Clinical trials: Adverse Cardiac Event
Major Adverse Cardiac Events, Adverse Effect of Unspecified General Anesthetic
Adverse Events in Acute Limb Ischemic Patient Undergoing Revascularization
Acute limb ischemia is one of the devastating vascular emergencies that lead to life and limb loss if the appropriate treatment is not reached.The revascularization is a cornerstone in treating acute limb ischemia.
- Trial name
- NCT05362266
- Where
- 2 sites in Thailand
- Volunteers
- 240 people
- Sponsor
- Mahidol University
Hypertension, Stroke
A Cluster-Randomized Controlled Trial
The goal of this study is to learn if an AI-generated personalized health report combined with face-to-face guidance from cardiologists can help rural adults with high blood pressure control their blood pressure better and reduce…
- Conditions
- Hypertension, Stroke, Cardiovascular, Coronary Heart Disease
- Trial name
- NCT07845448
- Testing
- AI-powered personalized health report with cardiologist consultation and prescription optimization, Integrated management (follow-up, education, quality control) without AI report and cardiologist consultation
- Volunteers
- 14,400 people
- Sponsor
- Second Affiliated Hospital of Nanchang University
Dementia, Postoperative Delirium (POD)
Prediction and Prevention of Postoperative Mortality and Morbidity
This study will contribute to creating a prospective and automated preoperative risk assessment algorithm for predicting 30-day mortality, major adverse cardiac and cerebrovascular events (MACCE), and postoperative neurocognitive…
- Conditions
- Dementia, Postoperative Delirium (POD), Postoperative Neurocognitive Disorder, Major Adverse Cardiac and Cerebrovascular Events
- Trial name
- NCT06042413
- Testing
- Personalized CPC Prehabilitation, Cognitive Training, Meditation
- Where
- 5 sites in United States
- Volunteers
- 1,200 people
- Sponsor
- University of Pittsburgh
Adverse Cardiac Event, Major Adverse Cardiac Events
Impact of Assessment and Management of Comorbidities in Internal Medicine on Cardiovascular Risk
The aim of assessing and managing cardiovascular risk is to avoid, limit or delay cardiovascular morbidity and mortality. Planned internal medicine hospitalization is developed around the management of cardiovascular risk in…
- Trial name
- COMMEDCARDIO (NCT06204549)
- Testing
- Screening and management of cormobidities
- Where
- France
- Volunteers
- 70 people
- Sponsor
- University Hospital, Montpellier
Myocardial Injury After Non-cardiac Surgery, Urologic Cancer
Prediction of Myocardial Injury After Non-Cardiac Surgery in Urologic Cancer Patients
This prospective multicenter observational study aims to evaluate the predictive value of artificial intelligence-based analysis of preoperative 12-lead electrocardiography for myocardial injury after non-cardiac surgery (MINS)…
- Conditions
- Myocardial Injury After Non-cardiac Surgery, Urologic Cancer, Major Adverse Cardiovascular Events (MACE)
- Trial name
- URO-MINS (NCT07634666)
- Testing
- No intervention assigned
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Korea University Anam Hospital
Heart Rate Monitoring, Vagal Bradycardia
Heart Rate Variability and Early Cytokine Profile in Pediatric Adenotonsillectomy
This prospective observational cohort study will assess whether perioperative short-term heart rate variability (HRV) indices and early inflammatory cytokine levels are associated with respiratory and cardiac adverse events in…
- Conditions
- Heart Rate Monitoring, Vagal Bradycardia, Adenotonsillar Hypertrophy, Tonsillitis; Hypertrophic
- Trial name
- NCT07719439
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people
- Sponsor
- Duzce University
Airway Management, Tracheal Intubation
Taiwan ED Airway Quality Surveillance Registry (TEAR)
This prospective, multicenter observational registry systematically captures all emergency department tracheal intubations across participating hospitals in Taiwan.
- Conditions
- Airway Management, Tracheal Intubation, Emergency Department, Peri-intubation Adverse Events
- Trial name
- NCT07574450
- Where
- Taiwan
- Volunteers
- 1,200 people
- Sponsor
- Chang Gung Memorial Hospital
Rheumatoid Arthritis, Major Adverse Cardiac Events
Major Adverse Cardiovascular Events (MACE) in Rheumatoid Arthritis Patient With Moderate to Severe Disease Activity Treated With Tofacitinib and Statins vs TNF Inhibitors: TOFSTAT CLINICAL TRIAL
The rationale of our study is to observe the incidence of MACE in RA patients treated with tofacitinib along with statins with one or more cardiovascular disease risks.
- Trial name
- TOFSTAT (NCT07554820)
- Testing
- Tofacitinib 5 MG
- Where
- Pakistan
- Volunteers
- 120 people
- Sponsor
- Shaikh Zayed Hospital, Lahore
Pregnancy-Associated Heart Disease, Fetal Congenital Heart Disease
Maternal-Fetal Heart Sound/Electrocardiogram Monitoring and Cardiac Risk Early Warning
This is a prospective observational cohort study conducted at Beijing Anzhen Hospital. The study aims to establish reference ranges of heart sound and electrocardiogram (ECG) parameters for both mothers and fetuses.
- Conditions
- Pregnancy-Associated Heart Disease, Fetal Congenital Heart Disease, Autoimmune-Related Fetal Heart Block, Perinatal Adverse Events
- Trial name
- NCT07526662
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Yihua He,MD
Major Adverse Cardiac Event (MACE)
How Clinical and Personal Information Shape Physicians' Risk Judgments
Physicians often form quick judgments about the risk for serious disease when interacting with patients. Underestimating risk can lead to underuse of diagnostic testing and untreated illness, which can worsen patient outcomes.
- Trial name
- NCT07162376
- Testing
- Personal Information Disclosure
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Maryland, College Park
Fall, Congestive Heart Failure
Reducing High-Risk Geriatric Polypharmacy Via EHR Nudges: Pilot Phase
Polypharmacy is common among older adults in the United States and is associated with harms such as adverse drug reactions and higher costs of care.
- Conditions
- Fall, Congestive Heart Failure, Chronic Kidney Failure, Adverse Drug Event
- Trial name
- NCT03791580
- Testing
- Commitment nudge, Justification nudge
- Where
- United States
- Sponsor
- RAND
URTI, Postoperative Complications
Perioperative Outcomes for Children With Preoperative URTI Symptoms After COVID-19 Pandemic
The goal of this observational study is to investigate the impact of the COVID-19 pandemic on perioperative outcomes in children with preoperative URTI symptoms and to explore whether the COVID-19 pandemic affected the additional…
- Conditions
- URTI, Postoperative Complications, COVID - 19, Elective Non-cardiac Surgery
- Trial name
- URTI (NCT07157111)
- Where
- China
- Volunteers
- 2,392 people
- Sponsor
- aijun xu
Type 2 Diabetes, Major Adverse Cardiac Events
Prediction of the SURPASS-CVOT Cardiovascular Outcome Trial in Healthcare Claims Data
Investigators are building an empirical evidence base for real world data through large-scale emulation of randomized controlled trials.
- Conditions
- Type 2 Diabetes, Major Adverse Cardiac Events, Cardiovascular (CV) Risk
- Trial name
- DUP-SURPASS (NCT07088718)
- Testing
- Tirzepatide, Dulaglutide
- Where
- United States
- Volunteers
- 44,671 people
- Sponsor
- Brigham and Women's Hospital
Coronary Artery Disease, Clopidogrel Resistance
The Study of CYP2C19 Genotype-Guided Clopidogrel Treatment Models
The study purposed to learn how clopidogrel-based antiplatelet treatment for preventing adverse cardiovascular events after ePCI works in chronic coronary artery disease when guided by personal genetic characteristics for drug…
- Conditions
- Coronary Artery Disease, Clopidogrel Resistance, Coronary Thrombosis, Adverse Cardiac Events
- Trial name
- NCT06665919
- Testing
- CYP2C19 Genotype-Guided Clopidogrel Treatment, CYP2C19 Genotype Guided Antiplatelet Treatment Alternative to Clopidogrel, The Conventional Clopidogrel Treatment
- Where
- 4 sites in Georgia
- Volunteers
- 283 people
- Sponsor
- Vistamedi Ltd.
Transthorcic Echocardiography, Stable Angina Pectoris
TTE Improves Clinical Management of Stable Chest Pain
The investigator aims to prospectively enroll patients who were referred for transthorcic echocardiography (TTE) for the assessment of stable chest pain (SCP) suspected of obstructive coronary artery disease (CAD).
- Conditions
- Transthorcic Echocardiography, Stable Angina Pectoris, Coronary Artery Disease, Major Adverse Cardiac Events
- Trial name
- TICM-SCP (NCT07063147)
- Testing
- TTE
- Where
- China
- Volunteers
- 50,000 people
- Sponsor
- Tianjin Chest Hospital
Major Adverse Cardiac Events, Acute Myocardial Infarction (AMI)
Preoperative Cardiology Consultation and the Incidence of Major Adverse Cardiac Events（MACE）
This cohort study aims to determine when preoperative cardiology consultation is needed to reduce the incidence of major adverse cardiac events (MACE) in elderly patients undergoing non-cardiac surgery.
- Conditions
- Major Adverse Cardiac Events, Acute Myocardial Infarction (AMI), Cardiac Death, Sudden, Cardiac Arrest (CA)
- Trial name
- MACE (NCT06884436)
- Where
- China
- Volunteers
- 22,000 people
- Sponsor
- Chinese PLA General Hospital
Cancer, Immune-related Adverse Event
Extensive CArdioVAscular Characterization and Follow-up of Patients Receiving Immune Checkpoint Inhibitors
The goal of this prospective, multicentre study is to investigate short- and long-term cardiovascular effects in cancer patients treated with immune checkpoint inhibitors (ICIs).
- Conditions
- Cancer, Immune-related Adverse Event, Cardiac Abnormalities, Variable, Immune Checkpoint Inhibitor-Related Myocarditis
- Trial name
- CAVACI (NCT05699915)
- Testing
- Cardiology consultation, Chest Computed Tomography (CT) without contrast, Non-invasive endothelial function tests
- Where
- 4 sites in Belgium
- Volunteers
- 105 people
- Sponsor
- Algemeen Ziekenhuis Maria Middelares
Atrial Fibrillation, Anticoagulant Adverse Reaction
Low-dose Versus Standard-dose Rivaroxaban in Elderly Patients With Atrial Fibrillation
To evaluate the efficacy and safety of low-dose versus standard-dose rivaroxaban anticoagulation therapy in elderly patients with atrial fibrillation.
- Conditions
- Atrial Fibrillation, Anticoagulant Adverse Reaction, Stroke, Major Adverse Cardiac Events
- Trial name
- NCT06108414
- Testing
- low-dose rivaroxaban, Standard-dose rivaroxaban
- Where
- China
- Volunteers
- 4,374 people
- Sponsor
- China National Center for Cardiovascular Diseases
Acute Coronary Syndrome, ST-segment Elevation Myocardial Infarction (STEMI)
Predictive Value of NT-proBNP on MACEs After Acute Coronary Syndrome
The role of N-terminal pro-B-type natriuretic peptide (NT-proBNP) as a cardiac biomarker in predicting short-term major adverse cardiovascular events (MACEs) in patients with Acute coronary syndrome (ACS) has been insufficiently…
- Conditions
- Acute Coronary Syndrome, ST-segment Elevation Myocardial Infarction (STEMI), Non-ST-Segment Elevation Myocardial Infarction (NSTEMI), Major Adverse Cardiac Events
- Trial name
- MACEstdy (NCT06569511)
- Testing
- N-terminal pro-B-type natriuretic peptide (NT-proBNP), high sensitive cardiac troponin T (hs-cTnT)
- Where
- Turkey (Türkiye)
- Volunteers
- 241 people
- Sponsor
- Haseki Training and Research Hospital
Type 2 Diabetes Mellitus, Obesity
Macrovascular and Microvascular Morbidity and Mortality After Metabolic Surgery Versus Medicines
The goal of this study is to compare the impact of metabolic surgery and a class of anti-diabetes medications (Glucagon-like peptide-1 receptor agonists,GLP-1 RAs) on occurrence of diseases involving small and large vessels such…
- Conditions
- Type 2 Diabetes Mellitus, Obesity, Microvascular Disease, Macrovascular Disease
- Trial name
- M6 (NCT06355219)
- Volunteers
- 3,932 people
- Sponsor
- Ali Aminian