Clinical trials: Acute Diverticulitis
Acute Diverticulitis
Neutrophil to Lymphocyte Ratio as a Predictor of Complicated Acute Diverticulitis
Introduction: Various biomarkers have been studied to predict the severity of acute diverticulitis (AD), such as the leukocyte count and CRP, which are useful but lack sufficient sensitivity.
- Trial name
- NCT04663490
- Testing
- Neutrophil to Lymphocyte Ratio
- Where
- Argentina
- Volunteers
- 325 people
- Sponsor
- Clinica Universitaria Reina Fabiola, Universidad Catolica de Cordoba
Diverticulitis
Italian Study Group on Complicated Diverticulosis
Patients were recruited over a four year period from 1996 to 1999. Those admitted in the years 1996 and 1997 were retrospectively accrued from the clinical records, while patients treated between 1998 and 1999 patients were…
- Trial name
- GISDIC (NCT01276886)
- Testing
- antibiotic, Colonic resection with or without stoma
- Where
- Italy
- Sponsor
- Gruppo Italiano per lo Studio della Diverticolite Complicata
Diverticulitis
Improving the Treatment of Acute Uncomplicated Diverticulitis in Routine Care
Acute uncomplicated diverticulitis is often treated with antibiotics, although current evidence shows that antibiotics are not always necessary.
- Trial name
- AUD (NCT07824180)
- Testing
- standardized treatment algorithm
- Volunteers
- 800 people
- Sponsor
- Ente Ospedaliero Cantonale, Bellinzona
Diverticular Disease of Colon, Acute Diverticulitis
Analysis of the Role of the Microbiota in Diverticular Disease
A single-center, prospective observational cohort study conducted at the University Hospital of Navarra. The primary objective is to expand knowledge of diverticular disease and its pathological variants, as well as the influence…
- Conditions
- Diverticular Disease of Colon, Acute Diverticulitis, Gut Microbiota
- Trial name
- NCT07681505
- Where
- Spain
- Volunteers
- 285 people
- Sponsor
- Hospital of Navarra
Acute Abdomen, Emergency Surgery
Primary Cecal Pathologies Presenting as Acute Abdomen
Background: The importance of cecal pathologies lie in the fact that being the first part of large intestine, any disease involving the cecum affects overall functioning of the large bowel.
- Conditions
- Acute Abdomen, Emergency Surgery, Laparotomy, Amoebic Colitis
- Trial name
- NCT03262025
- Testing
- Operated
- Volunteers
- 43 people
- Sponsor
- Jawaharlal Nehru Medical College
Diverticulitis, Colorectal Cancer
FIT in Diverticulitis
Background and study aims Diverticular disease or diverticulosis is a benign disease of the colon. Diverticulae are pockets of bowel wall which protrude through weaknesses in the muscular wall of the colon.
- Trial name
- NCT06210724
- Testing
- Faecal immunochemical test for haemoglobin, faecal calprotectin, faecal microbiome
- Where
- United Kingdom
- Volunteers
- 275 people
- Sponsor
- Royal Surrey County Hospital NHS Foundation Trust
Diverticular Perforation, Open Abdomen
Damage Control Surgery Over the World in Acute Diverticulitis (DACOSAD)
To analyze the possible benefit of damage control surgery by performing bowel resection, open abdomen, and delayed anastomosis in the treatment of Hinchey III or IV diverticulitis.
- Trial name
- DACOSAD (NCT06428370)
- Testing
- Damage Control Surgery
- Where
- 9 sites in Chile, Italy
- Volunteers
- 300 people
- Sponsor
- Link Campus University
Diverticulitis
Symptomatic Treatment of Acute Uncomplicated Diverticulitis
The purpose of this study is to determine the safety and efficacy of symptomatic treatment (i.e. without antimicrobial drugs) of acute uncomplicated diverticulitis.
- Trial name
- NCT02219698
- Testing
- Ibuprofen, Paracetamol
- Where
- Finland
- Volunteers
- 158 people
- Sponsor
- Helsinki University Central Hospital
Diverticulitis
Prospective Observational Analysis of Circulating Endocan Levels in Patients Presenting With Acute Diverticulitis
Quantify the level of endocan in blood samples collected from patients with acute diverticulitis in the emergency department. Determine if endocan levels are correlated with the severity of diverticulitis according to the WSES…
- Trial name
- DIVENDO (NCT07027007)
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- IRCCS Ospedale San Raffaele
Diverticulitis
LapLAND Laparoscopic Lavage for Acute Non-Faeculant Diverticulitis
The aim of the study is to compare patient outcome following standard of care (Hartmann's or resection with anastomosis and defunctioning stoma) and a 'new therapy' (laparoscopic lavage alone) for the treatment of acute…
- Trial name
- LapLAND (NCT01019239)
- Testing
- Laparoscopic Washout, Hartmann's Procedure/ Primary Resection and Anastomosis
- Where
- Ireland
- Volunteers
- 300 people
- Sponsor
- St Vincent's University Hospital, Ireland
Pregnancy Complications, Acute Appendicitis
Fetal Outcomes Among Pregnant Emergency General Surgery Patients
Approximately 1 in 500 pregnant women require non-obstetric surgery. Surgical care for the pregnant woman raises concern for complications adversely affecting pregnancy outcomes.
- Conditions
- Pregnancy Complications, Acute Appendicitis, Acute Cholecystitis, Biliary Pancreatitis
- Trial name
- NCT05085353
- Testing
- non-obstetric acute general surgical disease
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Methodist Health System
Diverticulitis, Colonic, Therapy
Probiotic After Acute Colonic Diverticulitis
The goal of this observational study is to assess the efficacy and safety of the probiotic Escherichia coli Nissle 1917 (EcN®, Ca.Di.Group S.p.A) in the treatment of symptomatic patients after an episode of both complicated and…
- Trial name
- NCT06040515
- Testing
- Probiotic Formula
- Where
- 12 sites in Italy
- Volunteers
- 145 people
- Sponsor
- Erasmo Spaziani
Acute Diverticulitis, Abdominal Pain
Diagnostic Accuracy of Bedside Ultrasound in Suspected Acute Diverticulitis
Colonic diverticulitis is a common clinical condition in patients presenting to the Emergency Department (ED) with abdominal pain.
- Trial name
- NCT03279588
- Testing
- Bedside Ultrasound
- Where
- 4 sites in Italy
- Volunteers
- 400 people
- Sponsor
- Azienda Ospedaliero-Universitaria Careggi
Acute Uncomplicated Diverticulitis
APLAUD Trial (Antibiotics vs PLacebo for Acute Uncomplicated Diverticulitis)
The goal of this clinical trial is to determine whether antibiotics improve recovery from acute uncomplicated diverticulitis (AUD) in racially and ethnically diverse United States clinical practice.
- Trial name
- NCT07492134
- Testing
- Amoxicillin-Clavulanate 875 Mg-125 Mg Oral Tablet, Metronidazole, Cefuroxime
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Vanderbilt University Medical Center
Diverticulitis Colon
Scandinavian Diverticulitis Trial SCANDIV-II
This study focuses on the treatment for complicated diverticulitis classified as Hinchey I-IV. The aim of this prospective observational study is to evaluate type of treatment and the success rate of treatment in acute…
- Trial name
- SCANDIV-II (NCT04254224)
- Testing
- colon resection, stoma
- Where
- Sweden
- Volunteers
- 500 people
- Sponsor
- Uppsala University
Acute Diverticulitis
Diagnostic Accuracy of Ultrasonography and Computed Tomography in the Diagnosis of Mild-moderate Acute Diverticulitis
Acute diverticulitis (AD) is the most common complication of diverticulosis and is divided into mild-moderate and complicated. Imaging methods are needed for its diagnosis, prognostic classification and therapeutic management.
- Trial name
- NCT05323968
- Testing
- Abdominal Ultrasonography, Abdominal Computerized Tomography
- Where
- Spain
- Volunteers
- 86 people
- Sponsor
- Hospital de Granollers
Colonic Diverticulitis
The Out-patient, Non Antibiotic Management of Patients With Acute Uncomplicated Colonic Diverticulitis
Previous multicentre study NCT 01008488 indicates that a patient with CT-proven uncomplicated diverticulitis has a very low risk (1.4%) of developing severe complications such as perforations or abscesses.
- Trial name
- P-VOD (NCT01515150)
- Where
- Sweden
- Volunteers
- 161 people
- Sponsor
- Uppsala University
Diverticulitis
Combination of Curcumin and Berberine Therapy in the Treatment of Post Acute Diverticulitis (SUDD)
Curcumin (Cur), an active ingredient of the Indian herb Rhizoma Curcuma Longa, has been extensively studied in the context of inflammatory diseases.
- Trial name
- NCT05596214
- Testing
- Curcumin-Berberine (coptis)
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Dr. Adi Lahat
Diverticulitis
Hospitalization or Ambulatory Treatment of Acute Diverticulitis
The purpose of 01DIVER is to evaluate efficacy and safety of a home treatment protocol for non complicated diverticulitis compared with management in the hospital.
- Trial name
- 01DIVER (NCT01081054)
- Testing
- Ambulatory versus hospitalisation
- Where
- 5 sites in Spain
- Volunteers
- 132 people
- Sponsor
- Hospital Universitari de Bellvitge
Acute Uncomplicated Diverticulitis
Non-antibiotic Management in Acute Uncomplicated Diverticulitis
Diverticulitis is a common condition that causes swelling and pain in part of the colon (the large intestine). Doctors classify it as "mild" when there are no serious complications.
- Trial name
- NAMAD (NCT07625267)
- Testing
- Symptomatic treatment (ibuprofen and acetaminophen), Amoxicillin-clavulanate, Ciprofloxacin plus metronidazole
- Sponsor
- Montefiore Medical Center