Clinical trials: Bone Marrow Oedema
Bone Marrow Edema
Assessment of Efficacy of Zoledronic Acid in the Treatment of Bone Marrow Edema Syndrome
The primary aim is to test the reduction of bone marrow edema syndrome after a singular intravenous treatment with Zoledronic Acid within 6 weeks compared to placebo.
- Trial name
- ZoMARS (NCT01348269)
- Testing
- Aclasta
- Where
- 2 sites in Germany
- Volunteers
- 48 people
- Sponsor
- Wuerzburg University Hospital
Bone Marrow Edema
Functional Magnetic Stimulation (FMS) for Bone Marrow Edema in Athletes
This randomized controlled trial evaluates whether Functional Magnetic Stimulation (FMS) can provide additional benefits when combined with a structured physiotherapy rehabilitation program in athletes with MRI-confirmed tibial…
- Trial name
- NCT07234084
- Testing
- Standardized physiotherapy rehabilitation with FMS, Standardized Physiotherapy without FMS
- Where
- Greece
- Volunteers
- 40 people
- Sponsor
- International Hellenic University
Bone Marrow Edema, Knee Pain Chronic
Subchondroplasty® Knee RCT
This is a multi-center, prospective, single-blinded, two-arm study, randomized to include approximately 134 subjects treated with Subchondroplasty (SCP) + Arthroscopy and 67 subjects with arthroscopy alone.
- Conditions
- Bone Marrow Edema, Knee Pain Chronic, Knee Osteoarthritis, Osteoarthritis, Knee
- Trial name
- PRESERVE Knee (NCT03112200)
- Testing
- Subchondroplasty with Arthroscopy, Arthroscopy Alone
- Where
- 13 sites in United States, Canada
- Volunteers
- 131 people
- Sponsor
- Zimmer Biomet
Bone Marrow Oedema Syndrome, High Turnover Bone Disease
Treatment of Atraumatic Bone Marrow Edema With Denosumab and Teriparatide vs Placebo
The etiology of bone marrow edema (BME) is still uncertain. Several studies report therapeutic success with antiresorptive drugs. This study investigates antiresorptive and osteoanabolic drugs versus placebo in BME
- Conditions
- Bone Marrow Oedema Syndrome, High Turnover Bone Disease, Quality of Life
- Trial name
- NCT01734824
- Testing
- Denosumab, Teriparatide
- Where
- Austria
- Volunteers
- 90 people
- Sponsor
- Medical University of Vienna
Bone Marrow Edema
SCP® Observational Study of the Knee
Post Market clinical outcomes study to collect data on the short - and long-term outcomes for subjects who are undergoing or who have undergone the Subchondroplasty (SCP) Procedure in the knee in a standard clinical setting.
- Trial name
- NCT03110224
- Testing
- Subchondroplasty Procedure with AccuFill
- Where
- 14 sites in United States
- Volunteers
- 516 people
- Sponsor
- Zimmer Biomet
Fractures, Bone, Bone Marrow Edema
Prospective Study of Diagnostic Accuracy of Spectral CT for the Detection of Bone Marrow Edema
Dual-Energy/Multi-Energy/Spectral-CT can visualize bone marrow edema associated with fractures, however, current scientific evidence is mostly derived from to retrospective analyses.
- Trial name
- NCT04963127
- Testing
- Computed Tomography of the skeleton using a Dual-Energy-/Multi-Energy-/Spectral acquisition mode, Computed Tomography of the skeleton using a conventional single-energy / non-spectral acquisition mode
- Where
- Germany
- Volunteers
- 800 people
- Sponsor
- University Hospital Augsburg
Chronic Pain, Bone Marrow Oedema
TEP Versus Open Repair of Sportsman's Hernia
Sportsman's hernia causes chronic groin pain in physically active adults. Open hernia repair without mesh or laparoscopic technique with mesh have been advocated in the treatment of sportsman's hernia.
- Trial name
- sports hernia (NCT01876342)
- Testing
- open repair, endoscopic TEP repair
- Where
- Finland
- Volunteers
- 60 people
- Sponsor
- Kuopio University Hospital
Retinitis, Behcet's Syndrome
Stem Cell Transplantation in Ocular Lesions of Behcet's Disease
The purpose of this study is to find if autologous stem cell transplantation can stop the progression of intractable eye lesions of Behcet's Disease or even to improve it.
- Trial name
- NCT00550498
- Testing
- Autologous Stem Cell Transplantation
- Where
- Iran
- Volunteers
- 5 people
- Sponsor
- Tehran University of Medical Sciences
Bone Marrow Edema
Evaluation of Subchondroplasty™ for Defects Associated With Bone Marrow Lesions
Studying long-term changes in a sub-set of patients who undergo the Subchondroplasty procedure including changes in pain, function, and overall health.
- Trial name
- SCP (NCT01621893)
- Testing
- Subchondroplasty
- Where
- 6 sites in United States
- Volunteers
- 70 people
- Sponsor
- Zimmer Biomet
Bone Marrow Edema
Clinical and Radiological Outcomes of Subchondroplasty in the Treatment of Bone Marrow Edema of the Knee
Bone marrow lesions (BMLs) of the knee are common subchondral defects, often associated with pain and functional limitation. Subchondroplasty is a percutaneous procedure in which calcium phosphate is injected inside BML areas…
- Trial name
- NCT04905394
- Testing
- subchondroplasty
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- University of Milan
Vertebral Fracture, Osteoporotic Fractures
CCEF in the Treatment of Acute VFFs: Randomized Controlled Trial
in recent years the search for therapeutic protocols that could enhance the VFFs healing, thus reducing bed rest-related complications and improving the quality of life of osteoporotic patients.
- Trial name
- NCT05803681
- Testing
- Capacitive Coupled Electric Fields (CCEF), Calssic clinical protocol
- Volunteers
- 70 people
- Sponsor
- University of Bari Aldo Moro
Osteonecrosis of the Knee, Bone Marrow Edema of the Knee
Study Into the Effect of Ibandronate for the Treatment of Bone Marrow Edema in Relation to Spontaneous or Non-traumatic Osteonecrosis of the Knee: A Randomized Double-blind, Placebo-controlled Trial
BACKGROUND: Bone marrow edema (BME) in the knee occurs as a localized inflammatory disease in relation to spontaneous or non-traumatic osteonecrosis (ON).
- Trial name
- NCT00532220
- Testing
- Ibandronate IV
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University Hospital, Basel, Switzerland
Bone Marrow Edema, Knee Osteoarthritis
Focused Extracorporeal Shockwave Therapy for Knee Arthritis
Subchondral bone marrow lesions (BMLs) in knee osteoarthritis (OA) are strongly associated with presence and severity of knee pain, structural deterioration, disease progression with an increased risk of total knee arthroplasty.
- Conditions
- Bone Marrow Edema, Knee Osteoarthritis, Knee Pain Chronic
- Trial name
- NCT05596591
- Testing
- Focused extracorporeal shockwave therapy
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- Kessler Foundation
Bone Marrow Edema
Impact of Sacroiliac Joint Injection on Bone Marrow Edema
SpA is a chronic, debilitating inflammatory rheumatic disease that affects axial and peripheral joints, internal organs, and other tissues. Sacroiliitis is a hallmark of axial SpA.
- Trial name
- NCT04895228
- Testing
- injection
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Sohag University
Bone Marrow Edema
Subchondroplasty for Treatment of Bone Marrow Edema in the Foot and Ankle
The subchondroplasty procedure has been used to treat bone marrow edema mostly located in the periarticular region of the knee. In the past few years, it has expanded its use in the foot and ankle.
- Trial name
- NCT03921489
- Testing
- Subchondroplasty
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Ellianne M. Nasser
Knee Arthritis, Osteoarthritis, Bone Marrow Edema of the Knee
Extracorporeal Shock Wave Therapy in the Treatment of Periarticular Bone Marrow Edema in Patients With Knee Osteoarthritis
Bone marrow edema (BME) is a radiological finding characterized by increased fluid content and structural changes within the bone marrow. It most commonly affects weight-bearing joints such as the hip, knee, and ankle.
- Conditions
- Knee Arthritis, Osteoarthritis, Bone Marrow Edema of the Knee, Bone Marrow Edema
- Trial name
- NCT07887893
- Testing
- Radial Extracorporeal Shock Wave Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Dokuz Eylul University
Subchondral Cysts, Subchondral Bone Edema
SCP Hip Outcomes Study
Post-market clinical outcomes study to collect data on the short- and long-term outcomes for subjects who are undergoing or have undergone the Subchondroplasty® (SCP®) Procedure in the hip in a standard clinical setting.
- Conditions
- Subchondral Cysts, Subchondral Bone Edema, Bone Marrow Edema, Insufficiency Fractures
- Trial name
- NCT03494660
- Testing
- Subchondroplasty Procedure with AccuFill
- Where
- 6 sites in United States
- Volunteers
- 77 people
- Sponsor
- Zimmer Biomet
Osteoarthritis, Knee, Arthroscopy
Evaluating the Effectiveness of Subchondroplasty for Treating Bone Marrow Lesions of the Knee
The primary objective of this randomized pilot study is to evaluate whether subchondroplasty combined with knee arthroscopy is more effective at reducing knee pain and improving knee function compared to knee arthroscopy alone.
- Conditions
- Osteoarthritis, Knee, Arthroscopy, Musculoskeletal Disease, Bone Marrow Edema
- Trial name
- NCT03699046
- Testing
- Subchondroplasty and Knee Arthroscopy, Knee Arthroscopy Alone, Subchondroplasty
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- University of Calgary
Compression Fracture of Thoracic Vertebral Body, Spinal Compression Fracture
Dual-energy CT in Detecting Bone Marrow Edema of Vertebral Compression Fractures
The purpose of this study is to 1. Assess bone marrow edema within the VCF by use of a DE CT virtual noncalcium image compared with MR imaging as standard reference. 2.
- Trial name
- NCT01281826
- Where
- Taiwan
- Volunteers
- 70 people
- Sponsor
- National Cheng-Kung University Hospital
Rheumatoid Arthritis
A Pilot Study of MabThera (Rituximab) Evaluated by MRI in Patients With Rheumatoid Arthritis.
This single arm study will measure the effect of MabThera in combination with methotrexate on the progression of synovitis, the extent of bone marrow edema, and the number of erosions in the wrist and hand of patients with…
- Trial name
- NCT00502853
- Testing
- rituximab [MabThera/Rituxan], Methotrexate
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- Hoffmann-La Roche