Clinical trials: Atrial Fibrillation Catheter Ablation
Atrial Fibrillation
Role of Cardiac Biomarkers in Prediction of Outcome in Atrial Fibrillation Patients Undergoing Catheter Ablation
The purpose of this study is to assess if pre-ablation levels of inflammatory biomarkers serve as independent predictors of procedure outcome To evaluate the inflammatory activation following catheter ablation by measuring…
- Trial name
- IMPACTII (NCT02208102)
- Testing
- Radio-frequency catheter ablation
- Where
- United States
- Volunteers
- 155 people
- Sponsor
- Texas Cardiac Arrhythmia Research Foundation
Atrial Fibrillation
STAR-AF:Substrate Versus Trigger Ablation for Reduction of Atrial Fibrillation Trial
Patient Population: Patients with AF that is symptomatic and refractory to at least one antiarrhythmic medication. Patients must have AF that is paroxysmal (>4 episodes within 6 months, two episodes >6 hours within 1 year) or…
- Trial name
- NCT00367757
- Testing
- Ablate AF triggers via PVI, Substrate via CFAEs, Combined approach for AF ablation
- Where
- 8 sites in Canada, Italy and 2 more
- Volunteers
- 107 people
- Sponsor
- Abbott Medical Devices
Obstructive Sleep Apnea, Sleep Disorder (Disorder)
Start CPAP Therapy in Obstructive Sleep Apnea Patients After Atrial Fibrillation Ablation
Atrial fibrillation (AF) is one of the most common clinical arrhythmias. Catheter ablation is an effective therapeutic strategy; however, recurrence rates remain substantial, ranging from 20% to 45%.
- Conditions
- Obstructive Sleep Apnea, Sleep Disorder (Disorder), Atrial Fibrillation (AF), Sleep Disordered Breathing (SDB)
- Trial name
- STOP-AFib (NCT07444372)
- Testing
- Continuous Positive Airway Pressure (CPAP), Usual Care
- Where
- 30 sites in China
- Volunteers
- 658 people
- Sponsor
- Beijing Anzhen Hospital
Paroxysmal Atrial Fibrillation
Adenosine vs AF Termination for Paroxysmal AF Ablation
This study investigates impact of adenosine versus AF inducibility and subsequent termination on the acute and long-term outcome of paroxysmal AF ablation.
- Trial name
- NCT02238392
- Testing
- Adenosine test, Termination of AF
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- Johannes Gutenberg University Mainz
Paroxysmal Atrial Fibrillation, Pulmonary Vein Isolation
ADenosine Following Pulmonary Vein Isolation to Target Dormant Conduction Elimination: the ADVICE Trial
Atrial fibrillation (AF) is the most common heart rhythm disorder, impairs quality of life and increases stroke risk and mortality. Despite advances in medical treatment, AF remains uncontrolled in many patients.
- Conditions
- Paroxysmal Atrial Fibrillation, Pulmonary Vein Isolation, Dormant Pulmonary Vein Conduction
- Trial name
- ADVICE (NCT01058980)
- Testing
- Additional ablation until elimination of dormant conduction, No additional ablation, Registry group
- Where
- 18 sites in Australia, Austria and 4 more
- Volunteers
- 550 people
- Sponsor
- Montreal Heart Institute
Persistent Atrial Fibrillation
Left Atrial Isolation by Catheter Ablation in Persistent Atrial Fibrillation With Severe Atrial Fibrosis
This is a single-arm clinical trial evaluating the efficacy and safety of left atrial isolation achieved by catheter ablation in patients with persistent atrial fibrillation with severe atrial fibrosis.
- Trial name
- NCT05173779
- Testing
- Left atrial isolation by catheter ablation
- Volunteers
- 50 people
- Sponsor
- Shanghai Chest Hospital
Atrial Fibrillation
Clinical Study for Workflow and Performance Evaluation of the THERMOCOOL SMARTTOUCH® SF-5D System for Treating Symptomatic Paroxysmal AF (QDOT-Micro)
The QDOT-Micro study is a prospective, multi-center, non-randomized, interventional clinical study.
- Trial name
- NCT02944968
- Testing
- THERMOCOOL SMARTTOUCH® SF-5D catheter
- Volunteers
- 51 people
- Sponsor
- Biosense Webster, Inc.
Atrial Fibrillation (AF), Atrial Tachycardia
Conduction Breakthrough in the Coronary Sinus Post Endocardial Mitral Isthmus Ablation
The goal of this observational study is to learn more about how doctors can create a complete electrical block in the heart during catheter ablation procedures used to treat certain abnormal heart rhythms.
- Conditions
- Atrial Fibrillation (AF), Atrial Tachycardia, Paroxysmal AF, Persisent Atrial Fibrillation
- Trial name
- COSMIC (NCT07889440)
- Volunteers
- 50 people
- Sponsor
- Sebastien Knecht
Atrial Fibrillation (AF)
Efficacy and Safety of Dapagliflozin in Preventing Atrial Fibrillation Recurrence After Catheter Ablation
Atrial fibrillation (AF) is a common arrhythmia, particularly prevalent in the elderly population. Catheter ablation is a common treatment for AF, but post-ablation recurrence of arrhythmias remains a significant clinical…
- Trial name
- NCT06740786
- Testing
- Dapagliflozin Treatment Group
- Volunteers
- 250 people
- Sponsor
- Xu Liu
Atrial Fibrillation
Contribution of Computed Tomography and Cardiac-MRI in Atrial Fibrillation Ablation
Atrial fibrillation ablation (AF) is a standard interventional treatment for patients with symptomatic AF refractory to medical treatment.
- Trial name
- CTStrain-AF (NCT04281329)
- Testing
- Magnetic resonance imaging
- Where
- France
- Volunteers
- 130 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Arterial Hypertension, Atrial Fibrillation
Combined Treatment of Arterial Hypertension and Atrial Fibrillation
The purpose of this study is the comparative evaluation of systolic blood pressure (SBP) lowering, atrial fibrillation (AF) recurrence and clinical data in patients with paroxysmal/persistent AF and resistant/non-resistant…
- Trial name
- NCT01897545
- Testing
- Circumferential PV isolation, PV isolation+renal denervation
- Where
- 3 sites in United States, Greece and 1 more
- Volunteers
- 60 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Heart Failure, Atrial Fibrillation
Rhythm Control - Catheter Ablation With or Without Anti-arrhythmic Drug Control of Maintaining Sinus Rhythm Versus Rate Control With Medical Therapy and/or Atrio-ventricular Junction Ablation and Pacemaker Treatment for Atrial Fibrillation
Atrial fibrillation and heart failure are two common heart conditions that are associated with an increase in death and suffering. When both of these two conditions occur in a patient the patient's prognosis is poor.
- Trial name
- RAFT-AF (NCT01420393)
- Testing
- Rhythm control, Rate Control
- Where
- 21 sites in Brazil, Canada and 2 more
- Volunteers
- 411 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Treatment of Atrial Fibrilation, Symptomatic Atrial Fibrillation
REal-world Valued Outcomes of a noveL Balloon-in-basket pUlsed Field ablaTION Catheter for Atrial Fibrillation RegistrY
describe real-world adaption, work-flow data as well as procedural and follow-up outcomes after balloon-in-basket guided PFA for AF in early European users.
- Trial name
- REVOLUTIONARY (NCT07459387)
- Testing
- PFA Ablation
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- Cardioangiologisches Centrum Bethanien
Atrial Fibrillation
Evaluation of Proper Radiofrequency Catheter Ablation Strategy for the Patients Who Were Changed to Paroxysmal Atrial Fibrillation From Persistent Atrial Fibrillation
1. Purpose of the study 1) To compare clinical outcome, procedure time, complication rate of patients who were changed to paroxysmal atrial fibrillation from persistent atrial fibrillation between ablation with conventional…
- Trial name
- NCT02176616
- Testing
- linear ablation, pulmonary vein isolation
- Where
- South Korea
- Volunteers
- 120 people
- Sponsor
- Yonsei University
Thromboembolism
Role of Coumadin in Preventing Thromboembolism in Atrial Fibrillation (AF) Patients Undergoing Catheter Ablation
This study aims to explore the risk of periprocedural thromboembolic events in continuous versus interrupted Coumadin therapy in a large, randomized high-risk patient population undergoing radio-frequency catheter ablation for…
- Trial name
- COMPARE (NCT01006876)
- Testing
- Coumadin
- Where
- United States
- Volunteers
- 1,584 people
- Sponsor
- Texas Cardiac Arrhythmia Research Foundation
Atrial Fibrillation
High Frequency Jet Ventilation in AF Ablation
Atrial fibrillation (AF) is a cardiac condition that results in patients experiencing an irregular heart beat resulting in symptoms including palpitations and breathlessness.
- Trial name
- NCT02968147
- Testing
- High frequency jet ventilation, Conventional ventilation
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Oxford University Hospitals NHS Trust
Atrial Fibrillation (AF)
The Modified "Pills-in-the-Pocket" Strategy
This is a multicentre, prospective, randomised controlled study of 328 patients with non-paroxysmal AF (within 5 years of first diagnosis of AF) with recurrent atrial arrhythmias after first catheter ablation, randomly divided in…
- Trial name
- ABD-AF (NCT06657404)
- Testing
- use Amiodarone, Bisoprolol and Digoxin
- Where
- China
- Volunteers
- 328 people
- Sponsor
- Yumei Xue
Atrial Fibrillation
A Study to Predict Atrial Fibrillation (AF) Burden in Participants With PAF and PsAF Treated With the VARIPULSE™ PFA Catheter
The purpose of this study is to evaluate how safe VARIPULSE™ Catheter is and how well it works in the treatment of participants with symptomatic paroxysmal atrial fibrillation (PAF; irregular heartbeat where episodes start and…
- Trial name
- SPECTRA-AF (NCT07788989)
- Testing
- VARIPULSE Catheter System (PVI), VARIPULSE Catheter System (PVI and PWI)
- Where
- United States
- Volunteers
- 2,300 people
- Sponsor
- Biosense Webster, Inc.
Atrial Fibrillation
2-Hydroxybenzylamine (2-HOBA) to Prevent Early Recurrence of Atrial Fibrillation After Catheter-based Ablation
The proposed studies will test this hypothesis by randomizing patients with AF to 2-HOBA or placebo 7 days prior to AF ablation to allow 2-HOBA to reach steady-state levels.
- Trial name
- NCT04433091
- Testing
- 2-Hydroxybenzylamine
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- Vanderbilt University Medical Center
Atrial Fibrillation, Thrombi
Exclusion of Intra-atrial Thrombus Before Catheter Ablation
Atrial fibrillation is the most frequent heart rhythm disorder. Its symptomatic forms, resistant to drug therapy, require invasive management (catheter ablation), which exposes to potentially serious complications including…
- Trial name
- EXTRALUCID (NCT03455673)
- Testing
- ATE score
- Where
- 15 sites in France, Switzerland
- Volunteers
- 3,160 people
- Sponsor
- Groupe Hospitalier de la Rochelle Ré Aunis