Clinical trials: Emergencies
Pain, Acute
Impact of Vitamin C on opioïd Consumption After an Emergency Department Visit for Acute Musculoskeletal Pain
Recent evidence has shown that vitamin C has some analgesic properties and can therefore reduce opioids used during healing. Vitamin C analgesic effect has been explored mostly during the short-term postoperative context or in…
- Trial name
- NCT05555576
- Testing
- Vitamin C
- Where
- Canada
- Volunteers
- 464 people
- Sponsor
- Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal
Sepsis
Comparison of Sepsis Prediction Algorithms
Sepsis is a severe response to infection resulting in organ dysfunction and often leading to death. More than 1.5 million people get sepsis every year in the U.S., and 270,000 Americans die from sepsis annually.
- Trial name
- NCT05943938
- Testing
- Epic Sepsis Model Version - 1, Epic Sepsis Model Version - 2, Emory Sepsis Model
- Where
- 7 sites in United States
- Volunteers
- 1,200 people
- Sponsor
- Emory University
End-of-life Care, Palliative Care
Prehospital Care of End-of-Life Patients by the Strasbourg Mobile Emergency and Resuscitation Service: A Qualitative Study of Healthcare Professionals' Experiences and Use of a Comfort Care Booklet
Prehospital end-of-life care presents complex clinical, ethical, relational, and organizational challenges for healthcare professionals working in the Strasbourg Mobile Emergency and Resuscitation Service (SMUR).
- Conditions
- End-of-life Care, Palliative Care, Prehospital Emergency Care, Healthcare Professionals' Experiences and Perceptions
- Trial name
- PALLI-SMUR1 (NCT07895940)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Strasbourg, France
HIV Infections
Screen Smart: Using Digital Health to Improve HIV Screening and Prevention
The goal of this interrupted time series quasi-experimental design study is to implement universal opt- out HIV testing and linkage to HIV preventive care in 15-21 year old adolescents visiting the pediatric emergency department…
- Trial name
- Screen Smart (NCT06003192)
- Testing
- Universal Opt-out HIV Screening
- Where
- 4 sites in United States
- Volunteers
- 63,000 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Communication Research
Evaluating AI for the Translation of KM Resources
Knowledge mobilization resources for parents provide information to help make health decisions for their children. These resources can include videos, infographics, and plain language summaries. They are often created in English.
- Trial name
- NCT07666399
- Testing
- KM Resource - English, KM Resource - Professionally Translated, KM Resouce - AI
- Where
- Canada
- Volunteers
- 576 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Virtual Reality Simulation, Medical Education
Comparison of Task Trainer and Virtual Reality Approaches in Dysrhythmia Management Education
The goal of this randomized, controlled simulation-based educational study is to compare the effectiveness of virtual reality (VR) and task trainer-based training in improving dysrhythmia management skills among intern…
- Conditions
- Virtual Reality Simulation, Medical Education, High Fidelity Simulation Training, Emergency Medicine
- Trial name
- NCT07892391
- Testing
- Virtual Reality-Based Dysrhythmia Management Training, Task Trainer-Based Dysrhythmia Management Training
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Karadeniz Technical University
Frail Elderly, Frailty
Frailty Training for Emergency Nurses: A Cluster RCT in Morocco
This study tests whether a training program helps nurses better recognize and care for older adults with frailty in hospital emergency departments.
- Trial name
- NCT07892612
- Testing
- Structured Educational Program on Geriatric Frailty
- Where
- Morocco
- Volunteers
- 144 people
- Sponsor
- Cadi Ayyad University
Ankle Injuries, Treatment Outcome
Assessment of the Quality of Life of Patients Visiting the Emergency Department of the Saint-Brieuc Hospital Following an Ankle Sprain
Lateral ankle sprains account for nearly 6,500 emergency department visits per day in France. They are clinically classified into three grades, which can be assessed approximately 3-5 days after an acute sprain.
- Trial name
- EntoQuaVie (NCT07054892)
- Testing
- FAAM - Activities of Daily Living (ADL) Subscale
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Centre Hospitalier de Saint-Brieuc
Emergency Abdominal Surgery, Opioid Sparing Anaesthesia
Effect of Opioid-sparing Anesthesia on Quality of Recovery After Emergency Laparotomy
Opioids are widely used during anesthesia for pain control, but they cause many side effects-such as nausea, constipation, respiratory depression, dependence, and delayed recovery.
- Trial name
- NCT07262242
- Testing
- Lidocaine (drug), Fentanyl (IV)
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Cairo University
Emergencies
Video Images About Decisions for Ethical Outcomes in the Emergency Department (VIDEO-ED)
A randomized controlled trial of a video decision aid in the Emergency Department Setting to improve advance care planning documentation.
- Trial name
- VIDEO-ED (NCT04931797)
- Testing
- video decision aid, control arm ACP information sheet
- Where
- 4 sites in United States
- Volunteers
- 598 people
- Sponsor
- Massachusetts General Hospital
Emergency Department Triage
PREMEDICAL is a Clinical Investigation Aiming to Create a Data Basis That Can be Used to Enrich Information Collected in the Course of the Classic Patient Journey. Patients in the Emergency Department Will be Asked to Answer Patient-related and Symptom-oriented Questions. Minimum Age is 18 Years
The goal of this clinical investigation is to create a new type of data basis that can be used to enrich information collected in the course of the classic patient journey, such as medical history forms and discharge letters.
- Trial name
- NCT06933550
- Where
- Austria
- Volunteers
- 351 people
- Sponsor
- XUND Solutions GmbH
Accidental Falls, Aged
Whole-Body Point-of-Care Ultrasound in Older Adults Presenting to the Emergency Department After a Fall
Falls are one of the most common reasons older adults visit the emergency department. In many older patients, a fall that looks "mechanical" is actually caused by an underlying medical problem such as syncope, heart disease…
- Conditions
- Accidental Falls, Aged, Syncope
- Trial name
- NCT07886164
- Testing
- Whole-body point-of-care ultrasound (POCUS)
- Where
- Turkey (Türkiye)
- Volunteers
- 105 people
- Sponsor
- Kocaeli City Hospital
Abdominal Pain, Isolated Extremity Fracture
Morphine or Ketamine for Analgesia
Pain is common in children presenting to the emergency department but is frequently undertreated, leading to both short- and long-term consequences.
- Conditions
- Abdominal Pain, Isolated Extremity Fracture, Pain, Pediatrics
- Trial name
- MoKA (NCT06835504)
- Testing
- Ketamine hydrochloride, Morphine sulphate
- Where
- 8 sites in United States
- Volunteers
- 1,010 people
- Sponsor
- Columbia University
Opioid Use Disorder
Contingency Management to Improve Medication for Opioid Use Disorder Continuation After the Emergency Department
Project Summary The goal of this pilot clinical trial is to assess contingency management (CM) for increasing attendance at outpatient clinics after Medication for Opioid Use Disorder (MOUD) prescription and clinic referral…
- Trial name
- CM+ED+MOUD (NCT07129902)
- Testing
- Contingency Management, Usual care as prescribed by the ED physicians
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Vermont
Head Injury Trauma, Traumatic Brain Injury, Mild
The PIONEER Comparative Effectiveness Study - Project 2
This is a pragmatic, open-label, multicenter, stepped-wedge, Type II hybrid effectiveness-implementation study. It is designed to evaluate both the comparative effectiveness and implementation feasibility of a…
- Trial name
- NCT07829107
- Testing
- Clinical pathway 1: Guidelines plus biomarkers, Clinical guidelines only
- Where
- 6 sites in United States
- Volunteers
- 3,000 people
- Sponsor
- University of Michigan
Wounds and Injuries, Out-of-Hospital Cardiac Arrest
Psychoactive Drug Use and Acute Care Use After Trauma and Out-of-Hospital Cardiac Arrest
This retrospective population-based cohort study uses linked administrative healthcare data from the Local Health Authority of Bologna (Italy) to describe the use of four classes of psychoactive drugs (opioids, antiepileptics…
- Conditions
- Wounds and Injuries, Out-of-Hospital Cardiac Arrest, Traumatic Brain Injury
- Trial name
- LIFT-C (NCT07882589)
- Testing
- Opioids (ATC N02A), Antiepileptics (ATC N03A), Antipsychotics (ATC N05A)
- Where
- 2 sites in Italy
- Volunteers
- 52,720 people
- Sponsor
- Azienda Usl di Bologna
Acute Coronary Syndromes, Chest Pain
AI-ECG Detection of Occlusion Myocardial Infarction at Emergency Department Triage (TRIACS)
Chest pain is among the most common reasons people attend an emergency department, and the electrocardiogram (ECG) recorded at triage is the first test used to decide who needs urgent treatment for a blocked coronary artery.
- Conditions
- Acute Coronary Syndromes, Chest Pain, Myocardial Infarction (MI), NSTEMI - Non-ST Segment Elevation MI
- Trial name
- TRIACS-MB (NCT07882849)
- Where
- Slovenia
- Volunteers
- 1,000 people
- Sponsor
- University Medical Centre Maribor
Suicide, Mental Health Issue
Proximal Risk for Suicide in Adolescents
The central hypothesis is that biometric data can continuously monitor and allow for early identification/intervention of escalating suicidal symptoms.
- Trial name
- NCT06400810
- Testing
- Analog Devices Inc.
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- Oregon Health and Science University
Emergency Department Visit, Home Care Services
Acute Hospital Care at Home for People Living With Dementia
The investigators will perform a parallel-group multicenter randomized controlled trial of a 1-year pre-enrolled acute hospital care at home intervention vs usual care for people living with dementia.
- Conditions
- Emergency Department Visit, Home Care Services, Dementia
- Trial name
- NCT06819852
- Testing
- Acute hospital care at home, Standard medical treatment
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Brigham and Women's Hospital
Rhabdomyolysis, Death
The Rhabdomyolysis Evaluation in the Emergency Department (REED) Score
One in three adults over 65 fall annually, with one in five remaining on the floor for greater than one hour, which is referred to as a long lie.
- Conditions
- Rhabdomyolysis, Death, Kidney Replacement Therapy, Fall Patients
- Trial name
- The REED Score (NCT07158554)
- Where
- United Kingdom
- Volunteers
- 1,161 people
- Sponsor
- University of Salford