the continuous pumping-dose of hydromorphone for ICU non-mechanical…
- Conditions
- Hydromorphone, Analgesia, ICU
- Trial name
- NCT04436224
- Testing
- Hydromorphone, Fentanyl, Butorphanol
- Where
- China
- Volunteers
- 530 people
- Sponsor
- Nanfang Hospital, Southern Medical University
ICU Acquired Weakness, Intensive Care Neuropathy
Predictive Validity of the Chelsea Critical Care Physical Assessment Tool (CPAx) for Regaining Autonomy Three Months After ICU Discharge
This single-center observational study aims to explore the relationship between the CPAx score (Chelsea Critical Care Physical Assessment Tool), measured at ICU discharge, and the 6-minute walk test (6MWT) distance performed 3…
- Trial name
- CPAx-Predict (NCT07167121)
- Testing
- CPAx
- Where
- France
- Volunteers
- 29 people
- Sponsor
- Centre Hospitalier Intercommunal Elbeuf-Louviers-Val de Reuil
Acute Respiratory Distress Syndrome (ARDS), Extracorporeal Membrane Oxygenation
Personalized Ventilator Settings for Patients on ECMO
While mechanical ventilation can be used to sustain life in those with lung injury, it, can further worsen lung injury or prevent lung healing resulting in high morbidity and mortality as seen in Acute Respiratory Distress…
- Conditions
- Acute Respiratory Distress Syndrome (ARDS), Extracorporeal Membrane Oxygenation, Respiratory Failure Patients Treated With ECMO, Respiratory Failure, ICU
- Trial name
- PEEPECMO (NCT07673250)
- Testing
- Personalized Positive End-Expiratory Pressure (PEEP)
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- University of California, San Diego
Multivisceral Failure Syndrome, Monovisceral Failure
Measurement of Intestinal Permeability in Intensive Care Patients With Single or Multiple Organ Failure
Multivisceral failure syndrome (MVFS) in humans is associated with a very high risk of mortality, ranging between 30 and 50%. This syndrome is associated with significant systemic inflammation and a high risk of bacteremia, the…
- Conditions
- Multivisceral Failure Syndrome, Monovisceral Failure, Infection in ICU
- Trial name
- BLUE-REA (NCT06845865)
- Testing
- enteric dyed solution
- Where
- France
- Volunteers
- 126 people
- Sponsor
- Direction Centrale du Service de Santé des Armées
Abirritation in the ICU
A Trial of Tegileridine Fumarate Lnjection for Prolonged Mechanical Ventilation Abirritation in the Intensive Care Unit (ICU)
The purpose of this study is to evaluate the efficacy and safety of Tegileridine Fumarate lnjection for prolonged abirritation(48h to 72h) during mechanical ventilation in the ICU.
- Trial name
- NCT07372924
- Testing
- Tegileridine Fumarate lnjection, Remifentanil Hydrochloride for Injection
- Where
- 2 sites in China
- Volunteers
- 121 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Severe Influenza, Intensive Care (ICU)
Early Corticosteroids in Severe Influenza Pneumonia
This is a Phase III, multicentre, randomized, controlled, double-blind, superiority trial aiming to evaluate the efficacy of dexamethasone versus placebo in patients admitted to intensive care or intermediate care with influenza…
- Conditions
- Severe Influenza, Intensive Care (ICU), Reanimation, Infectious Diseases
- Trial name
- ECSIP (NCT07786662)
- Testing
- Dexametasone
- Where
- 48 sites in France
- Volunteers
- 544 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Ultrasound-guided Fluid Management, Volume Responsiveness
Perceptions and Ultrasound Literacy for Sound Volume Management
The aim of this study is to assess the knowledge, attitudes, and practices of ICU physicians in Switzerland regarding the use of ultrasound for fluid management and evaluation of venous congestion.
- Conditions
- Ultrasound-guided Fluid Management, Volume Responsiveness, Venous Congestion Assessment, ICU Physician Practices
- Trial name
- PULSE (NCT07237347)
- Testing
- Quastionnaire
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- University Hospital, Basel, Switzerland