Clinical trials: BDNF
Atrial Fibrillation (AF), Cardiac Arrhythmia
Association Between Circulating BDNF Levels and Atrial Cardiomyopathy in Patients Undergoing Ablation for Persistent Atrial Fibrillation
trial fibrillation (AF) is the most common cardiac arrhythmia worldwide, and its prevalence continues to rise. AF is associated with serious complications, including embolic strokes, heart failure, and mortality.
- Conditions
- Atrial Fibrillation (AF), Cardiac Arrhythmia, Atrial Fibrillation Ablation, BDNF
- Trial name
- METAPROFIL 2 (NCT07648329)
- Testing
- blood draw, CT scan
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
BDNF, Small Side Game
Comparing Touch-Limited and Free-Play 4v4 Small-Sided Games (SSGs)
This study aimed to compare acute serum BDNF and cognitive performance following touch-limited versus free-play 4v4 small-sided games (SSGs) in male soccer players.
- Conditions
- BDNF, Small Side Game, Football Players
- Trial name
- TOUCH-BDNF (NCT07395765)
- Testing
- SSGf, SSGr
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Aksaray University Training and Research Hospital
BDNF
Daily Fluctuations in Brain-Derived Neurotrophic Factor and Cognition: Effects of Vigorous Exercise
Cognitive functions are fundamental to everyday life, underpinning the mental processes required to perform any activity. Recent studies have shown that improved cognitive performance is associated with elevated levels of…
- Trial name
- NCT07385118
- Testing
- Exercise
- Where
- Italy
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Padova
BDNF, Cognitive Performance
Acute Neurochemical and Cognitive Changes After HIIT vs MICT/LICT
This study examines whether the intensity of a single running session changes a blood marker related to brain health (brain-derived neurotrophic factor, BDNF), blood lactate, and performance on a short thinking task that measures…
- Conditions
- BDNF, Cognitive Performance, Lactate, Exercise Intensity
- Trial name
- ANCCR (NCT07379879)
- Testing
- Low Intensity Exercise, Moderate-Intensity Continuous Exercise, High-Intensity Interval Training
- Where
- Turkey (Türkiye)
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Aksaray University Training and Research Hospital
Exercise Training, BDNF
Effects of Different Types of Exercise on BDNF and Cognitive Performance (Exercise-BDNF)
Purpose The purpose of this study is to determine the acute effects of different exercise intensities (low, moderate, high) on brain-derived neurotrophic factor (BDNF) levels, trail making test performance, and perceived…
- Conditions
- Exercise Training, BDNF, Cognitive Functions, Lactate Blood Increase
- Trial name
- Exercise-BDNF (NCT07137611)
- Testing
- Low Exercise, Moderate-Intensity Exercise, HIIT Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Aksaray University Training and Research Hospital
Fibromyalgia (FM), tDCS
Home-based Transcranial Direct Current Stimulation (tDCS) Compared to Duloxetine: Non-inferiority Clinical Trial (FIBROSTIM)
Fibromyalgia is characterized by widespread pain, fatigue, non-restorative sleep, and psychocognitive alterations, compromising quality of life and leading to absenteeism and early retirement.
- Conditions
- Fibromyalgia (FM), tDCS, Duloxetine, BDNF
- Trial name
- FIBROSTIM (NCT07203339)
- Testing
- Duloxetine (60 mg) once daily, Home-based transcranial direct current stimulation, Duloxetine 60 mg
- Where
- Brazil
- Volunteers
- 610 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Depression Disorder, Anxiety
Impact of Nut Consumption on Mental Health in Young Adults
Nuts have a high nutrient density, and numerous studies have reported their cardiometabolic benefits. Although observational studies in adults have indicated a potential link between nut consumption and improved mental health…
- Conditions
- Depression Disorder, Anxiety, Mental Health, Stress
- Trial name
- NUTS4BRAIN-RCT (NCT07292610)
- Testing
- mixed nuts. Group A, mixed nuts. Group B, control group
- Where
- Spain
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- University of Castilla-La Mancha
BDNF, Irisin
The Acute Effect of Different Resistance Exercise Loads on Irisin and Brain-derived Neurotrophic Factor in Blood Serum and Plasma
The aim of this study is to investigate different resistance training loads on BNDF and irisin levels in platelets, blood serum and plasma.
- Conditions
- BDNF, Irisin, Resistance Exercise, Stroop Test
- Trial name
- NCT07189130
- Testing
- Exercise: 80% 1 RM with 2 minutes break, Exercise: 80% 1RM with1 minute break, Exercise: accenuated eccentric exercise
- Where
- Slovenia
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Ljubljana
Exercise Physiology, Cognitive Function
Jackfruit Effects on Adipokines and Cognition in Boxers
This study investigates the effects of jackfruit oil extract on adipokine levels (Irisin, Omentin-1), brain-derived neurotrophic factor (BDNF), cognitive performance, and body measurements in healthy young boxers aged 18-25.
- Conditions
- Exercise Physiology, Cognitive Function, Adipokine Response, Brain-Derived Neurotrophic Factor (BDNF)
- Trial name
- NCT07268976
- Testing
- Jackfruit Supplement
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Bayburt University
Cognition, BDNF
Investigating the Evolutionary Impact of Metabolic Flexibility on Physical Activity-Dependent BDNF and Cognition: Insights From the Val66Met Polymorphism
The goal of this clinical trial is to learn if a state of ketosis and physical activity will increase serum BDNF concentrations and improve cognition, specifically in individuals who possess the Met allele from the BDNF Val66Met…
- Trial name
- NCT07218497
- Testing
- d-beta-hydroxybutrate
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Southern California
BDNF, Lactate
Determination of BDNF Peak Time in Different Types of Exercises
Purpose The purpose of this study was to determine the peak point of BDNF following exercises of different intensities. Method This randomized crossover controlled trial aimed to examine the acute effects of three experimental…
- Conditions
- BDNF, Lactate, Exercise Intensity, Healthy
- Trial name
- BDNF Kinematic (NCT07175831)
- Testing
- Low-Intensity Continuous Training, Moderate intensity Interval training, High-Intensity Interval Training
- Where
- Turkey (Türkiye)
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Aksaray University Training and Research Hospital
BDNF, Cognitive Functions
BDNF Levels in Cancer Patients Receiving Chemotherapy
Cognitive impairment following chemotherapy is defined as chemotherapy-induced cognitive impairment (CCIID). CCIID, which significantly reduces the quality of life of cancer patients receiving chemotherapy, develops as a result…
- Conditions
- BDNF, Cognitive Functions, Chemotherapy
- Trial name
- CARE (NCT07019324)
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Cemre Aydeğer
Delirium - Postoperative, BDNF
The Relationship Between Delirium and BDNF in Coronary Artery Bypass Graft Surgery
This study is aimed at finding a correlation between postoperative delirium occurrence, severity and duration after cardiac surgery and the level of brain-derived neurotrophic factor (BDNF) in plasma as a marker of brain injury…
- Conditions
- Delirium - Postoperative, BDNF, CABG
- Trial name
- NCT06967779
- Where
- Poland
- Volunteers
- 107 people
- Sponsor
- Pomeranian Medical University Szczecin
Investigation the Role of BDNF and S100B Serum Level as a Predictive of Outcome of Pulsed Radiofrequency in Treatment Lumbar Disc Prolapse Patients
The Potential Role of SI00B and Brain Derived Neurotrophic Factor in Predicting Outcome From Using Pulsed Radiofrequency in Treatment of Patients With Lumbar Disc Prolapsed
Chronic lumbar radicular (CLR) pain is a term used to describe neuropathic pain symptoms in the distribution of a particular lumbar nerve root due to disc protrusion, spinal stenosis, facet hypertrophy, or fibrosis after previous…
- Trial name
- NCT05193461
- Testing
- Pulsed mood radiofrequency on dorsal root ganglion
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Beni-Suef University
BDNF, Memory Impairment
BDNF Promoter Methylation: Effects on Cognition, Stress and Anxiety and Depression Symptom in Healthy Women.
The purpose of this study is to explore the association between BDNF methylation and neurocognitive performance, perceived stress, and well-being in healthy women.
- Conditions
- BDNF, Memory Impairment, Stress, Well-being
- Trial name
- BDNFm (NCT04955457)
- Testing
- Healthy women active teachers
- Where
- Brazil
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ana Flávia Marçal Pessoa
Stroke, Biomarker
Serum BDNF Role as a Biomarker for Stroke Rehabilitation
This study aims to develop the quantitative biomarker to establish the individualized strategy in stroke rehabilitation. Brain-derived neurotrophic factor (BDNF) acts on certain neurons of the central nervous system (CNS) helping…
- Conditions
- Stroke, Biomarker, Rehabilitation, BDNF
- Trial name
- BDNF (NCT03164798)
- Testing
- Conventional inpatient rehabilitation
- Where
- South Korea
- Volunteers
- 150 people
- Sponsor
- Samsung Medical Center
BDNF, Polymorphism, Genetic
BDNF and Motor Learning
The purpose of the study is to assess the status of brain-derived neurotrophic factor brain (BDNF) and how the brain behaves in response to skill acquisition.
- Trial name
- BDNF (NCT02074696)
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Brain-derived Neurotrophic Factor (BDNF), Cognitive Function
Whole Coffee Fruit Concentrate Pilot Study 1
The purpose of this pilot study is to evaluate the potential effects of whole coffee fruit concentrate (WCFC, Neurofactor), a product that elevates circulating brain-derived neurotrophic factor (BDNF), on cognition and mood in…
- Conditions
- Brain-derived Neurotrophic Factor (BDNF), Cognitive Function, Affect
- Trial name
- WCFC (NCT01965795)
- Testing
- Whole Coffee Fruit Concentrate (WCFC), Nutrim
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
BDNF, DNA Methylation, Suicide, Drug Responses.
Epigenetic Regulation of BDNF in Schizophrenia
In this proposal, we will (1) detect the associations between BDNF and Trk B gene DNA methylation, histone modification, psychotic symptoms, obesity, suicide and antipsychotic drug responses in Taiwanese patients (2) discuss the…
- Trial name
- NCT01021449
- Where
- Taiwan
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital