Clinical trials: Hyperpigmentation
Gingival Hyperpigmentation, Oral Health-Related Quality of Life
MEBO Bio-Dressing on Patient-Reported Outcomes and Tissue Healing Following Rotary Gingival Depigmentation
The purpose of this randomized, single-blind, parallel-group clinical trial is to evaluate the clinical efficacy of Moist Exposed Burn Ointment (MEBO) as a biological topical dressing compared to open secondary healing (no…
- Conditions
- Gingival Hyperpigmentation, Oral Health-Related Quality of Life, Wound Healing
- Trial name
- NCT07876921
- Testing
- MEBO Ointment
- Where
- Egypt
- Volunteers
- 66 people
- Sponsor
- Cairo University
Malignant Melanoma of Skin, Other and Unspecified Malignant Neoplasm of Skin
Using an Artificial Intelligence (AI) Tool for Melanoma Diagnosis
The purpose of this study is to learn whether a computer-based support tool called DEXI (Dermoscopy EXplainable Intelligence) can help dermatologists decide whether a lesion may be melanoma, a serious type of skin cancer.
- Conditions
- Malignant Melanoma of Skin, Other and Unspecified Malignant Neoplasm of Skin, Melanoma in Situ, Carcinoma in Situ of Skin
- Trial name
- NCT07890415
- Testing
- Clinical decision support tool
- Where
- 8 sites in United States
- Volunteers
- 14,000 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Melasma
Baseline Dermoscopic Vascular Score and Response to Oral Tranexamic Acid in Facial Melasma
Melasma is a common, long-lasting pigmentation disorder of the face. Some patients improve well with treatment and others improve little, and there is no simple way to predict this at the first visit.
- Trial name
- NCT07881328
- Testing
- Tranexamic acid, Standardised sunscreen and emollient
- Where
- Pakistan
- Volunteers
- 128 people
- Sponsor
- Allied Hospital Faisalabad
Dark Eye Circles (Periorbital Hyperpigmentation)
Vitamin K2 (35) (MK-7) Reduces Dark Eye Circles: a Mechanistic and Human Efficacy Study
The goal of this clinical trial is to learn if an eye cream containing 0.05% Vitamin K2 (35) (MK-7) works to reduce vascular-type dark eye circles in women aged 20-60 years.
- Trial name
- NCT07881367
- Testing
- MK-7 Eye Cream
- Where
- China
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Nanjing Ascend Biotech Technology Co., Ltd.
Hyperpigmentation
An 18-week Study to Evaluate a Test Product With a Marketed Prescription Product
The purpose of this study is to assess the efficacy (ability to produce a desired or intended result) of a topical product (applied to the skin) to improve skin lightness, skin condition and appearance (hyperpigmentation [dark…
- Trial name
- NCT07136766
- Testing
- Facial Toner
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Good Molecules, LLC
Telangiectasias, Reticular Veins
Foam Sclerotherapy With or Without Transdermal Laser for Reticular Veins and Telangiectasias
This prospective, randomized, controlled, intraindividual split-leg clinical trial will compare isolated polidocanol foam sclerotherapy with the Cryo-Laser After Foam (CLaF) technique for the treatment of reticular veins and…
- Conditions
- Telangiectasias, Reticular Veins, Chronic Venous Disease
- Trial name
- NCT07793630
- Testing
- Polidocanol foam sclerotherapy, Transdermal 1064 nm Nd:YAG Laser
- Where
- Brazil
- Volunteers
- 70 people
- Sponsor
- University of Sao Paulo
Acne Scars - Mixed Atrophic and Hypertrophic, Hyperpigmentation
Efficacy and Tolerability of a Hybrid Fractional Laser for the Treatment of Acne Scars in Patients With Skin of Color
The investigators aim to investigate the efficacy and tolerability of a hybrid non-ablative/ablative laser for acne scarring in skin of color.
- Conditions
- Acne Scars - Mixed Atrophic and Hypertrophic, Hyperpigmentation, Laser-Induced Hyperpigmentation
- Trial name
- NCT05362929
- Testing
- Sciton Halo
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Physiological Gingival Hyperpigmentation
Evaluation of the Efficacy of Blue Laser in the Management of Gingival Hyperpigmentation Using Contact vs. Non-contact Mode
The goal of this clinical trial is to compare clinical and digital color parameter results of gingival depigmentation using blue laser in both contact and non- contact modes in patients with physiological gingival…
- Trial name
- NCT07836894
- Testing
- Gingival depigmentation using blue laser in non-contact mode, Gingival depigmentation using blue laser in contact mode
- Where
- Lebanon
- Volunteers
- 20 people
- Sponsor
- Beirut Arab University
Hyperpigmentation, Melasma (Facial Melasma)
Efficacy Evaluation of a Cosmetic Product for Facial Hyperpigmentation
This is a single-center, single-blind clinical study designed to evaluate the efficacy of a depigmenting gel cream through clinical, subjective, and instrumental assessments.
- Trial name
- HYPERPIG (NCT07769268)
- Testing
- Blancy Pro
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Brainfarma Industria Química e Farmacêutica S/A
Gingival Hyperpigmentation
Licorice Extract Gel Versus Diode Laser for Physiologic Gingival Pigmentation
This randomized controlled clinical trial aims to compare the effectiveness of topical licorice extract gel and diode laser (445 nm) in the treatment of physiologic gingival pigmentation.
- Trial name
- NCT07325825
- Testing
- Diode Laser 445 nm, Licorice Extract Gel
- Where
- Egypt
- Volunteers
- 26 people
- Sponsor
- Alexandria University
Gingival Pigmentation, Gingiival Hyperpigmentation
Evaluation of the Efficacy of Topical Application of Liquid Nitrogen and Ascorbic Acid in Treatment of Gingival Pigmentation
Aim of study The present study will be designed to evaluate the clinical and histomorphometric outcomes of using topical liquid nitrogen and topical ascorbic acid in gingival depigmentation.
- Trial name
- NCT07810101
- Testing
- Topical application of ascorbic acid for treatment of gingival pigmentation, Topical application of liquid nitrogen for treatment of gingival pigmentation, Treatment of gingival pigmentation by surgical technique
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Al-Azhar University
Skin Barrier to Water Loss, Skin Health
Apple Peptide Complex for Post-Surgical and Aesthetic Skin Recovery
This clinical study evaluates a topical botanical formulation for supporting skin recovery following invasive and non-invasive aesthetic procedures.
- Conditions
- Skin Barrier to Water Loss, Skin Health, Skin Discoloration, Skin Irritation
- Trial name
- APC-SKIN (NCT07807085)
- Testing
- Apple Peptide Complex Post-Aesthetic Care Protocol
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Grow Out Oils Clinical Aromatherapy Company
Epidermal Melasma, Facial Hyperpigmentation
Topical Metformin Versus Triple Regimen for Epidermal Melasma
Melasma is a common skin condition that causes dark brown patches, mainly on sun-exposed areas of the face. It is often persistent, may recur after treatment, and can affect a person's quality of life.
- Trial name
- MET-MEL (NCT07779811)
- Testing
- Topical 30% metformin cream, Topical Triple Regimen
- Where
- Pakistan
- Volunteers
- 104 people
- Sponsor
- Combined Military Hospital, Pakistan
Hyperpigmentation
Clinical Study to Assess Safety, Efficacy and In-Use Tolerability of Oziva Bioactive Gluta Fizzy Effervescent Tablets on Subjects With Facial Dark Spots Such as Pimple Marks, Sunspots, Age Spots and Uneven Skin Tone
This is a randomized, double-blinded, single-centre, two-arms, placebo-controlled, prospective study to evaluate clinical safety, efficacy and in-use tolerability of Test Product i.e.
- Trial name
- NCT07162623
- Testing
- Oziva Bioactive Gluta Fizzy Effervescent Tablets 4.1 g containing Glutathione
- Where
- India
- Volunteers
- 62 people
- Sponsor
- NovoBliss Research Pvt Ltd
Gingiival Hyperpigmentation
Comparison of Gingival Depigmentation Using Microneedling and Microneedling With Glutathione Gel - A Split Mouth Clinical Trial
The colour of gingiva is important determinant of smile esthetics.Owing to increasing awareness and demand for cosmetic procedures over the past decade, gingival depigmentation has gained popularity among periodontal plastic…
- Trial name
- NCT07748507
- Testing
- Microneedling using Dermapen device, Microneedling with 0.5 % Glutathione gel
- Where
- India
- Volunteers
- 15 people
- Sponsor
- Krishnadevaraya College of Dental Sciences & Hospital
Hyperpigmentation, Dry Skin
Clinical Efficacy and Safety of MB LuxuryⓇ Product Containing Epigallocathecin Gallate (EGCG) on Erythema, Melanin, and Skin Hydration
The purpose of this study is to evaluate the efficacy and safety of MB Luxury skincare containing the active ingredient Epigallocatechin Gallate (EGCG) from green tea (Camellia sinensis L.) on skin melanin index, erythema index…
- Conditions
- Hyperpigmentation, Dry Skin, Erythema
- Trial name
- NCT07725900
- Testing
- MB Luxury Skincare containing Epigallocatechin Gallate (EGCG)
- Where
- Indonesia
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Naniek Widyaningrum
Melasma
Efficacy and Safety of a Combined Topical Formula Versus Placebo in Patients With Melasma
The goal of this clinical trial is to learn whether a topical formulation containing 12% azelaic acid and 5% tranexamic acid is effective and safe for treating melasma in adults.
- Trial name
- NCT07727954
- Testing
- Topical azelaic acid 12% plus tranexamic acid 5%
- Where
- Mexico
- Volunteers
- 40 people
- Sponsor
- University of Guadalajara
Skin Aging, Hyperpigmentation
Homocysteic Acid Biostimulator for Photoaged Facial Skin
This study evaluated whether a chemical skin biostimulator containing ammonium trichloroacetate, homocysteic acid, phytic acid and citric acid can improve signs of photoaged skin in women with mature skin.
- Trial name
- NCT07722351
- Testing
- Chemical skin biostimulation with ammonium trichloroacetate and homocysteic acid
- Where
- Poland
- Volunteers
- 25 people
- Sponsor
- Medical University of Silesia
Post-inflammatory Hyperpigmentation, Melasma
A Clinical Study to Evaluate the Efficacy in Improving Dark Spots After 8 Weeks of Use of Facial Sunscreens in Adult Participants
The study aims to evaluate the efficacy of a facial sunscreen under two experimental conditions-untinted and tinted-in improving facial spots (melasma and solar lentigines/post-inflammatory hyperpigmentation) after 8 weeks of…
- Conditions
- Post-inflammatory Hyperpigmentation, Melasma, Solar Lentigo
- Trial name
- El Porto Ex-US (NCT07679945)
- Testing
- Sunscreen untinted, Sunscreen tinted
- Where
- Brazil
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Kenvue Brands LLC
Melasma, Rosacea
Microfocused Ultrasound for Facial Pigmentary Diseases and Rosacea
This clinical study will evaluate the efficacy and safety of microfocused ultrasound treatment in patients with facial pigmentary diseases and rosacea.
- Conditions
- Melasma, Rosacea, Periorbital Hyperpigmentation, Melanosis
- Trial name
- NCT07667972
- Testing
- Microfocused Ultrasound Treatment
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Xiangya Hospital of Central South University