Clinical trials: GI Cancer
Head and Neck Cancer, Breast Cancer
Evaluation of Improved Onboard Patient Imaging
The primary objective of radiation therapy is to deliver a therapeutic dose of radiation precisely to the target while minimizing exposure to healthy surrounding tissues.
- Conditions
- Head and Neck Cancer, Breast Cancer, Upper Gastrointestinal Cancer, Lung Cancer
- Trial name
- NCT06187103
- Testing
- HyperSight Imaging
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Varian, a Siemens Healthineers Company
Cachexia, Weight Loss
The Effects of a 12 Week Home-based Exercise Intervention on Physical Performance in Patients With Cancers of the Gastrointestinal Tract With Pre- Cachexia or Cachexia
The main purpose of this research study is to determine if exercise improve or worsen cachexia.
- Conditions
- Cachexia, Weight Loss, Gastrointestinal Cancer
- Trial name
- NCT04802486
- Testing
- EXCAP©®
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Rochester
Systemic Immune Activation, Cancer Gi
The Effect of Anesthesia on Systemic Inflammatory Immune Index in Major Abdominal Cancer Surgeries
The effects of different anesthesia methods on the immune system are variable. In this study, we investigated the effect of inhalation anesthesia and total intravenous anesthesia on the SII value in major abdominal cancer…
- Conditions
- Systemic Immune Activation, Cancer Gi, Cancer of Endometrium
- Trial name
- NCT04891146
- Testing
- Systemic inflammatory immmune index
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Gastrointestinal Neoplasms
Phase II Study of Everolimus Combined With Octreotide LAR to Treat Advanced GI NET
The underlying hypothesis of the synergistic activity of octreotide and everolimus is based on the combination of a) a direct action of everolimus over mTOR (mammalian target of rapamycin), and b) the inhibitory effect of…
- Trial name
- EVERLAR (NCT01567488)
- Testing
- Everolimus, octreotide LAR
- Where
- Spain
- Volunteers
- 43 people
- Sponsor
- Grupo Espanol de Tumores Neuroendocrinos
Anal Cancer, Colorectal Cancer
Oxaliplatin Plus Irinotecan in Treating Patients With Metastatic Gastrointestinal Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Conditions
- Anal Cancer, Colorectal Cancer, Esophageal Cancer, Extrahepatic Bile Duct Cancer
- Trial name
- NCT00003427
- Testing
- irinotecan hydrochloride, oxaliplatin
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Colon Cancer, Ovarian Cancer
Exercise Intervention Prior to CRS-HIPEC: Feasibility & Impact
Our objective is to initiate an exercise program for patients with advanced GI or Gyn cancer, as prehabilitation prior to surgery.
- Conditions
- Colon Cancer, Ovarian Cancer, GI Cancer, Gynecologic Cancer
- Trial name
- NCT04731441
- Testing
- Home-based Exercise Program Prior to CRS-HIPEC, Exercise Education
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Milton S. Hershey Medical Center
Gastrointestinal Cancer, Sarcopenia
Sarcopenia and Neuromuscular Block in Gastrointestinal Cancer Surgery
This prospective observational study aims to evaluate the effects of sarcopenia on intraoperative neuromuscular block (NMB) in patients undergoing gastrointestinal cancer surgery.
- Conditions
- Gastrointestinal Cancer, Sarcopenia, Neuromuscular Blockade
- Trial name
- NCT07003061
- Testing
- Standard Anesthesia Management
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Gastrointestinal Cancers
DPD Guided 5-FU Precision Treatment in Gastro-intestinal Cancer Patients
Rationale: Fluorouracil (5-FU) are broadly used in chemotherapeutic regimens for the treatment of cancers. Dihydropyrimidine dehydrogenase (DPD) is a major enzyme in the 5-FU metabolism pathway.
- Trial name
- COMBIGaPP (NCT06782022)
- Testing
- 5-Fluoro-Uracil
- Where
- Netherlands
- Volunteers
- 80 people
- Sponsor
- Jan Gerard Maring
Oesophageal Cancer, Gastric Cancer
Modulated Mid-frequency Whole-body Electromyostimulation and Nutritional Therapy in Gastrointestinal Cancer Patients
The purpose of this study is to assess the efficacy of modulated mid-frequency whole-body electromyostimulation (WB-EMS) combined with nutritional therapy in patients with gastrointestinal cancer.
- Conditions
- Oesophageal Cancer, Gastric Cancer, Duodenal Cancer, Colorectal Cancer
- Trial name
- MOMENT (NCT06414122)
- Testing
- mid-frequency whole-body electromyostimulation (WB-EMS), conventional exercise training, nutritional therapy
- Where
- Germany
- Volunteers
- 88 people
- Sponsor
- University of Cologne
Cancer
The Effect of Sujok Therapy on Cancer Symptoms
The aim of this study is to determine the effect of Sujok therapy on Pain, Fatigue, Insomnia, Nausea and Vomiting experienced by patients with gastrointestinal system cancer.
- Trial name
- NCT05265754
- Testing
- sujok therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 49 people
- Sponsor
- Ataturk University
Thrombosis, Deep Venous Thrombosis
Venous Thromboembolism and Haemostatic Disturbances in Patients With Upper Gastrointestinal Cancer
Cancer is a well known risk factor for venous thromboembolism (VTE) such as deep venous thrombosis (DVT) and pulmonary embolism (PE).
- Conditions
- Thrombosis, Deep Venous Thrombosis, Pulmonary Embolism, Venous Thromboembolism
- Trial name
- GIVTE (NCT00660205)
- Where
- Denmark
- Volunteers
- 285 people
- Sponsor
- University of Aarhus
Gastric Cancer, Pancreatic Cancer
Claudin18.2 CAR-T (CT041) in Patients With Gastric, Pancreatic Cancer, or Other Specified Digestive Cancers
A Phase 1b/2, open label, multi-center, clinical study of Chimeric Antigen Receptor T Cells (CAR-T) targeting claudin18.2 in patients with advanced gastric, pancreatic or other specified digestive system cancers
- Trial name
- NCT04404595
- Testing
- CT041
- Where
- 16 sites in United States, Canada
- Volunteers
- 110 people
- Sponsor
- CARsgen Therapeutics Co., Ltd.
Gastrointestinal Cancer
Effects of 3 Day Preoperative Immunonutrition in Well-nourished Patients With Gastrointestinal (GI) Cancer Undergoing Surgery
Major surgery is still associated with a high rate of postoperative morbidity despite improved techniques in surgical management.
- Trial name
- IPOD-3 (NCT01023412)
- Testing
- Immunonutrition
- Where
- 6 sites in Switzerland
- Volunteers
- 107 people
- Sponsor
- Société des Produits Nestlé (SPN)
Surgical Wound Infection
NPWT in Patients Undergoing Surgical Procedures for Management of GI Malignancies
This randomized trial will use a Negative Pressure Wound Therapy device or standard wound closure, in participants with gastrointestinal neoplasms, to measure the rate of surgical site infections
- Trial name
- NCT04955730
- Testing
- Negative Pressure Wound Therapy
- Where
- United States
- Volunteers
- 290 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Rectal Cancer, Gastric Cancer
The Effect of Bone Marrow-sparing Intensity-Modulated Radiotherapy to GI Cancer
Concurrent chemotherapy with external beam radiotherapy is the standard treatment of bulky or locally advanced cervical cancer, gastric cancer and rectal cancer.Despite excellent therapeutic results, acute hematologic toxicity…
- Conditions
- Rectal Cancer, Gastric Cancer, Bone Marrow Toxicity, Adverse Effect of Radiation Therapy
- Trial name
- IMRT (NCT01863420)
- Testing
- Bone Marrow-sparing Intensity-Modulated Radiotherapy
- Where
- China
- Volunteers
- 58 people
- Sponsor
- Chinese Academy of Medical Sciences
Haematological Malignancy, Malignant Neoplasm
DETERMINE Trial Treatment Arm 07: Dabrafenib in Combination With Trametinib in Adult, Paediatric and Teenage/Young Adult Patients With BRAF V600 Mutation-Positive Cancers.
This clinical trial is looking at two drugs called dabrafenib and trametinib. Dabrafenib and trametinib are approved as standard of care treatment for adult patients with melanoma (a type of skin cancer) or lung cancer and in…
- Conditions
- Haematological Malignancy, Malignant Neoplasm, Lymphoproliferative Disorders, Neoplasms by Histologic Type
- Trial name
- DETERMINE (NCT07440290)
- Testing
- Dabrafenib, Trametinib
- Where
- 27 sites in United Kingdom
- Volunteers
- 30 people
- Sponsor
- Cancer Research UK
Gastrointestinal Cancer
Remote Electronic Patient Monitoring in Gastrointestinal Cancer
The goal of this research study is to evaluate a program that involves remote electronic monitoring of vital signs and symptoms of patients with gastrointestinal cancer who were recently hospitalized at Massachusetts General…
- Trial name
- NCT04030624
- Testing
- Remote Electronic Patient Monitoring
- Sponsor
- Massachusetts General Hospital
Breast Cancer, Brain Cancer
Study of Insulin-like Growth Factor (IGF)-Methotrexate Conjugate in the Treatment of Advanced Tumors Expressing IGF-1R
This phase I dose escalation study will evaluate IGF-Methotrexate conjugate (765IGF-MTX) in patients with advanced, previously treated tumors.
- Conditions
- Breast Cancer, Brain Cancer, Gastrointestinal Cancers, Genitourinary Cancers
- Trial name
- NCT02045368
- Testing
- IGF-Methotrexate conjugate
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- IGF Oncology, LLC
Gastrointestinal Neoplasms
Cerebral Blood Flow During Propofol Anaesthesia
General anaesthesia often reduces blood pressure whereby blood flow to the brain and other vital organs may become insufficient. Thus, medicine is often administered during anaesthesia to maintain blood pressure.
- Trial name
- NCT02951273
- Testing
- Study of cerebral blood flow
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Malignant Digestive System Neoplasm, Nausea and Vomiting
Dolasetron Mesylate and Dexamethasone With or Without Aprepitant in Preventing Nausea and Vomiting in Patients Undergoing Oxaliplatin-Containing Chemotherapy for Gastrointestinal Malignancy
This randomized pilot clinical trial dolasetron mesylate and dexamethasone with or without aprepitant in preventing nausea and vomiting in patients undergoing oxaliplatin-containing chemotherapy for gastrointestinal malignancy.
- Trial name
- NCT02550119
- Testing
- Aprepitant, Dexamethasone, Dolasetron Mesylate
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Southern California