Clinical trials: Skin Barrier to Water Loss
Skin Barrier to Water Loss, PASI /SCORAD Index
Safety and Efficacy of Tripalmitoleoylglycerol in the Treatment of Dermatitis
This randomized, double-blind, placebo-controlled clinical trial is designed to evaluate the safety and efficacy of topical palmitoleic acid glyceride supplementation in improving skin barrier impairment associated with chronic…
- Trial name
- NCT07366255
- Testing
- 0.5% Tripalmitoleoylglycerol topical intervention
- Where
- China
- Volunteers
- 46 people
- Sponsor
- Shenzhen People's Hospital
Skin Barrier to Water Loss, Microbial Colonization
Oral Lactobacillus Reuteri for Skin Barrier Dysfunction in Obesity
This clinical trial aims to evaluate the safety and efficacy of oral Lactobacillus reuteri supplementation for treating obesity-induced skin barrier impairment in individuals aged 18-40 with a BMI ≥30.
- Trial name
- NCT07512050
- Testing
- Oral Lactobacillus reuteri group, Oral administration of inactive Lactobacillus reuteri group
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Shenzhen People's Hospital
Skin Barrier to Water Loss, Microbial Colonization
Oral Bifidobacterium Longum for Skin Barrier Dysfunction in Obesity
This clinical trial aims to evaluate the safety and efficacy of oral Bifidobacterium longum supplementation for treating obesity-induced skin barrier impairment in individuals aged 18-40 with BMI ≥30, compared to healthy…
- Trial name
- NCT07184905
- Testing
- Oral administration of inactive Bifidobacterium longum group, Oral Bifidobacterium longum group
- Where
- China
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Shenzhen People's Hospital
Skin Elasticity, Skin Hydration
Eggshell Membrane Beauty From Within Trial
This study is intended to evaluate the efficacy of oral supplementation of an unhydrolyzed eggshell membrane ingredient (uESM) vs placebo on both objective and subjective markers of skin aging in middle-aged and senior adults…
- Conditions
- Skin Elasticity, Skin Hydration, Skin Barrier to Water Loss, Fingernail Health
- Trial name
- NCT06148337
- Testing
- unhydrolyzed eggshell membrane
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- ESM Technologies, LLC
Atopy, Skin Barrier to Water Loss
Clinical Evaluation of an Atopic Skin Product Containing Picea Abies Resin Extract
This study evaluates the repairing efficacy of a cosmetic cream containing Picea abies extract compared to a placebo (cream without extract) and a benchmark product.
- Trial name
- NCT07573592
- Testing
- Atopic cream with Picea abies resin extract, Aqualan-L Cream
- Where
- Italy
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Repolar Pharmaceuticals Oy
Skin Barrier to Water Loss, Skin Health
Apple Peptide Complex for Post-Surgical and Aesthetic Skin Recovery
This clinical study evaluates a topical botanical formulation for supporting skin recovery following invasive and non-invasive aesthetic procedures.
- Conditions
- Skin Barrier to Water Loss, Skin Health, Skin Discoloration, Skin Irritation
- Trial name
- APC-SKIN (NCT07807085)
- Testing
- Apple Peptide Complex Post-Aesthetic Care Protocol
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Grow Out Oils Clinical Aromatherapy Company
Atopic Dermatitis (AD), Cholesterol
A Study on the Efficacy of 2% Cholesterol Cream in Atopic Dermatitis
Atopic dermatitis is a common chronic inflammatory skin condition characterized by impaired skin barrier function, leading to increased transepidermal water loss (TEWL), dry skin, and itching.
- Conditions
- Atopic Dermatitis (AD), Cholesterol, Skin Barrier to Water Loss, Skin Allergy
- Trial name
- NCT07503197
- Testing
- Topical 2% cholesterol cream
- Where
- Thailand
- Volunteers
- 30 people
- Sponsor
- Institute of Dermatology, Thailand
Sebum Production, Acne Scars
SMosE Safety and Efficacy Evaluation as a Skin Adaptogen
This study evaluates the biological activity, safety, and clinical efficacy of SMosE (Shiitake Mushroom Oil-Soluble Extract), a topical cosmetic ingredient developed to support skin barrier function, adaptogenic responses, and…
- Conditions
- Sebum Production, Acne Scars, Skin Barrier to Water Loss
- Trial name
- SMosE (NCT06338046)
- Testing
- Corthellus Shiitake(Mushroom) Extract
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Federico II University
Atopic Dermatitis
A Study to Investigate the Use of Hydrogel Vehicle in Maintaining the Skin Barrier in Persons With Atopic Dermatitis
While the repair of the epidermal barrier in atopic dermatitis is of major importance in the treatment of atopic dermatitis, most of the vehicles used may actually cause a worsening of an impaired epidermal barrier.
- Trial name
- NCT01065714
- Testing
- Hydrogel vehicle, Eucerin Lotion
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Derm Research, PLLC
Skin Barrier to Water Loss, Microbial Colonization
Topical Lactobacillus Crispatus for Skin Barrier Dysfunction in Obesity
This clinical trial aims to evaluate the safety and efficacy of topical application of Lactobacillus crispatuson the forearm for treating obesity-induced skin barrier impairment in individuals aged 18-45 with BMI ≥25.
- Trial name
- NCT07266532
- Testing
- Topical Inactivated Lactobacillus crispatus Application Group, Topical L. crispatus Treatment Group
- Where
- China
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Shenzhen People's Hospital