Clinical trials: Adults With Acquired Brain Injury, active
Spasticity
A Study to Assess the Safety and Efficacy of IPN10200 in Adult Participants With Upper Limb Spasticity.
The purpose of the study is to assess the safety and efficacy of increasing doses of Corabotase (also known as IPN10200) with the aim to evaluate the Pharmacodynamics (PD) profile of Corabotase and to establish the total…
- Trial name
- LANTIMA (NCT04752774)
- Testing
- Corabotase, Dysport
- Where
- 81 sites in United States, Austria and 12 more
- Volunteers
- 240 people
- Sponsor
- Ipsen
Acquired Brain Injury (Including Stroke)
Stimulus Equivalence Learning in Acquired Brain Injury.
Stimulus Equivalence Learning (SEL) is a form of learning in which stimuli (such as words, pictures, or sounds) become linked to one another in memory, even though this specific connection has not been directly taught.
- Trial name
- NCT07345481
- Where
- Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Klimmendaal Revalidatiespecialisten
Chronic Ischemic Stroke
A Study of ASP2246 for People Who Have Movement Problems Caused by Brain Injury After a Stroke
This study is for adults who have difficulty moving a few months after a stroke. In this study, ASP2246 will be given to people for the first time. This is known as a "first in human" study.
- Trial name
- NCT07318714
- Testing
- ASP2246, Brain surgery, Rehabilitation therapy
- Where
- 5 sites in Japan
- Volunteers
- 84 people
- Sponsor
- Astellas Pharma Inc
Fatigue Symptom, Fatigue Intensity
Monitoring Fatigue In Daily Life In Adults With Cerebral Palsy or Acquired Brain Injury
The goal of this observational study is to learn about levels and patterns of fatigue in adults with cerebral palsy (CP) and acquired brain injury (ABI) in daily life.
- Conditions
- Fatigue Symptom, Fatigue Intensity, Cerebral Palsy (CP), Acquired Brain Injury Including Stroke
- Trial name
- NCT07135791
- Testing
- Real-time monitoring
- Where
- Denmark
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Acquired Brain Injury
Transition From Pediatric to Adult Care in Young Adults With Acquired Brain Injury
This retrospective, single-center observational study evaluates young adults with acquired brain injury who attended a joint pediatric-adult Physical and Rehabilitation Medicine transition consultation at Hôpitaux Paris Est…
- Trial name
- NEURO-TEA (NCT07881042)
- Where
- France
- Volunteers
- 72 people
- Sponsor
- Hopitaux de Saint-Maurice
Traumatic Brain Injury
Verbal Working Memory and Attention Remediation for Adults With Traumatic Brain Injury.
This project will examine if computerized cognitive remediation will improve working memory and attention in 25 adults with a mild, moderate, or severe brain injury and compare their cognitive performance to the control group of…
- Trial name
- NCT04349852
- Testing
- BrainHQ Cognitive Training Modules, BrainHQ People Skills Modules
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- NYU Langone Health
Acquired Brain Injury
Exercise and Physical Activity in Adults With Acquired Brain Injury
Exercise and physical activity in adults with acquired brain injury
- Trial name
- PA_ABI (NCT06895226)
- Testing
- Exercise, Usual Care
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Universidade da Coruña
Acquired Brain Injury
Driving Simulator Training For Adults With Acquired Brain Injuries
The aim of this project is to prepare adults with acquired brain injuries for on-road driving by using the driving simulator and increase participant's comfort level, confidence, and independence within their occupation of…
- Trial name
- NCT07378592
- Testing
- Driving Simulation Intervention, Traditional Occupational Therapy
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Sacred Heart University
Mild Traumatic Brain Injury, Concussion
A Randomised, Double-blind, Placebo-controlled Phase 2a Pilot Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ONP-002 in Adults With Mild Traumatic Brain Injury
This is a Phase IIa, randomized, double-blind, placebo-controlled pilot study to evaluate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of ONP-002 in adults with mild traumatic brain injury (mTBI).
- Trial name
- NCT06870240
- Testing
- Neurosteroid enantiomer
- Where
- Australia
- Volunteers
- 40 people
- Sponsor
- Oragenics, Inc.
Mild Traumatic Brain Injury
Multicenter Early Intervention Study in Adults With Complaints After Mild Traumatic Brain Injury
Rationale: In the Netherlands, traumatic brain injury (TBI) is one of the most frequent neurological diseases and one of the leading causes of disability.
- Trial name
- BRAIN-RESET (NCT07341074)
- Testing
- Treatment by physical- and/or occupational therapist, Psychoeducation via telephonic counselling
- Where
- Netherlands
- Volunteers
- 655 people
- Sponsor
- University Medical Center Groningen
Brain Injury Traumatic Mild
Spotting and Managing Adult Repeated Traumas in the Brain
Emerging evidence suggests that concussions (a type of mild traumatic brain injury; mTBIs) may cause chronic neurological disturbances with effects lasting beyond 20 years, changing brain structure and nearly doubling the risks…
- Trial name
- SMARTBRAIN (NCT07025317)
- Testing
- Perceptual-cognitive
- Where
- 3 sites in Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Université de Montréal
Spinal Cord Injury (=3 Years), Traumatic Brain Injury (TBI) Patients
Evaluation of a Voice-Activated Call Light System for Clients With Limited Upper-Extremity Mobility
The goal of this study is to evaluate whether a voice-activated call light system enables people in a rehabilitation facility who have limited use of their arms and hands to call for help more independently and reliably than with…
- Conditions
- Spinal Cord Injury (=3 Years), Traumatic Brain Injury (TBI) Patients, Healthy Adult Participants
- Trial name
- NCT07873151
- Testing
- voice-activated call light
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Quality Living, Inc.
Caregivers
Feasibility and Acceptability of an LLM-based Chatbot for Family Caregivers: Evaluation Study
This study evaluates the feasibility and acceptability of using the artificial intelligence (AI) chatbot mobile application (an LLM-based Chatbot) to support the well-being of informal care partners of individuals with traumatic…
- Trial name
- NCT07280650
- Testing
- LLM-based Chatbot
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Michigan
Traumatic Brain Injury, Traumatic Brain Injury (TBI) Patients
Safety and Outcomes of MUSE Stem Cell Therapy in Individuals With Traumatic Brain Injury
This prospective observational study evaluates the safety profile and patient-reported outcomes associated with MUSE (Multilineage-differentiating Stress-Enduring) stem cell therapy in individuals aged 6 to 75 with chronic…
- Conditions
- Traumatic Brain Injury, Traumatic Brain Injury (TBI) Patients, Traumatic Brain Injury (TBI); Concussion, Initial Encounter, Traumatic Brain Injury (TBI); Concussion, Subsequent Encounter
- Trial name
- MUSE-TBI-OBS (NCT07326059)
- Testing
- MUSE Stem Cell Therapy
- Where
- 2 sites in United States, Mexico
- Volunteers
- 10 people
- Sponsor
- Healing Hope International
Mild Traumatic Brain Injury, Dizziness
Vestibular Rehabilitation App for Adults With Dizziness Related to mTBI
The goal of this clinical trial is to compare outcomes for standard vestibular rehabilitation home program to a digital vestibular rehabilitation home program in adults with dizziness related to mild traumatic brain injury…
- Trial name
- NCT06222450
- Testing
- Vestibular Rehabilitation Therapy (VRT)
- Where
- 3 sites in United States
- Volunteers
- 68 people
- Sponsor
- Mountain Home Research & Education Corporation
TBI (Traumatic Brain Injury)
Evaluation of Well-being Interventions in Adults With TBI
The purpose of this research is to evaluate the potential benefits of two Intervention programs in adults with TBI to improve well-being and other outcomes that are maintained over time.
- Trial name
- NCT05943756
- Testing
- Signature Strengths, TBI Education Course
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- Kessler Foundation
Lower Limb or Combined Lower Limb and Upper Limb Spasticity Due to Stroke or Traumatic Brain Injury
Study to Compare the Efficacy and Safety of NT 201 (Botulinum Toxin) With Placebo for the Treatment of Lower Limb Spasticity Caused by Stroke or Traumatic Brain Injury
The purpose of this study is to determine whether a single treatment with administration of 400 Units NT 201 (botulinum toxin) is superior to placebo (no medicine) for the treatment of lower limb spasticity caused by stroke or…
- Trial name
- PATTERN (NCT03992404)
- Testing
- NT 201
- Where
- 71 sites in United States, Belgium and 13 more
- Volunteers
- 603 people
- Sponsor
- Merz Pharmaceuticals GmbH
Post-Concussion Syndrome
Rehabilitation in Post Concussion Syndrome
This project evaluates and quantifies the effects of an individually tailored exercise program applied to patients with long-lasting symptoms after concussion, minor traumatic brain injury, so-called Post-Concussion Syndrome…
- Trial name
- REPCon (NCT05785000)
- Testing
- Physical exercise programme as an add-on, Control patients receiving usual care
- Where
- Denmark
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Adults With Acquired Brain Injury
Translation and Cultural Adaptation of the Erasmus Modified Nottingham Sensory Assessment Scale for the Lower Limb in Acquired Brain Injury Into French
There is a lack of validated and standardized tools in French for assessing somatosensory perception in adults with brain injuries.
- Trial name
- F-EmNSA-MI (NCT07613541)
- Testing
- French Erasmus modified Nottingham Sensory Assessment scale, Self-Reported Somatosensory Sensations questionnaire, Sensitive digital scale
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Toulouse
Stroke, Traumatic Brain Injury
Feasibility Study: The Contribution of Hypnosis in the Management of Adults With Brain Injuries
This controlled and randomized study aims to explore the feasibility and benefits of hypnosis in the management of patients who have suffered a traumatic brain injury or a stroke, by assessing its impact on behavioral disorders…
- Trial name
- NCT06817837
- Testing
- hypnosis
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire de Liege