Clinical trials: Focal Dystonia
Dystonia, Focal
Oral Zinc Supplementation to Enhance Botulinum Neurotoxin Response
Botulinum neurotoxin (BoNT) is injected into muscles for treatment of dystonia. BoNTs are zinc proteases, and their enzymatic effect is reduced in the setting of low zinc.
- Trial name
- NCT05095493
- Testing
- Zinc Acetate
- Volunteers
- 54 people
- Sponsor
- University of Texas Southwestern Medical Center
Cervical Dystonia
Theta Burst Transcranial Focused Ultrasound as a Novel Treatment for Cervical Dystonia
This study is a single-blinded, randomized control study that aims to recruit 48 participants. Participants will be "randomized" into one of the study arms of the study: active stimulation to GPi, active stimulation to DN, or…
- Trial name
- NCT07690514
- Testing
- LIFUS - GPi Active, LIFUS - DN Active
- Where
- Canada
- Volunteers
- 48 people
- Sponsor
- Robert Chen
Parkinson s Disease, Dystonic Disorders
Genetics of Motor Learning
Background: New studies in human genetics have revealed information about genetic connections to memory and motor behavior. Researchers are interested in investigating the role of genetics in motor learning, in conjunction with…
- Conditions
- Parkinson s Disease, Dystonic Disorders, Focal Dystonia, Movement Disorders
- Trial name
- NCT01105845
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Dystonia
Pathophysiology of Focal Hand Dystonia
Background: Little is known about the problems in brain function in focal hand dystonia (FHD) or complex regional pain syndrome (CRPS) dystonia. It is unclear why some CRPS patients develop dystonia but others do not.
- Trial name
- NCT03223623
- Testing
- TMS, MRI, VASO Imaging
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Parkinson's Disease (PD), Essential Tremor
LIFUS For Neurological Disorders
Low intensity focused ultrasound (LIFUS) has the potential to be used as a means of non-invasive neuro-modulation. To this day, the use of LIFUS is under investigation.
- Conditions
- Parkinson's Disease (PD), Essential Tremor, Orthostatic Tremor, Dystonia
- Trial name
- NCT07417280
- Testing
- LIFUS
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Focal Hand Dystonia
IncobotulinumtoxinA (Xeomin) to Treat Focal Hand Dystonia
This study is a multicenter, double-blind, randomized placebo controlled, parallel group, superiority trial in order to test the superiority of intramuscular injections of IncobotulinumtoxinA against placebo using a 1:1…
- Trial name
- NCT03977493
- Testing
- Xeomin
- Where
- 5 sites in Switzerland
- Volunteers
- 48 people
- Sponsor
- Alain Kaelin
Focal Dystonia
Electrophysiological and Neuroimaging Correlates of the Effect of Zolpidem in Patients With Focal Dystonia
To study electrophysiological and imaging correlations of the clinical effectiveness of zolpidem in task-specific dystonia and to elucidate mechanisms underlying its therapeutic effects, patients with focal dystonia will be…
- Trial name
- NCT04692285
- Testing
- Zolpidem
- Where
- 2 sites in Serbia, Slovenia
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Isolated Focal Hand Dystonia
Accelerated TMS for Focal Hand Dystonia
This study aims to investigate the impact of accelerated transcranial magnetic stimulation (TMS) on brain function and behavior in patients with focal hand dystonia.
- Trial name
- NCT06015672
- Testing
- Transcranial Magnetic Stimulation (TMS)
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Duke University
Dystonic Disorder, Focal Dystonia
Characterization of Manual Dexterity by Finger Force Manipuladum (FFM) in Patients With Writer's Cramp and in Control Subjects
Writer's cramp is a focal dystonia characterized by abnormal movements and postures during writing. Limited finger independence during writing manifests as difficulty suppressing unwanted activations of neighbouring non…
- Conditions
- Dystonic Disorder, Focal Dystonia, Writer's Cramp
- Trial name
- FFM_CT (NCT03797638)
- Testing
- Finger Force Manipuladum (FFM)
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Dystonia
Brain Function in Focal Dystonia
Objectives The main objectives of this proposal are (1) to characterize motor learning abnormalities in patients with focal dystonia; (2) to show, using transcranial magnetic stimulation, that this abnormal motor learning went…
- Trial name
- NCT00102999
- Where
- United States
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Isolated Focal Hand Dystonia
Neuromodulation Therapy for Task-Specific Dystonia
This study aims to apply a non-invasive brain stimulation technology called repetitive Transcranial Magnetic Stimulation (rTMS) in patients with focal hand dystonia (FHD).
- Trial name
- NCT06422104
- Testing
- Repetitive transcranial magnetic stimulation
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Duke University
Cervical Dystonia
Assessment of Long-term Clinical Response to BoNT in Cervical Dystonia
The goal of this retrospective, international, multi-center chart abstraction is to learn about the long-term impact of product-specific immunogenicity-related factors in different botulinum neurotoxin type A formulations in…
- Trial name
- RELY-CD (NCT05884528)
- Testing
- CC BoNT/A, CF BoNT/A, CF to CC BoNT/A
- Where
- Germany
- Volunteers
- 270 people
- Sponsor
- Merz Therapeutics GmbH
Cervical Dystonia, Dystonia
Cholinergic Receptor Imaging in Dystonia
Background: Dystonia is a movement disorder in which a person s muscles contract on their own. This causes different parts of the body to twist or turn. The cause of this movement is unknown.
- Conditions
- Cervical Dystonia, Dystonia, Movement Disorder, Focal Dystonia
- Trial name
- NCT02689466
- Testing
- [18F]FP-TZTP
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Focal Dystonia
EEG and EMG Studies of Hand Dystonia
This study will examine how the brain operates during execution and control of voluntary movement and what goes wrong with these processes in disease.
- Trial name
- NCT00025701
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Focal Dystonia, Peripheral Nervous System Disease
Association Between Focal Dystonia and Complex Regional Pain Syndrome
This study will investigate differences among people with focal dystonia (FD), complex regional pain syndrome (CRPS) and people who have both conditions to learn more about the cause of both disorders.
- Trial name
- NCT00595439
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Dystonic Disorders
Transcranial Magnetic Stimulation and Electrical Stimulation of Nerves to Study Focal Dystonia
This study will use transcranial magnetic stimulation (TMS) and electrical stimulation of nerves to examine how the brain controls muscle movement in focal hand dystonia (writer's cramp).
- Trial name
- NCT00050024
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Primary Cervical Dystonia
Segmental Muscle Vibration on Pain in Patients With Primary Cervical Dystonia
This pilot study aims to evaluate the effectiveness of Vibration Muscle Stimulation (VMS) in reducing pain and improving quality of life in patients with primary cervical dystonia (CD), a focal dystonia characterized by…
- Trial name
- VIBRA-DYSTONIA (NCT06748846)
- Testing
- Physiotherapy + Occupational therapy + Focal Muscle Vibration
- Where
- Italy
- Volunteers
- 28 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Focal Dystonia
Brain Changes in Patients With Focal Hand Dystonia
This study will examine how chemical changes in the brain produce symptoms of hand dystonia. Patients with dystonia have muscle spasms that cause uncontrolled twisting and repetitive movement or abnormal postures.
- Trial name
- NCT00306865
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Focal Dystonia
Quantifying Musical Performance After Treatment With Myobloc in Musician's Dystonia
This study uses a computerized method of musical instrument digital interface (MIDI) quantification of performance before and after treatment with botulinum toxin type B (Myobloc ®, Solstice Neurosciences).
- Trial name
- NCT00208091
- Testing
- Botulinum toxin, type B
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Columbia University
Movement Disorders, Essential Tremor
ExAblate Transcranial MRgFUS for the Management of Treatment-Refractory Movement Disorders
The proposed study is to evaluate the effectiveness of ExAblate Transcranial MRgFUS as a tool for creating a unilateral lesion in the Vim thalamus or the globus pallidus (GPi) in patients with treatment-refractory symptoms of…
- Conditions
- Movement Disorders, Essential Tremor, Holmes Tremor, Parkinson's Disease
- Trial name
- NCT02252380
- Testing
- Transcranial ExAblate System
- Where
- 2 sites in Canada
- Volunteers
- 10 people
- Sponsor
- InSightec