Clinical trials: Furcation Defects
Chronic Periodontitis
Locally Delivered Atorvastatin & Rosuvastatin for Treatment of Furcation Defects in Chronic Periodontitis
Statins are one of the lipid lowering drugs that help in reducing cholesterol levels in the body by specifically inhibiting 3-hydroxy-3-methylglutaryl coenzyme A reductase; which is a rate limiting enzyme for cholesterol…
- Trial name
- NCT02800902
- Testing
- Rosuvastatin, Atorvastatin
- Where
- India
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Government Dental College and Research Institute, Bangalore
Furcation Defects, Periodontal Diseases
Mandibular Furcation II Regeneration
Teeth with furcation grade II defects will be treated with open flap debridement and regenerative therapy with biphasic calcium phosphate combined with either enamel matrix proteins or a collagen membrane.
- Trial name
- FURC-II-REGEN (NCT04059445)
- Testing
- Biphasic calcium phosphate (Straumann Bone Ceramic) + collagen membrane (Straumann Jason Membrane), Biphasic calcium phosphate (Straumann Bone Ceramic) + enamel matrix proteins (Straumann Emdogain)
- Where
- Norway
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Oslo
Furcation Defects, Open Flap Debridement
Evaluation of Outcomes of Minimally Invasive Non- Surgical Versus Surgical Therapy in Furcation Involvement.
The reduced rate of success experienced in the treatment of Furcation involvement (FI) seems to result from the incomplete removal of subgingival plaque and calculus in the interradicular area owing to the peculiar anatomy of the…
- Conditions
- Furcation Defects, Open Flap Debridement, Periodontal Diseases
- Trial name
- NCT06025955
- Testing
- minimally invasive non- surgical therapy, open flap debridement
- Where
- India
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Chronic Periodontitis With Mandibular Degree 2 Furcation Defects
Boric Acid in Degree 2 Furcation Defect
The purpose of this double-masked, randomized, controlled clinical trial was to evaluate the effects of subgingival delivery of boric acid gel as an adjunct to scaling and root planing (SRP) on clinical and radiographic…
- Trial name
- NCT02738515
- Testing
- 0.75 % Boric Acid
- Where
- India
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Government Dental College and Research Institute, Bangalore
Periodontitis, Periodontal Diseases
MRI as Alternative to CBCT for the Assessment of Furcation Involvement in Molars
Aim of this prospective study is to compare magnetic resonance imaging (MRI) and cone beam computed tomography (CBCT) to diagnose furcation involvement (FI) in molars in patients with periodontitis.
- Conditions
- Periodontitis, Periodontal Diseases, Furcation Defects
- Trial name
- NCT06116487
- Where
- Austria
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Furcation Defects, Periodontal Disease
Conventional or Minimally Invasive Surgical Technique for the Treatment of Furcation Defects Using Enamel Matrix Derivative and Anorganic Bovine Bone - a Randomized Controlled Clinical Trial.
This clinical study compared a conventional surgical technique (CST) and a minimally invasive surgical technique (MIST) in the regenerative treatment of mandibular furcation defects.
- Trial name
- NCT02102360
- Testing
- Anorganic Bovine Bone, Enamel Matrix Derivative
- Where
- Brazil
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Chronic Periodontitis
Atorvastatin in the Treatment of Mandibular Degree II Furcation Defects
ABSTARCT Background: Atorvastatin is an inhibitor of 3-hydroxy-2-methyl-glutaryl coenzyme A reductase. Lately, it has shown to have anti-inflammatory and bone stimulatory effects.
- Trial name
- NCT02386033
- Testing
- Atorvastatin (ATV)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Government Dental College and Research Institute, Bangalore
Periodontitis
Bone Morphogenetic Protein-2 In Grade II Furcation Defects.
The present study evaluated clinically and radiographically the regenerative potential of rhBMP-2 in absorbable sponge and PRF in Grade II furcation.
- Trial name
- NCT04372420
- Testing
- RhBMP-2 absorbable sponge in grade II furcation, PLATELET RICH FIBRIN in grade II furcation
- Where
- India
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- SVS Institute of Dental Sciences
Concentrated Growth Factors, Periodontal Regeneration
Concentrated Growth Factors in Regenerative Therapy in Furcation Involvements in Humans
Objective: To compare the effect of guided tissue regeneration (GTR) + concentrated growth factors (CGF) + bone graft and CGF + bone graft in the treat of II° furcations of human mandibular molars.
- Conditions
- Concentrated Growth Factors, Periodontal Regeneration, Furcation Defects
- Trial name
- NCT03180658
- Testing
- GTR + CGF + bone graft, CGF + bone graft
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Jing Qiao
Furcation Defects
Comparison of Bone Graft and Photodynamic Therapy in Class II Furcation
This is a surgical comparative clinical trial which aims to assess class II buccal furcation defects treated with Xenograft alone or preceded by antimicrobial photodynamic therapy.
- Trial name
- NCT06519409
- Testing
- Open flap debridement and photodynamic therapy
- Where
- India
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Krishnadevaraya College of Dental Sciences & Hospital
Periodontal Attachment Loss, Periodontal Bone Loss
Added Benefit of L-PRF to Autogenous Bone Graft in the Treatment of Mandibular Degree II Furcation Defects
Different therapeutic approaches have been proposed for the treatment of furcation defects and the regeneration of periodontium within the furcation area is considered one of the most challenging aspect of surgical periodontal…
- Trial name
- NCT03756493
- Testing
- Periodontal Surgery with OFD+ABG+L-PRF, Periodontal Surgery with OFD+ABG, Periodontal Surgery OFD
- Where
- Italy
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- G. d'Annunzio University
Furcation Defects
Platelet Rich Fibrin+1.2% Atorvastatin in Treatment of Mandibular Degree II Furcation Defects
The present study was designed to explore the effectiveness of PRF combined with 1.2% ATV gel in treatment of mandibular degree II furcation defects in comparison to PRF and open flap debridement (OFD) alone.
- Trial name
- NCT02612792
- Testing
- Open flap debridement (OFD), OFD with Platelet rich fibrin (PRF), OFD with Platelet rich fibrin (PRF)+1.2% Atorvastatin (Drug) in gel form
- Where
- India
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Government Dental College and Research Institute, Bangalore
Furcation Defects
Piezosurgery in the Treatment of Class II Furcation Involvement
The purpose of this study is to evaluate the effectiveness of piezosurgery in the treatment of class II furcation involvement using biomaterials and new surgical techniques
- Trial name
- NCT02132806
- Testing
- Piezosurgery with biomaterial mp3 + bracket, Piezosurgery with biomaterial mp3, Piezosurgery
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Matteo Visintin
Furcation Defects
Rosuvastatin Gel With 1:1 Mixture of Platelet-rich Fibrin and Bone Graft in Mandibular Degree II Furcation Defects
Rosuvastatin (RSV) is a new synthetic, second-generation, sulfur-containing, hydrophilic statin, that stimulate bone formation in critical-size cortical bone defects adjacent to titanium implants, when administered locally in…
- Trial name
- NCT02369250
- Testing
- Rosuvastatin, platelet rich fibrin
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Government Dental College and Research Institute, Bangalore
Furcation Defects, Periodontal Diseases
Osteoplasty in Conjunction With Surgical Treatment of Mandibular Grade III Furcation Defects (FURC-III-OST)
Teeth with furcation grade III defects will be treated with open flap debridement, with or without osteoplasty. The study is designed to examine the effect of osteoplasty in the treatment of teeth with furcation grade III defects…
- Trial name
- FURC-III-OST (NCT04017429)
- Testing
- Open flap debridement with osteoplasty, Open flap debridement without osteoplasty
- Where
- Norway
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Oslo
Furcation Defects
Evaluation of Injectable Beta-tricalcium Phosphate Clinically in Treatment of Grade II Furcation Involvement
This study will be conducted to evaluate clinically and radiographically the use of PD VitalOs cement® bone graft in the treatment of class II furcation defects comparing with Hydroxyapatite bone graft and biodegradable collagen…
- Trial name
- NCT04443972
- Testing
- PD VitalOs cement®, Hydroxyapatite bone graft, biodegardable collagen membrane
- Where
- Egypt
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Hams Hamed Abdelrahman
Furcation Defects, Periodontitis
Effect of Laser Use on Guided Tissue Regeneration in Treatment of Molar Teeth With Class 2 Furcation Affected by Periodontitis
Purpose: The proposed study will evaluate and compare the clinical response of using bioresorbable collagen membrane alone or defect debridement with erbium Laser irradiation in conjunction with bioresorbable collagen membrane in…
- Conditions
- Furcation Defects, Periodontitis, Alveolar Bone Loss Beyond Furcation
- Trial name
- NCT01522131
- Testing
- bioresorbable membrane alonewill be used for regeneration of the periodontium(control)
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Furcation Defects
Furcation Treatment With L-PRF and aPDT
To treat grade II periodontally diseased furcation areas Leukocyte-Platelet Rich Fibrin (L-PRF) combined with antimicrobial Photo-Dynamic Therapy (a-PDT) was used.
- Trial name
- NCT04842188
- Testing
- L-PRF with aPDT, L-PRF
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Kafrelsheikh University
Chronic Periodontitis
1% Metformin Gel in the Treatment of Class II Furcation Defects
Metformin (MF), a biguanide group of anti-diabetic drug has been shown to enhance osteoblasts differentiation and inhibit osteoclast differentiation in vitro, thus may exhibit a favourable effect on alveolar bone.
- Trial name
- NCT02580331
- Testing
- SRP and 1% metformin
- Where
- India
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Government Dental College and Research Institute, Bangalore
Furcation Defects, Periodontal Diseases
Mandibular Furcation III Regeneration (FURC-III-REGEN)
Teeth with furcation grade III defects will be treated with open flap debridement and regenerative therapy with biphasic calcium phosphate combined with either enamel matrix proteins or a collagen membrane.
- Trial name
- FURC-III-REGEN (NCT04059458)
- Testing
- Biphasic calcium phosphate (Straumann Bone Ceramic) + collagen membrane (Straumann Jason Membrane), Biphasic calcium phosphate (Straumann Bone Ceramic) + enamel matrix proteins (Straumann Emdogain)
- Where
- Norway
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Oslo