Clinical trials: Amputation, Surgical
Amputation; Traumatic, Leg, Lower
Transtibial Osseointegration
Purpose: Aim 1: Quantify soft tissue complications and infections of service members with transtibial amputations treated with OPRA OI and compare them to transfemoral OI service members.
- Trial name
- TOSS (NCT06636136)
- Testing
- OPRA
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Walter Reed National Military Medical Center
Peripheral Arterial Disease (PAD), Amputation
Personalizing Thromboprophylaxis for Patients With Peripheral Artery Disease
The goal of this clinical trial is to determine whether a personalised blood clot prevention plan is more effective than standard treatment in adults with peripheral artery disease (PAD) who have undergone a procedure to restore…
- Conditions
- Peripheral Arterial Disease (PAD), Amputation, Thrombosis, Thrombosis (Stent Thrombosis)
- Trial name
- NCT07613840
- Testing
- Aspirin, Clopidogrel, Ticagrelor
- Where
- 2 sites in United States
- Volunteers
- 484 people
- Sponsor
- Massachusetts General Hospital
Anesthesia, Amputation; Traumatic, Leg, Lower
Anaesthetic Technique for Minor Lower Limb Amputation Surgery (ATLLAS)
Major lower limb amputation is recognised as a significant cause of morbidity and mortality. In the United Kingdom, 30-day in-hospital mortality is up to 8.7%.
- Trial name
- ATLLAS (NCT07244627)
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- University Hospitals of North Midlands NHS Trust
Amputation, Anesthesia, Local
Use of Long-acting Bupivacaine In Lower Extremity Amputation
The purpose of this investigator-initiated study is to assess the use of liposomal bupivacaine in major extremity amputation and its effects on post-operative opioid narcotic use, length of stay, and in-hospital costs.
- Conditions
- Amputation, Anesthesia, Local, Opioid Use
- Trial name
- NCT04360421
- Testing
- Liposomal bupivacaine
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Loma Linda University
Peripheral Vascular Disease, Peripheral Artery Disease
Platelet Activity in Vascular Surgery for Thrombosis and Bleeding
The proposed PIVOTAL study will examine a panel of platelet/coagulation activity markers during the perioperative period. The goal is to develop a clinically useful assessment of platelet/coagulation activity for risk…
- Conditions
- Peripheral Vascular Disease, Peripheral Artery Disease, Carotid Stenosis, Aortic Aneurysm, Abdominal
- Trial name
- PIVOTAL (NCT01897103)
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- NYU Langone Health
Amputation Stump, Amputation Neuroma
Comparison Between Digital Nerve Microanastomosis and Traction Neurectomy in Post-Digital Amputation Pain
The goal of this prospective observational study is to assess the post-operative pain in adults with digital amputation following two different surgical interventions: microanastomosis of digital nerves or traction neurectomy.
- Conditions
- Amputation Stump, Amputation Neuroma, Amputation, Traumatic/Surgery, Amputation, Surgical
- Trial name
- NCT07102654
- Volunteers
- 50 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Mastectomy, Upper Limb Amputation Below Elbow
Cryoanalgesia to Prevent Acute and Chronic Pain Following Surgery: A Randomized, Double-Masked, Sham-Controlled Study
The ultimate objective of the proposed line of research is to determine if cryoanalgesia is an effective adjunctive treatment for pain in the period immediately following various painful surgical procedures; and, if this…
- Conditions
- Mastectomy, Upper Limb Amputation Below Elbow, Upper Limb Amputation Above Elbow, Lower Limb Amputation Below Knee
- Trial name
- NCT03578237
- Testing
- Cryoneurolysis (active)
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- University of California, San Diego
Residual Limb Pain, Amputation Neuroma
Surgical Treatments for Postamputation Pain
This is a double-blind randomised controlled trial (RCT) which compares the effectiveness of three surgical techniques for alleviating residual limb pain (RLP), neuroma pain and phantom limb pain (PLP).
- Conditions
- Residual Limb Pain, Amputation Neuroma, Phantom Limb Pain, Pain, Neuropathic
- Trial name
- NCT05009394
- Testing
- Targeted Muscle Reinnervation (TMR), Regenerative Peripheral Nerve Interface (RPNI), Standard neuroma treatment, neuroma excision, and muscle burying
- Where
- 9 sites in United States, Australia and 5 more
- Volunteers
- 110 people
- Sponsor
- Prometei Pain Rehabilitation Center
Surgical Wound, Wound Heal
Evaluating the Outcomes for Incisional Application of Negative Pressure for Nontraumatic Amputations
The purpose of this study is to evaluate how well subjects heal after surgery who receive standard dressings or incisional negative pressure wound therapy for non-traumatic amputation sites.
- Conditions
- Surgical Wound, Wound Heal, Amputation
- Trial name
- NCT03250442
- Testing
- PrevenaTM Device, Standard Dry Dressing
- Where
- United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Surgical Wound, Surgical Site Infection
Clinical Assessment of Next Science Wound Gels in Healing Below the Knee Amputation Surgical Wound Compared to SOC
This is a 64-patient, 90-day, open -label study on adult patients undergoing below knee amputation for various etiologies. The objective of this study is to assess surgical wound healing and wound bioburden using combination…
- Conditions
- Surgical Wound, Surgical Site Infection, Surgical Wound Infection, Amputation Stump; Infection
- Trial name
- NCT04053946
- Testing
- Next Science Wounds Gels
- Sponsor
- Next Science TM
Diabetic Foot, Pressure Ulcer
A Real-World Registry of Chronic Wounds and Ulcers
WOUNDJOURNEY is a longitudinal, real-world, observational registry designed to capture the full clinical course and patient journey associated with chronic wounds and ulcers.
- Conditions
- Diabetic Foot, Pressure Ulcer, Surgical Wound Dehiscence, Vasculitis
- Trial name
- WOUNDJOURNEY (NCT02280733)
- Testing
- Usual care
- Where
- United States
- Volunteers
- 300,000 people
- Sponsor
- U.S. Wound Registry
Amputation, Surgical, Pain Management
Early Postoperative Pain Following a Limb Amputation
The primary aim of this study is to characterize the trajectory of pain and functional recovery in the first post-operative period following a limb amputation.
- Conditions
- Amputation, Surgical, Pain Management, Rehabilitation
- Trial name
- Pain-Amp (NCT07393139)
- Testing
- Pain assessment
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Istituto Ortopedico Rizzoli
Diabetic Foot Disease
Development and Application of a Decision-Making Aid Tool for Amputation Surgery in Diabetic Foot Patients Based on the Ottawa Decision Support Framework
To verify whether amputation decision-making aids can alleviate the decisional dilemma in diabetic foot patients.
- Trial name
- NCT07252089
- Testing
- Applications of Decision-Support Tools in Amputation Decision-Making for Diabetic Foot Patients, Routine Clinical Consultation and Nursing Care
- Volunteers
- 80 people
- Sponsor
- Shiwen Hong
Anesthesia
Comparison of Two Techniques of Sciatic Nerve Block With Levobupivacaine 0.5% in Orthopedic Surgery
The purpose of this study is to evaluate the latency period (timing between the injection of the local anesthetic and the onset of complete sensory nerve block) of two approaches for ultrasound-guided popliteal sciatic nerve…
- Trial name
- NCT01734954
- Testing
- Sciatic nerve anesthesia blockade at bifurcation., Sciatic nerve blockade 2 cm beyond the bifurcation, Levobupivacaine 0.5%: 20 ml
- Where
- 2 sites in Colombia
- Volunteers
- 66 people
- Sponsor
- CES University
Pain, Complications
Comparison of Two Kinds of Postoperative Analgesia After Amputation
Pain after amputation is a significant problem among amputees. Phantom limb pain may appear in up to 85% of patients and is usually resistant to a wide variety of treatments.It is believed that regional anesthesia, by preventing…
- Trial name
- NCT02114463
- Testing
- Local analgesic, Intravenous analgesic, ropivacaine
- Where
- China
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Guangzhou General Hospital of Guangzhou Military Command
Amputation
Hand Transplantation
The purpose of this study is to see if an investigational surgery that transfers tissue from a non-living donor to living individual will help restore greater function, appearance, and sensation to the hand and forearm areas of…
- Trial name
- NCT02476838
- Testing
- Hand Transplantation
- Where
- United States
- Sponsor
- NYU Langone Health
Abdominal Aortic Aneurysm, Carotid Atherosclerosis
Preconditioning Shields Against Vascular Events in Surgery
Major vascular surgery involves operations to repair swollen blood vessels, clear debris from blocked arteries or bypass blocked blood vessels.
- Conditions
- Abdominal Aortic Aneurysm, Carotid Atherosclerosis, Critical Lower Limb Ischaemia
- Trial name
- SAVES (NCT01691911)
- Testing
- Remote preconditioning
- Where
- Ireland
- Volunteers
- 200 people
- Sponsor
- Mid Western Regional Hospital, Ireland
Amputation, Wounds and Injuries
Human Penile Allotransplantation
Injuries to the genitalia are of concern to the military with emphasis placed on the surgical reconstruction and psychological health of these Wounded Warriors.
- Conditions
- Amputation, Wounds and Injuries, Amputation, Traumatic, Urologic Surgical Procedures, Male
- Trial name
- NCT02395497
- Testing
- Monoclonal Antibody (Humanized Anti-CD52), Tacrolimus, Penile Allotransplantation
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Johns Hopkins University
Type 2 Diabetes Mellitus, Obesity
The TRIABETES - ARMMS-T2D Study: A Randomized Trial to Compare Surgical and Medical Treatments for Type 2 Diabetes
This research study is being performed to begin to determine the effectiveness of two dominant bariatric surgery procedures versus an intensive lifestyle intervention to induce weight loss in patients and promote improvements in…
- Trial name
- TRIABETES (NCT01047735)
- Testing
- Roux-en-Y Gastric Bypass Surgery, Laparoscopic Adjustable Gastric Banding, Lifestyle Weight Loss Intervention
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- University of Pittsburgh
Vascular Surgical Procedures
Pain Management of Amputation Wounds With AutoHypnosis
Amputation in vascular surgery mainly concerns the lower limb and is often linked to Obliterative Arterial Disease of the Lower Limbs.
- Trial name
- MODOUPAAH (NCT05779852)
- Testing
- self-hypnosis and dressing, dressing
- Where
- France
- Volunteers
- 44 people
- Sponsor
- Rennes University Hospital