Clinical trials: Fluid Overload Pulmonary Edema
Mechanical Ventilation, Fluid Overload
Lung Ultrasound-Guided Fluid Deresuscitation in ICU Patients
Timely recognition and treatment of fluid overload can expedite liberation from invasive mechanical ventilation in intensive care unit (ICU) patients.
- Conditions
- Mechanical Ventilation, Fluid Overload, Deresuscitation, Ventilator-free Days
- Trial name
- CONFIDENCE (NCT05188092)
- Testing
- Lung ultrasound guided deresuscitation
- Where
- 3 sites in Netherlands
- Volunteers
- 1,000 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Acute Respiratory Distress Syndrome, Hemodynamic Instability
Thoracic Fluid Content by Bioimpedance-based Starling System
The Starling system is a completely non-invasive hemodynamic monitoring technique. It is able to measure the thoracic fluid content (TFC). The TFC is supposed to reflect the total content of fluid in the thorax.
- Conditions
- Acute Respiratory Distress Syndrome, Hemodynamic Instability, Shock, Fluid Overload Pulmonary Edema
- Trial name
- TFC-Bio (NCT05676723)
- Where
- France
- Volunteers
- 41 people
- Sponsor
- Bicetre Hospital
Coronavirus, SARS-CoV-2
Hemodynamic Characteristics of Patients With SARS-CoV-2
The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been declared a public health emergency of international concern.
- Conditions
- Coronavirus, SARS-CoV-2, COVID-19, Acute Respiratory Distress Syndrome
- Trial name
- PiCCOVID (NCT04337983)
- Testing
- Transpulmonary thermodilution, Echocardiography
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Bicetre Hospital
Lung Disease
Using Furosemide to Prevent Fluid Overload During Red Blood Cell Transfusion in Neonates
The purpose of this study is to investigate the effects of intravenous furosemide on cardio-respiratory performance in neonates receiving a packed red blood cell (PRBC) transfusion who are considered at high risk of volume…
- Trial name
- NCT00618852
- Testing
- Furosemide, Saline
- Where
- 2 sites in Canada
- Volunteers
- 64 people
- Sponsor
- The Hospital for Sick Children
Respiratory Infection, Fluid Overload
Fluid Restriction Keeps Children Dry
Rationale: Fluid overload is a common complication in children who are admitted to the pediatric intensive care for mechanical ventilation.
- Conditions
- Respiratory Infection, Fluid Overload, Critical Illness, Respiratory Insufficiency
- Trial name
- LESSER (NCT02989051)
- Testing
- Restrictive fluid regimen, Liberal fluid regimen
- Where
- Netherlands
- Volunteers
- 34 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Congestive Heart Failure
Ultrafiltration Versus Intravenous (IV) Diuretics for Patients Hospitalized for Acute Decompensated Heart Failure: (UNLOAD)
The purpose of this study is to compare patients who are suffering from heart failure and who are fluid overloaded to determine if ultrafiltration (UF) can remove more of the extra fluid as measured by weight loss while in the…
- Trial name
- NCT00124137
- Testing
- Aquadex system, IV diuretic
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Nuwellis, Inc.
Fluid Overload, Critical Illness
Role of Active Deresuscitation After Resuscitation:
The RADAR-Canada trial is a pilot RCT undertaken to assess the acceptability of, compliance with, and biologic consequences of a deresuscitation protocol designed to expedite the removal of excess interstitial fluid in patients…
- Conditions
- Fluid Overload, Critical Illness, Sepsis, ARDS
- Trial name
- RADAR-Canada (NCT06326112)
- Testing
- Furosemide Injection, Metolazone Tablets
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Unity Health Toronto
Fluid Overload, Kidney Injury
Association Between Venous Excess Ultrasound Grading System and Acute Kidney Injury in the ICU Population
Fluid resuscitation is one of the cornerstones of treatment in ICU patients. Nonetheless, excessive fluid administration can lead to fluid overload which has been associated with worse outcomes in the ICU.
- Conditions
- Fluid Overload, Kidney Injury, Make-30
- Trial name
- VExUS ICU (NCT06585722)
- Where
- Netherlands
- Volunteers
- 136 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Hemodynamic Instability, Surgery
End-expiratory Occlusion Test and Lung Recruitment Maneuver to Assess Fluid responsiVeness In Surgical Patients
The functional hemodynamic test (FHT) called passive leg raising (PLR) has been successfully used for assessing the fluid responsiveness in ICU patients since 2009 and its reliability has been confirmed by three large…
- Conditions
- Hemodynamic Instability, Surgery, Fluid Overload
- Trial name
- ELVIS (NCT03820440)
- Testing
- End-expiratory occlusion test (EEOT), Lung recruitment manovre (LRM)
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Humanitas Clinical and Research Center
Sepsis, Diastolic Dysfunction
Diastolic Dysfunction and Interstitial Lung Edema in Septic Patients
Sepsis is one of the most challenging conditions with an exceptionally high mortality rate. Diastolic Dysfunction is common in septic patients and has been found to be associated with mortality.
- Conditions
- Sepsis, Diastolic Dysfunction, Lung Edema, Fluid Overload
- Trial name
- NCT03768752
- Where
- Germany
- Volunteers
- 83 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Leukemia
Ultrafiltration (Aquapheresis) in Patients With Leukemia and Severe Fluid Overload
The goal of this clinical research study is to learn about the safety and level of effectiveness of aquapheresis compared to diuretic drugs. Diuretic drugs are designed to help the kidneys to form more urine.
- Trial name
- NCT01508260
- Testing
- Aquapheresis, Furosemide
- Sponsor
- M.D. Anderson Cancer Center
Transfusion-associated Circulatory Overload, Blood Transfusion Reaction
TACO Crossover TRIAL
This is an open-label, prospective crossover randomized controlled trial to investigate wether TACO is solely hydrostatic pressure overload or arises from a combination of hydrostatic pressure overload and capillary leakage, by…
- Trial name
- NCT03135457
- Testing
- Autologous RBC transfusion, Saline transfusion
- Where
- Netherlands
- Volunteers
- 16 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Respiratory Insufficiency
Description of Fluid Balance in Patients With Acute Respiratory Failure
The specific aim of this study is to gather data on fluid balance, intravenous medication administration, electrolyte balance, and diuretic and dialysis use in patients with acute respiratory failure who might benefit from a…
- Trial name
- NCT02523872
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Smiths Medical, ASD, Inc.
Critical Illness, Fluid Overload
Intrarenal Venous Flow Change During Fluid Removal in Critically Ill Patients: A Prospective Exploratory Study
This clinical trial aims to study intrarenal venous flow patterns change, VExUS score change, and LUS score change during fluid removal treatment in critically ill patients
- Trial name
- NCT06216119
- Where
- Thailand
- Volunteers
- 52 people
- Sponsor
- Mahidol University
Volume Overload
Perioperative Fluid Therapy in Pediatric Patients Undergoing Penile Hypospadias Repair
Optimization of perioperative fluid management is important for preventing adverse events, such as hypovolemia, cardiogenic shock, volume overload, and pulmonary edema, in both adult and pediatric patients.
- Trial name
- NCT04444089
- Testing
- lung ultrasound
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Cairo University
Pulmonary Edema - Acute, Preeclampsia
Lung Ultrasound for the Detection of Volume Overload in Patients With Severe Preeclampsia
This research aims to evaluate the usefulness of lung ultrasound (LUS) for detecting and monitoring fluid overload in patients with severe preeclampsia.
- Trial name
- NCT07261956
- Testing
- Lung ultrasound
- Where
- Panama
- Volunteers
- 202 people
- Sponsor
- Saint Thomas Hospital, Panama
Contusions Pulmonary, Lung Injury
Efficacy of Lung Ultrasound in Monitoring Fluid Resuscitation in Chest Trauma Patients
Efficacy of Lung ultrasound in monitoring fluid resuscitation in chest trauma patients with lung contusions
- Conditions
- Contusions Pulmonary, Lung Injury, Chest Trauma, Fluid Overload Pulmonary Edema
- Trial name
- NCT05054270
- Testing
- Chest examination with Ultrasound device
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Fluid Overload Pulmonary Edema, Peritoneal Dialysis Complication
Assessing Fluid Status of Peritoneal Dialysis Patients With Assistance of Lung Ultrasound
As studied previously, lung congestion is very prevalent however usually asymptomatic in dialysis patients. Fluid overload is associated with hospitalizations, worse cardiovascular outcomes and mortality in PD patients.
- Trial name
- Fluid-PLUS (NCT04176627)
- Testing
- Lung ultrasound
- Where
- 16 sites in United States
- Volunteers
- 44 people
- Sponsor
- Satellite Healthcare
Fluid Overload, Organ Edema
"The Effect of Reduced Fluid Load After Cardiac Surgery"
The purpose of this study is to verify that an infusion of hypertonic saline/colloids during cardio-pulmonary-bypass will reduce fluid overload and organ edema for cardiac patients with expected long-CPB-time.
- Conditions
- Fluid Overload, Organ Edema, Organ Function
- Trial name
- NCT01438502
- Testing
- HyperHAES® (hypertonic saline/HES)
- Sponsor
- Haukeland University Hospital
Respiratory Failure, Circulatory Failure
Influence of Fluid Challenge on End-Expiratory Lung Impedance in Mechanically Ventilated Patients Monitored With Electrical Impedance Tomography
The study investigates the influence of a clinically indicated fluid challenge on end-expiratory lung impedance, assessed by electrical impedance tomography (EIT).
- Conditions
- Respiratory Failure, Circulatory Failure, Fluid Responsiveness, Fluid Overload
- Trial name
- NCT02992002
- Testing
- Fluid Challenge
- Where
- Germany
- Volunteers
- 25 people
- Sponsor
- University Hospital Schleswig-Holstein