Clinical trials: Early Diagnosis
Fatty Liver, NAFLD - Non-Alcoholic Fatty Liver Disease
Detecting Liver Fibrosis in Patients At-risk
The project will establish a research cohort (called STELIR; STEatotisk Liver-risk In Rogaland) based on a biobank with an associated health register.
- Conditions
- Fatty Liver, NAFLD - Non-Alcoholic Fatty Liver Disease, Nash, MASLD (Metabolic Dysfunction-Associated Steatotic Liver Disease)
- Trial name
- STELIR (NCT07775638)
- Testing
- Routine study procedure
- Where
- Norway
- Volunteers
- 1,200 people
- Sponsor
- Helse Stavanger HF
Colorectal Cancer (Diagnosis), Non-cancer Controls
Epigenetic Signature for CRC Early Detection
The epiCED is a noninvasive blood-based assay designed for early detection of colorectal cancer (CRC) using circulating cell-free DNA (cfDNA) 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) epigenetic markers.
- Conditions
- Colorectal Cancer (Diagnosis), Non-cancer Controls, DNA Methylation, Cell Free DNA
- Trial name
- epiCED (NCT07224854)
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Spinal Muscular Atrophy, Fragile X Syndrome
Early Check: Expanded Screening in Newborns
Early Check provides voluntary screening of newborns for a selected panel of conditions. The study has three main objectives: 1) develop and implement an approach to identify affected infants, 2) address the impact on infants and…
- Conditions
- Spinal Muscular Atrophy, Fragile X Syndrome, Fragile X - Premutation, Duchenne Muscular Dystrophy
- Trial name
- NCT03655223
- Testing
- Confirmatory Testing
- Where
- United States
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- RTI International
Reference Intervals, Biomarker in Early Diagnosis
Generating Intervals of Reference FFor Early Life Brain Biomarkers.
Highly sensitive immunoassays for the detection of neuro-specific biomarkers are becoming more accessible. Currently, the majority of these biomarkers are detected with the use of labour-intensive and highly skilled wet lab work.
- Conditions
- Reference Intervals, Biomarker in Early Diagnosis, Neonatal
- Trial name
- GIRAFFE (NCT07585149)
- Where
- Ireland
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University College Cork
Periodontitis, Biomarker in Early Diagnosis
Discovery and Validation of Periodontitis Biomarkers
Periodontitis is a major public health issue in China: it is responsible for loss of masticatory function in 60 million older adults, and 400-500 million adults are on the same disease trajectory.
- Conditions
- Periodontitis, Biomarker in Early Diagnosis, Saliva
- Trial name
- NCT07293481
- Testing
- Diagnostic procedures
- Where
- China
- Volunteers
- 228 people, healthy volunteers welcome
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Cancer, Cancer Diagnosis
Avera Cancer Sequencing and Analytics Protocol (ASAP)
The purpose of this study is to characterize the breadth of molecular features present in participants receiving care within a large, integrated, community-based healthcare system.
- Conditions
- Cancer, Cancer Diagnosis, Early Detection of Cancer, Breast Cancer
- Trial name
- ASAP (NCT05142033)
- Where
- 6 sites in United States
- Volunteers
- 25,000 people
- Sponsor
- Avera McKennan Hospital & University Health Center
Mild Cognitive Impairment (MCI), Early Stages of Cognitive Decline
Mild Cognitive Impairment Community Screening and Early Intervention Via Stem Cell Therapy and Wearable Brain Computer Interface Device.
This study aims to evaluate the efficacy of community-based early detection and targeted interventions, including stem cell therapy and wearable non-invasive brain-computer interface (BCI) devices, for Mild Cognitive Impairment…
- Conditions
- Mild Cognitive Impairment (MCI), Early Stages of Cognitive Decline, Alzheimer's Disease Dementia, Alzheimer's Disease Diagnosis
- Trial name
- MCITestCare (NCT07214974)
- Testing
- Structured wellness care, Wearable brain-computer interface devices, Stem Cell Therapy - Experimental
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Noah Tech, Corp.
Alzheimer Disease, Biomarkers / Blood
Blood Biomarkers for Early and Accurate Diagnosis of Alzheimer's Disease in Primary Care
Alzheimer's disease is a degenerative condition affecting the brain and is the most common form of dementia in older adults. Dementia is currently a major healthcare issue in the UK, affecting approximately a million people.
- Conditions
- Alzheimer Disease, Biomarkers / Blood, Biomarker in Early Diagnosis, Mild Cognitive Impairment (MCI)
- Trial name
- BEAD-PC (NCT07401849)
- Volunteers
- 1,000 people
- Sponsor
- Imperial College London
Alzheimer Disease, Biomarker in Early Diagnosis
miR-342-5p/AnkG Pathway in Early AD Synaptic Dysfunction
Alzheimer's disease is the most common memory loss disease among the elderly. This disease affects the patient's memory, language, attention, and behavioral abilities.
- Trial name
- NCT07353502
- Testing
- Collect peripheral blood, and if the patient consents, also collect cerebrospinal fluid.
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Early Diagnosis of Acute Kidney Injury
Early Prediction and Diagnosis of Acute Kidney Injury
The goal of this clinical trial is to estimate the accuracy of renal resistive index in early diagnosis and prediction of acute kidney injury in patients with hemorrhagic stroke.
- Trial name
- NCT07181174
- Testing
- Ultrasonographic examination and doppler ultrasonography will be performed using a convex transducer.
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Aswan University
T1 Gastric Cancer Lymph Node Metastasis Early Gastric Cancer Artificial Intelligence-Assisted Diagnosis Multimodal Data Integration
Multimodal Deep Learning for Lymph Node Metastasis Prediction and Physician Performance Assessment in T1 Gastric Cancer
This study aims to develop and validate an artificial intelligence (AI) model that integrates clinical, pathological, and imaging data to predict the presence of lymph node metastasis (LNM) in patients with T1-stage gastric…
- Trial name
- NCT07124754
- Testing
- Multimodal Artificial Intelligence Diagnostic Model for Lymph Node Metastasis in T1 Gastric Cancer
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Qun Zhao
HIV Antiretroviral Therapy (ART) Adherence, PMTCT
Optimizing Prevention and Care for Pregnant and Postpartum Adolescent Girls and Young Women With HIV in Tanzania
The goal of this clinical trial is to find better ways to care for pregnant and postpartum adolescent girls and young women (AGYW) aged 15-24 years with HIV in Tanzania, and to prevent them from passing HIV to their babies.
- Conditions
- HIV Antiretroviral Therapy (ART) Adherence, PMTCT, Pregnancy, Retention in Care
- Trial name
- ENGAGE (NCT06605053)
- Testing
- Co-produced intervention to optimize PMTCT care engagement
- Where
- 2 sites in Tanzania
- Volunteers
- 222 people
- Sponsor
- Karolinska Institutet
Ovarian Neoplasms, Endometrial Neoplasms
DOvEEgene/WISE Genomics: Diagnosing Ovarian and Endometrial Cancer Early Using Genomics
This study aims to develop and validate a test for detecting ovarian and endometrial cancers early. It relies on detecting somatic mutations that are associated with these cancers from a uterine pap test.
- Conditions
- Ovarian Neoplasms, Endometrial Neoplasms, Endometrial Cancer, Ovarian Cancer
- Trial name
- DOvEEgene (NCT02288676)
- Where
- Canada
- Volunteers
- 1,200 people
- Sponsor
- McGill University
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
CoRDS, or the Coordination of Rare Diseases at Sanford, is based at Sanford Research in Sioux Falls, South Dakota. It provides researchers with a centralized, international patient registry for all rare diseases.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- 2 sites in United States, Australia
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Heart Failure, Ventricular Dysfunction, Left
ECG Low Ejection Fraction Detection and Guiding in AI Navigated Treatment Era
Asymptomatic left ventricular systolic dysfunction (ALVSD), identified as a key component of stage B heart failure (HF) by AHA/ACC guidelines, is a common precursor to clinically overt HF.
- Conditions
- Heart Failure, Ventricular Dysfunction, Left, Artificial Intelligence, Early Diagnosis
- Trial name
- ELEGANT (NCT06968533)
- Testing
- AI-ECG guided diagnosis
- Where
- Taiwan
- Volunteers
- 13,350 people, healthy volunteers welcome
- Sponsor
- National Defense Medical Center, Taiwan
Mammography, Early Diagnosis of Cancer
The Effect of Virtual Reality on Pain, Anxiety and Satisfaction Level Before Mammography
In this study, it is planned to determine the effect of virtual reality applied to women before mammography on pain, anxiety and satisfaction levels.
- Trial name
- NCT06265207
- Testing
- Virtual reality, routine maintenance
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Ardahan University
Dementia of Alzheimer Type, Alzheimer Disease
Prevalence of Alzheimer's Disease Pathology in the Community
The goal of this observational study is to (I) study the proportion of people with Alzheimer's disease pathology in a large Norwegian population-based cohort of people aged 70 years or older and to (II) study longitudinal changes…
- Conditions
- Dementia of Alzheimer Type, Alzheimer Disease, Mild Cognitive Impairment, Pathology
- Trial name
- HUNT4AD (NCT06719453)
- Volunteers
- 9,663 people, healthy volunteers welcome
- Sponsor
- Helse Stavanger HF
Oropharyngeal Cancers, Biomarker in Early Diagnosis
Active MMP-8 in Oral Fluid for the Detection of Oral and Oropharyngeal Cancer
The goal of this observational study is to evaluate whether the active-matrix metalloproteinase-8 (aMMP-8) mouth-rinse test can help detect oral and oropharyngeal cancers.
- Conditions
- Oropharyngeal Cancers, Biomarker in Early Diagnosis, Oral Cancer , Oral Squamous Cell Carcinoma, Oral Cavity Cancer, Periodontal Diseases
- Trial name
- NCT06701058
- Where
- Finland
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
HIV, Neonatal HIV Early-Infant-Diagnosis (EID), Point-of-Care Testing (PoC)
Neonatal HIV Early Infant Diagnosis (EID) Versus Standard of Care EID- Long Term Impact on inFant hEalth (LIFE)
This study we will evaluate the benefit of HIV testing in neonates born from HIV-infected mothers in Tanzania and Mozambique. The study will use and evaluate novel point-of-care diagnostic systems, that can provide neonatal HIV…
- Trial name
- LIFE (NCT04032522)
- Testing
- point-of care (PoC) neonatal HIV early infant diagnosis (EID)
- Where
- 2 sites in Mozambique, Tanzania
- Volunteers
- 6,602 people
- Sponsor
- Michael Hoelscher
Nasopharyngeal Carcinoma, Early Diagnosis of Cancer
Methylation-specific PCR Test for Early Screening and Early Diagnosis of Nasopharyngeal Carcinoma
Nasopharyngeal carcinoma is one of the most common malignant tumors in China, with the progress of radiochemical comprehensive treatment, early stage The 5-year survival rate of nasopharyngeal cancer is more than 95%.
- Trial name
- NCT06367049
- Testing
- Methylation-specific PCR
- Where
- China
- Volunteers
- 470 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University