Clinical trials: sponsored by Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Immunosenescence, Overweight
The Impact of Nicotinamide Mononucleotide Sustained-release Tablets on Immunosenescence and Metabolism in Middle-aged and Elderly Individuals With Metabolic Disorders.
This study evaluates whether nicotinamide mononucleotide (NMN) sustained-release tablets affect markers of immune system aging in adults aged 50 to 70 years with overweight or obesity and metabolic disorders.
- Conditions
- Immunosenescence, Overweight, Obesity, Metabolic Dysfunction-Associated Fatty Liver Disease
- Trial name
- NCT06907329
- Testing
- NMN
- Where
- China
- Volunteers
- 124 people
- Sponsor
- Qing Su
Carbapenem-Resistant Acinetobacter Baumannii Infection
Targeted Antimicrobial Comparison for Treatment Individualization in Critically Ill Patients With CRAB Infection
The goal of this prospective, multicenter observational study is to learn which antibiotic treatment strategies are associated with better outcomes in critically ill adults with severe infections caused by carbapenem-resistant…
- Trial name
- TACTIC-CRAB (NCT07905235)
- Testing
- Antibiotic Therapy for CRAB Infection
- Volunteers
- 1,000 people
- Sponsor
- Central South University
Mobilization of Hematopoietic Stem Cells (HSC) to Peripheral Blood (PB), Hematopoetic Stem Cell Transplantation
G-CSF Combined With IL-11 on Hematopoietic Reconstitution After Autologous Hematopoietic Stem Cell Transplantation
Autologous hematopoietic stem cell transplantation(auto-HSCT) plays an important role in treating hematologic malignancies. Mobilization and collection of peripheral blood stem/progenitor cells is the key to successful autologous…
- Conditions
- Mobilization of Hematopoietic Stem Cells (HSC) to Peripheral Blood (PB), Hematopoetic Stem Cell Transplantation, Hemato-oncologic Patients
- Trial name
- NCT07362810
- Testing
- G-CSF+IL-11, G-CSF Granulocyte-Colony Stimulating Factor
- Where
- 7 sites in China
- Volunteers
- 224 people
- Sponsor
- Fudan University
Congenital Heart Disease (CHD), Artifical Intelligence
AI-Assisted Versus Independent Heart Sound Screening for Congenital Heart Disease in Children
This is a prospective, school-based, cluster-randomized controlled trial conducted in Qinghai Province, China. The study will evaluate whether artificial intelligence (AI) can help primary care physicians identify congenital…
- Conditions
- Congenital Heart Disease (CHD), Artifical Intelligence, Screening, Cardiac Auscultation
- Trial name
- NCT07830251
- Testing
- AI-Assisted Cardiac Auscultation
- Where
- China
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Kun Sun
Iron Deficiency Anemia
Preconception vs First-Trimester Screening and Treatment for Iron Deficiency Anemia
This cluster randomized trial compares preconception with early-pregnancy anemia screening and iron supplementation, assessing late pregnancy iron deficiency anemia and maternal and infant outcomes.
- Trial name
- NCT07811765
- Testing
- Preconception Anemia Screening and Treatment Strategy, Early-Pregnancy Anemia Screening and Treatment Strategy
- Where
- China
- Volunteers
- 960 people, healthy volunteers welcome
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
RETT Syndrome With Proven MECP2 Mutation
GCB-002 in Treatment of Patients With Rett Syndrome
Study Brief Summary overall design This study explored dose escalation of single-arm, open, single intrathecal injection in female RTT subjects with MECP2 gene mutations. The investigator plans to conduct 2-3 dose groups.
- Trial name
- GITFPWRS (NCT06739434)
- Testing
- GCB-002
- Where
- China
- Volunteers
- 6 people
- Sponsor
- Genecombio Ltd.
End Stage Renal Disease on Dialysis
Effects of pHA Hemoperfusion Plus Hemodialysis on Protein-Bound Uremic Toxins
This single-center, prospective cohort Study evaluates whether adding the pHA130 hemoperfusion cartridge to conventional hemodialysis (HD) or hemodiafiltration (HDF) more effectively reduces protein-bound uremic…
- Trial name
- NCT07016841
- Testing
- pHA130 hemoperfusion device, HD/HDF, HA130 hemoperfusion device
- Where
- China
- Volunteers
- 109 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Autoimmune / Connective Tissue Diseases, Anti-Nuclear Antibody
Realistic in Generation of HEp-2 Cell Images Using Latent Diffusion Models: a Multi-center Visual Turing Test
The objective of this prospective observational study is to rigorously examine the feasibility and efficacy of utilizing latent diffusion models for data augmentation in anti-nuclear antibody (ANA) Hep-2 cell immunofluorescence…
- Conditions
- Autoimmune / Connective Tissue Diseases, Anti-Nuclear Antibody, Visual Turing Tests, Artifical Intelligence
- Trial name
- NCT06542783
- Testing
- referring to the results of AI model output
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Attention Deficit Hyperactivity Disorder (ADHD)
A Random Controlled Trial of Home-based Digital Therapy for Treating ADHD in Children
Explore the interventional effects of neurofeedback games on school-aged children with mild to moderate ADHD, with the aim of providing evidence-based new methods for intervening in the core symptoms of ADHD in children.
- Trial name
- NCT07552909
- Testing
- Home-based digital therapy with brain-controlled games
- Where
- China
- Volunteers
- 146 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Multiple System Atrophy
High-Altitude Neurodegeneration Cohort (HANC) Study
Chronic physiological hypoxia has been implicated in the pathogenesis of multiple system atrophy (MSA), a fatal neurodegenerative disorder of unknown etiology.
- Trial name
- HANC (NCT07657520)
- Testing
- No Intervention: Observational Cohort
- Where
- China
- Volunteers
- healthy volunteers welcome
- Sponsor
- West China Hospital
Chronic Pain
Mixed Reality-Based Rehabilitation Software for Chronic Secondary Musculoskeletal Pain
This study evaluated the efficacy and safety of a mixed reality-based chronic pain rehabilitation software (PK-MPT) for adults with chronic secondary musculoskeletal pain.
- Trial name
- NCT06936059
- Testing
- Mixed Reality based analgesic therapy
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Idiopathic Epiretinal Membrane
Macular Resurfacing Using Autologous ILM Patch Transposition for Idiopathic Epiretinal Membrane
Idiopathic epiretinal membrane is a condition in which abnormal tissue grows on the surface of the retina and can cause blurred vision and distortion.
- Trial name
- NCT07767539
- Testing
- Non-Inverted Autologous Internal Limiting Membrane (ILM) Patch Transposition, Conventional Epiretinal Membrane and Internal Limiting Membrane Peeling
- Volunteers
- 90 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Nephrotic Syndrome
Zuberitamab in the First Episode of Paediatric Nephrotic Syndrome
The goal of this clinical trial is to learn whether adding Zuberitamab to standard corticosteroid therapy can help prevent relapse in children and adolescents aged 1 to 18 years with newly diagnosed steroid-sensitive nephrotic…
- Trial name
- NCT07765914
- Testing
- Zuberitamab, standard corticosteroid treatment
- Where
- 9 sites in China
- Volunteers
- 120 people
- Sponsor
- Children's Hospital of Fudan University
Magnetic Resonance Imaging, Hysteroscopy
Hysteroscopic Evaluation and the Clinical Outcomes of Vaginal Repair of Cesarean Section Scar Defects
Cesarean section scar defects (CSDs) are one of the long-term complications following cesarean section. They can be detected by transvaginal sonography, hysterosalpingography, sonohysterography and magnetic resonance imaging…
- Trial name
- CSD (NCT05858931)
- Testing
- vaginal repair
- Where
- China
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Congenital Heart Disease, Bronchopneumonia
Research on Body Voice AI Recognition System for Children's Health Management
The purpose of this research is to develop a body voice artificial intelligence (AI) recognition device, also referred to as an AI-assisted body sound identification device, by utilizing a deep learning-based novel AI algorithm…
- Conditions
- Congenital Heart Disease, Bronchopneumonia, Abdominal Disease
- Trial name
- NCT06542120
- Testing
- Heart Auscultation and Echocardiography, Chest Auscultation and Chest imaging examinations, Abdominal Auscultation and Abdominal imaging examinations
- Where
- 5 sites in China
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Wilson Disease
An Exploratory Study to Evaluate the Tolerability and Safety of MWAV201 in Subjects With Wilson Disease
The primary objective of this study is to evaluate the tolerability and safety of MWAV201 in patients with Wilson disease.
- Trial name
- NCT06663878
- Testing
- MWAV201
- Where
- China
- Volunteers
- 9 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Constipation
Prebiotic Fructans Effect on 1-3 Years Constipated Children's Bowel Habits
The aim of the study is to confirm the effectiveness of chicory-derived prebiotic inulin-type fructans on bowel function in young children.
- Trial name
- CONSTICHILD (NCT03941925)
- Testing
- Prebiotic fructans, Non-prebiotic maltodextrin
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Idiopathic Scoliosis
Efficacy of a Three-dimensionally Corrective Exercise Therapy for Scoliosis
Idiopathic scoliosis (AIS) is one of the most prevalent spinal deformity that may progress sharply during growth. It is recommended that the physiotherapeutic scoliosis-specific exercises should be the first step to treat…
- Trial name
- NCT04539522
- Testing
- Three-dimensionally corrective exercise for scoliosis, Conventional exercise
- Where
- China
- Volunteers
- 104 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Steatohepatitis, Nonalcoholic, Nonalcoholic Fatty Liver
Digital Therapy for Fatty Liver Disease
This study is a randomised controlled trial of the clinical application of the Fatty Liver Data Analysis and Intervention System (FLDAS) to compare the effectiveness of traditional lifestyle interventions in patients with fatty…
- Trial name
- DTFLD (NCT07007741)
- Testing
- Software Group
- Where
- China
- Volunteers
- 141 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Chronic Liver Injury, Mindray Hepatus 9 Ultrasound Diagnostic System
Multicenter Clinical Study on Noninvasive Assessment of Hepatic Steatosis and Fibrosis Using Visual Transient Elastography
Using liver biopsy as the gold standard, this study will conduct visual transient elastography (ViTE) examinations using Mindray Hepatus 9 ultrasound diagnostic system in patients with liver injury to evaluate the diagnostic…
- Trial name
- NCT07128108
- Testing
- Visual Transient Elastography (ViTE) Examination
- Where
- China
- Volunteers
- 225 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine