Major Adverse Cardiac Event (MACE)NCT07162376
How Clinical and Personal Information Shape Physicians' Risk Judgments
A study testing Personal Information Disclosure in people with Major Adverse Cardiac Event (MACE), run by University of Maryland, College Park at 1 site in United States.
Trial summary
Physicians often form quick judgments about the risk for serious disease when interacting with patients. Underestimating risk can lead to underuse of diagnostic testing and untreated illness, which can worsen patient outcomes. Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- Major Adverse Cardiac Event (MACE)
- What is being tested?
- Personal Information Disclosure
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 300 participants
- Where
- 1 siteUnited States
- Study dates
- 16 Sep 2025to 26 Sep 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Emergency medicine physicians
- Cardiologists
- Hospitalists (i.e., internists whose practice is primarily in the hospital)
- If there are duplicate participant IDs in the data, only the first response will be included in the analysis
Who cannot join
- Participants who indicate they are retired
- Participants who write gibberish in the open-ended items
- Incomplete responses
Trial locations and contacts
1 site in 1 country.
About this study
Physicians often form quick judgments about the risk for serious disease when interacting with patients. Underestimating risk can lead to underuse of diagnostic testing and untreated illness, which can worsen patient outcomes. On the other hand, overestimating risk can lead to overuse of diagnostic testing, which is costly for health systems.
To form judgments of risk, physicians should attend to a host of validated factors that are predictive of disease. However, research suggests that physicians may rely on demographic factors-such as race and gender. Physicians' judgments could also be influenced by non-health-related, personal information about their patients (e.g., hobbies, nicknames), which may moderate the impact of demographics on those judgments.
Read more
The investigators examine these dynamics in the context of heart disease. The History, Electrocardiogram, Age, Risk factors and Troponin (HEART) Score is a validated model that specifies a correspondence between certain risk factors and the likelihood of Major Adverse Cardiac Event (MACE). Importantly, there are substantially different diagnostic tests (e.g., noninvasive stress test versus coronary angiogram) that should be used depending on a patient's MACE likelihood.
Specifically, the investigators have three research questions:
- Research Question 1 (RQ1): How accurate are physicians relative to the benchmarks from the HEART score model?
- Research Question 2 (RQ2): How do clinically-relevant risk factors (e.g., smoking history), race, gender, and personal information disclosure influence risk judgments?
- Research Question 3 (RQ3): Does personal information disclosure moderate the effects of race and gender on risk judgments?
Note that when the investigators discuss accuracy and error, they are referring to the comparison of physician judgments to the HEART score model benchmarks.
Read the detailed description
The investigators designed a survey to assess physicians' perception of MACE likelihood. Each physician rates a panel of patient profiles. The profiles randomly vary in risk factors, race, gender, and personal information disclosure (e.g., non-health related information about their hobbies). Using the HEART Score model as a benchmark, the investigators will assess how accurately physicians perceive MACE Likelihood based on the risk factors in a given profile. The investigators will further estimate how race, gender, and personal information disclosure causally affect physician judgments.
To do this, the investigators designed a mixed-design experiment. Each participant will respond to eight patient profiles that vary along three fully-crossed within-subject factors: (i) race: black vs. white, (ii) gender: man vs. woman, and (iii) risk factors: low vs. medium risk (based on risk levels from the HEART score model). Each participant will also be randomly assigned (between-subjects) to (iv) either see non-health-related personal information (e.g., hobbies) for all eight of their patients, or not see this information for any of their patients. The investigators refer to each factor as a profile attribute.
For each profile, participants indicate the perceived risk of a major adverse cardiac event in the six weeks following the visit. Our primary outcome is a measure of absolute error in perceived risk of MACE (described under the Primary Outcome section). They also indicate the diagnostic test they believe is most appropriate (Secondary Outcome #4).
Analysis plan
For all analyses, the investigators will format the data such that there are eight observations per participant, each corresponding to a patient profile the participant responded to.
- To test RQ1, the investigators will estimate an Ordinary Least Squares (OLS) regression predicting the primary outcome. The investigators will cluster standard errors by physician. The constant reflects the mean of our primary outcome, reflecting the extent to which physicians are inaccurate.
- To test RQ2, the investigators will estimate an OLS regression predicting the primary outcome. The independent variables include four indicators to model the profile attributes: an indicator for risk factors, an indicator for gender, an indicator for race, and an indicator for personal information disclosure. The model will also include fixed effects for physician specialty (emergency medicine, cardiologists, and hospitalists). The investigators will cluster standard errors by physician.
- To test RQ3, the investigators will reestimate the primary model testing RQ2 twice: In one model, the investigators will add an interaction term between personal information disclosure and race; and in the second model, the investigators will add an interaction term between personal information disclosure and gender.
As secondary analyses,
- The investigators will estimate the models above except using Secondary Outcomes Measures #1-3
- The investigators will measure participants' choice of appropriate diagnostic test for each patient as a secondary outcome (see Secondary Outcome #4). The investigators will estimate a multinomial logistic regression predicting choice of appropriate diagnostic test as the categorical outcome (with "routine follow-up" as the reference category). The independent variables include the four profile attribute indicators and physician specialty fixed effects. The investigators will cluster standard errors by physician.
- The investigators will reestimate the primary models testing RQ2, except including pairwise interactions between the physician specialty fixed effects and each of the four attributes.
- The investigators will reestimate the primary model testing RQ2, except adding all pairwise interactions between the four attributes as independent variables.
- The investigators will measure overconfidence (see Secondary Outcome Measure #5). With data at the physician-level, the investigators will estimate an OLS regression predicting overconfidence. The investigators will reestimate the model, except adding the two indicators for physician specialty and the indicator for personal information disclosure as independent variables.
The investigators will also measure and explore (i) qualitative open-ended responses about how they made their risk estimations, (ii) whether participants use the HEART score model at their jobs (or another model), (iii) if they use a model, why they use it, (iv) if they have heard of the HEART score model, (v) if they looked up anything while taking the study, and (vi) if yes, what they looked up.
The investigators plan to recruit 300 physicians using the Medscape panel.
- Conditions
- Major Adverse Cardiac Event (MACE)
- Being tested
- Personal Information Disclosure
- Keywords
- Major Adverse Cardiac Event (MACE), Physician Perception, Risk Judgment, HEART Score, Diagnostic Testing, Cardiology, Personal Information
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Personal Information DisclosureBehavioural
Each profile also contains non-health related personal information that the patient has disclosed (e.g., nickname, hobbies).
| Study group | Role | What they receive |
|---|---|---|
| No Personal Information Disclosure | No intervention | Participants rate 8 patient profiles of patients with chest pain. The profiles each contain info about the patient's race, gender, and risk factors associated with MACE. |
| Personal Information Disclosure | Experimental | Participants rate 8 patient profiles of patients with chest pain. The profiles each contain info about the patient's race, gender, and risk factors associated with MACE. Each profile also contains non-health related personal information that the patient has disclosed (e.g., nickname, hobbies). Receives: Behavioral: Personal Information Disclosure |
What is being measured
The primary outcome is the main question the study is designed to answer.
Absolute Error in Perceived Risk of MACE
For each patient profile, all participants will be asked about their perceived risk of MACE: What is the likelihood that this patient experiences a major adverse cardiac event in the six weeks following the visit? [0-100].
The paradigm uses two levels of risk factors, each associated with a specific risk of MACE range as defined by the HEART score model: low risk factors = 0.9-1.7% (midpoint = 1.3%); and medium risk factors = 12-16.6% (midpoint = 14.3%). To calculate each participant's directional error, the investigators will take the difference between participants' perceived risk of MACE and the midpoint of the risk of MACE range from the HEART score model at each patient's corresponding risk level.
The absolute error is calculated by taking the absolute value of the directional error.
Measured: At the time of survey completion, within approximately 2 weeks
Secondary outcomes (5)
Perceived Risk of MACE
This reflects the raw, untransformed value of participants' response to the question: What is the likelihood that this patient experiences a major adverse cardiac event in the six weeks following the visit? [0-100].
Measured: At the time of survey completion, within approximately 2 weeks
Directional Error
This reflects the directional error variable, explained under the primary outcome description.
Measured: At the time of survey completion, within approximately 2 weeks
Categorical Error
This is a binary variable for whether participants' perceived risk of MACE falls outside of the HEART score model's risk of MACE range at each patient's corresponding risk level [1 = outside of the range; 0 = within than range].
Measured: At the time of survey completion, within approximately 2 weeks
Diagnostic Test Decision
"What would you recommend for this patient?" [(a) Coronary computed tomography angiography (cCTA), (b) noninvasive stress test, (c) left heart catheterization (coronary angiogram with potential percutaneous coronary intervention), or (d) routine follow-up.]
Measured: At the time of survey completion, within approximately 2 weeks
Overconfidence
"I believe my responses were more accurate than ____% of participants in this study." [0 to 100; there is more information in the survey about the meaning of "accurate" and the response options]. To measure true percentile placement, the investigators will calculate each participant's mean absolute error of perceived risk of MACE across the eight profiles and then calculate their percentile rank. The investigators will then calculate overconfidence by taking the difference between their perceived and true percentile placement. Note that this is specifically a measure of over-placement (rather than over-precision or over-estimation).
Measured: At the time of survey completion, within approximately 2 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted9 Sep 2025
- Study start16 Sep 2025
- Primary completion26 Sep 2025
- Study completion26 Sep 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Major Adverse Cardiac Event (MACE)Studies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Health services research
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Parallel randomized trial at the physician level.
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 300 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Maryland, College Park
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Joseph Reiff, University of Maryland, College Park
- Investigators
- Joseph Reiff, PhD, Principal investigator, University of Maryland Robert H. Smith School of BusinessAneesh Rai, PhD, Principal investigator, University of Maryland Robert H. Smith School of Business
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07162376
- Sponsor's protocol ID
- 2281657-2
- Status last verified
- Sep 2025
- First submitted
- 25 Aug 2025
- Last updated
- 16 Jan 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: The investigators will share anonymized responses from participants containing all their responses to our survey.
Study at a glance
From the registry record, last updated by the sponsor on 16 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- How Clinical and Personal Information Shape Physicians' Risk Judgments
- ClinicalTrials.gov ID
- NCT07162376
- Acronym / sponsor ID
- 2281657-2
- Conditions
- Major Adverse Cardiac Event (MACE)
- Keywords
- Major Adverse Cardiac Event (MACE), Physician Perception, Risk Judgment, HEART Score, Diagnostic Testing, Cardiology, Personal Information
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 300 participants (actual)
- Lead sponsor
- University of Maryland, College ParkUniversity, hospital or other
- Study start
- 16 Sep 2025 (actual)
- Primary completion
- 26 Sep 2025 (actual)
- Study completion
- 26 Sep 2025 (actual)
- First posted
- 9 Sep 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Physicians often form quick judgments about the risk for serious disease when interacting with patients. Underestimating risk can lead to underuse of diagnostic testing and untreated illness, which can worsen patient outcomes. On the other hand, overestimating risk can lead to overuse of diagnostic testing, which is costly for health systems.
To form judgments of risk, physicians should attend to a host of validated factors that are predictive of disease. However, research suggests that physicians may rely on demographic factors-such as race and gender. Physicians' judgments could also be influenced by non-health-related, personal information about their patients (e.g., hobbies, nicknames), which may moderate the impact of demographics on those judgments.
The investigators examine these dynamics in the context of heart disease. The History, Electrocardiogram, Age, Risk factors and Troponin (HEART) Score is a validated model that specifies a correspondence between certain risk factors and the likelihood of Major Adverse Cardiac Event (MACE). Importantly, there are substantially different diagnostic tests (e.g., noninvasive stress test versus coronary angiogram) that should be used depending on a patient's MACE likelihood.
Specifically, the investigators have three research questions:
- Research Question 1 (RQ1): How accurate are physicians relative to the benchmarks from the HEART score model?
- Research Question 2 (RQ2): How do clinically-relevant risk factors (e.g., smoking history), race, gender, and personal information disclosure influence risk judgments?
- Research Question 3 (RQ3): Does personal information disclosure moderate the effects of race and gender on risk judgments?
Note that when the investigators discuss accuracy and error, they are referring to the comparison of physician judgments to the HEART score model benchmarks.
Detailed description
The investigators designed a survey to assess physicians' perception of MACE likelihood. Each physician rates a panel of patient profiles. The profiles randomly vary in risk factors, race, gender, and personal information disclosure (e.g., non-health related information about their hobbies). Using the HEART Score model as a benchmark, the investigators will assess how accurately physicians perceive MACE Likelihood based on the risk factors in a given profile. The investigators will further estimate how race, gender, and personal information disclosure causally affect physician judgments.
To do this, the investigators designed a mixed-design experiment. Each participant will respond to eight patient profiles that vary along three fully-crossed within-subject factors: (i) race: black vs. white, (ii) gender: man vs. woman, and (iii) risk factors: low vs. medium risk (based on risk levels from the HEART score model). Each participant will also be randomly assigned (between-subjects) to (iv) either see non-health-related personal information (e.g., hobbies) for all eight of their patients, or not see this information for any of their patients. The investigators refer to each factor as a profile attribute.
For each profile, participants indicate the perceived risk of a major adverse cardiac event in the six weeks following the visit. Our primary outcome is a measure of absolute error in perceived risk of MACE (described under the Primary Outcome section). They also indicate the diagnostic test they believe is most appropriate (Secondary Outcome #4).
Analysis plan
For all analyses, the investigators will format the data such that there are eight observations per participant, each corresponding to a patient profile the participant responded to.
- To test RQ1, the investigators will estimate an Ordinary Least Squares (OLS) regression predicting the primary outcome. The investigators will cluster standard errors by physician. The constant reflects the mean of our primary outcome, reflecting the extent to which physicians are inaccurate.
- To test RQ2, the investigators will estimate an OLS regression predicting the primary outcome. The independent variables include four indicators to model the profile attributes: an indicator for risk factors, an indicator for gender, an indicator for race, and an indicator for personal information disclosure. The model will also include fixed effects for physician specialty (emergency medicine, cardiologists, and hospitalists). The investigators will cluster standard errors by physician.
- To test RQ3, the investigators will reestimate the primary model testing RQ2 twice: In one model, the investigators will add an interaction term between personal information disclosure and race; and in the second model, the investigators will add an interaction term between personal information disclosure and gender.
As secondary analyses,
- The investigators will estimate the models above except using Secondary Outcomes Measures #1-3
- The investigators will measure participants' choice of appropriate diagnostic test for each patient as a secondary outcome (see Secondary Outcome #4). The investigators will estimate a multinomial logistic regression predicting choice of appropriate diagnostic test as the categorical outcome (with "routine follow-up" as the reference category). The independent variables include the four profile attribute indicators and physician specialty fixed effects. The investigators will cluster standard errors by physician.
- The investigators will reestimate the primary models testing RQ2, except including pairwise interactions between the physician specialty fixed effects and each of the four attributes.
- The investigators will reestimate the primary model testing RQ2, except adding all pairwise interactions between the four attributes as independent variables.
- The investigators will measure overconfidence (see Secondary Outcome Measure #5). With data at the physician-level, the investigators will estimate an OLS regression predicting overconfidence. The investigators will reestimate the model, except adding the two indicators for physician specialty and the indicator for personal information disclosure as independent variables.
The investigators will also measure and explore (i) qualitative open-ended responses about how they made their risk estimations, (ii) whether participants use the HEART score model at their jobs (or another model), (iii) if they use a model, why they use it, (iv) if they have heard of the HEART score model, (v) if they looked up anything while taking the study, and (vi) if yes, what they looked up.
The investigators plan to recruit 300 physicians using the Medscape panel.
Study design
- Primary purpose
- Health services research
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
- Model description
- Parallel randomized trial at the physician level.
| Arm | Type | Receives |
|---|---|---|
| No Personal Information Disclosure | No intervention | –Participants rate 8 patient profiles of patients with chest pain. The profiles each contain info about the patient's race, gender, and risk factors associated with MACE. |
| Personal Information Disclosure | Experimental | Behavioral: Personal Information DisclosureParticipants rate 8 patient profiles of patients with chest pain. The profiles each contain info about the patient's race, gender, and risk factors associated with MACE. Each profile also contains non-health related personal information that the patient has disclosed (e.g., nickname, hobbies). |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Emergency medicine physicians
- Cardiologists
- Hospitalists (i.e., internists whose practice is primarily in the hospital)
- If there are duplicate participant IDs in the data, only the first response will be included in the analysis
Key exclusion criteria (3 listed)
- Participants who indicate they are retired
- Participants who write gibberish in the open-ended items
- Incomplete responses
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Personal Information DisclosureEach profile also contains non-health related personal information that the patient has disclosed (e.g., nickname, hobbies). | Behavioural | Personal Information Disclosure |
Primary outcome
Absolute Error in Perceived Risk of MACE
Time frame: At the time of survey completion, within approximately 2 weeks
For each patient profile, all participants will be asked about their perceived risk of MACE: What is the likelihood that this patient experiences a major adverse cardiac event in the six weeks following the visit? [0-100]. The paradigm uses two levels of risk factors, each associated with a specific risk of MACE range as defined by the HEART score model: low risk factors = 0.9-1.7% (midpoint = 1.3%); and medium risk factors = 12-16.6% (midpoint = 14.3%). To calculate each participant's directional error, the investigators will take the difference between participants' perceived risk of MACE and the midpoint of the risk of MACE range from the HEART score model at each patient's corresponding risk level. The absolute error is calculated by taking the absolute value of the directional error.
5 secondary outcomes
Perceived Risk of MACE
Time frame: At the time of survey completion, within approximately 2 weeks
Directional Error
Time frame: At the time of survey completion, within approximately 2 weeks
Categorical Error
Time frame: At the time of survey completion, within approximately 2 weeks
Diagnostic Test Decision
Time frame: At the time of survey completion, within approximately 2 weeks
Overconfidence
Time frame: At the time of survey completion, within approximately 2 weeks
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 16 Jan 2026.
- Individual participant dataSharing planned: Yes. The investigators will share anonymized responses from participants containing all their responses to our survey.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Joseph Reiff, PhD principal investigator
University of Maryland Robert H. Smith School of Business
Aneesh Rai, PhD principal investigator
University of Maryland Robert H. Smith School of Business
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Personal Information Disclosure in people with Major Adverse Cardiac Event (MACE), run by University of Maryland, College Park at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 16 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Absolute Error in Perceived Risk of MACE (time frame: At the time of survey completion, within approximately 2 weeks). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 16 Jan 2026.