Clinical trials: Brain Metastasases
Brain (Nervous System) Cancers, Brain Metastasases
Combined Gamma Knife/Linac Radiosurgery for Large Brain Tumors / Metastases
When cancer spreads to the brain, doctors often use a precise type of radiation therapy called stereotactic radiosurgery (SRS) to treat these tumors.
- Conditions
- Brain (Nervous System) Cancers, Brain Metastasases, SRS
- Trial name
- GK-LIVE (NCT07162246)
- Testing
- Radiation Therapy
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Sunnybrook Health Sciences Centre
Brain Metastasases
Precision Radiotherapy for Refractory Brain Metastases: A Multicenter Study
Conventional image-guided techniques (such as cone-beam CT) have poor soft tissue contrast and unsatisfactory treatment outcomes.
- Trial name
- NCT07586657
- Testing
- adaptive radiotherapy
- Volunteers
- 200 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Brain Metastasases
Evaluation of Repeated Whole Brain Radiotherapy Versus Best Supportive Care for Multiple Brain Metastases.
Whole Brain Radiotherapy (WBRT) has been established as the treatment standard in patients with multiple cerebral metastases from solid tumors.
- Trial name
- ERASER (NCT03288272)
- Testing
- Whole Brain Radiotherapy, Best Supportive Care
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Stephanie Combs
Glioblastoma (GBM), Brain Metastasases
A Phase 0/1 Clinical Trial With an Expansion Phase of GSK5764227, a B7-H3-Targeted Antibody-Drug Conjugate (ADC), in Patients With Recurrent Grade 4 Glioma and Patients With Brain Metastases
This will be an open-label Phase 0/1 study that will enroll approximately 15 participants, 9 participants with recurrent WHO Grade 4 glioma (rGBM) and 6 participants with brain metastases, who will receive the investigational…
- Trial name
- NCT07268053
- Testing
- Risvutatug rezetecan
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Nader Sanai
Triple Negative Breast Cancer (TNBC), Brain Metastasases
JK-1201I in Triple Negative Breast Cancer Patients with Brain Metastases
This study was designed to evaluate the safety, efficacy and pharmacokinetics of JK-1201I in triple negative breast cancer patients with brain metastases.
- Trial name
- NCT06586866
- Testing
- JK-1201I
- Volunteers
- 25 people
- Sponsor
- JenKem Technology Co., Ltd.
NSCLC (Advanced Non-small Cell Lung Cancer), Brain Metastasases
AI-guided Prognostication and Cranial Radiotherapy Optimization in EGFR-TKI-treated Non-small Cell Lung Cancer Patients With Baseline Brain Metastases
The goal of this observational study is to extract the imaging features of brain lesions and primary lung lesions in NSCLC patients with brain metastases by deep learning, as well as common clinicopathological parameters, which…
- Trial name
- NCT06604689
- Testing
- third-generation EGFR TKIs (Almonertinib/Furmonertinib/Osimertinib)
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Fudan University
Brain Metastasases
A Study of Stereotactic Radiosurgery (SRS) in People With Brain Cancer Having Tumor Resection Surgery
The researchers are doing this study to see if treating people's brain tumors with stereotactic radiosurgery (SRS) before tumor resection surgery will prevent cancer cells from spreading to other areas of the brain, including the…
- Trial name
- NCT07802353
- Testing
- Stereotactic Radiosurgery, Surgical Resection
- Where
- 7 sites in United States
- Volunteers
- 50 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Brain (Nervous System) Cancers, Glioma
Connectome-guided Onco-functional Resection With Tractography-Extended Neuronavigation in Brain Tumor Surgery
Brain tumor surgery in so-called "eloquent" brain areas aims to remove as much tumor as possible while preserving neurological functions.
- Conditions
- Brain (Nervous System) Cancers, Glioma, Brain Metastasases, Brain Connectivity
- Trial name
- CORTEx (NCT07717827)
- Testing
- Connectome-guided network-based neuronavigation, Advanced diffusion MRI tractography and connectome pipeline
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- ARNAS Civico Di Cristina Benfratelli Hospital
Non Small Cell Lung, Brain Metastasases
Impact of Radiotherapy-Immunotherapy Timing in NSCLC Brain Metastases
The goal of this observational study is to learn about the effects of the timing of radiation therapy and immunotherapy in adults with non-small cell lung cancer (NSCLC) that has spread to the brain.
- Trial name
- (RT-ICI) (NCT07638709)
- Testing
- Brain radiotherapy
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Xiangya Hospital of Central South University
Brain Metastasases
Magnetic Resonance-Guided Laser Interstitial Thermal Therapy for Brain Metastases Trial
In accordance with the requirements of the "Good Clinical Practice for Medical Devices", this clinical trial is conducted to further evaluate the safety and efficacy of the magnetic resonance-guided laser ablation treatment…
- Trial name
- NCT07132203
- Testing
- Laser interstitial thermal therapy
- Where
- 6 sites in China
- Volunteers
- 98 people
- Sponsor
- Beijing Tiantan Hospital
Melanoma (Skin Cancer), Breast Cancer
Phase Ib Study of AlpeliSib With PEmbroLizumab in Patients With mEtastatic Breast caNcer or melanomA (SELENA)
To find a recommended dose of the combination of alpelisib and pembrolizumab that can be given to patients with metastatic breast cancer or melanoma.
- Conditions
- Melanoma (Skin Cancer), Breast Cancer, Brain Metastasases
- Trial name
- NCT06545682
- Testing
- Alpelisib + Pembrolizumab
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- M.D. Anderson Cancer Center
Radiation Necrosis, High Grade Glioma (III or IV)
Bevacizumab Versus Corticosteroids as First-line Treatment in Patients With Symptomatic Cerebral Radiation Necrosis After Radiation for High-grade Glioma or Brain Metastases
Cerebral radiation necrosis (CRN) is a severe complication of high-dose radiation for brain metastases (BM) or glioma, which can potentially cause significant neurologic symptoms leading to serious morbidity and impaired quality…
- Conditions
- Radiation Necrosis, High Grade Glioma (III or IV), Brain Metastasases, Radiation Toxicity
- Trial name
- BRAINS (NCT06888817)
- Testing
- Bevacizumab, Dexamethasone
- Where
- 6 sites in Netherlands
- Volunteers
- 408 people
- Sponsor
- The Netherlands Cancer Institute
TNBC, Triple Negative Breast Cancer, Brain Metastasases
Study of Radiotherapy Combined With Cisplatin/Carboplatin, Adebrelimab and Bevacizumab in the Treatment of TNBC-BM.
This is an open-label, prospective, two-arm, multicenter phase II clinical trial. The aim is to explore the efficacy and safety of radiotherapy combined with cisplatin/carboplatin, adebrelimab, and bevacizumab in patients with…
- Trial name
- ABC-R (NCT07638852)
- Testing
- Radiation Therapy, Adebelimab, Bevacizumab
- Where
- China
- Volunteers
- 58 people
- Sponsor
- Fudan University
Breast Cancer Metastatic, Brain Metastasases
Study Investigating the Role of Routine Screening and Molecular Characterisation of Brain Metastasis in the Management of High-risk Metastatic Breast Cancer
The purpose of this study is to improve outcome of breast cancer patients who develop brain metastases. This will investigate the benefits of early detection of brain metastases using brain imaging.
- Trial name
- STORM (NCT06728150)
- Testing
- computerized tomography
- Where
- Australia
- Volunteers
- 45 people
- Sponsor
- Monash University
Solid Tumor Malignancies, Brain Metastasases
Exploring the Feasibility of Cerebrospinal Fluid (CSF) and Blood Plasma Liquid Biopsy in Patients With Metastatic Solid Tumours and Primary Central Nervous System (CNS) Tumours: A Pilot Study
This is a prospective, single-centre feasibility study of CSF ctDNA conducted at the Sunnybrook Odette Cancer Centre (SOCC), Toronto, Canada, including multiple solid tumor, stratified into cohorts according to CNS disease…
- Conditions
- Solid Tumor Malignancies, Brain Metastasases, Leptomeningeal Disease (LMD), Central Nervous System
- Trial name
- ECLIPSE (NCT07476781)
- Testing
- One time CSF and blood sample
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Sunnybrook Health Sciences Centre
NSCLC, Brain Metastasases
A Multicenter, Single-arm, Open-label Study Evaluating the Safety and Efficacy of AK112 Combined With Chemotherapy as First-line Treatment for Non-squamous NSCLC Patients With BRAIN Metastases and Negative Driver Genes (IVO BRAIN)
A multicenter, single-arm, open-label study evaluating the safety and efficacy of AK112 combined with chemotherapy as first-line treatment for non-squamous NSCLC patients with BRAIN metastases and negative driver genes
- Trial name
- NCT06684873
- Testing
- AK112 Injection
- Where
- China
- Volunteers
- 55 people
- Sponsor
- Sun Yat-sen University
Lung Cancer, Brain Metastasases
Annual Brain MRI Surveillance for Detection of Brain Metastasis in Patients With Lung Cancer
This retrospective observational study will evaluate the effectiveness of periodic brain magnetic resonance imaging surveillance for detecting brain metastasis in patients with lung cancer.
- Conditions
- Lung Cancer, Brain Metastasases, MRI, Surveillance
- Trial name
- NCT07646041
- Volunteers
- 229,323 people
- Sponsor
- Samsung Medical Center