DiverticulitisAUDNCT07824180
Improving the Treatment of Acute Uncomplicated Diverticulitis in Routine Care
A study testing standardized treatment algorithm in people with Diverticulitis, run by Ente Ospedaliero Cantonale, Bellinzona.
Trial summary
Acute uncomplicated diverticulitis is often treated with antibiotics, although current evidence shows that antibiotics are not always necessary. This study will evaluate whether a more standardized approach to treatment can reduce unnecessary antibiotic use without increasing the risk of treatment failure. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Diverticulitis
- What is being tested?
- standardized treatment algorithm
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 800 participants
- Where
- No sites listed yet
- Study dates
- Oct 2026to Jul 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Age 18 years or older
- CT-confirmirmed acute uncomplicated diverticulitis of the left colon
- Ability to provide informed consent for participants in the prospective phase
Who cannot join
- Complicated acute diverticulitis, defined as diverticulitis with abscess, perforation (free air), fistula, or distant free fluid
- Diverticulitis of the right or transverse colon
- -.Alternative diagnosis explaining the participant's symptoms
- No possibility of completing the 90-day follow-up
- Inability to provide informed consent for the prospective phase
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
Dimitri Christoforidis, MD contact
About this study
Official title: From Guidelines to Real-world Practice: a Pragmatic Before and After Study on the Treatment of Acute Uncomplicated Diverticulitis (AUD) Based on a Risk Factor Driven Treatment Algorithm (AUD Management Algorithm Protocol)
Acute uncomplicated diverticulitis is often treated with antibiotics, although current evidence shows that antibiotics are not always necessary. This study will evaluate whether a more standardized approach to treatment can reduce unnecessary antibiotic use without increasing the risk of treatment failure.
The study will compare patients treated before and after the new treatment approach is introduced in participating Swiss hospitals. Information on treatment, hospital admissions, complications and recurrence of diverticulitis will be collected. Patients will be followed for up to 24 months.
- Conditions
- Diverticulitis
- Being tested
- standardized treatment algorithm
- Medical subject headings
- Diverticulitis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
standardized treatment algorithmOther
A standardized treatment approach based on clinical findings, laboratory results, comorbidities, immunosuppression status, and CT findings is introduced to support treatment decisions in patients with acute uncomplicated diverticulitis. Depending on these factors, patients may be managed with or without antibiotics.
| Study group | Role | What they receive |
|---|---|---|
| Antibiotic Treatment | Other | Participants with acute uncomplicated diverticulitis who receive antibiotic treatment according to the standardized treatment approach. Receives: Other: standardized treatment algorithm |
| No Antibiotic Treatment Arm Description: | Other | Participants with acute uncomplicated diverticulitis who are managed without antibiotics according to the standardized treatment approach. Receives: Other: standardized treatment algorithm |
What is being measured
The primary outcome is the main question the study is designed to answer.
Treatment failure
Treatment failure is defined as a composite outcome including progression to complicated diverticulitis requiring percutaneous abscess drainage or surgery, delayed initiation of antibiotics after initial management without antibiotics, or unplanned hospital admission following initial outpatient treatment.
Measured: Within 90 days after diagnosis
Secondary outcomes (5)
Antibiotic use
Proportion of participants receiving antibiotics
Measured: Within 90 days after diagnosis
Adherence to the standardized treatment approach
Proportion of participants whose management is consistent with the standardized treatment approach.
Measured: At the initial treatment decision
Outpatient versus inpatient management
Proportion of participants initially managed as outpatients versus inpatients.
Measured: At the initial treatment decision
Hospital admission
Proportion of participants readmitted to hospital.
Measured: Within 30 days after diagnosis
Recurrence of diverticulitis
Proportion of participants experiencing recurrence of diverticulitis.
Measured: Within 24 months after diagnosis
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted17 Sep 2026
- Study startOct 2026 (estimated)
- Primary completionApr 2027 (estimated)
- Study completionJul 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for DiverticulitisStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Model description
- Before-and-after study comparing a retrospective control cohort treated according to usual care with a prospective cohort treated after introduction of a standardized treatment approach. The two cohorts are enrolled in different time periods and participants are not randomized. In the prospective phase, participants are managed with or without antibiotics based on clinical, laboratory, and CT findings.
- Masking
- None (open label)
- Enrolment
- 800 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Ente Ospedaliero Cantonale, Bellinzona
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Dimitri Christoforidis, MD, Principal investigator, EOC
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07824180
- Sponsor's protocol ID
- ORL-CHIR-040_aud
- Acronym
- AUD
- Status last verified
- Sep 2026
- First submitted
- 11 Sep 2026
- Last updated
- 21 Sep 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 21 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- From Guidelines to Real-world Practice: a Pragmatic Before and After Study on the Treatment of Acute Uncomplicated Diverticulitis (AUD) Based on a Risk Factor Driven Treatment Algorithm (AUD Management Algorithm Protocol)
- ClinicalTrials.gov ID
- NCT07824180
- Acronym / sponsor ID
- AUD / ORL-CHIR-040_aud
- Conditions
- Diverticulitis
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 800 participants (estimated)
- Lead sponsor
- Ente Ospedaliero Cantonale, BellinzonaUniversity, hospital or other
- Study start
- Oct 2026 (estimated)
- Primary completion
- Apr 2027 (estimated)
- Study completion
- Jul 2027 (estimated)
- First posted
- 17 Sep 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Acute uncomplicated diverticulitis is often treated with antibiotics, although current evidence shows that antibiotics are not always necessary. This study will evaluate whether a more standardized approach to treatment can reduce unnecessary antibiotic use without increasing the risk of treatment failure.
The study will compare patients treated before and after the new treatment approach is introduced in participating Swiss hospitals. Information on treatment, hospital admissions, complications and recurrence of diverticulitis will be collected. Patients will be followed for up to 24 months.
Study design
- Primary purpose
- Treatment
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
- Model description
- Before-and-after study comparing a retrospective control cohort treated according to usual care with a prospective cohort treated after introduction of a standardized treatment approach. The two cohorts are enrolled in different time periods and participants are not randomized. In the prospective phase, participants are managed with or without antibiotics based on clinical, laboratory, and CT findings.
| Arm | Type | Receives |
|---|---|---|
| Antibiotic Treatment | Other | Other: standardized treatment algorithmParticipants with acute uncomplicated diverticulitis who receive antibiotic treatment according to the standardized treatment approach. |
| No Antibiotic Treatment Arm Description: | Other | Other: standardized treatment algorithmParticipants with acute uncomplicated diverticulitis who are managed without antibiotics according to the standardized treatment approach. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (3 listed)
- Age 18 years or older
- CT-confirmirmed acute uncomplicated diverticulitis of the left colon
- Ability to provide informed consent for participants in the prospective phase
Key exclusion criteria (5 listed)
- Complicated acute diverticulitis, defined as diverticulitis with abscess, perforation (free air), fistula, or distant free fluid
- Diverticulitis of the right or transverse colon
- -.Alternative diagnosis explaining the participant's symptoms
- No possibility of completing the 90-day follow-up
- Inability to provide informed consent for the prospective phase
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| standardized treatment algorithmA standardized treatment approach based on clinical findings, laboratory results, comorbidities, immunosuppression status, and CT findings is introduced to support treatment decisions in patients with acute uncomplicated diverticulitis. Depending on these factors, patients may be managed with or without antibiotics. | Other | Antibiotic Treatment, No Antibiotic Treatment Arm Description: |
Primary outcome
Treatment failure
Time frame: Within 90 days after diagnosis
Treatment failure is defined as a composite outcome including progression to complicated diverticulitis requiring percutaneous abscess drainage or surgery, delayed initiation of antibiotics after initial management without antibiotics, or unplanned hospital admission following initial outpatient treatment.
5 secondary outcomes
Antibiotic use
Time frame: Within 90 days after diagnosis
Adherence to the standardized treatment approach
Time frame: At the initial treatment decision
Outpatient versus inpatient management
Time frame: At the initial treatment decision
Hospital admission
Time frame: Within 30 days after diagnosis
Recurrence of diverticulitis
Time frame: Within 24 months after diagnosis
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 21 Sep 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Dimitri Christoforidis, MD contact
Dimitri Christoforidis, MD principal investigator
EOC
Questions about this trial
What is this clinical trial studying?
A study testing standardized treatment algorithm in people with Diverticulitis, run by Ente Ospedaliero Cantonale, Bellinzona.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 21 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Dimitri Christoforidis, MD (Dimitrios.Christoforidis@eoc.ch), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Treatment failure (time frame: Within 90 days after diagnosis). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 21 Sep 2026.