Clinical trials: Clinical High Risk
Clinical High Risk for Psychosis (CHR), Suicidal Ideation
Developing a Recovery-Oriented Suicide Prevention Program for Young People at Clinical High Risk for Psychosis
Young people at clinical high risk for psychosis are more likely to experience suicide thoughts than the general population, but there are few suicide prevention programs designed specifically for them.
- Conditions
- Clinical High Risk for Psychosis (CHR), Suicidal Ideation, Psychosis, Suicidal Behavior
- Trial name
- NCT07756567
- Testing
- Suicide Prevention Intervention, Standard Care (in control arm)
- Where
- 2 sites in United States
- Volunteers
- 108 people
- Sponsor
- University of California, San Diego
Schizophrenia, Clinical High Risk for Psychosis (CHR)
Mobile Thinking Intervention: A Inital Test
This study will test the inital efficacy of a brief mobile intervention targeting biased thinking.
- Trial name
- NCT06909422
- Testing
- Mobile Intervention for Biased Thinking
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Alabama at Birmingham
Clinical High Risk for Psychosis (CHR), Clinical High Risk for Psychosis
Stratification and Treatment in Early Psychosis Study - PROMOTE
The purpose of this trial is: To investigate whether cannabidiol (CBD), compared to placebo, can reduce the severity of attenuated psychotic symptoms in individuals at clinical high risk for psychosis.
- Conditions
- Clinical High Risk for Psychosis (CHR), Clinical High Risk for Psychosis, Clinical High Risk for Developing Psychosis
- Trial name
- STEP-PROMOTE (NCT07434973)
- Testing
- Cannabidiol (CBD)
- Where
- 19 sites in Austria, Canada and 8 more
- Volunteers
- 586 people, healthy volunteers welcome
- Sponsor
- University of Oxford
First Episode Psychosis (FEP), Clinical High Risk for Psychosis (CHR)
Reducing the Duration of Untreated Psychosis in the United States: The Impact of Screening and Systematic Communication
The goal of this project is to investigate whether a systematic screening approach enhanced by an innovative model of communicating information about psychosis and treatment options to patients and families (ComPsych) can reduce…
- Trial name
- EaSIE (NCT05509998)
- Testing
- Screening Method (SM), Screening and Communication Method (SCM)
- Where
- United States
- Volunteers
- 912 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Clinical High Risk for Developing Psychosis
Stepped Care for Youth at Risk of Psychosis
The study will recruit 60 young people who meet established criteria for being at clinical high risk for psychosis. They will be offered a range of psychological interventions starting with the most benign treatments in different…
- Trial name
- NCT04829292
- Testing
- Supportive therapy and CBT
- Where
- Canada
- Volunteers
- 61 people
- Sponsor
- University of Calgary
Clinical High Risk for Psychosis (CHR)
Digital Dialectical Behavioural Therapy (d-DBT) for Youth at Clinical High Risk (CHR) for Psychosis
This study examines the feasibility and acceptability of a digital dialectical behavior therapy (d-DBT) intervention for youth at clinical high risk (CHR) for psychosis.
- Trial name
- NCT06928935
- Testing
- d-DBT
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Centre for Addiction and Mental Health
Clinical High Risk for Psychosis (CHR), Psychotic Disorders
Accelerated Neuromodulation Therapy and Neurocomputational Biomarkers in Individuals at Clinical High Risk for Psychosis
The goal of this study is to learn whether an accelerated form of neuromodulation therapy is safe, feasible, and well tolerated in young people at clinical high risk for psychosis (CHR-P), and whether it is associated with…
- Conditions
- Clinical High Risk for Psychosis (CHR), Psychotic Disorders, Prodromal Symptoms
- Trial name
- TMS-CHR (NCT07786714)
- Testing
- Active Intermittent Theta Burst Stimulation (BEAM-F3 Targeting)
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Douglas Mental Health University Institute
Clinical High Risk for Psychosis (CHR)
A Multimodal Imaging Study of Dopamine in Early Psychosis
The development of new treatments for psychosis, a psychiatric condition that is prevalent and highly disabling despite antipsychotic medications, has been limited, in part, by a lack of information from brain imaging studies…
- Trial name
- MISDEP (NCT06977308)
- Testing
- Methylphenidate (MPH), [11C]raclopride
- Volunteers
- 115 people
- Sponsor
- New York State Psychiatric Institute
Schizophrenia, Cognitive Impairment
Eye-Movement Intervention for Cognitive Impairment Across Schizophrenia Spectrum
The goal of this clinical trial is to determine whether a gamified eye-movement intervention can improve cognitive function in individuals across the schizophrenia spectrum, including clinical high-risk individuals, first-episode…
- Conditions
- Schizophrenia, Cognitive Impairment, Clinical High Risk for Psychosis
- Trial name
- NCT07702526
- Testing
- Eye-Movement Training, Finger-Controlled Game Training
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
High-Risk Multidisciplinary Care, Clinical Decision Support
ANCHOR Validation Trial in High-Risk Multidisciplinary Care
This pre-registered, pragmatic, three-arm (1:1:1) patient-level randomized controlled trial with mixed-effects analysis at the encounter level tests two questions in real high-risk multidisciplinary clinical encounters at the…
- Conditions
- High-Risk Multidisciplinary Care, Clinical Decision Support, Artificial Intelligence-Assisted Care, Telemedicine
- Trial name
- NCT07597499
- Testing
- Gemini 3.1 Pro with Safety Prompt, ANCHOR Clinical AI Verification Layer (with Gemini 3.1 Pro)
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Waymark
Clinical High Risk, Early Psychosis
Digital Strategies to Advance Help-Seeking - Aim 3
This proposal aims to establish a Digital Laboratory focused on advancing help-seeking and expediting treatment initiation in youth ages 12-29 who are at Clinical High-Risk (CHR) for developing psychosis.
- Conditions
- Clinical High Risk, Early Psychosis, First Episode Psychosis
- Trial name
- NCT06774417
- Testing
- Digital nudge
- Where
- United States
- Volunteers
- 25,000 people
- Sponsor
- Columbia University
Clinical High Risk for Psychosis (CHR)
A Study Exploring Changes in a Variety of Biomarkers Following Dosing With MT1988 in Participants at Clinical High Risk for Psychosis
The goal of this clinical trial is to learn how tests undertaken by people at high risk of developing psychosis (aged 17 to 30 years old) change when those people are given the study drug MT1988 daily for 8 weeks.
- Trial name
- NCT07226895
- Testing
- MT1988 Low Dose, MT1988 High Dose
- Where
- 15 sites in United States
- Volunteers
- 150 people
- Sponsor
- Monument Therapeutics Limited
Clinical High Risk Syndrome of Psychosis
Decreasing Risk of Psychosis by Sulforaphane (DROPS Trial)
This is a randomized, double-blind, placebo-controlled, multi-centre trial. A total of 300 CHR subjects will be identified in the course of face-to-face interviews using the Structured Interview for Prodromal Syndromes.
- Trial name
- NCT03932136
- Testing
- Sulforaphane
- Where
- 9 sites in China
- Volunteers
- 300 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Lung Protective Ventilation, Cardiopulmonary Bypass
Unilateral Ventilation on Cardiopulmonary Bypass During Cardiac Surgery
This study investigates if single lung ventilation on cardiopulmonary bypass can mitigate postoperative lung water accumulation determined by lung ultrasound in the ventilated lung as compared to the non-ventilated lung in…
- Conditions
- Lung Protective Ventilation, Cardiopulmonary Bypass, High-risk Cardiac Patients, Lung Ultrasound
- Trial name
- NCT07612709
- Testing
- Ventilated lung, Non-ventilated lung.
- Where
- Austria
- Volunteers
- 45 people
- Sponsor
- Medical University of Vienna
Clinical High Risk, Early Psychosis
Digital Strategies to Advance Help-Seeking Aim 1 and 2
This proposal aims to establish a Digital Laboratory focused on advancing help-seeking and expediting treatment initiation in youth ages 12-29 who are at Clinical High-Risk (CHR) for developing psychosis.
- Conditions
- Clinical High Risk, Early Psychosis, First Episode Psychosis
- Trial name
- NCT06774430
- Where
- United States
- Volunteers
- 25,000 people
- Sponsor
- Columbia University
Clinical High Risk for Psychosis (CHR)
French Validation of Schizophrenia Proneness Instrument- Child Youth
The clinical concept of a at risk mental state of developing psychosis is based on the identification of attenuated psychotic symptoms during the prodromal phase of psychoses (Schmidt et al., 2015).
- Trial name
- SPI-CY-Fr (NCT06649552)
- Testing
- Psychiatric and psychological diagnostic tests
- Where
- 3 sites in France
- Volunteers
- 52 people
- Sponsor
- Centre Psychothérapique de Nancy
Clinical High Risk for Psychosis (CHR)
Experience of UHR and PEP Individuals During Mindfulness: a Qualitative Phenomenological Study
The goal of this qualitative study is to explore and describe the lived experiences of individuals at ultra-high risk (UHR) or first episode of psychosis (FEP) who have participated in a group-based mindfulness-based…
- Trial name
- EMIP (NCT07499934)
- Testing
- Qualitative interview
- Where
- 2 sites in France
- Volunteers
- 20 people
- Sponsor
- Centre Psychothérapique de Nancy
Clinical High Risk for Psychosis (CHR)
Efficacy of Mindfulness in PREventing Progression to Psychosis in Individuals With an Ultra High Risk for Psychosis
The main objective is to evaluate the efficacy of a group-based mindfulness therapy programme in reducing distress associated with symptoms of UHR (Ultra High Risk) or FEP (first psychotic episode) compared with usual treatment.
- Trial name
- EM-PREPS (NCT06870305)
- Testing
- MBTP : Mindflulness based training for psychosis
- Where
- 2 sites in France
- Volunteers
- 270 people
- Sponsor
- Centre Psychothérapique de Nancy
Clinical High-Risk, Psychological
Skills Group for Youth at Clinical High-Risk for Psychosis
This study is intended to test the feasibility of an integrated cognitive behavioral therapy (CBT) and dialectical behavioral therapy (DBT) skills group for adolescents and young adults at clinical high-risk (CHR) for psychosis.
- Trial name
- NCT05398120
- Testing
- Skills Group
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Pittsburgh
Clinical High Risk for Psychosis
Individualized Vocational and Educational Support and Training for Clinical High Risk for Psychosis (InVEST)
The purpose of this study is to test the efficacy of InVEST (Individualized Vocational and Educational Support and Training) for CHR-P (clinical high risk for psychosis) to address specific role functioning difficulties…
- Trial name
- InVEST (NCT05114733)
- Testing
- InVEST
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Beth Israel Deaconess Medical Center