Skin Barrier to Water LossAPC-SKINNCT07807085

Apple Peptide Complex for Post-Surgical and Aesthetic Skin Recovery

A study testing Apple Peptide Complex Post-Aesthetic Care Protocol in people with Skin Barrier to Water Loss and Skin Health, run by Grow Out Oils Clinical Aromatherapy Company at 1 site in United States.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record

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Trial summary

This clinical study evaluates a topical botanical formulation for supporting skin recovery following invasive and non-invasive aesthetic procedures. These procedures include liposuction, breast augmentation, Brazilian butt lift (BBL), laser treatments, and micro needling, pregnancy stretch mark and weight loss skin. Read more about this study

Who is it for?: Any age, women onlyHealthy volunteers can take part
Conditions the study is for: Skin Barrier to Water Loss, Skin Health, Skin Discoloration
What is being tested?: Apple Peptide Complex Post-Aesthetic Care Protocol
Could I receive a placebo?: No, everyone receives an active treatment
How many people: 50 participants
Where: 1 siteUnited States
Study dates: 20 Jan 2021to 29 Dec 2025
Phase: Interventional

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

Ages Any age
Women only
Healthy volunteers accepted
Child, Adult, Older adult

Who may be able to join

Female participants aged 45-65 years
Undergoing or have undergone aesthetic or surgical procedures (e.g., liposuction, breast augmentation, laser treatments, microneedling)
Presence of skin concerns such as hyperpigmentation, scarring, or reduced elasticity
Willing and able to comply with study procedures and follow-up
Physician clearance for participation

Who cannot join

Active skin infections, open wounds, or delayed wound healing
Pregnancy or breastfeeding
Use of conflicting topical or systemic treatments
Known allergy to botanical ingredients in the formulation

Trial locations and contacts

1 site in 1 country.

United States1 site

Grow Out Oils Clinical Aromatherapy Company
Weston, Florida, 33326

Other trials in United States

About this study

Official title: Evaluation of the Efficacy of the Breast and Body Apple Peptide Complex in Post-Surgical Recovery and Non-Invasive Aesthetic Treatments in Medical Aesthetic Clinics, Dermatology Practices, and Med Spas

The study will assess the effects of the formulation on skin elasticity, hydration, and overall appearance when used as part of post-procedure care under the supervision of licensed medical professionals. Participants will apply the product to treatment areas over a defined study period, and outcomes will be compared to a control group receiving standard care or placebo.

Read the detailed description

The investigational product is a topical botanical formulation composed of plant-derived extracts including Pyrus malus (apple) fruit extract, Vanilla planifolia fruit extract, Jasminum officinale (jasmine) flower extract, and Vitis vinifera derivatives. These components are commonly used in dermatologic and cosmetic applications for their antioxidant, emollient, and skin barrier-supporting properties.

The formulation contains fatty acid components, including linoleic acid, which may contribute to maintaining skin hydration and barrier integrity. The product is intended for topical use following invasive and non-invasive aesthetic procedures, including liposuction, breast augmentation, Brazilian butt lift (BBL), laser therapies, and micro needling, pregnancy stretch mark and weight loss skin.

This study is designed as a randomized, interventional clinical trial conducted in medical aesthetic clinics, dermatology practices, and med spa settings. Participants were assigned to either an intervention group receiving the investigational product for standard post-procedure usage for topical skincare use.

Primary outcome measures include assessment of skin elasticity, hydration, and visible skin appearance. Secondary outcomes include time to visible recovery and incidence of adverse skin reactions.

Conditions: Skin Barrier to Water Loss, Skin Health, Skin Discoloration, Skin Irritation, Skin Abnormalities, Hyperpigmentation
Being tested: Apple Peptide Complex Post-Aesthetic Care Protocol
Keywords: aesthetic care healing modality, bbl post care treatment, breast augmentation and reconstructive post care treatment, stretch marks, skin hyperpigmentation, skin irritation, skin barrier health, skin discoloration
Medical subject headings: Skin Abnormalities, Hyperpigmentation, Striae Distensae, Lymphatic Abnormalities

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

Apple Peptide Complex Post-Aesthetic Care ProtocolOther
Participants receive the Apple Peptide Complex topical formulation as a standardized post-aesthetic care intervention following invasive and non-invasive aesthetic procedures. Participants apply the formulation to designated treatment areas according to the protocol-defined frequency, amount, and duration. Outcomes are evaluated to assess the formulation's effects on post-procedural skin recovery and overall cellular repair. Apple Peptide Complex is administered topically as a standardized post-aesthetic care intervention following invasive and non-invasive aesthetic procedures. Participants apply the formulation to designated treatment areas according to protocol-defined instructions regarding frequency and duration. The study evaluates predefined outcomes associated with post-procedural recovery and overall cellular repair.

Study groups in NCT07807085
Study group	Role	What they receive
Apple Peptide Complex Post-Aesthetic Care Protocol	Experimental	Participants receive the Apple Peptide Complex topical formulation as a standardized post-aesthetic care intervention following an invasive or non-invasive aesthetic procedure. The formulation is applied to designated treatment areas according to the study protocol-defined frequency and duration. Participants are evaluated for predefined biomedical and/or health-related outcomes associated with post-procedural recovery and overall cellular repair. Receives: Other: Apple Peptide Complex Post-Aesthetic Care Protocol

What is being measured

The primary outcome is the main question the study is designed to answer.

Clinician-Graded Visual Skin Evaluation Score
Clinician assessment of skin surface appearance to monitor reductions in post-procedural redness and dryness. Evaluation is performed using a standard 0 to 4 scale, where 0 indicates no redness/dryness and 4 indicates severe redness/dryness. Unit of Measure: Units on a scale (0 to 4)
Measured: Baseline, Day 14, and Day 28 post-procedure
Change in Trans epidermal Water Loss (TEWL)
Evaluation of skin barrier function following daily topical use of the cosmetic Apple Peptide Complex. Data are collected via a tewameter to assess absolute changes in skin moisture retention. Unit of Measure: g/h/m²
Measured: 28 days post-procedure (with assessments conducted at day 14 and day 28)
Participant Comfort Rating Score
Self-reported participant feedback regarding skin comfort, including soothing sensations and lack of irritation. Scores are recorded using a feedback scale from 0 (extreme discomfort/irritation) to 10 (complete skin comfort/highly soothed). Unit of Measure: Units on a scale (0 to 10)
Measured: Baseline, Day 14, and Day 28 post-procedure

Secondary outcomes (2)

Presence of Post-Inflammatory Hyperpigmentation (PIH)Description
Clinical observation of the treated area to identify the development of post-procedural hyperpigmentation. Unit of Measure: Percentage of participants with observed hyperpigmentation.
Measured: Baseline (pre-procedure), immediately post-procedure, Day 14, and Day 28
Clinician-Graded Skin Desquamation Score
Assessment of skin flaking or peeling in the treated area using a standard clinical scaling chart. Evaluation is graded on a 0 to 4 scale, where 0 indicates no desquamation and 4 indicates severe desquamation.
Measured: Baseline (pre-procedure), immediately post-procedure, Day 14, and Day 28

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

20 Jan 202129 Dec 2025

First posted8 Sep 2026
Study start20 Jan 2021
Primary completion4 Dec 2025
Study completion29 Dec 2025

Resources

Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
Publications (4)Papers the sponsor has linked to this study.
Other trials for Skin Barrier to Water LossStudies of the same condition, open and under way.
What the trial phases meanHow a treatment moves from first tests in people to approval.

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design

Study type: Interventional
Phase: Phase N/A
Primary purpose: Supportive care
Allocation: Not applicable
Intervention model: Single group
Model description: Participants were randomized into two parallel groups: an intervention group receiving the topical Apple Peptide Complex as part of post-procedural care, and a control group receiving standard post-procedure care. Both groups were monitored over the same study period following invasive and non-invasive aesthetic procedures, including surgical and dermatologic treatments, to evaluate skin recovery outcomes.
Masking: None (open label)
Enrolment: 50 participants (actual)

IDs, dates and publications

ClinicalTrials.gov ID: NCT07807085
Sponsor's protocol ID: GOO-APPLE-PEPTIDE-001
Acronym: APC-SKIN
Status last verified: Sep 2026
First submitted: 27 Apr 2026
Last updated: 8 Sep 2026
Results posted: No
Data monitoring committee: No
FDA-regulated drug: No
FDA-regulated device: No
Individual data sharing: Yes: Detailed information for each subject, such as participant ID, treatment received, age, race, gender, disease, aesthetic surgical procedure specific outcomes at different time points during the post care treatment healing process and protocol timeline.

Publications

Proksch E, Brandner JM, Jensen JM. The skin: an indispensable barrier. Exp Dermatol. 2008 Dec;17(12):1063-72. doi: 10.1111/j.1600-0625.2008.00786.x.
PubMed 19043850
Citation 3 (Post-Procedure Skin Care) Draelos ZD. The role of skin care in optimizing outcomes following cosmetic procedures. Journal of Cosmetic Dermatology. 2012;11(3):169-173.
Pullar JM, Carr AC, Vissers MCM. The Roles of Vitamin C in Skin Health. Nutrients. 2017 Aug 12;9(8):866. doi: 10.3390/nu9080866.
PubMed 28805671
Saxena S. Mobile pediatric service. Indian Pediatr. 1972 Nov;9(11):641-2. No abstract available.
PubMed 4658681

Want to know more?

The sponsor has not listed a contact. The official record may have more details.

Talk to your doctor first and take this page with you. Only the study team can confirm whether you can join.

Questions to ask the study team

What is the study trying to find out?
What would I need to do, and how often would I visit?
Could I receive a placebo instead of the treatment?
What are the possible risks and benefits for me?
Will it cost me anything? Are travel or time paid for?
Can I keep seeing my own doctor during the study?
What happens when the study ends?

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