SchizophreniaNCT06909422
Mobile Thinking Intervention: A Inital Test
A study testing Mobile Intervention for Biased Thinking in people with Schizophrenia and Clinical High Risk for Psychosis (CHR), run by University of Alabama at Birmingham at 1 site in United States.
Trial summary
This study will test the inital efficacy of a brief mobile intervention targeting biased thinking. Read more about this study
- Who is it for?
- Ages 18 to 65 years
- Conditions the study is for
- Schizophrenia, Clinical High Risk for Psychosis (CHR)
- What is being tested?
- Mobile Intervention for Biased Thinking
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 100 participants
- Where
- 1 siteUnited States
- Study dates
- Dec 2026to Dec 2028
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 65 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Diagnosis of schizophrenia or related psychotic disorder OR
- Identified as being at clinical high risk for psychosis in symptom interviews
Who cannot join
- Recent changes in mental health treatment in past month or two months if on depot
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United States1 site
University of Alabama at Birmingham
Birmingham, Alabama, 35223-1517
Lauren Luther, 205-530-1117, cas-treatlab@uab.edu
About this study
Official title: A Mobile Intervention to Enhance Your Mood: A Test of the Acceptability and Efficacy
This study will test the inital efficacy of a brief mobile intervention targeting biased thinking.
- Being tested
- Mobile Intervention for Biased Thinking
- Medical subject headings
- Schizophrenia
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Mobile Intervention for Biased ThinkingBehavioural
This intervention will be delivered via a mobile application.
| Study group | Role | What they receive |
|---|---|---|
| Mobile Intervention to Target Biased Thinking | Experimental | Not described Receives: Behavioral: Mobile Intervention for Biased Thinking |
What is being measured
The primary outcome is the main question the study is designed to answer.
Defeatist Beliefs Scale - 15
Measure of Defeatist Performance Beliefs
Measured: Measured at Baseline and post intervention (6 weeks)
Brief Negative Symptoms Scale
Measure of negative symptoms
Measured: Measured at Baseline and post intervention (6 weeks)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted3 Apr 2025
- Study startDec 2026 (estimated)
- Primary completionAug 2028 (estimated)
- Study completionDec 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for SchizophreniaStudies of the same condition, open and under way.
- More trials run by University of Alabama at BirminghamThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Non-randomised
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 100 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of Alabama at Birmingham
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Lauren Luther, University of Alabama at Birmingham
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06909422
- Sponsor's protocol ID
- IRB-300013893
- Other IDs
- Internal Award
- Status last verified
- Oct 2026
- First submitted
- 27 Mar 2025
- Last updated
- 13 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided: Will be shared upon reasonable request
Publications
Granholm E, Holden J, Dwyer K, Mikhael T, Link P, Depp C. Mobile-Assisted Cognitive Behavioral Therapy for Negative Symptoms: Open Single-Arm Trial With Schizophrenia Patients. JMIR Ment Health. 2020 Dec 1;7(12):e24406. doi: 10.2196/24406.
PubMed 33258792
Study at a glance
From the registry record, last updated by the sponsor on 13 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- A Mobile Intervention to Enhance Your Mood: A Test of the Acceptability and Efficacy
- ClinicalTrials.gov ID
- NCT06909422
- Acronym / sponsor ID
- IRB-300013893
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 100 participants (estimated)
- Lead sponsor
- University of Alabama at BirminghamUniversity, hospital or other
- Study start
- Dec 2026 (estimated)
- Primary completion
- Aug 2028 (estimated)
- Study completion
- Dec 2028 (estimated)
- First posted
- 3 Apr 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study will test the inital efficacy of a brief mobile intervention targeting biased thinking.
Study design
- Primary purpose
- Treatment
- Allocation
- Non-randomised
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Mobile Intervention to Target Biased Thinking | Experimental | Behavioral: Mobile Intervention for Biased Thinking |
Who may qualify
- Ages
- 18 to 65 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (2 listed)
- Diagnosis of schizophrenia or related psychotic disorder OR
- Identified as being at clinical high risk for psychosis in symptom interviews
Key exclusion criteria (1 listed)
- Recent changes in mental health treatment in past month or two months if on depot
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Mobile Intervention for Biased ThinkingThis intervention will be delivered via a mobile application. | Behavioural | Mobile Intervention to Target Biased Thinking |
Primary outcome
Defeatist Beliefs Scale - 15
Time frame: Measured at Baseline and post intervention (6 weeks)
Measure of Defeatist Performance Beliefs
Brief Negative Symptoms Scale
Time frame: Measured at Baseline and post intervention (6 weeks)
Measure of negative symptoms
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 13 Oct 2026.
- Background: PubMed 33258792Granholm E, Holden J, Dwyer K, Mikhael T, Link P, Depp C. Mobile-Assisted Cognitive Behavioral Therapy for Negative Symptoms: Open Single-Arm Trial With Schizophrenia Patients. JMIR Ment Health. 2020 Dec 1;7(12):e24406. doi: 10.2196/24406.
- Individual participant dataSharing planned: Undecided. Will be shared upon reasonable request
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Mobile Intervention for Biased Thinking in people with Schizophrenia and Clinical High Risk for Psychosis (CHR), run by University of Alabama at Birmingham at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 13 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Lauren Luther (205-530-1117, cas-treatlab@uab.edu), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Defeatist Beliefs Scale - 15 (time frame: Measured at Baseline and post intervention (6 weeks)). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06909422, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 13 Oct 2026.